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10 Experimental research

Experimental research—often considered to be the ‘gold standard’ in research designs—is one of the most rigorous of all research designs. In this design, one or more independent variables are manipulated by the researcher (as treatments), subjects are randomly assigned to different treatment levels (random assignment), and the results of the treatments on outcomes (dependent variables) are observed. The unique strength of experimental research is its internal validity (causality) due to its ability to link cause and effect through treatment manipulation, while controlling for the spurious effect of extraneous variable.

Experimental research is best suited for explanatory research—rather than for descriptive or exploratory research—where the goal of the study is to examine cause-effect relationships. It also works well for research that involves a relatively limited and well-defined set of independent variables that can either be manipulated or controlled. Experimental research can be conducted in laboratory or field settings. Laboratory experiments , conducted in laboratory (artificial) settings, tend to be high in internal validity, but this comes at the cost of low external validity (generalisability), because the artificial (laboratory) setting in which the study is conducted may not reflect the real world. Field experiments are conducted in field settings such as in a real organisation, and are high in both internal and external validity. But such experiments are relatively rare, because of the difficulties associated with manipulating treatments and controlling for extraneous effects in a field setting.

Experimental research can be grouped into two broad categories: true experimental designs and quasi-experimental designs. Both designs require treatment manipulation, but while true experiments also require random assignment, quasi-experiments do not. Sometimes, we also refer to non-experimental research, which is not really a research design, but an all-inclusive term that includes all types of research that do not employ treatment manipulation or random assignment, such as survey research, observational research, and correlational studies.

Basic concepts

Treatment and control groups. In experimental research, some subjects are administered one or more experimental stimulus called a treatment (the treatment group ) while other subjects are not given such a stimulus (the control group ). The treatment may be considered successful if subjects in the treatment group rate more favourably on outcome variables than control group subjects. Multiple levels of experimental stimulus may be administered, in which case, there may be more than one treatment group. For example, in order to test the effects of a new drug intended to treat a certain medical condition like dementia, if a sample of dementia patients is randomly divided into three groups, with the first group receiving a high dosage of the drug, the second group receiving a low dosage, and the third group receiving a placebo such as a sugar pill (control group), then the first two groups are experimental groups and the third group is a control group. After administering the drug for a period of time, if the condition of the experimental group subjects improved significantly more than the control group subjects, we can say that the drug is effective. We can also compare the conditions of the high and low dosage experimental groups to determine if the high dose is more effective than the low dose.

Treatment manipulation. Treatments are the unique feature of experimental research that sets this design apart from all other research methods. Treatment manipulation helps control for the ‘cause’ in cause-effect relationships. Naturally, the validity of experimental research depends on how well the treatment was manipulated. Treatment manipulation must be checked using pretests and pilot tests prior to the experimental study. Any measurements conducted before the treatment is administered are called pretest measures , while those conducted after the treatment are posttest measures .

Random selection and assignment. Random selection is the process of randomly drawing a sample from a population or a sampling frame. This approach is typically employed in survey research, and ensures that each unit in the population has a positive chance of being selected into the sample. Random assignment, however, is a process of randomly assigning subjects to experimental or control groups. This is a standard practice in true experimental research to ensure that treatment groups are similar (equivalent) to each other and to the control group prior to treatment administration. Random selection is related to sampling, and is therefore more closely related to the external validity (generalisability) of findings. However, random assignment is related to design, and is therefore most related to internal validity. It is possible to have both random selection and random assignment in well-designed experimental research, but quasi-experimental research involves neither random selection nor random assignment.

Threats to internal validity. Although experimental designs are considered more rigorous than other research methods in terms of the internal validity of their inferences (by virtue of their ability to control causes through treatment manipulation), they are not immune to internal validity threats. Some of these threats to internal validity are described below, within the context of a study of the impact of a special remedial math tutoring program for improving the math abilities of high school students.

History threat is the possibility that the observed effects (dependent variables) are caused by extraneous or historical events rather than by the experimental treatment. For instance, students’ post-remedial math score improvement may have been caused by their preparation for a math exam at their school, rather than the remedial math program.

Maturation threat refers to the possibility that observed effects are caused by natural maturation of subjects (e.g., a general improvement in their intellectual ability to understand complex concepts) rather than the experimental treatment.

Testing threat is a threat in pre-post designs where subjects’ posttest responses are conditioned by their pretest responses. For instance, if students remember their answers from the pretest evaluation, they may tend to repeat them in the posttest exam.

Not conducting a pretest can help avoid this threat.

Instrumentation threat , which also occurs in pre-post designs, refers to the possibility that the difference between pretest and posttest scores is not due to the remedial math program, but due to changes in the administered test, such as the posttest having a higher or lower degree of difficulty than the pretest.

Mortality threat refers to the possibility that subjects may be dropping out of the study at differential rates between the treatment and control groups due to a systematic reason, such that the dropouts were mostly students who scored low on the pretest. If the low-performing students drop out, the results of the posttest will be artificially inflated by the preponderance of high-performing students.

Regression threat —also called a regression to the mean—refers to the statistical tendency of a group’s overall performance to regress toward the mean during a posttest rather than in the anticipated direction. For instance, if subjects scored high on a pretest, they will have a tendency to score lower on the posttest (closer to the mean) because their high scores (away from the mean) during the pretest were possibly a statistical aberration. This problem tends to be more prevalent in non-random samples and when the two measures are imperfectly correlated.

Two-group experimental designs

R

Pretest-posttest control group design . In this design, subjects are randomly assigned to treatment and control groups, subjected to an initial (pretest) measurement of the dependent variables of interest, the treatment group is administered a treatment (representing the independent variable of interest), and the dependent variables measured again (posttest). The notation of this design is shown in Figure 10.1.

Pretest-posttest control group design

Statistical analysis of this design involves a simple analysis of variance (ANOVA) between the treatment and control groups. The pretest-posttest design handles several threats to internal validity, such as maturation, testing, and regression, since these threats can be expected to influence both treatment and control groups in a similar (random) manner. The selection threat is controlled via random assignment. However, additional threats to internal validity may exist. For instance, mortality can be a problem if there are differential dropout rates between the two groups, and the pretest measurement may bias the posttest measurement—especially if the pretest introduces unusual topics or content.

Posttest -only control group design . This design is a simpler version of the pretest-posttest design where pretest measurements are omitted. The design notation is shown in Figure 10.2.

Posttest-only control group design

The treatment effect is measured simply as the difference in the posttest scores between the two groups:

\[E = (O_{1} - O_{2})\,.\]

The appropriate statistical analysis of this design is also a two-group analysis of variance (ANOVA). The simplicity of this design makes it more attractive than the pretest-posttest design in terms of internal validity. This design controls for maturation, testing, regression, selection, and pretest-posttest interaction, though the mortality threat may continue to exist.

C

Because the pretest measure is not a measurement of the dependent variable, but rather a covariate, the treatment effect is measured as the difference in the posttest scores between the treatment and control groups as:

Due to the presence of covariates, the right statistical analysis of this design is a two-group analysis of covariance (ANCOVA). This design has all the advantages of posttest-only design, but with internal validity due to the controlling of covariates. Covariance designs can also be extended to pretest-posttest control group design.

Factorial designs

Two-group designs are inadequate if your research requires manipulation of two or more independent variables (treatments). In such cases, you would need four or higher-group designs. Such designs, quite popular in experimental research, are commonly called factorial designs. Each independent variable in this design is called a factor , and each subdivision of a factor is called a level . Factorial designs enable the researcher to examine not only the individual effect of each treatment on the dependent variables (called main effects), but also their joint effect (called interaction effects).

2 \times 2

In a factorial design, a main effect is said to exist if the dependent variable shows a significant difference between multiple levels of one factor, at all levels of other factors. No change in the dependent variable across factor levels is the null case (baseline), from which main effects are evaluated. In the above example, you may see a main effect of instructional type, instructional time, or both on learning outcomes. An interaction effect exists when the effect of differences in one factor depends upon the level of a second factor. In our example, if the effect of instructional type on learning outcomes is greater for three hours/week of instructional time than for one and a half hours/week, then we can say that there is an interaction effect between instructional type and instructional time on learning outcomes. Note that the presence of interaction effects dominate and make main effects irrelevant, and it is not meaningful to interpret main effects if interaction effects are significant.

