difference between a research paper and an essay

Essay vs Research Paper: Key Disparities

Table of contents

• 1.1 What Is an Essay?
• 1.2 What Is a Research Paper?
• 2.1 Purpose and Objective
• 2.2 Structure and Organization
• 2.3 Length and Depth
• 2.4 Sources and Evidence
• 2.5 Voice and Style
• 2.6 Audience and Presentation
• 3 Essay vs Research Paper: 10 Points of Difference
• 4 What Is the Difference Between Research Paper and Different Types of Papers
• 5 Let’s Sum Up

Every student needs to write some academic papers for the university. However, even young people with experience can't determine the difference between an essay and a research paper. Although these two areas of academic writing have many similarities, the requirements are still significantly different.

• In this article, you will get a clear definition of an essay and research paper.
• We will outline the key differences between these two types of academic writing.
• You will learn more about the organization, structure, essay and research paper requirements.
• Finally, you will be able to tell the difference between a research paper and an essay.

To get to the heart of the matter of these two academic assignments, we should start by getting an essay vs research paper definition.

Definition and Overview

What is an essay.

An essay is a short piece of work, the purpose of which is to present individual thoughts regarding a chosen topic. Often, essays do not pretend to be scientific but require a defined structure. The basic requirements for an essay suggest writing a five-paragraph piece that contains an introduction, a body, and a conclusion.

What makes your essay unique is your creativity and the novelty of your ideas. To easily structure your thoughts and present them clearly to the reader, you should devote time to drafting an essay . Before you start writing your essay, brainstorm the freshest ideas. Thus, even though all your classmates will use the same five-paragraph structure as you, your ideas will impress the teacher. Experiment with meaning, not form.

What Is a Research Paper?

The difference between an essay and a research paper revolves around the academic approaches. Research work is the depth of study of a selected scientific topic, which should bring scientific novelty by drawing conclusions based on existing research and experiments conducted. For students, it’s not enough to state the facts or express their point of view regarding the topic. Your task is to comprehensively study the subject of research, familiarize yourself with existing opinions, and outline the direction of the upcoming study.

Your teacher will expect you to demonstrate analytical skills, the ability to select reliable sources, and a broad theoretical base on your research topic. Research papers require creativity, erudition, and orientation in the topic.

Key Differences Between Essay and Research Paper

The central difference is the goal of these academic assignments. The essay aims to express an individual point of view and find a creative, fresh approach to an existing topic. A good research paper seeks to introduce scientific novelty by examining existing data and conducting new experiments to analyze the information obtained.

Purpose and Objective

The first and main difference between an essay and a research paper is the purpose of writing . An essay as an academic task has the goal of developing students' creative thinking. It also teaches us a structured presentation of thoughts regarding a certain topic. The student is required to have a non-standard approach, fresh thoughts, and reasoned conclusions on the given topic.

The purpose of the research work is to study a scientific topic in detail. This academic assignment is aimed at assessing the student’s analytical abilities and competence to determine cause-and-effect relationships, filter sources, and formulate logical conclusions. Such work requires theoretical knowledge, preliminary study of existing scientific works, and the ability to formulate goals and research methods.

Moreover, a student is supposed to show the capacity to draw comprehensive conclusions based on available data and information obtained during independent research. This task may seem complicated to students, so they opt for resorting to the help of PapersOwl writing service to save time.

Structure and Organization

To start with, the basic structure of any college essay involves a text consisting of five paragraphs, divided into three main factions: introduction, body part, and conclusion. When students lack time to compose a nicely structured academic essay, they can always pay to write a research paper and have their tasks done by a professional. The introduction presents the topic, sets the main direction for further text, and also works as a bait to motivate the reader to study further work. The introduction is followed by three body paragraphs. Each of the three body paragraphs presents a separate idea.

The last paragraph of any essay is a conclusion. In this paragraph, the college or university student must resume the arguments and ideas presented in the text, summarizing them into the main message of the essay. Often, the idea that you present in your conclusions will be most memorable to the reader.

Consequently, let’s overview the structure of a research paper. Compared to the structure of an essay, the organization of a research paper is much more ornate. This type of work requires a title page and abstract that go before the main body of text. On the title page, the student describes his topic of work, as well as gives contact details. An abstract is a short description of the main ideas and research methods of your work. The research work itself consists of an introduction, background, main part, and conclusions. Also, at the very end, they often add acknowledgments and a list of references, which must be formatted following the required international format.

Length and Depth

The length and depth of analysis between these two academic assignments also differ significantly. As for the essay, it is often a short prose piece whose length does not exceed 1000 words. You are faced with the task of fitting a large array of ideas into a small amount of text. The essay format itself rarely requires rigorous and thorough research of the topic, but you should work on creativity and the presence of a message in your essay. Most academic papers fall in the 300 to 600-word range.

On the other hand, a research paper is a scientific project that includes many theoretical aspects that require analysis and clarification. Thus, the volume is significantly bigger. Basic research paper lengths range from 4,000 to 6,000 words. In this case, you will no doubt have to conduct a comprehensive analysis of the selected sources, formulate a research vector, and spend time conducting your experiments, or ask PapersOwl to do a research paper for you . A research paper is a scientific project that includes many theoretical aspects that require analysis and clarification.

Sources and Evidence

The presence of theoretical sources and references is not a mandatory requirement for an essay. You can state your own thoughts on a given topic without resorting to the help of existing sources. Present your ideas on the topic, giving arguments that seem logical to you. If you do decide to base your paper on existing works, you must be sure to indicate where the information was taken from. And yet, the teacher needs to see your own thoughts rather than a dry listing of existing ideas.

Unlike an essay, a quality research paper must include primary and secondary sources, as well as a specific citation format. Surely, you are not the first person to study this scientific topic. In order not to repeat existing thoughts, you need to conduct a search to form a reliable basis for your study. If you skip this step, you risk basing your paper on misleading scientific findings.

Voice and Style

The very specificity of the essay as an academic paper is the subjective presentation of information. A large percentage of your essay should consist of your perspective and vision of the chosen topic. For this reason, essays often use a less formal and more subjective tone. However, you can still use a large amount of colloquial vocabulary, completely disregarding the norms of formal style. Students often have trouble figuring out the right style for their university assignments. In such cases, a reasonable solution is to seek help from a specialist. When you buy custom-written essays from PapersOwl, you’ll always get a perfectly balanced academic paper.

On the other hand, a research paper is a serious scientific work. The student must maintain a formal tone while complying with all structural requirements. Also, in investigative work, there is little room for subjectivity and a personal approach since an objective style is required. At the same time, do not oversaturate your research work with formalism and standard clichés.

Audience and Presentation

The essay format can be used both in the educational process and in an independent literary style. Therefore, the audience for such a written assignment can be wide and varied. When you’re writing an essay, make sure it’s understandable in academia and for a wide audience.

Research work, on the contrary, is aimed at a range of professionals in the chosen field. Written in scientific language, the goal of this work is to attract the attention of scientists and students of certain majors. Your scientific work should be rich in theory and related terms.

Essay vs Research Paper: 10 Points of Difference

As you may have noticed, research papers and essays have many differences, both global and specific. These two types of academic assignments differ in the purpose of writing, have different structures and formats, and are aimed at testing different skills. And yet, every day, students face difficulties in understanding the basic requirements, which leads to incorrect execution of the task. To summarize the main differences, let's look at the table below.

What Is the Difference Between Research Paper and Different Types of Papers

There are many types of papers, each focusing on different topics, serving different purposes, and requiring a specific structure. Those are different types of essays that share a common ground but differ in the way they present information and arguments.

Analytical paper. The purpose of such an essay is an in-depth analysis of the chosen topic, studying different approaches and points of view, and formulating one’s own conclusions based on the information studied and scientific evidence.

Argumentative paper. This type of essay takes as a basis an ambiguous topic; the author must take a certain position and provide a number of arguments.

Informative paper. It has an informative purpose — a presentation of information to the reader, preceded by careful analysis and selection of data.

Persuasive paper . The purpose of this paper is to present convincing arguments, using chosen writing techniques, confirming the author’s position regarding the selected scientific topic.

To get a high grade, you need to understand the requirements of academic requirements. No matter how informatively rich your work is, if it does not meet the requirements, it cannot be highly appreciated. Each type of academic assignment has its own clearly defined, unique format. It’s necessary to know the difference between a research paper vs argumentative essay so as not to get confused while completing a college assignment. So before you start writing an assignment, make sure you understand the type of academic writing required of you.

Let’s Sum Up

Research papers and essays are aimed at testing various skills of the student, following different structures, and having several requirements. An essay is a more creative writing task, which involves showing originality and expressing a personal opinion on a certain topic. At the same time, a research paper is a type of scientific writing that adheres to a strict structure and uses a formal tone. Understanding the main differences will make your writing process easier, saving you time researching the requirements. Remember that knowing the essence of the assignment is a key factor in writing a decent paper.

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Research Papers Vs. Essays (Differences and Similarities)

In high school, college, university, and even professional life, you will write many assignments, including research papers and essays. In school, instructors and professors use essays and research papers to test your understanding of concepts taught in class. It is, therefore, imperative to know the difference between essays and research papers.

You came to the right place if you struggle to get the facts right about essays vs. research papers. This guide guides you through the similarities and differences between the two common papers written at all academic levels.

In a nutshell, research papers focus on facts to argue a point, while essays focus on an individual's understanding of a topic. Understanding the difference between these two pieces of writing will help you succeed in school.

With that said, here is an overview of essays and research papers.

What is an Essay?

An essay is a short piece of writing demonstrating your comprehension, critical thinking, analytical skills, creativity, and awareness of a given topic. The length of the essay will determine the citations it should have and how long it takes to write it. So for a 500 words essay, the instructor will require at least five verifiable sources. Since they are short in length, they usually have five paragraphs starting with an introduction, followed by the body, and then a conclusion.

The main objectives of an essay are to:

• Inform the reader by providing accurate and proven information about a particular topic
• Convince the audience of a specific headline using researched evidence
• Explain a topic by providing in-depth information with flowing content
• Entertain the readers through humor and other funny statements

Check out our comprehensive guide on how to write a good essay .

Format and Structure

The basic format of an essay is an introduction, body, and conclusion. You must fashion all the ideas- one at a time - in the order that makes sense. To successfully deliver the content to the readers, you must attend to their logic. You have to introduce the arguments, analyze all the data, provide counterarguments and conclude the topic.

You should consider every part of the essay answering basic questions the reader is probably asking. These questions are: what, how, why.

The "what" explains what evidence leads you to your thesis statement, and you must therefore examine all the evidence demonstrating the truth of your fact.

The "how" explains how other arguments can counter your thesis statements. In other words, how does another way of looking at things affect your claims?

The "why" shows why the readers should care about your statements and allows them to learn more about what you are saying in a larger context.

An essay follows different formats depending on the academic style of writing requested; it could be MLA, APA, or Chicago format. For example, the APA style is used in social and health sciences, MLA in liberal arts, Language, Literature, and humanities, and the Chicago style in literature, history, and arts.

However, the structure is as follows:

Introduction

The introduction paragraph sets the stage for what is to come. It has three main parts:

• Background information
• Thesis statement

The first sentence of the introduction should grab the reader's attention . Next, you should arouse curiosity through an eye-catching statement for the reader to continue reading the essay. You can achieve this by using a joke, statistics, or research findings.

Background Information

Give the readers the context of the essay by providing some background information depending on the essay's subject. Don't give too much information — mention just a few points you will divulge later in the text. Just make sure you save the evidence for the body of the essay. The length of this information will depend on the scope of your essay.

Thesis Statement

A thesis statement sums up the main ideas of your topic and helps control the essay's narrative. Therefore, the statement should state clearly the main idea you want readers to grasp.

Body (Arguments)

The body is the longest part of the essay, which is organized into different paragraphs. Each paragraph elaborates on one idea and contains between four to five sentences. Every paragraph contains three sections starting with the topic sentence, followed by a supporting sentence and a concluding sentence.

The topic sentence informs the reader about the paragraph, and the supporting sentence expounds on the central idea. And the concluding sentence summarizes what you have talked about.

The conclusion is the last paragraph of the essay. It aims to summarize the essay's main parts, show the essence of your argument, and leave the reader with a sense of closure.

When writing the conclusion paragraph of an essay , you should restate the thesis statement to remind the reader what you talked about, followed by a summary of your arguments and counterarguments. Finally, the last sentence of the paragraph should state your concluding thought.

Types of Essays

There are different types of essays, each with its own objectives. They include:

• Descriptive
• Argumentative

Narrative Essays

Narrative essays are mostly personal, and they tell a story. This essay is written from a first-person perspective.

Descriptive Essays

Descriptive essays describe something— object, person, place, emotion, or situation from your own perspective.

Expository Essays

Expository essays aim at explaining a topic with facts. This is where you analyze a given piece of information and explain in detail how you have reached your conclusion.

Argumentative Essay

An argumentative essay presents both sides of an argument to inform the reader. An instructor will give this type of essay to gauge your debating skills.

Persuasive Essay

The persuasive essay aims to convince the reader. The writing presents logical information with an emotional appeal to the reader to believe your point of view.

What is a Research Paper?

A research paper is academic writing that involves supportive evidence about a given topic. It provides a perspective on a given topic using various sources supported by qualitative and quantitative research methods.

Research papers are usually similar to essays, but they are much longer and involve in-depth research conducted independently. In addition, you must spend time investigating and evaluating multiple sources to offer an interpretation of a given text.