Hybrid experimental designs

Hybrid designs are those that are formed by combining features of more established designs. Three such hybrid designs are randomised bocks design, Solomon four-group design, and switched replications design.

Randomised block design. This is a variation of the posttest-only or pretest-posttest control group design where the subject population can be grouped into relatively homogeneous subgroups (called blocks ) within which the experiment is replicated. For instance, if you want to replicate the same posttest-only design among university students and full-time working professionals (two homogeneous blocks), subjects in both blocks are randomly split between the treatment group (receiving the same treatment) and the control group (see Figure 10.5). The purpose of this design is to reduce the ‘noise’ or variance in data that may be attributable to differences between the blocks so that the actual effect of interest can be detected more accurately.

Randomised blocks design

Solomon four-group design . In this design, the sample is divided into two treatment groups and two control groups. One treatment group and one control group receive the pretest, and the other two groups do not. This design represents a combination of posttest-only and pretest-posttest control group design, and is intended to test for the potential biasing effect of pretest measurement on posttest measures that tends to occur in pretest-posttest designs, but not in posttest-only designs. The design notation is shown in Figure 10.6.

Solomon four-group design

Switched replication design . This is a two-group design implemented in two phases with three waves of measurement. The treatment group in the first phase serves as the control group in the second phase, and the control group in the first phase becomes the treatment group in the second phase, as illustrated in Figure 10.7. In other words, the original design is repeated or replicated temporally with treatment/control roles switched between the two groups. By the end of the study, all participants will have received the treatment either during the first or the second phase. This design is most feasible in organisational contexts where organisational programs (e.g., employee training) are implemented in a phased manner or are repeated at regular intervals.

Switched replication design

Quasi-experimental designs

Quasi-experimental designs are almost identical to true experimental designs, but lacking one key ingredient: random assignment. For instance, one entire class section or one organisation is used as the treatment group, while another section of the same class or a different organisation in the same industry is used as the control group. This lack of random assignment potentially results in groups that are non-equivalent, such as one group possessing greater mastery of certain content than the other group, say by virtue of having a better teacher in a previous semester, which introduces the possibility of selection bias . Quasi-experimental designs are therefore inferior to true experimental designs in interval validity due to the presence of a variety of selection related threats such as selection-maturation threat (the treatment and control groups maturing at different rates), selection-history threat (the treatment and control groups being differentially impacted by extraneous or historical events), selection-regression threat (the treatment and control groups regressing toward the mean between pretest and posttest at different rates), selection-instrumentation threat (the treatment and control groups responding differently to the measurement), selection-testing (the treatment and control groups responding differently to the pretest), and selection-mortality (the treatment and control groups demonstrating differential dropout rates). Given these selection threats, it is generally preferable to avoid quasi-experimental designs to the greatest extent possible.

N

In addition, there are quite a few unique non-equivalent designs without corresponding true experimental design cousins. Some of the more useful of these designs are discussed next.

Regression discontinuity (RD) design . This is a non-equivalent pretest-posttest design where subjects are assigned to the treatment or control group based on a cut-off score on a preprogram measure. For instance, patients who are severely ill may be assigned to a treatment group to test the efficacy of a new drug or treatment protocol and those who are mildly ill are assigned to the control group. In another example, students who are lagging behind on standardised test scores may be selected for a remedial curriculum program intended to improve their performance, while those who score high on such tests are not selected from the remedial program.

RD design

Because of the use of a cut-off score, it is possible that the observed results may be a function of the cut-off score rather than the treatment, which introduces a new threat to internal validity. However, using the cut-off score also ensures that limited or costly resources are distributed to people who need them the most, rather than randomly across a population, while simultaneously allowing a quasi-experimental treatment. The control group scores in the RD design do not serve as a benchmark for comparing treatment group scores, given the systematic non-equivalence between the two groups. Rather, if there is no discontinuity between pretest and posttest scores in the control group, but such a discontinuity persists in the treatment group, then this discontinuity is viewed as evidence of the treatment effect.

Proxy pretest design . This design, shown in Figure 10.11, looks very similar to the standard NEGD (pretest-posttest) design, with one critical difference: the pretest score is collected after the treatment is administered. A typical application of this design is when a researcher is brought in to test the efficacy of a program (e.g., an educational program) after the program has already started and pretest data is not available. Under such circumstances, the best option for the researcher is often to use a different prerecorded measure, such as students’ grade point average before the start of the program, as a proxy for pretest data. A variation of the proxy pretest design is to use subjects’ posttest recollection of pretest data, which may be subject to recall bias, but nevertheless may provide a measure of perceived gain or change in the dependent variable.

Proxy pretest design

Separate pretest-posttest samples design . This design is useful if it is not possible to collect pretest and posttest data from the same subjects for some reason. As shown in Figure 10.12, there are four groups in this design, but two groups come from a single non-equivalent group, while the other two groups come from a different non-equivalent group. For instance, say you want to test customer satisfaction with a new online service that is implemented in one city but not in another. In this case, customers in the first city serve as the treatment group and those in the second city constitute the control group. If it is not possible to obtain pretest and posttest measures from the same customers, you can measure customer satisfaction at one point in time, implement the new service program, and measure customer satisfaction (with a different set of customers) after the program is implemented. Customer satisfaction is also measured in the control group at the same times as in the treatment group, but without the new program implementation. The design is not particularly strong, because you cannot examine the changes in any specific customer’s satisfaction score before and after the implementation, but you can only examine average customer satisfaction scores. Despite the lower internal validity, this design may still be a useful way of collecting quasi-experimental data when pretest and posttest data is not available from the same subjects.

Separate pretest-posttest samples design

An interesting variation of the NEDV design is a pattern-matching NEDV design , which employs multiple outcome variables and a theory that explains how much each variable will be affected by the treatment. The researcher can then examine if the theoretical prediction is matched in actual observations. This pattern-matching technique—based on the degree of correspondence between theoretical and observed patterns—is a powerful way of alleviating internal validity concerns in the original NEDV design.

NEDV design

Perils of experimental research

Experimental research is one of the most difficult of research designs, and should not be taken lightly. This type of research is often best with a multitude of methodological problems. First, though experimental research requires theories for framing hypotheses for testing, much of current experimental research is atheoretical. Without theories, the hypotheses being tested tend to be ad hoc, possibly illogical, and meaningless. Second, many of the measurement instruments used in experimental research are not tested for reliability and validity, and are incomparable across studies. Consequently, results generated using such instruments are also incomparable. Third, often experimental research uses inappropriate research designs, such as irrelevant dependent variables, no interaction effects, no experimental controls, and non-equivalent stimulus across treatment groups. Findings from such studies tend to lack internal validity and are highly suspect. Fourth, the treatments (tasks) used in experimental research may be diverse, incomparable, and inconsistent across studies, and sometimes inappropriate for the subject population. For instance, undergraduate student subjects are often asked to pretend that they are marketing managers and asked to perform a complex budget allocation task in which they have no experience or expertise. The use of such inappropriate tasks, introduces new threats to internal validity (i.e., subject’s performance may be an artefact of the content or difficulty of the task setting), generates findings that are non-interpretable and meaningless, and makes integration of findings across studies impossible.

The design of proper experimental treatments is a very important task in experimental design, because the treatment is the raison d’etre of the experimental method, and must never be rushed or neglected. To design an adequate and appropriate task, researchers should use prevalidated tasks if available, conduct treatment manipulation checks to check for the adequacy of such tasks (by debriefing subjects after performing the assigned task), conduct pilot tests (repeatedly, if necessary), and if in doubt, use tasks that are simple and familiar for the respondent sample rather than tasks that are complex or unfamiliar.

In summary, this chapter introduced key concepts in the experimental design research method and introduced a variety of true experimental and quasi-experimental designs. Although these designs vary widely in internal validity, designs with less internal validity should not be overlooked and may sometimes be useful under specific circumstances and empirical contingencies.

Social Science Research: Principles, Methods and Practices (Revised edition) Copyright © 2019 by Anol Bhattacherjee is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License , except where otherwise noted.

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A Complete Guide to Experimental Research

Published by Carmen Troy at August 14th, 2021 , Revised On August 25, 2023

A Quick Guide to Experimental Research

Experimental research refers to the experiments conducted in the laboratory or observation under controlled conditions. Researchers try to find out the cause-and-effect relationship between two or more variables. 

The subjects/participants in the experiment are selected and observed. They receive treatments such as changes in room temperature, diet, atmosphere, or given a new drug to observe the changes. Experiments can vary from personal and informal natural comparisons. It includes three  types of variables ;

  • Independent variable
  • Dependent variable
  • Controlled variable

Before conducting experimental research, you need to have a clear understanding of the experimental design. A true experimental design includes  identifying a problem , formulating a  hypothesis , determining the number of variables, selecting and assigning the participants,  types of research designs , meeting ethical values, etc.

There are many  types of research  methods that can be classified based on:

  • The nature of the problem to be studied
  • Number of participants (individual or groups)
  • Number of groups involved (Single group or multiple groups)
  • Types of data collection methods (Qualitative/Quantitative/Mixed methods)
  • Number of variables (single independent variable/ factorial two independent variables)
  • The experimental design

Types of Experimental Research

Types of Experimental Research

Laboratory Experiment  

It is also called experimental research. This type of research is conducted in the laboratory. A researcher can manipulate and control the variables of the experiment.

Example: Milgram’s experiment on obedience.

Field Experiment

Field experiments are conducted in the participants’ open field and the environment by incorporating a few artificial changes. Researchers do not have control over variables under measurement. Participants know that they are taking part in the experiment.

Natural Experiments

The experiment is conducted in the natural environment of the participants. The participants are generally not informed about the experiment being conducted on them.

Examples: Estimating the health condition of the population. Did the increase in tobacco prices decrease the sale of tobacco? Did the usage of helmets decrease the number of head injuries of the bikers?

Quasi-Experiments

A quasi-experiment is an experiment that takes advantage of natural occurrences. Researchers cannot assign random participants to groups.

Example: Comparing the academic performance of the two schools.

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How to Conduct Experimental Research?

Step 1. identify and define the problem.

You need to identify a problem as per your field of study and describe your  research question .

Example: You want to know about the effects of social media on the behavior of youngsters. It would help if you found out how much time students spend on the internet daily.

Example: You want to find out the adverse effects of junk food on human health. It would help if you found out how junk food frequent consumption can affect an individual’s health.

Step 2. Determine the Number of Levels of Variables

You need to determine the number of  variables . The independent variable is the predictor and manipulated by the researcher. At the same time, the dependent variable is the result of the independent variable.

In the first example, we predicted that increased social media usage negatively correlates with youngsters’ negative behaviour.

In the second example, we predicted the positive correlation between a balanced diet and a good healthy and negative relationship between junk food consumption and multiple health issues.

Step 3. Formulate the Hypothesis

One of the essential aspects of experimental research is formulating a hypothesis . A researcher studies the cause and effect between the independent and dependent variables and eliminates the confounding variables. A  null hypothesis is when there is no significant relationship between the dependent variable and the participants’ independent variables. A researcher aims to disprove the theory. H0 denotes it.  The  Alternative hypothesis  is the theory that a researcher seeks to prove.  H1or HA denotes it. 

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Step 4. Selection and Assignment of the Subjects

It’s an essential feature that differentiates the experimental design from other research designs . You need to select the number of participants based on the requirements of your experiment. Then the participants are assigned to the treatment group. There should be a control group without any treatment to study the outcomes without applying any changes compared to the experimental group.

Randomisation:  The participants are selected randomly and assigned to the experimental group. It is known as probability sampling. If the selection is not random, it’s considered non-probability sampling.

Stratified sampling : It’s a type of random selection of the participants by dividing them into strata and randomly selecting them from each level. 

Matching:   Even though participants are selected randomly, they can be assigned to the various comparison groups. Another procedure for selecting the participants is ‘matching.’ The participants are selected from the controlled group to match the experimental groups’ participants in all aspects based on the dependent variables.  

What is Replicability?

When a researcher uses the same methodology  and subject groups to carry out the experiments, it’s called ‘replicability.’ The  results will be similar each time. Researchers usually replicate their own work to strengthen external validity.

Step 5. Select a Research Design

You need to select a  research design  according to the requirements of your experiment. There are many types of experimental designs as follows.

Step 6. Meet Ethical and Legal Requirements

  • Participants of the research should not be harmed.
  • The dignity and confidentiality of the research should be maintained.
  • The consent of the participants should be taken before experimenting.
  • The privacy of the participants should be ensured.
  • Research data should remain confidential.
  • The anonymity of the participants should be ensured.
  • The rules and objectives of the experiments should be followed strictly.
  • Any wrong information or data should be avoided.

Tips for Meeting the Ethical Considerations

To meet the ethical considerations, you need to ensure that.

  • Participants have the right to withdraw from the experiment.
  • They should be aware of the required information about the experiment.
  • It would help if you avoided offensive or unacceptable language while framing the questions of interviews, questionnaires, or Focus groups.
  • You should ensure the privacy and anonymity of the participants.
  • You should acknowledge the sources and authors in your dissertation using any referencing styles such as APA/MLA/Harvard referencing style.

Step 7. Collect and Analyse Data.

Collect the data  by using suitable data collection according to your experiment’s requirement, such as observations,  case studies ,  surveys ,  interviews , questionnaires, etc. Analyse the obtained information.

Step 8. Present and Conclude the Findings of the Study.

Write the report of your research. Present, conclude, and explain the outcomes of your study .  

Frequently Asked Questions

What is the first step in conducting an experimental research.

The first step in conducting experimental research is to define your research question or hypothesis. Clearly outline the purpose and expectations of your experiment to guide the entire research process.

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  • A Quick Guide to Experimental Design | 5 Steps & Examples

A Quick Guide to Experimental Design | 5 Steps & Examples

Published on 11 April 2022 by Rebecca Bevans . Revised on 5 December 2022.

Experiments are used to study causal relationships . You manipulate one or more independent variables and measure their effect on one or more dependent variables.

Experimental design means creating a set of procedures to systematically test a hypothesis . A good experimental design requires a strong understanding of the system you are studying. 

There are five key steps in designing an experiment:

  • Consider your variables and how they are related
  • Write a specific, testable hypothesis
  • Design experimental treatments to manipulate your independent variable
  • Assign subjects to groups, either between-subjects or within-subjects
  • Plan how you will measure your dependent variable

For valid conclusions, you also need to select a representative sample and control any  extraneous variables that might influence your results. If if random assignment of participants to control and treatment groups is impossible, unethical, or highly difficult, consider an observational study instead.

Table of contents

Step 1: define your variables, step 2: write your hypothesis, step 3: design your experimental treatments, step 4: assign your subjects to treatment groups, step 5: measure your dependent variable, frequently asked questions about experimental design.

You should begin with a specific research question . We will work with two research question examples, one from health sciences and one from ecology:

To translate your research question into an experimental hypothesis, you need to define the main variables and make predictions about how they are related.

Start by simply listing the independent and dependent variables .

Then you need to think about possible extraneous and confounding variables and consider how you might control  them in your experiment.

Finally, you can put these variables together into a diagram. Use arrows to show the possible relationships between variables and include signs to show the expected direction of the relationships.

Diagram of the relationship between variables in a sleep experiment

Here we predict that increasing temperature will increase soil respiration and decrease soil moisture, while decreasing soil moisture will lead to decreased soil respiration.

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Now that you have a strong conceptual understanding of the system you are studying, you should be able to write a specific, testable hypothesis that addresses your research question.

The next steps will describe how to design a controlled experiment . In a controlled experiment, you must be able to:

  • Systematically and precisely manipulate the independent variable(s).
  • Precisely measure the dependent variable(s).
  • Control any potential confounding variables.

If your study system doesn’t match these criteria, there are other types of research you can use to answer your research question.

How you manipulate the independent variable can affect the experiment’s external validity – that is, the extent to which the results can be generalised and applied to the broader world.

First, you may need to decide how widely to vary your independent variable.