Since the main aim of a research paper is to develop a new argument, you must include a literature review. A literature review is a foundation and support for your research, and it is a survey of academic sources on a given topic that helps you identify theories, methods, and gaps in the existing research.

They are more formal as they involve rigorous and thorough research resulting in a central idea. Only when a paper meets this requirement will the instructor give a good grade. Their aim is to differentiate between opinions and facts, provide a detailed understanding of a given topic, and critique previously written work.

To effectively write a research paper, you must clearly define your research question. If your instructor has already assigned you a topic, there is no need. If not, try to choose an interesting research question.

Choose a research strategy by analyzing the materials you will use for your research. Then evaluate all the sources by focusing on their credibility and whether they support your research question.

Like essays, research papers also have paragraphs and follow the same academic writing formats, but their structure is much different. Their structure is as follows:

• Materials/methods

Acknowledgments

A title page contains all the vital information about the paper you are writing. The page is usually placed in front of the research paper. It contains your name, the name of the project, and your learning institution. Since it's the first page the reader will see, it should be well formatted. The title on the page should clearly display your thesis statement.

The abstract highlights the main points of your projects to help inform the readers what the paper is about. They are recorded along with keywords to help readers find your content more easily. The abstract should be clear and accurate.

An introduction part allows you to define the topic and establish your voice. The introduction should be interesting enough to get the reader hooked. It usually aims at:

• Presenting the problem statement, topic, and research investigation in the first part of the introduction
• Establish the aim and focus of your research in the second part
• Present the summary of your arguments in the third part

Research papers also have a thesis statement, like essays mostly found at the end of the introduction. It aims to explain what you are trying to prove and provide the main points in the research.

Materials/ Methods

The material/ methods section clearly defines what materials you used to perform your research. The aim is to direct readers to specialized materials, general procedures, and methods to weigh the value of your project. For example, these materials could be questionnaires that provide information about your paper. The materials should be specific and relevant to your field of study.

You should describe in detail how you conducted the analysis in their personal narrative and briefly list the methods used.

The results section is where you report what your findings are based on all the information you gathered with the materials you had. You should state the findings without biases or interpretation, allowing the reader to do that themselves. The findings should only be from your study, and they could be:

• Quantitative information - is data that can be measured and is presented in graphs, tables, or charts.
• Qualitative information - which is brief descriptions or explanations and is often presented as lists or essay like form

The discussion section shows the results and outcomes of your paper. It reviews and interprets the findings of the research and allows the readers to see the connection between all the parts of the paper. The discussion should include the following:

• Results you gathered from the research
• Discussion of related research
• Comparison between the research and your initial hypothesis

You must demonstrate your critical thinking skills when developing your arguments and establishing the relationship between each part the same way you would in an essay.

The conclusion section outlines why the research is important to the reader and why they should care. It summarizes all the parts mentioned in the paper and demonstrates the implications of your research. The writing should be on point to deliver your message to the readers.

The acknowledgment section appreciates all the contributors for their efforts in the research. You should mention all the contributors directly involved in your research. They could be:

• Funding Organization/ Donor
• Administrative personnel
• Your professors
• Work supervisors

The reference section is the last part of your research paper. This section shows that you have clearly and carefully conducted your research. It demonstrates that your work is credible, and readers can rely on it. You should list all the research material used. The average number of references in most research papers is 45.

Types of Research Papers

Like essays, there are different research papers, each requiring different preparation. These are argumentative and analytical research papers:

Argumentative Research Paper

When writing an argumentative research paper, you discuss your topic and then choose the stand you will be taking. The hope is to persuade the reader to take your stand.

Analytical Research Paper

You state your topic in an analytical research paper and take a neutral stance. You will then provide your arguments and facts, leaving the reader to choose their stance. The aim is not to persuade the reader but to present a well-supported analysis of a given topic.

Survey Research Paper

Survey research involves collecting data from a group of people through quantitative and qualitative research methods.

Experimental Research Paper

Based on experimental research or empirical research, this type of paper provides information about the procedures you have used in your research. It is mainly written as a scientific or empirical paper following the IMRAD format.

Definition Paper

In definition papers, you will describe an argument's facts without sharing personal emotions and only provide a list of facts without analyzing them.

What is the Aim of the Research Paper?

Learning how to write a research paper is to:

Provide Knowledge

Through research, you will gain new insights about a particular topic making you more knowledgeable.

Boost the Success, Not Business

The findings of a research paper will influence decision-makers to take positive action. For instance, if you wrote a paper about the importance of using laptops in schools, more laptops will be provided even to learners.

Enhance Public Awareness

By writing compelling research about a given headline and sharing it with the public, you give them an understanding of your ideas. Providing detailed and well-researched information will help the readers see the relevance of your conclusion.

What Are the Differences Between an Essay and a Research Paper?

After looking at each of them individually, what are the differences between them?

  They Have Different Purposes

Even though they are both academic writings, they have different purposes. When an instructor assigns you a research paper, they want to know your deep understanding of a given topic by sharing how you have come to that realization. In other words, it demonstrates your opinions and those of other scientists. On the other hand, an essay shows your opinion about something even though you will research your information, and your point of view about the topic should be unique.

  A Research Paper is More Formal

A research paper involves in-depth research from reputable sources, which you should prove in the form of references. On the other hand, an essay doesn't need in-depth research; it mainly relies on your thoughts and opinion. They are also not as complex as a research paper in terms of headings and subheadings.

  More Time and Effort Are Needed in Writing a Research Paper Than an Essay

A research paper is a long piece of academic writing that requires multiple sources and a deeper understanding of information to reach a conclusion. Since there is tons of information to find and go through, more time is taken to do the research.

So while an essay can be completed in a few hours, a research paper can take days or even weeks to complete.

  Differences in Length

Both essays and research papers are organized the same way. An essay has three parts: an introduction which includes a thesis statement, a body, and a supportive conclusion. You will need to hook your readers when writing the introduction for them to proceed with writing. The body usually has between four to five paragraphs which must be arranged systematically to make sense to the reader. Their word count ranges between 500 and 1000 words with about 5 citations.

Because research papers require in-depth research, they are much longer than essays and are usually referred to as multipage writing. A research paper typically has nine parts arranged in order with between 8 to 100 references. Regardless, both forms of academic writing follow the same organizational structure.

Here is a table that shows the similarities and differences between the two.

More differences and similarities between essays and research papers ( source )

Final Words

An essay and research paper are common types of academic writing assigned to high school, college, and university students. Essays are the shortest pieces of writing which show your understanding of a given topic during a research paper. The above difference will help you in your academic writing journey.

Life is full of demands, and you will juggle work, home duties, family responsibilities, and social life. When you add studies and writing papers to the packed schedule, you might break down mentally.

Do you need help with a research paper or an essay ? GradeCrest is the most preferred place for students and professionals who want their research papers done. We have expert paper writers who can handle papers on various topics and almost all subjects; no subject lacks an expert or is too hard to crack for us. You can order your essay or research paper by filling out the order form on our home page.

Gradecrest is a professional writing service that provides original model papers. We offer personalized services along with research materials for assistance purposes only. All the materials from our website should be used with proper references. See our Terms of Use Page for proper details.

Difference Between Research Paper and Essay

October 23, 2023

Description: Comparison of research papers vs. essays, along with the explanation of the differences and similarities between the two types of academic papers. A short guide to understanding essay writing and research writing with definitions of the terms “essay” and “research paper”.

How Does Research Paper Differ From Essay?

Students often have to deal with two different types of academic writing assignments: an essay and a research paper. Writing essays and research papers can be difficult and confusing due to the many similarities they have. To avoid confusion when writing either of these, it’s important to learn their differences. Understanding the differences between an essay and a research paper is also a great way to improve your academic writing skills. This article aims to help you understand the key differences between essay and research paper writing assignments when you come across them. We’ll study their features, look for relevant academic terminology, and learn what differentiates them. To get to the bottom of the difference between these two academic assignments, we should first define essay vs research paper.

What is an Essay?

An essay is a short piece of writing that aims to express personal views on a particular topic. It should have at least three pieces of evidence to back up the argument. Essays are typically shorter in length and less complex than research writing. At the same time, essay writing has its own specifics, so using expert proofreading services is a good idea if you aren’t confident in your skills. It’s likely that you’ll write your first essay and research paper when in high school or college. Then arises the question, “Who will write my paper for me ?” A good essay should always have a creative component, so having good writing skills is a must. Essays often aren’t as scientific as research papers, yet they nevertheless need a clear structure. The basic essay writing guidelines recommend following a five-paragraph structure with an introduction, a body, and a conclusion.

What is a Research Paper?

A research paper is the in-depth study of a chosen scientific topic that aims to generate new scientific findings based on previous studies and experiments. It isn’t enough for students to just state the facts or give their opinion on this topic. Your professor will evaluate your ability to think critically, choose trustworthy sources, and have a solid theoretical grounding in the topic of your research. Writing a research paper takes originality, knowledge, and subject matter expertise. Compared to traditional essay writing, research work has a different objective and structure. Research papers use data from primary sources like books on the topic, academic papers, interviews, web sources, and journals. The basic research writing guidelines recommend following this pattern: introduction, methods, results, discussion, and conclusions/recommendations. Research papers may also include acknowledgments, a brief biography of the author for some Master’s or Ph.D. works, references, endnotes, footnotes, and so on.

Key Differences Between Essay and Research Paper

The biggest difference between a research paper and an essay is that a research paper must have a strict methodology and set of study objectives. A research paper should outline a problem and the approaches that can be used to solve it effectively. Meanwhile, an essay can present a personal opinion without any references. Now let us go over other key differences between an essay and a research paper. The following comparison table outlines the key differences between essays and research papers:

Similarities Differences Between Essay and Research Paper

It makes sense that you could find it challenging to tell the difference between an essay and a research paper since there’re so many similarities between the two types of academic papers. That’s why it’s important to learn about the similarities of the two as well.

• Research: Basic research is still necessary in both. Even though you don’t need to do in-depth study for an essay, you still need to at least fact-check your information. However, for a research paper, you’ll need to cite more sources to demonstrate that you’re doing more than simply skimming the topic.
• Structure: The research paper has multiple paragraphs, much like an essay. Although the structure is a little different, the material presented in each paragraph should be in an easy-to-follow format to save the reader’s time from having to wade through irrelevant data and concepts. There should be an introduction, body paragraphs, and a conclusion in both types of papers. When you want to conduct research, there’re some differences, but there’re also a few similarities because you need to present the topic properly.
• Thesis statement: Both types of papers should have a thesis statement that presents an opinion, an argument, or a hypothesis. Even though it isn’t always required for an essay, adding a thesis statement will make your essay sound even more scientific.
• Format and Style: Your professor might recommend a specific format for your paper depending on the topic matter and the class itself. The liberal arts and humanities normally utilize the MLA and Chicago/Turabian formats, while the social sciences typically use the APA format. Both research papers and essays must follow specific formatting guidelines for headers, footers, in-text citations, reference pages, and other elements. These forms guarantee consistency and point readers to the relevant sources.

Research papers and essays are two different types of writing. We can draw the conclusion that the key differences between essays and research papers are those relating to purpose, structure, and format. Even though these two types of papers have many things in common, essays and research papers are written for different purposes. The requirements for a research paper are stricter because it must follow the right structure, format, and methodology. However, an essay is more forgiving because it has a descriptive narrative that allows the author to express their own opinions. Please be advised that the views, thoughts, and opinions expressed in this blog are solely that of the author or his/her sources and do not necessarily reflect those of English Forward. This includes, but is not limited to, third-party content contained on or accessible through the English Forward websites and web pages or sites displayed as search results or contained within a directory of links on the English Forward network.

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Home » Essay Vs Research Paper

Essay Vs Research Paper

Table of Contents

An essay and a research paper are two different types of academic writing assignments that students are often required to complete during their academic careers.

An Essay is a piece of academic writing that typically presents the author’s personal opinion or interpretation on a particular topic. It is a relatively short piece of writing that may be persuasive, descriptive, or informative in nature. Essays may be assigned to students as homework, in-class assignments, or as part of an exam.

Research Paper

A Research Paper , on the other hand, is a type of academic writing that involves conducting research on a particular topic, analyzing and interpreting the findings, and presenting the results in a written format. Research papers are usually longer and more complex than essays, and require a more extensive analysis of the topic. Research papers are often assigned to students as part of a course, such as a research methods course or a capstone project.

Difference Between Essay and Research Paper

Here’s a comparison table that highlights the differences between essays and research papers:

Also see Research Methods

About the author

Muhammad Hassan

Researcher, Academic Writer, Web developer

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Essay vs Research Paper: What are the Differences?

by  Antony W

September 10, 2021

This is the most comprehensive guide on essay vs research paper . 

We’ll look at the differences and similarities between the two papers so that you can approach either assignment with clarity and certainty.

To begin with, essays and research paper examine your research, writing and analytical skills. They also require adherence to strict formatting and the inclusion of citation and bibliography.

What’s an Essay?

An essay is a written academic assignment that requires you to look into an issue and then provide your personal opinion while using credible sources and verifiable evidence to support your work.

In addition to knowing the different types of essays , you need to have excellent research and writing skills to write great essays   that earn full marks.

The length of an essay varies from topic to topic. A shorter essay is about 500 words   and longer ones can go up to 4,000 words . 