  • just slightly above the natural range for your study region.
  • over a wider range of temperatures to mimic future warming.
  • over an extreme range that is beyond any possible natural variation.

Second, you may need to choose how finely to vary your independent variable. Sometimes this choice is made for you by your experimental system, but often you will need to decide, and this will affect how much you can infer from your results.

  • a categorical variable : either as binary (yes/no) or as levels of a factor (no phone use, low phone use, high phone use).
  • a continuous variable (minutes of phone use measured every night).

How you apply your experimental treatments to your test subjects is crucial for obtaining valid and reliable results.

First, you need to consider the study size : how many individuals will be included in the experiment? In general, the more subjects you include, the greater your experiment’s statistical power , which determines how much confidence you can have in your results.

Then you need to randomly assign your subjects to treatment groups . Each group receives a different level of the treatment (e.g. no phone use, low phone use, high phone use).

You should also include a control group , which receives no treatment. The control group tells us what would have happened to your test subjects without any experimental intervention.

When assigning your subjects to groups, there are two main choices you need to make:

  • A completely randomised design vs a randomised block design .
  • A between-subjects design vs a within-subjects design .

Randomisation

An experiment can be completely randomised or randomised within blocks (aka strata):

  • In a completely randomised design , every subject is assigned to a treatment group at random.
  • In a randomised block design (aka stratified random design), subjects are first grouped according to a characteristic they share, and then randomly assigned to treatments within those groups.

Sometimes randomisation isn’t practical or ethical , so researchers create partially-random or even non-random designs. An experimental design where treatments aren’t randomly assigned is called a quasi-experimental design .

Between-subjects vs within-subjects

In a between-subjects design (also known as an independent measures design or classic ANOVA design), individuals receive only one of the possible levels of an experimental treatment.

In medical or social research, you might also use matched pairs within your between-subjects design to make sure that each treatment group contains the same variety of test subjects in the same proportions.

In a within-subjects design (also known as a repeated measures design), every individual receives each of the experimental treatments consecutively, and their responses to each treatment are measured.

Within-subjects or repeated measures can also refer to an experimental design where an effect emerges over time, and individual responses are measured over time in order to measure this effect as it emerges.

Counterbalancing (randomising or reversing the order of treatments among subjects) is often used in within-subjects designs to ensure that the order of treatment application doesn’t influence the results of the experiment.

Finally, you need to decide how you’ll collect data on your dependent variable outcomes. You should aim for reliable and valid measurements that minimise bias or error.

Some variables, like temperature, can be objectively measured with scientific instruments. Others may need to be operationalised to turn them into measurable observations.

  • Ask participants to record what time they go to sleep and get up each day.
  • Ask participants to wear a sleep tracker.

How precisely you measure your dependent variable also affects the kinds of statistical analysis you can use on your data.

Experiments are always context-dependent, and a good experimental design will take into account all of the unique considerations of your study system to produce information that is both valid and relevant to your research question.

Experimental designs are a set of procedures that you plan in order to examine the relationship between variables that interest you.

To design a successful experiment, first identify:

  • A testable hypothesis
  • One or more independent variables that you will manipulate
  • One or more dependent variables that you will measure

When designing the experiment, first decide:

  • How your variable(s) will be manipulated
  • How you will control for any potential confounding or lurking variables
  • How many subjects you will include
  • How you will assign treatments to your subjects

The key difference between observational studies and experiments is that, done correctly, an observational study will never influence the responses or behaviours of participants. Experimental designs will have a treatment condition applied to at least a portion of participants.

A confounding variable , also called a confounder or confounding factor, is a third variable in a study examining a potential cause-and-effect relationship.

A confounding variable is related to both the supposed cause and the supposed effect of the study. It can be difficult to separate the true effect of the independent variable from the effect of the confounding variable.

In your research design , it’s important to identify potential confounding variables and plan how you will reduce their impact.

In a between-subjects design , every participant experiences only one condition, and researchers assess group differences between participants in various conditions.

In a within-subjects design , each participant experiences all conditions, and researchers test the same participants repeatedly for differences between conditions.

The word ‘between’ means that you’re comparing different conditions between groups, while the word ‘within’ means you’re comparing different conditions within the same group.

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Neag School of Education

Educational Research Basics by Del Siegle

Experimental research.

The major feature that distinguishes experimental research from other types of research is that the researcher manipulates the independent variable.  There are a number of experimental group designs in experimental research. Some of these qualify as experimental research, others do not.

  • In true experimental research , the researcher not only manipulates the independent variable, he or she also randomly assigned individuals to the various treatment categories (i.e., control and treatment).
  • In quasi experimental research , the researcher does not randomly assign subjects to treatment and control groups. In other words, the treatment is not distributed among participants randomly. In some cases, a researcher may randomly assigns one whole group to treatment and one whole group to control. In this case, quasi-experimental research involves using intact groups in an experiment, rather than assigning individuals at random to research conditions. (some researchers define this latter situation differently. For our course, we will allow this definition).
  • In causal comparative ( ex post facto ) research, the groups are already formed. It does not meet the standards of an experiment because the independent variable in not manipulated.

The statistics by themselves have no meaning. They only take on meaning within the design of your study. If we just examine stats, bread can be deadly . The term validity is used three ways in research…

  • I n the sampling unit, we learn about external validity (generalizability).
  • I n the survey unit, we learn about instrument validity .
  • In this unit, we learn about internal validity and external validity . Internal validity means that the differences that we were found between groups on the dependent variable in an experiment were directly related to what the researcher did to the independent variable, and not due to some other unintended variable (confounding variable). Simply stated, the question addressed by internal validity is “Was the study done well?” Once the researcher is satisfied that the study was done well and the independent variable caused the dependent variable (internal validity), then the research examines external validity (under what conditions [ecological] and with whom [population] can these results be replicated [Will I get the same results with a different group of people or under different circumstances?]). If a study is not internally valid, then considering external validity is a moot point (If the independent did not cause the dependent, then there is no point in applying the results [generalizing the results] to other situations.). Interestingly, as one tightens a study to control for treats to internal validity, one decreases the generalizability of the study (to whom and under what conditions one can generalize the results).

There are several common threats to internal validity in experimental research. They are described in our text.  I have review each below (this material is also included in the  PowerPoint Presentation on Experimental Research for this unit):

  • Subject Characteristics (Selection Bias/Differential Selection) — The groups may have been different from the start. If you were testing instructional strategies to improve reading and one group enjoyed reading more than the other group, they may improve more in their reading because they enjoy it, rather than the instructional strategy you used.
  • Loss of Subjects ( Mortality ) — All of the high or low scoring subject may have dropped out or were missing from one of the groups. If we collected posttest data on a day when the honor society was on field trip at the treatment school, the mean for the treatment group would probably be much lower than it really should have been.
  • Location — Perhaps one group was at a disadvantage because of their location.  The city may have been demolishing a building next to one of the schools in our study and there are constant distractions which interferes with our treatment.
  • Instrumentation Instrument Decay — The testing instruments may not be scores similarly. Perhaps the person grading the posttest is fatigued and pays less attention to the last set of papers reviewed. It may be that those papers are from one of our groups and will received different scores than the earlier group’s papers
  • Data Collector Characteristics — The subjects of one group may react differently to the data collector than the other group. A male interviewing males and females about their attitudes toward a type of math instruction may not receive the same responses from females as a female interviewing females would.
  • Data Collector Bias — The person collecting data my favors one group, or some characteristic some subject possess, over another. A principal who favors strict classroom management may rate students’ attention under different teaching conditions with a bias toward one of the teaching conditions.
  • Testing — The act of taking a pretest or posttest may influence the results of the experiment. Suppose we were conducting a unit to increase student sensitivity to prejudice. As a pretest we have the control and treatment groups watch Shindler’s List and write a reaction essay. The pretest may have actually increased both groups’ sensitivity and we find that our treatment groups didn’t score any higher on a posttest given later than the control group did. If we hadn’t given the pretest, we might have seen differences in the groups at the end of the study.
  • History — Something may happen at one site during our study that influences the results. Perhaps a classmate dies in a car accident at the control site for a study teaching children bike safety. The control group may actually demonstrate more concern about bike safety than the treatment group.
  • Maturation –There may be natural changes in the subjects that can account for the changes found in a study. A critical thinking unit may appear more effective if it taught during a time when children are developing abstract reasoning.
  • Hawthorne Effect — The subjects may respond differently just because they are being studied. The name comes from a classic study in which researchers were studying the effect of lighting on worker productivity. As the intensity of the factor lights increased, so did the work productivity. One researcher suggested that they reverse the treatment and lower the lights. The productivity of the workers continued to increase. It appears that being observed by the researchers was increasing productivity, not the intensity of the lights.
  • John Henry Effect — One group may view that it is competition with the other group and may work harder than than they would under normal circumstances. This generally is applied to the control group “taking on” the treatment group. The terms refers to the classic story of John Henry laying railroad track.
  • Resentful Demoralization of the Control Group — The control group may become discouraged because it is not receiving the special attention that is given to the treatment group. They may perform lower than usual because of this.
  • Regression ( Statistical Regression) — A class that scores particularly low can be expected to score slightly higher just by chance. Likewise, a class that scores particularly high, will have a tendency to score slightly lower by chance. The change in these scores may have nothing to do with the treatment.
  • Implementation –The treatment may not be implemented as intended. A study where teachers are asked to use student modeling techniques may not show positive results, not because modeling techniques don’t work, but because the teacher didn’t implement them or didn’t implement them as they were designed.
  • Compensatory Equalization of Treatmen t — Someone may feel sorry for the control group because they are not receiving much attention and give them special treatment. For example, a researcher could be studying the effect of laptop computers on students’ attitudes toward math. The teacher feels sorry for the class that doesn’t have computers and sponsors a popcorn party during math class. The control group begins to develop a more positive attitude about mathematics.
  • Experimental Treatment Diffusion — Sometimes the control group actually implements the treatment. If two different techniques are being tested in two different third grades in the same building, the teachers may share what they are doing. Unconsciously, the control may use of the techniques she or he learned from the treatment teacher.

When planning a study, it is important to consider the threats to interval validity as we finalize the study design. After we complete our study, we should reconsider each of the threats to internal validity as we review our data and draw conclusions.

Del Siegle, Ph.D. Neag School of Education – University of Connecticut [email protected] www.delsiegle.com

Experimental Research

  • First Online: 25 February 2021

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Experiments are part of the scientific method that helps to decide the fate of two or more competing hypotheses or explanations on a phenomenon. The term ‘experiment’ arises from Latin, Experiri, which means, ‘to try’. The knowledge accrues from experiments differs from other types of knowledge in that it is always shaped upon observation or experience. In other words, experiments generate empirical knowledge. In fact, the emphasis on experimentation in the sixteenth and seventeenth centuries for establishing causal relationships for various phenomena happening in nature heralded the resurgence of modern science from its roots in ancient philosophy spearheaded by great Greek philosophers such as Aristotle.

The strongest arguments prove nothing so long as the conclusions are not verified by experience. Experimental science is the queen of sciences and the goal of all speculation . Roger Bacon (1214–1294)

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Experimental Research: What it is + Types of designs

Experimental Research Design

Any research conducted under scientifically acceptable conditions uses experimental methods. The success of experimental studies hinges on researchers confirming the change of a variable is based solely on the manipulation of the constant variable. The research should establish a notable cause and effect.

What is Experimental Research?

Experimental research is a study conducted with a scientific approach using two sets of variables. The first set acts as a constant, which you use to measure the differences of the second set. Quantitative research methods , for example, are experimental.

If you don’t have enough data to support your decisions, you must first determine the facts. This research gathers the data necessary to help you make better decisions.

You can conduct experimental research in the following situations:

  • Time is a vital factor in establishing a relationship between cause and effect.
  • Invariable behavior between cause and effect.
  • You wish to understand the importance of cause and effect.

Experimental Research Design Types

The classic experimental design definition is: “The methods used to collect data in experimental studies.”

There are three primary types of experimental design:

  • Pre-experimental research design
  • True experimental research design
  • Quasi-experimental research design

The way you classify research subjects based on conditions or groups determines the type of research design  you should use.

0 1. Pre-Experimental Design

A group, or various groups, are kept under observation after implementing cause and effect factors. You’ll conduct this research to understand whether further investigation is necessary for these particular groups.

You can break down pre-experimental research further into three types:

  • One-shot Case Study Research Design
  • One-group Pretest-posttest Research Design
  • Static-group Comparison

0 2. True Experimental Design

It relies on statistical analysis to prove or disprove a hypothesis, making it the most accurate form of research. Of the types of experimental design, only true design can establish a cause-effect relationship within a group. In a true experiment, three factors need to be satisfied:

  • There is a Control Group, which won’t be subject to changes, and an Experimental Group, which will experience the changed variables.
  • A variable that can be manipulated by the researcher
  • Random distribution

This experimental research method commonly occurs in the physical sciences.

0 3. Quasi-Experimental Design

The word “Quasi” indicates similarity. A quasi-experimental design is similar to an experimental one, but it is not the same. The difference between the two is the assignment of a control group. In this research, an independent variable is manipulated, but the participants of a group are not randomly assigned. Quasi-research is used in field settings where random assignment is either irrelevant or not required.

Importance of Experimental Design

Experimental research is a powerful tool for understanding cause-and-effect relationships. It allows us to manipulate variables and observe the effects, which is crucial for understanding how different factors influence the outcome of a study.

But the importance of experimental research goes beyond that. It’s a critical method for many scientific and academic studies. It allows us to test theories, develop new products, and make groundbreaking discoveries.

For example, this research is essential for developing new drugs and medical treatments. Researchers can understand how a new drug works by manipulating dosage and administration variables and identifying potential side effects.

Similarly, experimental research is used in the field of psychology to test theories and understand human behavior. By manipulating variables such as stimuli, researchers can gain insights into how the brain works and identify new treatment options for mental health disorders.

It is also widely used in the field of education. It allows educators to test new teaching methods and identify what works best. By manipulating variables such as class size, teaching style, and curriculum, researchers can understand how students learn and identify new ways to improve educational outcomes.

In addition, experimental research is a powerful tool for businesses and organizations. By manipulating variables such as marketing strategies, product design, and customer service, companies can understand what works best and identify new opportunities for growth.

Advantages of Experimental Research

When talking about this research, we can think of human life. Babies do their own rudimentary experiments (such as putting objects in their mouths) to learn about the world around them, while older children and teens do experiments at school to learn more about science.

Ancient scientists used this research to prove that their hypotheses were correct. For example, Galileo Galilei and Antoine Lavoisier conducted various experiments to discover key concepts in physics and chemistry. The same is true of modern experts, who use this scientific method to see if new drugs are effective, discover treatments for diseases, and create new electronic devices (among others).

It’s vital to test new ideas or theories. Why put time, effort, and funding into something that may not work?

This research allows you to test your idea in a controlled environment before marketing. It also provides the best method to test your theory thanks to the following advantages:

Advantages of experimental research

  • Researchers have a stronger hold over variables to obtain desired results.
  • The subject or industry does not impact the effectiveness of experimental research. Any industry can implement it for research purposes.
  • The results are specific.
  • After analyzing the results, you can apply your findings to similar ideas or situations.
  • You can identify the cause and effect of a hypothesis. Researchers can further analyze this relationship to determine more in-depth ideas.
  • Experimental research makes an ideal starting point. The data you collect is a foundation for building more ideas and conducting more action research .

Whether you want to know how the public will react to a new product or if a certain food increases the chance of disease, experimental research is the best place to start. Begin your research by finding subjects using  QuestionPro Audience  and other tools today.

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Experimental design: Guide, steps, examples

Last updated

27 April 2023

Reviewed by

Miroslav Damyanov

Experimental research design is a scientific framework that allows you to manipulate one or more variables while controlling the test environment. 

When testing a theory or new product, it can be helpful to have a certain level of control and manipulate variables to discover different outcomes. You can use these experiments to determine cause and effect or study variable associations. 

This guide explores the types of experimental design, the steps in designing an experiment, and the advantages and limitations of experimental design. 