Shorter essays don’t require extended research and you can therefore write them in one sitting.

Longer essays, on the other hand, demand in-depth research and attention to details. They can be quite time consuming to write and edit, which part of the reasons why students seek for writing help. 

So if you have a longer essay to complete within a short deadline, check our essay writing service   and let us help you get the essay completed in time.

What Essays Do Students Write in School? 

The following are some of the most common essays that you’ll write in high school, college, or university.

1. Descriptive Essays

If asked to write a descriptive essay, focus on explaining the characteristics of a subject or issue.

Descriptive essays require some literary devices ,  such as similes and metaphors, to read well and communicate your message. You can check our guide on how to write description essays . 

2. Comparison Essays

In a compare and contrast essay ,  you have to explain the differences and similarities between two subject. You can organize your writing based either on individual points or on the subjects.

3. Analytical Essays

Analytical essays don’t just appear in academic journals, newspapers, and magazines. They’re also common in academic settings.

In analytical essay writing ,  your work is to provide a substantive analysis of the topic without being biased.

3. Reflective Essays

In reflective essay writing ,  students have to examine experiences and explore the changes, challenges, developments, and growth that those experiences bring.

The standard format for a reflective essay is the same for all, but the format may change a little depending on the audience.

4. Argumentative Essays 

In argumentative essay writing ,  you have to take a stance on an issue and use objective evidence to support your position.

Check out our argumentative essay hub here   to learn more. 

5. Academic Essays 

Written at college and university levels, academic essay cover content in your coursework to gauge your writing skills and intelligence’s level.

These essays tend to be longer with the word count ranging between 3,000 and 5,000 words.

What’s a Research Paper?

A research paper   is an academic assignment that requires students to express their views on a subject using supportive sources such as books and journal articles.

They’re longer than typical essays and therefore take more time to research, write, and proofread.

In the case where you have more demanding assignments and a research paper waiting for you to complete, you can take advantage of our research paper writing service to get the project done in time.

Types of Research Papers

The following are the common types of research papers that you’ll write in college or university:

1. Analytical Research Paper

With this type of research paper, you choose a topic, collect information from credible sources, and use the data to draw your conclusion on the subject.

Maintain a neutral position when writing an analytical research paper.

2. Argumentative Research Paper

In argumentative research paper, you look into two controversial issues in the same document.

While you’ll look into both sides of the argument, you’ll have to take a side and use information from different reliable sources to persuade reader to take your side.

3. Experimental Research

Experimental research papers are practical in form. Your instructor expects you to describe procedures you used in your experiment, accompanied by in-depth data analysis and a written report.

4. Survey Research Paper

With survey research papers, you have to collect information from as many respondents as you can find. Then, you have to analyze the information and write a final report.

In this section, we’ll look at the differences between essays and research papers to give you more insight.

Differences in Writing

Since the primary objective of a research paper is to present a deeper knowledge of the subject, you have to do extensive research from different sources. 

You also have to do a deep data analysis before writing so you can make a concrete conclusion. 

Moreover, you have to be very conversant with the primary sources   on the subject to write a good research paper.  

With an essay, your goal is to show your teacher that you have good research and writing skills and can articulate your ideas in a way that shows your understanding of the given topic.

As such, essays won’t require deep research. In essay writing,   you don’t necessarily have to be familiar with the main sources on a given subject although it’s important to.

Differences in Outline and Length

An essay has three parts: an introduction, the main body, and a conclusion. The body section has at least 3 paragraphs, but there can be more depending on the subject, research, and the number of ideas you’d like to present.

A research paper has more sections. Your work needs to feature a title page, an abstract (summary of the research), the main body (divided into sections such as methodology and results), a conclusion, references, acknowledgements, and references.

An essay can be as short as one page, especially if it’s on a topic that doesn’t require extensive research. In some cases, you may have to make your essay longer .  So check the prompt to know how long your instructor expects you to make the essay.

On the other hand, a research paper is longer than a typical essay’s length and can span up to 8 pages or more.

Differences in Presentation

In essay writing,   students present their personal views on a given issue or subject and use reliable academic sources to support their opinions.

In research paper writing, you have to present other scientists and researchers’ point of views of a subject and also add your opinion as a writer. Therefore, you must not only logically organize your ideas but also formulate them academically.

About the author 

Antony W is a professional writer and coach at Help for Assessment. He spends countless hours every day researching and writing great content filled with expert advice on how to write engaging essays, research papers, and assignments.

Essay vs. Research Paper: What’s the difference?

Is there actually a difference between a research paper and an essay? For some people, these two terms have so many similarities that they use them interchangeably. However, there are quite a few major differences that must be clarified. Let’s compare the key purpose of research papers and essays, their structure, and writing style.

The definition of essay and research paper

An essay is a creative but short composition on a variety of given topics. Its main purpose is to reveal the proposed topic by bringing a number of arguments written in the form of abstracts supported by personal experience and all sorts of examples.

A research paper is a report on the topic chosen by the author or a description of the content of any article, book, or other scientific work. That is, it’s an author’s research that reveals the essence of a given topic, gives different opinions on the researched issue or problem, reflects on it, and represents the author’s findings and ways to solve the problem.

The key purpose

A research paper is based on an analysis of certain literature sources that the writer used when studying the topic. It consists of the facts indicated in the source. While working on it, the writer cannot make up his or her own facts or distort information from the source with his or her own opinion. The key word in this type of work is “information,” and it can’t be taken from personal experience. It’s collected from all kinds of sources: encyclopedic and educational literature, the Internet, magazines, and so on.

Writing an essay, the author strives to show her or his own attitude towards the problem, argue his/her position, and make the reader believe that this position is right. In this case, there are no restrictions for the writer. After all, the main purpose of the author is to express the attitude to the topic and his or her opinion, not being afraid that someone will doubt it.

Differences in writing style

The essay’s arbitrary composition allows the author to use different techniques to enhance the impact on the reader’s perception, like inversions, antithesis, irony, and other kinds of allegory. Its writing style encourages the author to use assumptions, rhetorical questions, and phraseological units. They add stylistic expressiveness to the text.

The research paper, on the other hand, must have a more restricted structure, with academic style of writing prevailing. The author must follow the formal tone of his or her work, carefully choosing each word to suit the topic. It’s the formal nature of the work that puts certain restrictions on using the same units of speech that are considered acceptable when writing an essay. Instead of convincing the reader, the author needs to answer all the questions raised in the paper.

Structural features

The research paper should meet certain stylistic and structural standards. Its obligatory components include an introduction, main part, methodology, findings, and conclusion. The introductory part contains a reference to the sources used in a paper indicating the name of the authors and the date and place of publication. It’s also here that the writer describes the relevance of the topic. Then the writer specifies ways of structuring the work and explains research methods. In the main part, the author sets out the essence of the problem. In the last two parts, the writer lists the results of the analysis and the options for their application.

The structure of the essay consists of an introduction with explanation of the topic’s relevance, the main part of the work, and the conclusion. Due to the content and form, it has many similarities with a composition, but the author faces a more complicated task: he or she must encourage the reader to reflect on the topic using persuasiveness and writing skills and evoke an emotional response.

These differences should be enough for you to understand why an essay and a research paper are not the same things. Still can’t write a single page? Save your precious time for something that really matters – buying research paper and let our creative team handle it for you!

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Differences Between an Essay and a Research Paper

The majority of college students will easily identify an essay by stating that it is always shorter and does not contain those complex analytical elements that are always typical for an average research paper. While it’s true to some extent, the core difference with essay writing is that you have to make your opinion and thoughts clear by supporting it with some evidence . Now the research paper will require not only your opinion but the ideas and thoughts of other people. You must present a clever synthesis of the information to show that you have done your research correctly. Without a doubt, the length will also play an important matter, but will not always be the same for every task!

• 1.1 Personal Opinion vs Data Synthesis.
• 1.2 Length And Structure.
• 1.3 The Presence of Methodology.
• 1.4 Comparison & Presentation.
• 2 The Different Types of Essay Writing & Research

The Main Differences Between an Essay & Research Paper

Personal Opinion vs Data Synthesis.

Every research paper will require a synthesis of available information and analysis while an essay can focus on what you think over some event, attitude, or subject. It is more personalized in terms of writing. It can take narrative forms while research papers will always remain within argumentative and analytical forms. If you have to research, you turn to more than one opinion! Essay writing provides more freedom to represent your thoughts as you show your writing skills.

Length And Structure.

The research paper will often be longer since it contains an abstract, an extended bibliography, the objectives of your research, the outcomes, samples, and many other scientific paragraphs. It’s what makes it longer. A classic college essay will have an introduction with a thesis, three body paragraphs, and a conclusion. If it sounds confusing, consider getting cheap essay help and ensure that you share your requirements to avoid confusion. It’s essential to meet the word count and follow the structure with either task!

The Presence of Methodology.

A good research paper always implements a certain methodology or the way how you would like to achieve your scientific objectives. It can be quantitative (numeric data and variables), qualitative (sorted by category), or a mixture of both.

Comparison & Presentation.

Another important difference between essays and research papers is the use of comparison methods and the way how information is being presented. While an essay will revolve around a certain opinion and focus on structure and writing skills, a good research paper compares and analyzes different opinions. A research paper must be written according to a clear structure. If you write a perfect essay , you can have some variations, depending on your creativity, yet research paper writing will always stick to strict rules.

The Different Types of Essay Writing & Research

Remember that there are different purposes and types of research papers, which is also true for most college essays. In the majority of cases, your research paper will be subject-based with deep exposure to a certain topic with the statement of opinions and your analysis. Dealing with an essay, you can write a narrative or philosophical essay among other things where the purpose is to show your writing skills and an ability to summarize, analyze, and clarify what has been chosen in your opinion. It does not mean that essay writing is always easier, yet when you are dealing with an essay, there is more freedom to state your opinion and work depending on what essay type has been requested.

• Robertson Library

What is the difference between a paper and an essay?

Usually, nothing!

Papers and essays are the same thing. A research paper is a paper or essay that uses information from other sources, such as books and articles.

A paper or essay might also be referred to as an assignment . An assignment is any work you need to do for a course. 

Instructors often use project to describe large assignments. Some projects include writing a paper.

If you are unsure of your assignment or paper requirements, ask your instructor. They are the ones who will be marking your work, so they will know what is needed for a good grade.

If you want to know more about how to write a research paper, you should make an appointment at the Writing Centre .

The Difference between an Essay and a Research Paper

If you don't know the difference between an essay and a research paper, you are not alone. The descriptions of the two types of writing are similar, but there are key differences. Most importantly, the difference is the work involved. If you're preparing to write your first research paper, get comfortable. It's going to take time and a lot of study.

For an essay, the most important viewpoint on the topic being written about is the writer's. After an essay writer does some research on their topic, they will develop a thesis statement and write body paragraphs with topic sentences that relate back to the thesis statement in order to develop their argument. An essay ends with a conclusion that summarizes the writer's point of view on the topic.

For a research paper, the most important viewpoint is that of others who have written on the topic. A research paper presents all the findings and conclusions other researchers have drawn.

The average essay will include approximately five paragraphs: an introduction, three body paragraphs, and a conclusion.

A research paper can get quite lengthy. Unless the topic being discussed is very new and there hasn't been a lot of prior research by other scholars, presenting all of the other conclusions reached on the topic may require many pages of writing.

Doing research for an essay is important and finding outside sources to support your argument may take some time, but research for a good research paper should be comprehensive. In other words, you'll need to know what every other scholar has argued about your topic in order to fully complete a research paper.

Essays have four basic types and structures: expository (presenting the information), descriptive (painting a picture for a reader using words), persuasive (arguing your point of view), and narrative (telling a story).

Research papers come in many different forms, but the most common are compare and contrast, argumentative, analytical, cause and effect, and interpretive. While a persuasive essay and an argumentative research paper use similar tones, a research paper must include as many of the existing arguments as possible for the writer's conclusion to be considered soundly formed.

No matter which type of writing you'll do, it's important to pick a topic that interests you. After all, you're going to be doing a lot of reading and writing about it. You'll just do a lot more reading and writing with a research paper than you will with an essay.

Reference management. Clean and simple.

Types of research papers

Analytical research paper

Argumentative or persuasive paper, definition paper, compare and contrast paper, cause and effect paper, interpretative paper, experimental research paper, survey research paper, frequently asked questions about the different types of research papers, related articles.

There are multiple different types of research papers. It is important to know which type of research paper is required for your assignment, as each type of research paper requires different preparation. Below is a list of the most common types of research papers.

➡️ Read more:  What is a research paper?

In an analytical research paper you:

• pose a question
• collect relevant data from other researchers
• analyze their different viewpoints

You focus on the findings and conclusions of other researchers and then make a personal conclusion about the topic. It is important to stay neutral and not show your own negative or positive position on the matter.

The argumentative paper presents two sides of a controversial issue in one paper. It is aimed at getting the reader on the side of your point of view.

You should include and cite findings and arguments of different researchers on both sides of the issue, but then favor one side over the other and try to persuade the reader of your side. Your arguments should not be too emotional though, they still need to be supported with logical facts and statistical data.

Tip: Avoid expressing too much emotion in a persuasive paper.

The definition paper solely describes facts or objective arguments without using any personal emotion or opinion of the author. Its only purpose is to provide information. You should include facts from a variety of sources, but leave those facts unanalyzed.