Make research less tedious

Dovetail streamlines research to help you uncover and share actionable insights

  • What is experimental research design?

You can determine the relationship between each of the variables by: 

Manipulating one or more independent variables (i.e., stimuli or treatments)

Applying the changes to one or more dependent variables (i.e., test groups or outcomes)

With the ability to analyze the relationship between variables and using measurable data, you can increase the accuracy of the result. 

What is a good experimental design?

A good experimental design requires: 

Significant planning to ensure control over the testing environment

Sound experimental treatments

Properly assigning subjects to treatment groups

Without proper planning, unexpected external variables can alter an experiment's outcome. 

To meet your research goals, your experimental design should include these characteristics:

Provide unbiased estimates of inputs and associated uncertainties

Enable the researcher to detect differences caused by independent variables

Include a plan for analysis and reporting of the results

Provide easily interpretable results with specific conclusions

What's the difference between experimental and quasi-experimental design?

The major difference between experimental and quasi-experimental design is the random assignment of subjects to groups. 

A true experiment relies on certain controls. Typically, the researcher designs the treatment and randomly assigns subjects to control and treatment groups. 

However, these conditions are unethical or impossible to achieve in some situations.

When it's unethical or impractical to assign participants randomly, that’s when a quasi-experimental design comes in. 

This design allows researchers to conduct a similar experiment by assigning subjects to groups based on non-random criteria. 

Another type of quasi-experimental design might occur when the researcher doesn't have control over the treatment but studies pre-existing groups after they receive different treatments.

When can a researcher conduct experimental research?

Various settings and professions can use experimental research to gather information and observe behavior in controlled settings. 

Basically, a researcher can conduct experimental research any time they want to test a theory with variable and dependent controls. 

Experimental research is an option when the project includes an independent variable and a desire to understand the relationship between cause and effect. 

  • The importance of experimental research design

Experimental research enables researchers to conduct studies that provide specific, definitive answers to questions and hypotheses. 

Researchers can test Independent variables in controlled settings to:

Test the effectiveness of a new medication

Design better products for consumers

Answer questions about human health and behavior

Developing a quality research plan means a researcher can accurately answer vital research questions with minimal error. As a result, definitive conclusions can influence the future of the independent variable. 

Types of experimental research designs

There are three main types of experimental research design. The research type you use will depend on the criteria of your experiment, your research budget, and environmental limitations. 

Pre-experimental research design

A pre-experimental research study is a basic observational study that monitors independent variables’ effects. 

During research, you observe one or more groups after applying a treatment to test whether the treatment causes any change. 

The three subtypes of pre-experimental research design are:

One-shot case study research design

This research method introduces a single test group to a single stimulus to study the results at the end of the application. 

After researchers presume the stimulus or treatment has caused changes, they gather results to determine how it affects the test subjects. 

One-group pretest-posttest design

This method uses a single test group but includes a pretest study as a benchmark. The researcher applies a test before and after the group’s exposure to a specific stimulus. 

Static group comparison design

This method includes two or more groups, enabling the researcher to use one group as a control. They apply a stimulus to one group and leave the other group static. 

A posttest study compares the results among groups. 

True experimental research design

A true experiment is the most common research method. It involves statistical analysis to prove or disprove a specific hypothesis . 

Under completely experimental conditions, researchers expose participants in two or more randomized groups to different stimuli. 

Random selection removes any potential for bias, providing more reliable results. 

These are the three main sub-groups of true experimental research design:

Posttest-only control group design

This structure requires the researcher to divide participants into two random groups. One group receives no stimuli and acts as a control while the other group experiences stimuli.

Researchers perform a test at the end of the experiment to observe the stimuli exposure results.

Pretest-posttest control group design

This test also requires two groups. It includes a pretest as a benchmark before introducing the stimulus. 

The pretest introduces multiple ways to test subjects. For instance, if the control group also experiences a change, it reveals that taking the test twice changes the results.

Solomon four-group design

This structure divides subjects into two groups, with two as control groups. Researchers assign the first control group a posttest only and the second control group a pretest and a posttest. 

The two variable groups mirror the control groups, but researchers expose them to stimuli. The ability to differentiate between groups in multiple ways provides researchers with more testing approaches for data-based conclusions. 

Quasi-experimental research design

Although closely related to a true experiment, quasi-experimental research design differs in approach and scope. 

Quasi-experimental research design doesn’t have randomly selected participants. Researchers typically divide the groups in this research by pre-existing differences. 

Quasi-experimental research is more common in educational studies, nursing, or other research projects where it's not ethical or practical to use randomized subject groups.

  • 5 steps for designing an experiment

Experimental research requires a clearly defined plan to outline the research parameters and expected goals. 

Here are five key steps in designing a successful experiment:

Step 1: Define variables and their relationship

Your experiment should begin with a question: What are you hoping to learn through your experiment? 

The relationship between variables in your study will determine your answer.

Define the independent variable (the intended stimuli) and the dependent variable (the expected effect of the stimuli). After identifying these groups, consider how you might control them in your experiment. 

Could natural variations affect your research? If so, your experiment should include a pretest and posttest. 

Step 2: Develop a specific, testable hypothesis

With a firm understanding of the system you intend to study, you can write a specific, testable hypothesis. 

What is the expected outcome of your study? 

Develop a prediction about how the independent variable will affect the dependent variable. 

How will the stimuli in your experiment affect your test subjects? 

Your hypothesis should provide a prediction of the answer to your research question . 

Step 3: Design experimental treatments to manipulate your independent variable

Depending on your experiment, your variable may be a fixed stimulus (like a medical treatment) or a variable stimulus (like a period during which an activity occurs). 

Determine which type of stimulus meets your experiment’s needs and how widely or finely to vary your stimuli. 

Step 4: Assign subjects to groups

When you have a clear idea of how to carry out your experiment, you can determine how to assemble test groups for an accurate study. 

When choosing your study groups, consider: 

The size of your experiment

Whether you can select groups randomly

Your target audience for the outcome of the study

You should be able to create groups with an equal number of subjects and include subjects that match your target audience. Remember, you should assign one group as a control and use one or more groups to study the effects of variables. 

Step 5: Plan how to measure your dependent variable

This step determines how you'll collect data to determine the study's outcome. You should seek reliable and valid measurements that minimize research bias or error. 

You can measure some data with scientific tools, while you’ll need to operationalize other forms to turn them into measurable observations.

  • Advantages of experimental research

Experimental research is an integral part of our world. It allows researchers to conduct experiments that answer specific questions. 

While researchers use many methods to conduct different experiments, experimental research offers these distinct benefits:

Researchers can determine cause and effect by manipulating variables.

It gives researchers a high level of control.

Researchers can test multiple variables within a single experiment.

All industries and fields of knowledge can use it. 

Researchers can duplicate results to promote the validity of the study .

Replicating natural settings rapidly means immediate research.

Researchers can combine it with other research methods.

It provides specific conclusions about the validity of a product, theory, or idea.

  • Disadvantages (or limitations) of experimental research

Unfortunately, no research type yields ideal conditions or perfect results. 

While experimental research might be the right choice for some studies, certain conditions could render experiments useless or even dangerous. 

Before conducting experimental research, consider these disadvantages and limitations:

Required professional qualification

Only competent professionals with an academic degree and specific training are qualified to conduct rigorous experimental research. This ensures results are unbiased and valid. 

Limited scope

Experimental research may not capture the complexity of some phenomena, such as social interactions or cultural norms. These are difficult to control in a laboratory setting.

Resource-intensive

Experimental research can be expensive, time-consuming, and require significant resources, such as specialized equipment or trained personnel.

Limited generalizability

The controlled nature means the research findings may not fully apply to real-world situations or people outside the experimental setting.

Practical or ethical concerns

Some experiments may involve manipulating variables that could harm participants or violate ethical guidelines . 

Researchers must ensure their experiments do not cause harm or discomfort to participants. 

Sometimes, recruiting a sample of people to randomly assign may be difficult. 

  • Experimental research design example

Experiments across all industries and research realms provide scientists, developers, and other researchers with definitive answers. These experiments can solve problems, create inventions, and heal illnesses. 

Product design testing is an excellent example of experimental research. 