Compare and contrast papers are used to analyze the difference between two:

Make sure to sufficiently describe both sides in the paper, and then move on to comparing and contrasting both thesis and supporting one.

Cause and effect papers are usually the first types of research papers that high school and college students write. They trace probable or expected results from a specific action and answer the main questions "Why?" and "What?", which reflect effects and causes.

In business and education fields, cause and effect papers will help trace a range of results that could arise from a particular action or situation.

An interpretative paper requires you to use knowledge that you have gained from a particular case study, for example a legal situation in law studies. You need to write the paper based on an established theoretical framework and use valid supporting data to back up your statement and conclusion.

This type of research paper basically describes a particular experiment in detail. It is common in fields like:

Experiments are aimed to explain a certain outcome or phenomenon with certain actions. You need to describe your experiment with supporting data and then analyze it sufficiently.

This research paper demands the conduction of a survey that includes asking questions to respondents. The conductor of the survey then collects all the information from the survey and analyzes it to present it in the research paper.

➡️ Ready to start your research paper? Take a look at our guide on how to start a research paper .

In an analytical research paper, you pose a question and then collect relevant data from other researchers to analyze their different viewpoints. You focus on the findings and conclusions of other researchers and then make a personal conclusion about the topic.

The definition paper solely describes facts or objective arguments without using any personal emotion or opinion of the author. Its only purpose is to provide information.

Cause and effect papers are usually the first types of research papers that high school and college students are confronted with. The answer questions like "Why?" and "What?", which reflect effects and causes. In business and education fields, cause and effect papers will help trace a range of results that could arise from a particular action or situation.

This type of research paper describes a particular experiment in detail. It is common in fields like biology, chemistry or physics. Experiments are aimed to explain a certain outcome or phenomenon with certain actions.

Difference Between an Essay & a Paper

Jennifer brozak.

Whether you’re in middle school, high school or toiling away at college, paper writing is a fundamental facet of schooling. While essays and other forms of creative writing are common in English classes, you’ll also need to understand how to write informative pieces, such as research or term papers. By understanding the difference between the various types of writing styles, you’ll be able to draft compelling prose that is appropriate for any given assignment.

Explore this article

• What Is an Essay?
• What Is a Research Paper?
• What Is the Difference Between a Research Paper and Term Paper?
• Avoid Getting a Free Essay Writer

1 What Is an Essay?

One of the most common forms of writing is the essay. Starting in your later elementary school years and into middle school, you’ll likely be exposed to the five-paragraph essay, which is a fundamental starting point for creating longer-length writing assignments as you move upward through the higher grades. While they’re typically shorter pieces of writing (often under 1,000 words), they allow teachers to evaluate students on different writing, reading and analysis skills, including the art of persuasion and exposition.

Essays can take on many forms: They can be narrative, or tell a story; expository, or require investigation and evidential support; descriptive, in which a student is required to describe, creatively, a person, place or object; and finally, persuasive, in which a student is asked to argue a specific position on a particular topic.

As a whole, paper essay writing typically allows for more creativity than more formal writing styles, such as research papers.

2 What Is a Research Paper?

The phrase “research paper” can conjure anxiety in even the most adequate student writers. However, this need not be the case. In fact, it’s helpful to think of a research paper as an inflated essay. The structure will basically be the same, but you’ll need a thesis statement (which is not required in some forms of essay writing), significant research and evidence to support your ideas. You’ll also be required to include several credible sources in your paper, which will be listed on a reference page. And consider this: If you choose a subject you’re interested in researching, writing an informative paper can actually be quite a rewarding experience.

3 What Is the Difference Between a Research Paper and Term Paper?

Teachers, especially college professors, sometimes refer to longer research papers as “term papers,” which are similar in their structure and format. They’re expanded essays that will require evidence and credible sources to support your ideas. The difference lies in the subject matter. Research papers may allow you to cover a topic outside of the general subject matter (such as writing a persuasive research paper about global warming in an English class), while term papers will focus solely on the subject matter discussed in the course. High-quality research and term paper examples can be found on numerous sites, such as the Purdue University Online Writing Lab.

4 Avoid Getting a Free Essay Writer

A note of caution about submitting any writing assignment: While the Internet abounds with sources to help you in your quest to write the perfect paper, avoid using “essay generators” or hiring a free essay writer or buying papers from a database. Even if you’re procrastinating and panicking about finishing your assignment, it’s always better to turn in your own work. Not only do many teachers utilize online plagiarism checkers, but they also learn to recognize a student’s specific writing style over the course of an academic year. While it’s perfectly fine to use a term paper example as a guideline, it’s always better to submit your own paper or essay with minor errors than to attempt to pass off someone else’s writing as your own.

• 1 SUNY Empire State College: Research Writing: Elements and Steps
• 2 Enago Academy: How to Avoid Plagiarism in Research Papers (Part1 )

About the Author

Jennifer Brozak earned her state teaching certificate in Secondary English and Communications from St. Vincent College in Latrobe, Pa., and her bachelor's degree in journalism from the University of Pittsburgh. A former high school English teacher, Jennifer enjoys writing articles about parenting and education and has contributed to Reader's Digest, Mamapedia, Shmoop and more.

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How to Write a High-Quality Conference Paper

Presenting and submitting conference papers at seminars and academic conferences is a crucial part of academic life, especially for early-career researchers. These events offer attending scholars and researchers a great opportunity to meet and exchange ideas and perspectives on their work. Therefore, when organizers issue a call for submission of conference papers, researchers must try to participate by submitting their papers. When published, these conference proceedings go on to serve as essential academic and research resources for students and early-career researchers.   

Table of Contents

• Why are conference papers important?  
• Difference between conference papers and journal papers  

Research methodology

Findings/ results.

• Writing a high-quality conference paper  

Why are conference papers important?

Conferences offer an excellent opportunity for researchers to share their work with wider audiences through conference papers, receive feedback, and network with other researchers. They also serve as a stepping stone to publishing in peer-reviewed journals, as they allow researchers to refine their ideas and receive insights from peers and mentors before submitting a manuscript for publication. Additionally, presenting research at conferences can not only help establish one’s credibility and reputation as a thought leader in a particular field. Still, it can also lead to new collaborations, exciting research opportunities, and even job offers or promotions.  

Difference between conference papers and journal papers

Compared to journal papers, conference papers are usually short and aim to present initial findings and analysis of ongoing research. Journal papers, on the other hand, tend to be longer and more detailed and are screened through a peer-review process. Depending on the type of presentation that you are going to give at the conference or depending on your specific role, conference papers can be customized as respondent (speaker and respondent roll out presentations), panel (a few speakers speak for a designated period with a discussant), poster (visual presentation), roundtable (few speakers speak with time limits) and workshops (scope for a detailed presentation).   

Tips on writing a conference paper

Writing an impactful conference paper requires a careful blend of good research and clarity in writing. To be accepted on submission, researchers must ensure that they follow the specific guidelines laid out by organizers. A typical conference paper usually begins with a title page, followed by the abstract, an examination of the research problem, the methodology followed and the principal conclusions. It must include the following elements:  

This page should provide the title of the conference paper, your name and credentials, the institution you are working with, and the date of submission. It must also succinctly convey the crux of your research study.  

An essential component of the conference paper, this section must provide a brief synopsis that includes the aims and objectives of your study, methodology, research findings and principal conclusions. Ensure that the length of the abstract is in accordance with the guidelines provided by the conference committee.  

This section is important for conference organizers to assess your paper, and therefore, it must be presented clearly, concisely, and accurately.  

The main findings should be clearly stated, drawing on evidence-based conclusions. Tables and figures are recommended as they help convey complex data more effectively.   

Ensure that you accurately list references to the work you have cited. Most conference organizers have specific formats for citations and references, so do check before submitting your conference paper.  

Writing a high-quality conference paper

• Focus on the audience profile: When writing a conference paper, it is essential to keep the audience in mind. This will help you write your paper in a more engaging and impactful way. Experts suggest keeping in mind both the broader research questions that are sought to be addressed in the conference and the fundamental issues in the primary or related field of study – this will go a long way in helping you link your research to these aspects and consequently, enable you to connect more effectively with audiences.  
• Keep your writing structured and organized. It is essential to organize conference papers logically and convincingly. Focus on the key aspects of your study, and provide solid examples and illustrations to strengthen your argument and make it more attractive to those present.  
• Reading aloud : Experts suggest reading your conference paper aloud several times. This technique helps you identify possible errors in language and grammar and brings clarity to your ideas and presentation.  
• Conference guidelines: It is important to ensure that you follow the guidelines, structure, format, and length requested by conference organizers. This helps ensure that your conference paper is accepted upon submission without too many changes and alterations. 

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Cultural Relativity and Acceptance of Embryonic Stem Cell Research

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Main Article Content

There is a debate about the ethical implications of using human embryos in stem cell research, which can be influenced by cultural, moral, and social values. This paper argues for an adaptable framework to accommodate diverse cultural and religious perspectives. By using an adaptive ethics model, research protections can reflect various populations and foster growth in stem cell research possibilities.

INTRODUCTION

Stem cell research combines biology, medicine, and technology, promising to alter health care and the understanding of human development. Yet, ethical contention exists because of individuals’ perceptions of using human embryos based on their various cultural, moral, and social values. While these disagreements concerning policy, use, and general acceptance have prompted the development of an international ethics policy, such a uniform approach can overlook the nuanced ethical landscapes between cultures. With diverse viewpoints in public health, a single global policy, especially one reflecting Western ethics or the ethics prevalent in high-income countries, is impractical. This paper argues for a culturally sensitive, adaptable framework for the use of embryonic stem cells. Stem cell policy should accommodate varying ethical viewpoints and promote an effective global dialogue. With an extension of an ethics model that can adapt to various cultures, we recommend localized guidelines that reflect the moral views of the people those guidelines serve.

Stem cells, characterized by their unique ability to differentiate into various cell types, enable the repair or replacement of damaged tissues. Two primary types of stem cells are somatic stem cells (adult stem cells) and embryonic stem cells. Adult stem cells exist in developed tissues and maintain the body’s repair processes. [1] Embryonic stem cells (ESC) are remarkably pluripotent or versatile, making them valuable in research. [2] However, the use of ESCs has sparked ethics debates. Considering the potential of embryonic stem cells, research guidelines are essential. The International Society for Stem Cell Research (ISSCR) provides international stem cell research guidelines. They call for “public conversations touching on the scientific significance as well as the societal and ethical issues raised by ESC research.” [3] The ISSCR also publishes updates about culturing human embryos 14 days post fertilization, suggesting local policies and regulations should continue to evolve as ESC research develops. [4]  Like the ISSCR, which calls for local law and policy to adapt to developing stem cell research given cultural acceptance, this paper highlights the importance of local social factors such as religion and culture.

I.     Global Cultural Perspective of Embryonic Stem Cells

Views on ESCs vary throughout the world. Some countries readily embrace stem cell research and therapies, while others have stricter regulations due to ethical concerns surrounding embryonic stem cells and when an embryo becomes entitled to moral consideration. The philosophical issue of when the “someone” begins to be a human after fertilization, in the morally relevant sense, [5] impacts when an embryo becomes not just worthy of protection but morally entitled to it. The process of creating embryonic stem cell lines involves the destruction of the embryos for research. [6] Consequently, global engagement in ESC research depends on social-cultural acceptability.

a.     US and Rights-Based Cultures

In the United States, attitudes toward stem cell therapies are diverse. The ethics and social approaches, which value individualism, [7] trigger debates regarding the destruction of human embryos, creating a complex regulatory environment. For example, the 1996 Dickey-Wicker Amendment prohibited federal funding for the creation of embryos for research and the destruction of embryos for “more than allowed for research on fetuses in utero.” [8] Following suit, in 2001, the Bush Administration heavily restricted stem cell lines for research. However, the Stem Cell Research Enhancement Act of 2005 was proposed to help develop ESC research but was ultimately vetoed. [9] Under the Obama administration, in 2009, an executive order lifted restrictions allowing for more development in this field. [10] The flux of research capacity and funding parallels the different cultural perceptions of human dignity of the embryo and how it is socially presented within the country’s research culture. [11]

b.     Ubuntu and Collective Cultures

African bioethics differs from Western individualism because of the different traditions and values. African traditions, as described by individuals from South Africa and supported by some studies in other African countries, including Ghana and Kenya, follow the African moral philosophies of Ubuntu or Botho and Ukama , which “advocates for a form of wholeness that comes through one’s relationship and connectedness with other people in the society,” [12] making autonomy a socially collective concept. In this context, for the community to act autonomously, individuals would come together to decide what is best for the collective. Thus, stem cell research would require examining the value of the research to society as a whole and the use of the embryos as a collective societal resource. If society views the source as part of the collective whole, and opposes using stem cells, compromising the cultural values to pursue research may cause social detachment and stunt research growth. [13] Based on local culture and moral philosophy, the permissibility of stem cell research depends on how embryo, stem cell, and cell line therapies relate to the community as a whole. Ubuntu is the expression of humanness, with the person’s identity drawn from the “’I am because we are’” value. [14] The decision in a collectivistic culture becomes one born of cultural context, and individual decisions give deference to others in the society.

Consent differs in cultures where thought and moral philosophy are based on a collective paradigm. So, applying Western bioethical concepts is unrealistic. For one, Africa is a diverse continent with many countries with different belief systems, access to health care, and reliance on traditional or Western medicines. Where traditional medicine is the primary treatment, the “’restrictive focus on biomedically-related bioethics’” [is] problematic in African contexts because it neglects bioethical issues raised by traditional systems.” [15] No single approach applies in all areas or contexts. Rather than evaluating the permissibility of ESC research according to Western concepts such as the four principles approach, different ethics approaches should prevail.

Another consideration is the socio-economic standing of countries. In parts of South Africa, researchers have not focused heavily on contributing to the stem cell discourse, either because it is not considered health care or a health science priority or because resources are unavailable. [16] Each country’s priorities differ given different social, political, and economic factors. In South Africa, for instance, areas such as maternal mortality, non-communicable diseases, telemedicine, and the strength of health systems need improvement and require more focus [17] Stem cell research could benefit the population, but it also could divert resources from basic medical care. Researchers in South Africa adhere to the National Health Act and Medicines Control Act in South Africa and international guidelines; however, the Act is not strictly enforced, and there is no clear legislation for research conduct or ethical guidelines. [18]

Some parts of Africa condemn stem cell research. For example, 98.2 percent of the Tunisian population is Muslim. [19] Tunisia does not permit stem cell research because of moral conflict with a Fatwa. Religion heavily saturates the regulation and direction of research. [20] Stem cell use became permissible for reproductive purposes only recently, with tight restrictions preventing cells from being used in any research other than procedures concerning ART/IVF.  Their use is conditioned on consent, and available only to married couples. [21] The community's receptiveness to stem cell research depends on including communitarian African ethics.

c.     Asia

Some Asian countries also have a collective model of ethics and decision making. [22] In China, the ethics model promotes a sincere respect for life or human dignity, [23] based on protective medicine. This model, influenced by Traditional Chinese Medicine (TCM), [24] recognizes Qi as the vital energy delivered via the meridians of the body; it connects illness to body systems, the body’s entire constitution, and the universe for a holistic bond of nature, health, and quality of life. [25] Following a protective ethics model, and traditional customs of wholeness, investment in stem cell research is heavily desired for its applications in regenerative therapies, disease modeling, and protective medicines. In a survey of medical students and healthcare practitioners, 30.8 percent considered stem cell research morally unacceptable while 63.5 percent accepted medical research using human embryonic stem cells. Of these individuals, 89.9 percent supported increased funding for stem cell research. [26] The scientific community might not reflect the overall population. From 1997 to 2019, China spent a total of $576 million (USD) on stem cell research at 8,050 stem cell programs, increased published presence from 0.6 percent to 14.01 percent of total global stem cell publications as of 2014, and made significant strides in cell-based therapies for various medical conditions. [27] However, while China has made substantial investments in stem cell research and achieved notable progress in clinical applications, concerns linger regarding ethical oversight and transparency. [28] For example, the China Biosecurity Law, promoted by the National Health Commission and China Hospital Association, attempted to mitigate risks by introducing an institutional review board (IRB) in the regulatory bodies. 5800 IRBs registered with the Chinese Clinical Trial Registry since 2021. [29] However, issues still need to be addressed in implementing effective IRB review and approval procedures.

The substantial government funding and focus on scientific advancement have sometimes overshadowed considerations of regional cultures, ethnic minorities, and individual perspectives, particularly evident during the one-child policy era. As government policy adapts to promote public stability, such as the change from the one-child to the two-child policy, [30] research ethics should also adapt to ensure respect for the values of its represented peoples.

Japan is also relatively supportive of stem cell research and therapies. Japan has a more transparent regulatory framework, allowing for faster approval of regenerative medicine products, which has led to several advanced clinical trials and therapies. [31] South Korea is also actively engaged in stem cell research and has a history of breakthroughs in cloning and embryonic stem cells. [32] However, the field is controversial, and there are issues of scientific integrity. For example, the Korean FDA fast-tracked products for approval, [33] and in another instance, the oocyte source was unclear and possibly violated ethical standards. [34] Trust is important in research, as it builds collaborative foundations between colleagues, trial participant comfort, open-mindedness for complicated and sensitive discussions, and supports regulatory procedures for stakeholders. There is a need to respect the culture’s interest, engagement, and for research and clinical trials to be transparent and have ethical oversight to promote global research discourse and trust.

d.     Middle East

Countries in the Middle East have varying degrees of acceptance of or restrictions to policies related to using embryonic stem cells due to cultural and religious influences. Saudi Arabia has made significant contributions to stem cell research, and conducts research based on international guidelines for ethical conduct and under strict adherence to guidelines in accordance with Islamic principles. Specifically, the Saudi government and people require ESC research to adhere to Sharia law. In addition to umbilical and placental stem cells, [35] Saudi Arabia permits the use of embryonic stem cells as long as they come from miscarriages, therapeutic abortions permissible by Sharia law, or are left over from in vitro fertilization and donated to research. [36] Laws and ethical guidelines for stem cell research allow the development of research institutions such as the King Abdullah International Medical Research Center, which has a cord blood bank and a stem cell registry with nearly 10,000 donors. [37] Such volume and acceptance are due to the ethical ‘permissibility’ of the donor sources, which do not conflict with religious pillars. However, some researchers err on the side of caution, choosing not to use embryos or fetal tissue as they feel it is unethical to do so. [38]

Jordan has a positive research ethics culture. [39] However, there is a significant issue of lack of trust in researchers, with 45.23 percent (38.66 percent agreeing and 6.57 percent strongly agreeing) of Jordanians holding a low level of trust in researchers, compared to 81.34 percent of Jordanians agreeing that they feel safe to participate in a research trial. [40] Safety testifies to the feeling of confidence that adequate measures are in place to protect participants from harm, whereas trust in researchers could represent the confidence in researchers to act in the participants’ best interests, adhere to ethical guidelines, provide accurate information, and respect participants’ rights and dignity. One method to improve trust would be to address communication issues relevant to ESC. Legislation surrounding stem cell research has adopted specific language, especially concerning clarification “between ‘stem cells’ and ‘embryonic stem cells’” in translation. [41] Furthermore, legislation “mandates the creation of a national committee… laying out specific regulations for stem-cell banking in accordance with international standards.” [42] This broad regulation opens the door for future global engagement and maintains transparency. However, these regulations may also constrain the influence of research direction, pace, and accessibility of research outcomes.

e.     Europe

In the European Union (EU), ethics is also principle-based, but the principles of autonomy, dignity, integrity, and vulnerability are interconnected. [43] As such, the opportunity for cohesion and concessions between individuals’ thoughts and ideals allows for a more adaptable ethics model due to the flexible principles that relate to the human experience The EU has put forth a framework in its Convention for the Protection of Human Rights and Dignity of the Human Being allowing member states to take different approaches. Each European state applies these principles to its specific conventions, leading to or reflecting different acceptance levels of stem cell research. [44]

For example, in Germany, Lebenzusammenhang , or the coherence of life, references integrity in the unity of human culture. Namely, the personal sphere “should not be subject to external intervention.” [45]  Stem cell interventions could affect this concept of bodily completeness, leading to heavy restrictions. Under the Grundgesetz, human dignity and the right to life with physical integrity are paramount. [46] The Embryo Protection Act of 1991 made producing cell lines illegal. Cell lines can be imported if approved by the Central Ethics Commission for Stem Cell Research only if they were derived before May 2007. [47] Stem cell research respects the integrity of life for the embryo with heavy specifications and intense oversight. This is vastly different in Finland, where the regulatory bodies find research more permissible in IVF excess, but only up to 14 days after fertilization. [48] Spain’s approach differs still, with a comprehensive regulatory framework. [49] Thus, research regulation can be culture-specific due to variations in applied principles. Diverse cultures call for various approaches to ethical permissibility. [50] Only an adaptive-deliberative model can address the cultural constructions of self and achieve positive, culturally sensitive stem cell research practices. [51]

II.     Religious Perspectives on ESC

Embryonic stem cell sources are the main consideration within religious contexts. While individuals may not regard their own religious texts as authoritative or factual, religion can shape their foundations or perspectives.

The Qur'an states:

“And indeed We created man from a quintessence of clay. Then We placed within him a small quantity of nutfa (sperm to fertilize) in a safe place. Then We have fashioned the nutfa into an ‘alaqa (clinging clot or cell cluster), then We developed the ‘alaqa into mudgha (a lump of flesh), and We made mudgha into bones, and clothed the bones with flesh, then We brought it into being as a new creation. So Blessed is Allah, the Best of Creators.” [52]

Many scholars of Islam estimate the time of soul installment, marked by the angel breathing in the soul to bring the individual into creation, as 120 days from conception. [53] Personhood begins at this point, and the value of life would prohibit research or experimentation that could harm the individual. If the fetus is more than 120 days old, the time ensoulment is interpreted to occur according to Islamic law, abortion is no longer permissible. [54] There are a few opposing opinions about early embryos in Islamic traditions. According to some Islamic theologians, there is no ensoulment of the early embryo, which is the source of stem cells for ESC research. [55]

In Buddhism, the stance on stem cell research is not settled. The main tenets, the prohibition against harming or destroying others (ahimsa) and the pursuit of knowledge (prajña) and compassion (karuna), leave Buddhist scholars and communities divided. [56] Some scholars argue stem cell research is in accordance with the Buddhist tenet of seeking knowledge and ending human suffering. Others feel it violates the principle of not harming others. Finding the balance between these two points relies on the karmic burden of Buddhist morality. In trying to prevent ahimsa towards the embryo, Buddhist scholars suggest that to comply with Buddhist tenets, research cannot be done as the embryo has personhood at the moment of conception and would reincarnate immediately, harming the individual's ability to build their karmic burden. [57] On the other hand, the Bodhisattvas, those considered to be on the path to enlightenment or Nirvana, have given organs and flesh to others to help alleviate grieving and to benefit all. [58] Acceptance varies on applied beliefs and interpretations.

Catholicism does not support embryonic stem cell research, as it entails creation or destruction of human embryos. This destruction conflicts with the belief in the sanctity of life. For example, in the Old Testament, Genesis describes humanity as being created in God’s image and multiplying on the Earth, referencing the sacred rights to human conception and the purpose of development and life. In the Ten Commandments, the tenet that one should not kill has numerous interpretations where killing could mean murder or shedding of the sanctity of life, demonstrating the high value of human personhood. In other books, the theological conception of when life begins is interpreted as in utero, [59] highlighting the inviolability of life and its formation in vivo to make a religious point for accepting such research as relatively limited, if at all. [60] The Vatican has released ethical directives to help apply a theological basis to modern-day conflicts. The Magisterium of the Church states that “unless there is a moral certainty of not causing harm,” experimentation on fetuses, fertilized cells, stem cells, or embryos constitutes a crime. [61] Such procedures would not respect the human person who exists at these stages, according to Catholicism. Damages to the embryo are considered gravely immoral and illicit. [62] Although the Catholic Church officially opposes abortion, surveys demonstrate that many Catholic people hold pro-choice views, whether due to the context of conception, stage of pregnancy, threat to the mother’s life, or for other reasons, demonstrating that practicing members can also accept some but not all tenets. [63]

Some major Jewish denominations, such as the Reform, Conservative, and Reconstructionist movements, are open to supporting ESC use or research as long as it is for saving a life. [64] Within Judaism, the Talmud, or study, gives personhood to the child at birth and emphasizes that life does not begin at conception: [65]

“If she is found pregnant, until the fortieth day it is mere fluid,” [66]

Whereas most religions prioritize the status of human embryos, the Halakah (Jewish religious law) states that to save one life, most other religious laws can be ignored because it is in pursuit of preservation. [67] Stem cell research is accepted due to application of these religious laws.

We recognize that all religions contain subsets and sects. The variety of environmental and cultural differences within religious groups requires further analysis to respect the flexibility of religious thoughts and practices. We make no presumptions that all cultures require notions of autonomy or morality as under the common morality theory , which asserts a set of universal moral norms that all individuals share provides moral reasoning and guides ethical decisions. [68] We only wish to show that the interaction with morality varies between cultures and countries.

III.     A Flexible Ethical Approach

The plurality of different moral approaches described above demonstrates that there can be no universally acceptable uniform law for ESC on a global scale. Instead of developing one standard, flexible ethical applications must be continued. We recommend local guidelines that incorporate important cultural and ethical priorities.

While the Declaration of Helsinki is more relevant to people in clinical trials receiving ESC products, in keeping with the tradition of protections for research subjects, consent of the donor is an ethical requirement for ESC donation in many jurisdictions including the US, Canada, and Europe. [69] The Declaration of Helsinki provides a reference point for regulatory standards and could potentially be used as a universal baseline for obtaining consent prior to gamete or embryo donation.

For instance, in Columbia University’s egg donor program for stem cell research, donors followed standard screening protocols and “underwent counseling sessions that included information as to the purpose of oocyte donation for research, what the oocytes would be used for, the risks and benefits of donation, and process of oocyte stimulation” to ensure transparency for consent. [70] The program helped advance stem cell research and provided clear and safe research methods with paid participants. Though paid participation or covering costs of incidental expenses may not be socially acceptable in every culture or context, [71] and creating embryos for ESC research is illegal in many jurisdictions, Columbia’s program was effective because of the clear and honest communications with donors, IRBs, and related stakeholders.  This example demonstrates that cultural acceptance of scientific research and of the idea that an egg or embryo does not have personhood is likely behind societal acceptance of donating eggs for ESC research. As noted, many countries do not permit the creation of embryos for research.