A company in the product development phase creates multiple prototypes for testing. With a randomized selection, researchers introduce each test group to a different prototype. 

When groups experience different product designs , the company can assess which option most appeals to potential customers. 

Experimental research design provides researchers with a controlled environment to conduct experiments that evaluate cause and effect. 

Using the five steps to develop a research plan ensures you anticipate and eliminate external variables while answering life’s crucial questions.

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Experimental Research Design — 6 mistakes you should never make!

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Since school days’ students perform scientific experiments that provide results that define and prove the laws and theorems in science. These experiments are laid on a strong foundation of experimental research designs.

An experimental research design helps researchers execute their research objectives with more clarity and transparency.

In this article, we will not only discuss the key aspects of experimental research designs but also the issues to avoid and problems to resolve while designing your research study.

Table of Contents

What Is Experimental Research Design?

Experimental research design is a framework of protocols and procedures created to conduct experimental research with a scientific approach using two sets of variables. Herein, the first set of variables acts as a constant, used to measure the differences of the second set. The best example of experimental research methods is quantitative research .

Experimental research helps a researcher gather the necessary data for making better research decisions and determining the facts of a research study.

When Can a Researcher Conduct Experimental Research?

A researcher can conduct experimental research in the following situations —

  • When time is an important factor in establishing a relationship between the cause and effect.
  • When there is an invariable or never-changing behavior between the cause and effect.
  • Finally, when the researcher wishes to understand the importance of the cause and effect.

Importance of Experimental Research Design

To publish significant results, choosing a quality research design forms the foundation to build the research study. Moreover, effective research design helps establish quality decision-making procedures, structures the research to lead to easier data analysis, and addresses the main research question. Therefore, it is essential to cater undivided attention and time to create an experimental research design before beginning the practical experiment.

By creating a research design, a researcher is also giving oneself time to organize the research, set up relevant boundaries for the study, and increase the reliability of the results. Through all these efforts, one could also avoid inconclusive results. If any part of the research design is flawed, it will reflect on the quality of the results derived.

Types of Experimental Research Designs

Based on the methods used to collect data in experimental studies, the experimental research designs are of three primary types:

1. Pre-experimental Research Design

A research study could conduct pre-experimental research design when a group or many groups are under observation after implementing factors of cause and effect of the research. The pre-experimental design will help researchers understand whether further investigation is necessary for the groups under observation.

Pre-experimental research is of three types —

  • One-shot Case Study Research Design
  • One-group Pretest-posttest Research Design
  • Static-group Comparison

2. True Experimental Research Design

A true experimental research design relies on statistical analysis to prove or disprove a researcher’s hypothesis. It is one of the most accurate forms of research because it provides specific scientific evidence. Furthermore, out of all the types of experimental designs, only a true experimental design can establish a cause-effect relationship within a group. However, in a true experiment, a researcher must satisfy these three factors —

  • There is a control group that is not subjected to changes and an experimental group that will experience the changed variables
  • A variable that can be manipulated by the researcher
  • Random distribution of the variables

This type of experimental research is commonly observed in the physical sciences.

3. Quasi-experimental Research Design

The word “Quasi” means similarity. A quasi-experimental design is similar to a true experimental design. However, the difference between the two is the assignment of the control group. In this research design, an independent variable is manipulated, but the participants of a group are not randomly assigned. This type of research design is used in field settings where random assignment is either irrelevant or not required.

The classification of the research subjects, conditions, or groups determines the type of research design to be used.

experimental research design

Advantages of Experimental Research

Experimental research allows you to test your idea in a controlled environment before taking the research to clinical trials. Moreover, it provides the best method to test your theory because of the following advantages:

  • Researchers have firm control over variables to obtain results.
  • The subject does not impact the effectiveness of experimental research. Anyone can implement it for research purposes.
  • The results are specific.
  • Post results analysis, research findings from the same dataset can be repurposed for similar research ideas.
  • Researchers can identify the cause and effect of the hypothesis and further analyze this relationship to determine in-depth ideas.
  • Experimental research makes an ideal starting point. The collected data could be used as a foundation to build new research ideas for further studies.

6 Mistakes to Avoid While Designing Your Research

There is no order to this list, and any one of these issues can seriously compromise the quality of your research. You could refer to the list as a checklist of what to avoid while designing your research.

1. Invalid Theoretical Framework

Usually, researchers miss out on checking if their hypothesis is logical to be tested. If your research design does not have basic assumptions or postulates, then it is fundamentally flawed and you need to rework on your research framework.

2. Inadequate Literature Study

Without a comprehensive research literature review , it is difficult to identify and fill the knowledge and information gaps. Furthermore, you need to clearly state how your research will contribute to the research field, either by adding value to the pertinent literature or challenging previous findings and assumptions.

3. Insufficient or Incorrect Statistical Analysis

Statistical results are one of the most trusted scientific evidence. The ultimate goal of a research experiment is to gain valid and sustainable evidence. Therefore, incorrect statistical analysis could affect the quality of any quantitative research.

4. Undefined Research Problem

This is one of the most basic aspects of research design. The research problem statement must be clear and to do that, you must set the framework for the development of research questions that address the core problems.

5. Research Limitations

Every study has some type of limitations . You should anticipate and incorporate those limitations into your conclusion, as well as the basic research design. Include a statement in your manuscript about any perceived limitations, and how you considered them while designing your experiment and drawing the conclusion.

6. Ethical Implications

The most important yet less talked about topic is the ethical issue. Your research design must include ways to minimize any risk for your participants and also address the research problem or question at hand. If you cannot manage the ethical norms along with your research study, your research objectives and validity could be questioned.

Experimental Research Design Example

In an experimental design, a researcher gathers plant samples and then randomly assigns half the samples to photosynthesize in sunlight and the other half to be kept in a dark box without sunlight, while controlling all the other variables (nutrients, water, soil, etc.)

By comparing their outcomes in biochemical tests, the researcher can confirm that the changes in the plants were due to the sunlight and not the other variables.

Experimental research is often the final form of a study conducted in the research process which is considered to provide conclusive and specific results. But it is not meant for every research. It involves a lot of resources, time, and money and is not easy to conduct, unless a foundation of research is built. Yet it is widely used in research institutes and commercial industries, for its most conclusive results in the scientific approach.

Have you worked on research designs? How was your experience creating an experimental design? What difficulties did you face? Do write to us or comment below and share your insights on experimental research designs!

Frequently Asked Questions

Randomization is important in an experimental research because it ensures unbiased results of the experiment. It also measures the cause-effect relationship on a particular group of interest.

Experimental research design lay the foundation of a research and structures the research to establish quality decision making process.

There are 3 types of experimental research designs. These are pre-experimental research design, true experimental research design, and quasi experimental research design.

The difference between an experimental and a quasi-experimental design are: 1. The assignment of the control group in quasi experimental research is non-random, unlike true experimental design, which is randomly assigned. 2. Experimental research group always has a control group; on the other hand, it may not be always present in quasi experimental research.

Experimental research establishes a cause-effect relationship by testing a theory or hypothesis using experimental groups or control variables. In contrast, descriptive research describes a study or a topic by defining the variables under it and answering the questions related to the same.

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  • Experimental Research Designs: Types, Examples & Methods

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Experimental research is the most familiar type of research design for individuals in the physical sciences and a host of other fields. This is mainly because experimental research is a classical scientific experiment, similar to those performed in high school science classes.

Imagine taking 2 samples of the same plant and exposing one of them to sunlight, while the other is kept away from sunlight. Let the plant exposed to sunlight be called sample A, while the latter is called sample B.

If after the duration of the research, we find out that sample A grows and sample B dies, even though they are both regularly wetted and given the same treatment. Therefore, we can conclude that sunlight will aid growth in all similar plants.

What is Experimental Research?

Experimental research is a scientific approach to research, where one or more independent variables are manipulated and applied to one or more dependent variables to measure their effect on the latter. The effect of the independent variables on the dependent variables is usually observed and recorded over some time, to aid researchers in drawing a reasonable conclusion regarding the relationship between these 2 variable types.

The experimental research method is widely used in physical and social sciences, psychology, and education. It is based on the comparison between two or more groups with a straightforward logic, which may, however, be difficult to execute.