Proper communication and education regarding the process and purpose of stem cell research may bolster comprehension and garner more acceptance. “Given the sensitive subject material, a complete consent process can support voluntary participation through trust, understanding, and ethical norms from the cultures and morals participants value. This can be hard for researchers entering countries of different socioeconomic stability, with different languages and different societal values. [72]

An adequate moral foundation in medical ethics is derived from the cultural and religious basis that informs knowledge and actions. [73] Understanding local cultural and religious values and their impact on research could help researchers develop humility and promote inclusion.

IV.     Concerns

Some may argue that if researchers all adhere to one ethics standard, protection will be satisfied across all borders, and the global public will trust researchers. However, defining what needs to be protected and how to define such research standards is very specific to the people to which standards are applied. We suggest that applying one uniform guide cannot accurately protect each individual because we all possess our own perceptions and interpretations of social values. [74] Therefore, the issue of not adjusting to the moral pluralism between peoples in applying one standard of ethics can be resolved by building out ethics models that can be adapted to different cultures and religions.

Other concerns include medical tourism, which may promote health inequities. [75] Some countries may develop and approve products derived from ESC research before others, compromising research ethics or drug approval processes. There are also concerns about the sale of unauthorized stem cell treatments, for example, those without FDA approval in the United States. Countries with robust research infrastructures may be tempted to attract medical tourists, and some customers will have false hopes based on aggressive publicity of unproven treatments. [76]

For example, in China, stem cell clinics can market to foreign clients who are not protected under the regulatory regimes. Companies employ a marketing strategy of “ethically friendly” therapies. Specifically, in the case of Beike, China’s leading stem cell tourism company and sprouting network, ethical oversight of administrators or health bureaus at one site has “the unintended consequence of shifting questionable activities to another node in Beike's diffuse network.” [77] In contrast, Jordan is aware of stem cell research’s potential abuse and its own status as a “health-care hub.” Jordan’s expanded regulations include preserving the interests of individuals in clinical trials and banning private companies from ESC research to preserve transparency and the integrity of research practices. [78]

The social priorities of the community are also a concern. The ISSCR explicitly states that guidelines “should be periodically revised to accommodate scientific advances, new challenges, and evolving social priorities.” [79] The adaptable ethics model extends this consideration further by addressing whether research is warranted given the varying degrees of socioeconomic conditions, political stability, and healthcare accessibilities and limitations. An ethical approach would require discussion about resource allocation and appropriate distribution of funds. [80]

While some religions emphasize the sanctity of life from conception, which may lead to public opposition to ESC research, others encourage ESC research due to its potential for healing and alleviating human pain. Many countries have special regulations that balance local views on embryonic personhood, the benefits of research as individual or societal goods, and the protection of human research subjects. To foster understanding and constructive dialogue, global policy frameworks should prioritize the protection of universal human rights, transparency, and informed consent. In addition to these foundational global policies, we recommend tailoring local guidelines to reflect the diverse cultural and religious perspectives of the populations they govern. Ethics models should be adapted to local populations to effectively establish research protections, growth, and possibilities of stem cell research.

For example, in countries with strong beliefs in the moral sanctity of embryos or heavy religious restrictions, an adaptive model can allow for discussion instead of immediate rejection. In countries with limited individual rights and voice in science policy, an adaptive model ensures cultural, moral, and religious views are taken into consideration, thereby building social inclusion. While this ethical consideration by the government may not give a complete voice to every individual, it will help balance policies and maintain the diverse perspectives of those it affects. Embracing an adaptive ethics model of ESC research promotes open-minded dialogue and respect for the importance of human belief and tradition. By actively engaging with cultural and religious values, researchers can better handle disagreements and promote ethical research practices that benefit each society.

This brief exploration of the religious and cultural differences that impact ESC research reveals the nuances of relative ethics and highlights a need for local policymakers to apply a more intense adaptive model.

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[36] Association for the Advancement of Blood and Biotherapies.  https://www.aabb.org/regulatory-and-advocacy/regulatory-affairs/regulatory-for-cellular-therapies/international-competent-authorities/saudi-arabia

[37] Alahmad, G., Aljohani, S., & Najjar, M. F. (2020). Ethical challenges regarding the use of stem cells: Interviews with researchers from Saudi Arabia.  BMC medical ethics ,  21 (1), 35. https://doi.org/10.1186/s12910-020-00482-6

[38] Alahmad, G., Aljohani, S., & Najjar, M. F. (2020). Ethical challenges regarding the use of stem cells: Interviews with researchers from Saudi Arabia. BMC medical ethics , 21(1), 35. https://doi.org/10.1186/s12910-020-00482-6

Culturally, autonomy practices follow a relational autonomy approach based on a paternalistic deontological health care model. The adherence to strict international research policies and religious pillars within the regulatory environment is a great foundation for research ethics. However, there is a need to develop locally targeted ethics approaches for research (as called for in Alahmad, G., Aljohani, S., & Najjar, M. F. (2020). Ethical challenges regarding the use of stem cells: interviews with researchers from Saudi Arabia. BMC medical ethics, 21(1), 35. https://doi.org/10.1186/s12910-020-00482-6), this decision-making approach may help advise a research decision model. For more on the clinical cultural autonomy approaches, see: Alabdullah, Y. Y., Alzaid, E., Alsaad, S., Alamri, T., Alolayan, S. W., Bah, S., & Aljoudi, A. S. (2022). Autonomy and paternalism in Shared decision‐making in a Saudi Arabian tertiary hospital: A cross‐sectional study. Developing World Bioethics , 23 (3), 260–268. https://doi.org/10.1111/dewb.12355 ; Bukhari, A. A. (2017). Universal Principles of Bioethics and Patient Rights in Saudi Arabia (Doctoral dissertation, Duquesne University). https://dsc.duq.edu/etd/124; Ladha, S., Nakshawani, S. A., Alzaidy, A., & Tarab, B. (2023, October 26). Islam and Bioethics: What We All Need to Know . Columbia University School of Professional Studies. https://sps.columbia.edu/events/islam-and-bioethics-what-we-all-need-know

[39] Ababneh, M. A., Al-Azzam, S. I., Alzoubi, K., Rababa’h, A., & Al Demour, S. (2021). Understanding and attitudes of the Jordanian public about clinical research ethics.  Research Ethics ,  17 (2), 228-241.  https://doi.org/10.1177/1747016120966779

[40] Ababneh, M. A., Al-Azzam, S. I., Alzoubi, K., Rababa’h, A., & Al Demour, S. (2021). Understanding and attitudes of the Jordanian public about clinical research ethics.  Research Ethics ,  17 (2), 228-241.  https://doi.org/10.1177/1747016120966779

[41] Dajani, R. (2014). Jordan’s stem-cell law can guide the Middle East.  Nature  510, 189. https://doi.org/10.1038/510189a

[42] Dajani, R. (2014). Jordan’s stem-cell law can guide the Middle East.  Nature  510, 189. https://doi.org/10.1038/510189a

[43] The EU’s definition of autonomy relates to the capacity for creating ideas, moral insight, decisions, and actions without constraint, personal responsibility, and informed consent. However, the EU views autonomy as not completely able to protect individuals and depends on other principles, such as dignity, which “expresses the intrinsic worth and fundamental equality of all human beings.” Rendtorff, J.D., Kemp, P. (2019). Four Ethical Principles in European Bioethics and Biolaw: Autonomy, Dignity, Integrity and Vulnerability. In: Valdés, E., Lecaros, J. (eds) Biolaw and Policy in the Twenty-First Century. International Library of Ethics, Law, and the New Medicine, vol 78. Springer, Cham. https://doi.org/10.1007/978-3-030-05903-3_3

[44] Council of Europe. Convention for the protection of Human Rights and Dignity of the Human Being with regard to the Application of Biology and Medicine: Convention on Human Rights and Biomedicine (ETS No. 164) https://www.coe.int/en/web/conventions/full-list?module=treaty-detail&treatynum=164 (forbidding the creation of embryos for research purposes only, and suggests embryos in vitro have protections.); Also see Drabiak-Syed B. K. (2013). New President, New Human Embryonic Stem Cell Research Policy: Comparative International Perspectives and Embryonic Stem Cell Research Laws in France.  Biotechnology Law Report ,  32 (6), 349–356. https://doi.org/10.1089/blr.2013.9865

[45] Rendtorff, J.D., Kemp, P. (2019). Four Ethical Principles in European Bioethics and Biolaw: Autonomy, Dignity, Integrity and Vulnerability. In: Valdés, E., Lecaros, J. (eds) Biolaw and Policy in the Twenty-First Century. International Library of Ethics, Law, and the New Medicine, vol 78. Springer, Cham. https://doi.org/10.1007/978-3-030-05903-3_3

[46] Tomuschat, C., Currie, D. P., Kommers, D. P., & Kerr, R. (Trans.). (1949, May 23). Basic law for the Federal Republic of Germany. https://www.btg-bestellservice.de/pdf/80201000.pdf

[47] Regulation of Stem Cell Research in Germany . Eurostemcell. (2017, April 26). https://www.eurostemcell.org/regulation-stem-cell-research-germany

[48] Regulation of Stem Cell Research in Finland . Eurostemcell. (2017, April 26). https://www.eurostemcell.org/regulation-stem-cell-research-finland

[49] Regulation of Stem Cell Research in Spain . Eurostemcell. (2017, April 26). https://www.eurostemcell.org/regulation-stem-cell-research-spain

[50] Some sources to consider regarding ethics models or regulatory oversights of other cultures not covered:

Kara MA. Applicability of the principle of respect for autonomy: the perspective of Turkey. J Med Ethics. 2007 Nov;33(11):627-30. doi: 10.1136/jme.2006.017400. PMID: 17971462; PMCID: PMC2598110.

Ugarte, O. N., & Acioly, M. A. (2014). The principle of autonomy in Brazil: one needs to discuss it ...  Revista do Colegio Brasileiro de Cirurgioes ,  41 (5), 374–377. https://doi.org/10.1590/0100-69912014005013

Bharadwaj, A., & Glasner, P. E. (2012). Local cells, global science: The rise of embryonic stem cell research in India . Routledge.

For further research on specific European countries regarding ethical and regulatory framework, we recommend this database: Regulation of Stem Cell Research in Europe . Eurostemcell. (2017, April 26). https://www.eurostemcell.org/regulation-stem-cell-research-europe   

[51] Klitzman, R. (2006). Complications of culture in obtaining informed consent. The American Journal of Bioethics, 6(1), 20–21. https://doi.org/10.1080/15265160500394671 see also: Ekmekci, P. E., & Arda, B. (2017). Interculturalism and Informed Consent: Respecting Cultural Differences without Breaching Human Rights.  Cultura (Iasi, Romania) ,  14 (2), 159–172.; For why trust is important in research, see also: Gray, B., Hilder, J., Macdonald, L., Tester, R., Dowell, A., & Stubbe, M. (2017). Are research ethics guidelines culturally competent?  Research Ethics ,  13 (1), 23-41.  https://doi.org/10.1177/1747016116650235

[52] The Qur'an  (M. Khattab, Trans.). (1965). Al-Mu’minun, 23: 12-14. https://quran.com/23

[53] Lenfest, Y. (2017, December 8). Islam and the beginning of human life . Bill of Health. https://blog.petrieflom.law.harvard.edu/2017/12/08/islam-and-the-beginning-of-human-life/

[54] Aksoy, S. (2005). Making regulations and drawing up legislation in Islamic countries under conditions of uncertainty, with special reference to embryonic stem cell research. Journal of Medical Ethics , 31: 399-403.; see also: Mahmoud, Azza. "Islamic Bioethics: National Regulations and Guidelines of Human Stem Cell Research in the Muslim World." Master's thesis, Chapman University, 2022. https://doi.org/10.36837/ chapman.000386

[55] Rashid, R. (2022). When does Ensoulment occur in the Human Foetus. Journal of the British Islamic Medical Association , 12 (4). ISSN 2634 8071. https://www.jbima.com/wp-content/uploads/2023/01/2-Ethics-3_-Ensoulment_Rafaqat.pdf.

[56] Sivaraman, M. & Noor, S. (2017). Ethics of embryonic stem cell research according to Buddhist, Hindu, Catholic, and Islamic religions: perspective from Malaysia. Asian Biomedicine,8(1) 43-52.  https://doi.org/10.5372/1905-7415.0801.260

[57] Jafari, M., Elahi, F., Ozyurt, S. & Wrigley, T. (2007). 4. Religious Perspectives on Embryonic Stem Cell Research. In K. Monroe, R. Miller & J. Tobis (Ed.),  Fundamentals of the Stem Cell Debate: The Scientific, Religious, Ethical, and Political Issues  (pp. 79-94). Berkeley: University of California Press.  https://escholarship.org/content/qt9rj0k7s3/qt9rj0k7s3_noSplash_f9aca2e02c3777c7fb76ea768ba458f0.pdf https://doi.org/10.1525/9780520940994-005

[58] Lecso, P. A. (1991). The Bodhisattva Ideal and Organ Transplantation.  Journal of Religion and Health ,  30 (1), 35–41. http://www.jstor.org/stable/27510629 ; Bodhisattva, S. (n.d.). The Key of Becoming a Bodhisattva . A Guide to the Bodhisattva Way of Life. http://www.buddhism.org/Sutras/2/BodhisattvaWay.htm

[59] There is no explicit religious reference to when life begins or how to conduct research that interacts with the concept of life. However, these are relevant verses pertaining to how the fetus is viewed. (( King James Bible . (1999). Oxford University Press. (original work published 1769))

Jerimiah 1: 5 “Before I formed thee in the belly I knew thee; and before thou camest forth out of the womb I sanctified thee…”

In prophet Jerimiah’s insight, God set him apart as a person known before childbirth, a theme carried within the Psalm of David.

Psalm 139: 13-14 “…Thou hast covered me in my mother's womb. I will praise thee; for I am fearfully and wonderfully made…”

These verses demonstrate David’s respect for God as an entity that would know of all man’s thoughts and doings even before birth.

[60] It should be noted that abortion is not supported as well.

[61] The Vatican. (1987, February 22). Instruction on Respect for Human Life in Its Origin and on the Dignity of Procreation Replies to Certain Questions of the Day . Congregation For the Doctrine of the Faith. https://www.vatican.va/roman_curia/congregations/cfaith/documents/rc_con_cfaith_doc_19870222_respect-for-human-life_en.html

[62] The Vatican. (2000, August 25). Declaration On the Production and the Scientific and Therapeutic Use of Human Embryonic Stem Cells . Pontifical Academy for Life. https://www.vatican.va/roman_curia/pontifical_academies/acdlife/documents/rc_pa_acdlife_doc_20000824_cellule-staminali_en.html ; Ohara, N. (2003). Ethical Consideration of Experimentation Using Living Human Embryos: The Catholic Church’s Position on Human Embryonic Stem Cell Research and Human Cloning. Department of Obstetrics and Gynecology . Retrieved from https://article.imrpress.com/journal/CEOG/30/2-3/pii/2003018/77-81.pdf.

[63] Smith, G. A. (2022, May 23). Like Americans overall, Catholics vary in their abortion views, with regular mass attenders most opposed . Pew Research Center. https://www.pewresearch.org/short-reads/2022/05/23/like-americans-overall-catholics-vary-in-their-abortion-views-with-regular-mass-attenders-most-opposed/

[64] Rosner, F., & Reichman, E. (2002). Embryonic stem cell research in Jewish law. Journal of halacha and contemporary society , (43), 49–68.; Jafari, M., Elahi, F., Ozyurt, S. & Wrigley, T. (2007). 4. Religious Perspectives on Embryonic Stem Cell Research. In K. Monroe, R. Miller & J. Tobis (Ed.),  Fundamentals of the Stem Cell Debate: The Scientific, Religious, Ethical, and Political Issues  (pp. 79-94). Berkeley: University of California Press.  https://escholarship.org/content/qt9rj0k7s3/qt9rj0k7s3_noSplash_f9aca2e02c3777c7fb76ea768ba458f0.pdf https://doi.org/10.1525/9780520940994-005

[65] Schenker J. G. (2008). The beginning of human life: status of embryo. Perspectives in Halakha (Jewish Religious Law).  Journal of assisted reproduction and genetics ,  25 (6), 271–276. https://doi.org/10.1007/s10815-008-9221-6

[66] Ruttenberg, D. (2020, May 5). The Torah of Abortion Justice (annotated source sheet) . Sefaria. https://www.sefaria.org/sheets/234926.7?lang=bi&with=all&lang2=en

[67] Jafari, M., Elahi, F., Ozyurt, S. & Wrigley, T. (2007). 4. Religious Perspectives on Embryonic Stem Cell Research. In K. Monroe, R. Miller & J. Tobis (Ed.),  Fundamentals of the Stem Cell Debate: The Scientific, Religious, Ethical, and Political Issues  (pp. 79-94). Berkeley: University of California Press.  https://escholarship.org/content/qt9rj0k7s3/qt9rj0k7s3_noSplash_f9aca2e02c3777c7fb76ea768ba458f0.pdf https://doi.org/10.1525/9780520940994-005

[68] Gert, B. (2007). Common morality: Deciding what to do . Oxford Univ. Press.

[69] World Medical Association (2013). World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA , 310(20), 2191–2194. https://doi.org/10.1001/jama.2013.281053 Declaration of Helsinki – WMA – The World Medical Association .; see also: National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research. (1979).  The Belmont report: Ethical principles and guidelines for the protection of human subjects of research . U.S. Department of Health and Human Services.  https://www.hhs.gov/ohrp/regulations-and-policy/belmont-report/read-the-belmont-report/index.html

[70] Zakarin Safier, L., Gumer, A., Kline, M., Egli, D., & Sauer, M. V. (2018). Compensating human subjects providing oocytes for stem cell research: 9-year experience and outcomes.  Journal of assisted reproduction and genetics ,  35 (7), 1219–1225. https://doi.org/10.1007/s10815-018-1171-z https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063839/ see also: Riordan, N. H., & Paz Rodríguez, J. (2021). Addressing concerns regarding associated costs, transparency, and integrity of research in recent stem cell trial. Stem Cells Translational Medicine , 10 (12), 1715–1716. https://doi.org/10.1002/sctm.21-0234

[71] Klitzman, R., & Sauer, M. V. (2009). Payment of egg donors in stem cell research in the USA.  Reproductive biomedicine online ,  18 (5), 603–608. https://doi.org/10.1016/s1472-6483(10)60002-8

[72] Krosin, M. T., Klitzman, R., Levin, B., Cheng, J., & Ranney, M. L. (2006). Problems in comprehension of informed consent in rural and peri-urban Mali, West Africa.  Clinical trials (London, England) ,  3 (3), 306–313. https://doi.org/10.1191/1740774506cn150oa

[73] Veatch, Robert M.  Hippocratic, Religious, and Secular Medical Ethics: The Points of Conflict . Georgetown University Press, 2012.

[74] Msoroka, M. S., & Amundsen, D. (2018). One size fits not quite all: Universal research ethics with diversity.  Research Ethics ,  14 (3), 1-17.  https://doi.org/10.1177/1747016117739939

[75] Pirzada, N. (2022). The Expansion of Turkey’s Medical Tourism Industry.  Voices in Bioethics ,  8 . https://doi.org/10.52214/vib.v8i.9894

[76] Stem Cell Tourism: False Hope for Real Money . Harvard Stem Cell Institute (HSCI). (2023). https://hsci.harvard.edu/stem-cell-tourism , See also: Bissassar, M. (2017). Transnational Stem Cell Tourism: An ethical analysis.  Voices in Bioethics ,  3 . https://doi.org/10.7916/vib.v3i.6027

[77] Song, P. (2011) The proliferation of stem cell therapies in post-Mao China: problematizing ethical regulation,  New Genetics and Society , 30:2, 141-153, DOI:  10.1080/14636778.2011.574375

[78] Dajani, R. (2014). Jordan’s stem-cell law can guide the Middle East.  Nature  510, 189. https://doi.org/10.1038/510189a

[79] International Society for Stem Cell Research. (2024). Standards in stem cell research . International Society for Stem Cell Research. https://www.isscr.org/guidelines/5-standards-in-stem-cell-research

[80] Benjamin, R. (2013). People’s science bodies and rights on the Stem Cell Frontier . Stanford University Press.

Olivia Bowers

MS Bioethics Columbia University (Disclosure: affiliated with Voices in Bioethics)

Mifrah Hayath

SM Candidate Harvard Medical School, MS Biotechnology Johns Hopkins University

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Exploring the Difference between Research Papers and Articles

Research papers and articles are common forms of academic writing that have distinct differences. This article explores the various components that distinguish a research paper from an article, including purpose, audience, structure, and content. Moreover, it examines how these factors vary depending on context and provides tips for successful composition in each genre. Ultimately, by understanding the key distinctions between research papers and articles—as well as when to apply them appropriately—scholars can craft high-quality works that effectively communicate their ideas.

I. Introduction

Ii. definition of research papers and articles, iii. overview of research papers vs articles, iv. reasons for writing research papers and articles, v. elements included in a research paper or article, vi. different types of sources used to write research papers/articles, vii conclusion.

A brief overview The concept of research papers and articles is one that has been around for centuries. For those who have a basic understanding, they may think that the two terms are interchangeable – however this is far from true! A research paper involves an in-depth analysis and evaluation of scholarly literature on a particular topic. It often requires multiple stages of research to be completed before the paper can be written, as well as requiring significant knowledge within the specific subject area it pertains to. On the other hand, an article usually takes much less time to complete than does a research paper; while still involving some degree of examination or investigation into certain topics or ideas related to its field, it tends not to go as deep into detail compared with more involved studies such as those associated with most academic courses.

Analytical components When creating either type of writing project there will always exist numerous analytical components – including referencing material from both primary (firsthand) sources such as interviews/surveys etc., and secondary (background) sources which includes journal articles/books etc. Depending on what kind of work is being done these references must allude towards different kinds critical thinking – whether qualitative (describing qualities), quantitative (measuring amount) or mixed methods (combining above). Furthermore when considering specific topics further exploration should also consider if deductive reasoning applies alongside inductive reasoning in order for appropriate conclusions regarding content matter at hand can be drawn up correctly by synthesising material accessed throughout entire composition process mentioned earlier.

Research papers and articles are integral to academia, but they often have different definitions. A research paper is a form of academic writing that has theoretical and substantial information regarding a certain topic. It requires the thorough investigation of sources and it typically follows an established structure: introduction, body paragraphs, conclusion. Additionally, research papers can include extensive quotes or references from other publications as part of their evidence-based claims.

In contrast to a research paper, an article , generally speaking, presents the author’s own opinion on some subject matter without necessarily having any formalized structure or referencing system in place. Articles are usually found in magazines such as Time Magazine or The Economist; newspapers like The New York Times or USA Today; scholarly journals such as American Journal for Social Science Research; and online blogs. In many cases authors tend to incorporate personal anecdotes which may not be present within more conventional forms of academic writing (e.g., journaling).

Research Papers vs Articles It is important to recognize the differences between research papers and articles when considering which type of content should be written. Research papers generally require extensive amounts of data collection, analysis, and synthesis from a variety of sources; they are written in an academic or scientific format that follows certain conventions. On the other hand, articles tend to focus more on opinion-based pieces with personal experience anecdotes as their main source material. Additionally, while both types often cite similar resources for reference information (such as peer reviewed journals), it is typically not necessary for an article’s citations to meet the same standards as those used in a research paper.

Another key difference between research papers and articles lies within their overall goal – while most research papers aim to answer specific questions about a subject matter by providing credible evidence through rigorous study methods, many articles are simply meant to inform readers on topics without necessarily drawing any conclusions or pushing any particular agenda/viewpoint. This makes them more suitable for use cases such as educational publications where concise explanations may be preferred over longer analyses into complex theories and ideas.

Benefits of Scholarly Writing:

Writing research papers and articles can offer a variety of benefits to scholars. By delving into an area of study, the researcher is able to obtain greater understanding and clarity about their subject matter. Through this type of writing, one has the ability to demonstrate their knowledge and comprehension while presenting compelling arguments that will support or refute existing theories within a specific field. In addition, research-based publications are essential for individuals wishing to gain recognition as experts in their respective fields.

Another benefit offered by scholarly writing is its potential impact on society at large; it allows ideas and evidence from various disciplines – such as medicine, psychology or economics –  to be integrated together thus providing holistic solutions addressing complex problems our world faces today. This also provides opportunities for different groups of people with diverse backgrounds to learn from each other which may lead to mutual understanding between them.

Difference Between Research Papers & Articles: Although both types require rigorous investigation prior to producing any kind content there are key differences between these two types academic works. Generally speaking, a research paper , requires more comprehensive data collection than that expected in articles due its lengthier format allowing for more detailed information regarding the topic being discussed including background history along with interpretation results provided by primary sources used throughout the paper’s body text sections itself.

. On contrary , an article tends lean towards shorter length publication requiring less detail although same investigative process still remains necessary followed further revision carried out prior submitting draft editorial board review consideration where they then decide if ready publishing under relevant journal name associated specified discipline field .

When writing research papers or articles, the elements included in them can vary depending on the nature of the work. However, there are some general components which usually appear regardless of field.

• Abstract: An abstract is a brief summary which outlines what is discussed and presents main conclusions drawn from it. It’s also used to introduce readers to an article before they read it in full.

The difference between a research paper and an article comes down to purpose. Research papers often delve into complex theories whereas articles are intended more for informing people about topics in simple terms so that they can apply this knowledge practically. Articles generally require less background information than research papers as well as being shorter overall.

• Introduction: The introduction should be catchy enough to attract interest but not contain too much detail; its job is simply to provide context for your project by summarising what you plan to do in order words.

In addition, while both types include references/citations at the end (which cite sources used), these tend to be formatted differently due – again –to their differing purposes; academic journals have different requirements than books or magazines when citing sources because such publications deal with more complex material involving specialized terminology etc.

When writing a research paper or article, it is essential to understand the various types of sources that can be used. There are three main categories of sources – primary, secondary and tertiary – each with their own characteristics and benefits for authors:

• Primary Sources : These are original materials on which other research may be based. They usually include documents created by an author who had direct personal knowledge of an event or topic (e.g., diaries, letters). Primary source material also includes photographs, audio recordings, interviews and surveys.
• Secondary Sources : These refer to materials that have been already analyzed and interpreted by another researcher(s) (e.g., books analyzing the works of one author). Secondary source materials can also include biographies written about someone else’s life as well as journal articles.
• Tertiary Sources : Tertiary sources summarize or organize information from primary and secondary sources such as dictionaries, textbooks, encyclopedias or directories.

Authors should use multiple types of sources when composing both research papers and articles in order to provide evidence-based conclusions backed up by reliable data points from different perspectives. For example if researching a historical personage then combining a biography book outlining their achievements with records from archives could create well rounded opinion piece regarding this individual’s legacy in history. It is important for authors to note that while most elements remain consistent between both assignments there exists some subtle differences; namely -for instance- whilst citing 2+ primary resources within academic pieces tends encourage credibility towards any stated hypothesis so too does linking several relevant external publications make articles more persuasive/informative overall due its journalistic nature .

Drawing to a Close As we have seen in this paper, there are several differences between research papers and articles. Research papers delve deeply into the subject matter; often containing original research or data compiled from sources that support the author’s perspective. Articles tend to be more concise summaries of topics, usually lacking primary research or data analysis yet providing an overview of existing information on a topic.

On the other hand, both mediums can provide valuable insight for readers. The takeaway is simple: when seeking further details about particular subject matter it would be wise to look at both options before drawing any conclusions. Indeed, reading multiple points-of-view on a single topic may give us greater clarity regarding its complexity – something we could all benefit from in these times of polarization and uncertainty!

In conclusion, the primary distinction between research papers and articles lies in their purpose. Research papers are typically longer in length and more comprehensive than articles as they seek to answer a specific hypothesis or question through an extensive analysis of the available evidence. Articles tend to focus on one particular issue or topic from an opinion-based perspective, rather than conducting original research into a subject. Regardless of whether you’re writing for academic publication or professional purposes, understanding these two forms can help ensure that your content meets its intended audience’s expectations effectively.

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• Published: 06 May 2024

APOE4 homozygozity represents a distinct genetic form of Alzheimer’s disease

• Juan Fortea   ORCID: orcid.org/0000-0002-1340-638X 1 , 2 , 3   na1 ,
• Jordi Pegueroles   ORCID: orcid.org/0000-0002-3554-2446 1 , 2 ,
• Daniel Alcolea   ORCID: orcid.org/0000-0002-3819-3245 1 , 2 ,
• Olivia Belbin   ORCID: orcid.org/0000-0002-6109-6371 1 , 2 ,
• Oriol Dols-Icardo   ORCID: orcid.org/0000-0003-2656-8748 1 , 2 ,
• Lídia Vaqué-Alcázar 1 , 4 ,
• Laura Videla   ORCID: orcid.org/0000-0002-9748-8465 1 , 2 , 3 ,
• Juan Domingo Gispert 5 , 6 , 7 , 8 , 9 ,
• Marc Suárez-Calvet   ORCID: orcid.org/0000-0002-2993-569X 5 , 6 , 7 , 8 , 9 ,
• Sterling C. Johnson   ORCID: orcid.org/0000-0002-8501-545X 10 ,
• Reisa Sperling   ORCID: orcid.org/0000-0003-1535-6133 11 ,
• Alexandre Bejanin   ORCID: orcid.org/0000-0002-9958-0951 1 , 2 ,
• Alberto Lleó   ORCID: orcid.org/0000-0002-2568-5478 1 , 2 &
• Víctor Montal   ORCID: orcid.org/0000-0002-5714-9282 1 , 2 , 12   na1  

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• Alzheimer's disease
• Predictive markers

This study aimed to evaluate the impact of APOE4 homozygosity on Alzheimer’s disease (AD) by examining its clinical, pathological and biomarker changes to see whether APOE4 homozygotes constitute a distinct, genetically determined form of AD. Data from the National Alzheimer’s Coordinating Center and five large cohorts with AD biomarkers were analyzed. The analysis included 3,297 individuals for the pathological study and 10,039 for the clinical study. Findings revealed that almost all APOE4 homozygotes exhibited AD pathology and had significantly higher levels of AD biomarkers from age 55 compared to APOE3 homozygotes. By age 65, nearly all had abnormal amyloid levels in cerebrospinal fluid, and 75% had positive amyloid scans, with the prevalence of these markers increasing with age, indicating near-full penetrance of AD biology in APOE4 homozygotes. The age of symptom onset was earlier in APOE4 homozygotes at 65.1, with a narrower 95% prediction interval than APOE3 homozygotes. The predictability of symptom onset and the sequence of biomarker changes in APOE4 homozygotes mirrored those in autosomal dominant AD and Down syndrome. However, in the dementia stage, there were no differences in amyloid or tau positron emission tomography across haplotypes, despite earlier clinical and biomarker changes. The study concludes that APOE4 homozygotes represent a genetic form of AD, suggesting the need for individualized prevention strategies, clinical trials and treatments.

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Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

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Access to tabular data from ADNI ( https://adni.loni.usc.edu/ ), OASIS ( https://oasis-brains.org/ ), A4 ( https://ida.loni.usc.edu/collaboration/access/appLicense.jsp ) and NACC ( https://naccdata.org/ ) can be requested online, as publicly available databases. All requests will be reviewed by each studyʼs scientific board. Concrete inquiries to access the WRAP ( https://wrap.wisc.edu/data-requests-2/ ) and ALFA + ( https://www.barcelonabeta.org/en/alfa-study/about-the-alfa-study ) cohort data can be directed to each study team for concept approval and feasibility consultation. Requests will be reviewed to verify whether the request is subject to any intellectual property.

Code availability

All statistical analyses and raw figures were generated using R (v.4.2.2). We used the open-sourced R packages of ggplot2 (v.3.4.3), dplyr (v.1.1.3), ggstream (v.0.1.0), ggpubr (v.0.6), ggstatsplot (v.0.12), Rmisc (v.1.5.1), survival (v.3.5), survminer (v.0.4.9), gtsummary (v.1.7), epitools (v.0.5) and statsExpression (v.1.5.1). Rscripts to replicate our findings can be found at https://gitlab.com/vmontalb/apoe4-asdad (ref. 32 ). For neuroimaging analyses, we used Free Surfer (v.6.0) and ANTs (v.2.4.0).

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Acknowledgements

We acknowledge the contributions of several consortia that provided data for this study. We extend our appreciation to the NACC, the Alzheimer’s Disease Neuroimaging Initiative, The A4 Study, the ALFA Study, the Wisconsin Register for Alzheimer’s Prevention and the OASIS3 Project. Without their dedication to advancing Alzheimer’s disease research and their commitment to data sharing, this study would not have been possible. We also thank all the participants and investigators involved in these consortia for their tireless efforts and invaluable contributions to the field. We also thank the institutions that funded this study, the Fondo de Investigaciones Sanitario, Carlos III Health Institute, the Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas and the Generalitat de Catalunya and La Caixa Foundation, as well as the NIH, Horizon 2020 and the Alzheimer’s Association, which was crucial for this research. Funding: National Institute on Aging. This study was supported by the Fondo de Investigaciones Sanitario, Carlos III Health Institute (INT21/00073, PI20/01473 and PI23/01786 to J.F., CP20/00038, PI22/00307 to A.B., PI22/00456 to M.S.-C., PI18/00435 to D.A., PI20/01330 to A.L.) and the Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas Program 1, partly jointly funded by Fondo Europeo de Desarrollo Regional, Unión Europea, Una Manera de Hacer Europa. This work was also supported by the National Institutes of Health grants (R01 AG056850; R21 AG056974, R01 AG061566, R01 AG081394 and R61AG066543 to J.F., S10 OD025245, P30 AG062715, U54 HD090256, UL1 TR002373, P01 AG036694 and P50 AG005134 to R.S.; R01 AG027161, R01 AG021155, R01 AG037639, R01 AG054059; P50 AG033514 and P30 AG062715 to S.J.) and ADNI (U01 AG024904), the Department de Salut de la Generalitat de Catalunya, Pla Estratègic de Recerca I Innovació en Salut (SLT006/17/00119 to J.F.; SLT002/16/00408 to A.L.) and the A4 Study (R01 AG063689, U24 AG057437 to R.A.S). It was also supported by Fundación Tatiana Pérez de Guzmán el Bueno (IIBSP-DOW-2020-151 o J.F.) and Horizon 2020–Research and Innovation Framework Programme from the European Union (H2020-SC1-BHC-2018-2020 to J.F.; 948677 and 847648 to M.S.-C.). La Caixa Foundation (LCF/PR/GN17/50300004 to M.S.-C.) and EIT Digital (Grant 2021 to J.D.G.) also supported this work. The Alzheimer Association also participated in the funding of this work (AARG-22-923680 to A.B.) and A4/LEARN Study AA15-338729 to R.A.S.). O.D.-I. receives funding from the Alzheimer’s Association (AARF-22-924456) and the Jerome Lejeune Foundation postdoctoral fellowship.

Author information

These authors contributed equally: Juan Fortea, Víctor Montal.

Authors and Affiliations

Sant Pau Memory Unit, Hospital de la Santa Creu i Sant Pau - Biomedical Research Institute Sant Pau, Barcelona, Spain

Juan Fortea, Jordi Pegueroles, Daniel Alcolea, Olivia Belbin, Oriol Dols-Icardo, Lídia Vaqué-Alcázar, Laura Videla, Alexandre Bejanin, Alberto Lleó & Víctor Montal

Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas. CIBERNED, Barcelona, Spain

Juan Fortea, Jordi Pegueroles, Daniel Alcolea, Olivia Belbin, Oriol Dols-Icardo, Laura Videla, Alexandre Bejanin, Alberto Lleó & Víctor Montal

Barcelona Down Medical Center, Fundació Catalana Síndrome de Down, Barcelona, Spain

Juan Fortea & Laura Videla

Department of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Barcelona, Spain

Lídia Vaqué-Alcázar

Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain

Juan Domingo Gispert & Marc Suárez-Calvet

Neurosciences Programme, IMIM - Hospital del Mar Medical Research Institute, Barcelona, Spain

Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain

Centro de Investigación Biomédica en Red Bioingeniería, Biomateriales y Nanomedicina. Instituto de Salud carlos III, Madrid, Spain

Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain

Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA

Sterling C. Johnson

Brigham and Women’s Hospital Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

Reisa Sperling

Barcelona Supercomputing Center, Barcelona, Spain

Víctor Montal

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Contributions

J.F. and V.M. conceptualized the research project and drafted the initial manuscript. V.M., J.P. and J.F. conducted data analysis, interpreted statistical findings and created visual representations of the data. O.B. and O.D.-I. provided valuable insights into the genetics of APOE. L.V., A.B. and L.V.-A. meticulously reviewed and edited the manuscript for clarity, accuracy and coherence. J.D.G., M.S.-C., S.J. and R.S. played pivotal roles in data acquisition and securing funding. A.L. and D.A. contributed to the study design, offering guidance and feedback on statistical analyses, and provided critical review of the paper. All authors carefully reviewed the manuscript, offering pertinent feedback that enhanced the study’s quality, and ultimately approved the final version.

Corresponding authors

Correspondence to Juan Fortea or Víctor Montal .

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Competing interests.

S.C.J. has served at scientific advisory boards for ALZPath, Enigma and Roche Diagnostics. M.S.-C. has given lectures in symposia sponsored by Almirall, Eli Lilly, Novo Nordisk, Roche Diagnostics and Roche Farma, received consultancy fees (paid to the institution) from Roche Diagnostics and served on advisory boards of Roche Diagnostics and Grifols. He was granted a project and is a site investigator of a clinical trial (funded to the institution) by Roche Diagnostics. In-kind support for research (to the institution) was received from ADx Neurosciences, Alamar Biosciences, Avid Radiopharmaceuticals, Eli Lilly, Fujirebio, Janssen Research & Development and Roche Diagnostics. J.D.G. has served as consultant for Roche Diagnostics, receives research funding from Hoffmann–La Roche, Roche Diagnostics and GE Healthcare, has given lectures in symposia sponsored by Biogen, Philips Nederlands, Esteve and Life Molecular Imaging and serves on an advisory board for Prothena Biosciences. R.S. has received personal consulting fees from Abbvie, AC Immune, Acumen, Alector, Bristol Myers Squibb, Janssen, Genentech, Ionis and Vaxxinity outside the submitted work. O.B. reported receiving personal fees from Adx NeuroSciences outside the submitted work. D.A. reported receiving personal fees for advisory board services and/or speaker honoraria from Fujirebio-Europe, Roche, Nutricia, Krka Farmacéutica and Esteve, outside the submitted work. A.L. has served as a consultant or on advisory boards for Almirall, Fujirebio-Europe, Grifols, Eisai, Lilly, Novartis, Roche, Biogen and Nutricia, outside the submitted work. J.F. reported receiving personal fees for service on the advisory boards, adjudication committees or speaker honoraria from AC Immune, Adamed, Alzheon, Biogen, Eisai, Esteve, Fujirebio, Ionis, Laboratorios Carnot, Life Molecular Imaging, Lilly, Lundbeck, Perha, Roche and outside the submitted work. O.B., D.A., A.L. and J.F. report holding a patent for markers of synaptopathy in neurodegenerative disease (licensed to Adx, EPI8382175.0). The remaining authors declare no competing interests.

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Supplementary Methods, Results, Bibliography, Figs. 1–7 and Tables 1–3.

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Fortea, J., Pegueroles, J., Alcolea, D. et al. APOE4 homozygozity represents a distinct genetic form of Alzheimer’s disease. Nat Med (2024). https://doi.org/10.1038/s41591-024-02931-w

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Received : 03 November 2023

Accepted : 19 March 2024

Published : 06 May 2024

DOI : https://doi.org/10.1038/s41591-024-02931-w

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