Mostly related to a laboratory test procedure, experimental research designs involve collecting quantitative data and performing statistical analysis on them during research. Therefore, making it an example of quantitative research method .

What are The Types of Experimental Research Design?

The types of experimental research design are determined by the way the researcher assigns subjects to different conditions and groups. They are of 3 types, namely; pre-experimental, quasi-experimental, and true experimental research.

Pre-experimental Research Design

In pre-experimental research design, either a group or various dependent groups are observed for the effect of the application of an independent variable which is presumed to cause change. It is the simplest form of experimental research design and is treated with no control group.

Although very practical, experimental research is lacking in several areas of the true-experimental criteria. The pre-experimental research design is further divided into three types

  • One-shot Case Study Research Design

In this type of experimental study, only one dependent group or variable is considered. The study is carried out after some treatment which was presumed to cause change, making it a posttest study.

  • One-group Pretest-posttest Research Design: 

This research design combines both posttest and pretest study by carrying out a test on a single group before the treatment is administered and after the treatment is administered. With the former being administered at the beginning of treatment and later at the end.

  • Static-group Comparison: 

In a static-group comparison study, 2 or more groups are placed under observation, where only one of the groups is subjected to some treatment while the other groups are held static. All the groups are post-tested, and the observed differences between the groups are assumed to be a result of the treatment.

Quasi-experimental Research Design

  The word “quasi” means partial, half, or pseudo. Therefore, the quasi-experimental research bearing a resemblance to the true experimental research, but not the same.  In quasi-experiments, the participants are not randomly assigned, and as such, they are used in settings where randomization is difficult or impossible.

 This is very common in educational research, where administrators are unwilling to allow the random selection of students for experimental samples.

Some examples of quasi-experimental research design include; the time series, no equivalent control group design, and the counterbalanced design.

True Experimental Research Design

The true experimental research design relies on statistical analysis to approve or disprove a hypothesis. It is the most accurate type of experimental design and may be carried out with or without a pretest on at least 2 randomly assigned dependent subjects.

The true experimental research design must contain a control group, a variable that can be manipulated by the researcher, and the distribution must be random. The classification of true experimental design include:

  • The posttest-only Control Group Design: In this design, subjects are randomly selected and assigned to the 2 groups (control and experimental), and only the experimental group is treated. After close observation, both groups are post-tested, and a conclusion is drawn from the difference between these groups.
  • The pretest-posttest Control Group Design: For this control group design, subjects are randomly assigned to the 2 groups, both are presented, but only the experimental group is treated. After close observation, both groups are post-tested to measure the degree of change in each group.
  • Solomon four-group Design: This is the combination of the pretest-only and the pretest-posttest control groups. In this case, the randomly selected subjects are placed into 4 groups.

The first two of these groups are tested using the posttest-only method, while the other two are tested using the pretest-posttest method.

Examples of Experimental Research

Experimental research examples are different, depending on the type of experimental research design that is being considered. The most basic example of experimental research is laboratory experiments, which may differ in nature depending on the subject of research.

Administering Exams After The End of Semester

During the semester, students in a class are lectured on particular courses and an exam is administered at the end of the semester. In this case, the students are the subjects or dependent variables while the lectures are the independent variables treated on the subjects.

Only one group of carefully selected subjects are considered in this research, making it a pre-experimental research design example. We will also notice that tests are only carried out at the end of the semester, and not at the beginning.

Further making it easy for us to conclude that it is a one-shot case study research. 

Employee Skill Evaluation

Before employing a job seeker, organizations conduct tests that are used to screen out less qualified candidates from the pool of qualified applicants. This way, organizations can determine an employee’s skill set at the point of employment.

In the course of employment, organizations also carry out employee training to improve employee productivity and generally grow the organization. Further evaluation is carried out at the end of each training to test the impact of the training on employee skills, and test for improvement.

Here, the subject is the employee, while the treatment is the training conducted. This is a pretest-posttest control group experimental research example.

Evaluation of Teaching Method

Let us consider an academic institution that wants to evaluate the teaching method of 2 teachers to determine which is best. Imagine a case whereby the students assigned to each teacher is carefully selected probably due to personal request by parents or due to stubbornness and smartness.

This is a no equivalent group design example because the samples are not equal. By evaluating the effectiveness of each teacher’s teaching method this way, we may conclude after a post-test has been carried out.

However, this may be influenced by factors like the natural sweetness of a student. For example, a very smart student will grab more easily than his or her peers irrespective of the method of teaching.

What are the Characteristics of Experimental Research?  

Experimental research contains dependent, independent and extraneous variables. The dependent variables are the variables being treated or manipulated and are sometimes called the subject of the research.

The independent variables are the experimental treatment being exerted on the dependent variables. Extraneous variables, on the other hand, are other factors affecting the experiment that may also contribute to the change.

The setting is where the experiment is carried out. Many experiments are carried out in the laboratory, where control can be exerted on the extraneous variables, thereby eliminating them. 

Other experiments are carried out in a less controllable setting. The choice of setting used in research depends on the nature of the experiment being carried out.

  • Multivariable

Experimental research may include multiple independent variables, e.g. time, skills, test scores, etc.

Why Use Experimental Research Design?  

Experimental research design can be majorly used in physical sciences, social sciences, education, and psychology. It is used to make predictions and draw conclusions on a subject matter. 

Some uses of experimental research design are highlighted below.

  • Medicine: Experimental research is used to provide the proper treatment for diseases. In most cases, rather than directly using patients as the research subject, researchers take a sample of the bacteria from the patient’s body and are treated with the developed antibacterial

The changes observed during this period are recorded and evaluated to determine its effectiveness. This process can be carried out using different experimental research methods.

  • Education: Asides from science subjects like Chemistry and Physics which involves teaching students how to perform experimental research, it can also be used in improving the standard of an academic institution. This includes testing students’ knowledge on different topics, coming up with better teaching methods, and the implementation of other programs that will aid student learning.
  • Human Behavior: Social scientists are the ones who mostly use experimental research to test human behaviour. For example, consider 2 people randomly chosen to be the subject of the social interaction research where one person is placed in a room without human interaction for 1 year.

The other person is placed in a room with a few other people, enjoying human interaction. There will be a difference in their behaviour at the end of the experiment.

  • UI/UX: During the product development phase, one of the major aims of the product team is to create a great user experience with the product. Therefore, before launching the final product design, potential are brought in to interact with the product.

For example, when finding it difficult to choose how to position a button or feature on the app interface, a random sample of product testers are allowed to test the 2 samples and how the button positioning influences the user interaction is recorded.

What are the Disadvantages of Experimental Research?  

  • It is highly prone to human error due to its dependency on variable control which may not be properly implemented. These errors could eliminate the validity of the experiment and the research being conducted.
  • Exerting control of extraneous variables may create unrealistic situations. Eliminating real-life variables will result in inaccurate conclusions. This may also result in researchers controlling the variables to suit his or her personal preferences.
  • It is a time-consuming process. So much time is spent on testing dependent variables and waiting for the effect of the manipulation of dependent variables to manifest.
  • It is expensive. 
  • It is very risky and may have ethical complications that cannot be ignored. This is common in medical research, where failed trials may lead to a patient’s death or a deteriorating health condition.
  • Experimental research results are not descriptive.
  • Response bias can also be supplied by the subject of the conversation.
  • Human responses in experimental research can be difficult to measure. 

What are the Data Collection Methods in Experimental Research?  

Data collection methods in experimental research are the different ways in which data can be collected for experimental research. They are used in different cases, depending on the type of research being carried out.

1. Observational Study

This type of study is carried out over a long period. It measures and observes the variables of interest without changing existing conditions.

When researching the effect of social interaction on human behavior, the subjects who are placed in 2 different environments are observed throughout the research. No matter the kind of absurd behavior that is exhibited by the subject during this period, its condition will not be changed.

This may be a very risky thing to do in medical cases because it may lead to death or worse medical conditions.

2. Simulations

This procedure uses mathematical, physical, or computer models to replicate a real-life process or situation. It is frequently used when the actual situation is too expensive, dangerous, or impractical to replicate in real life.

This method is commonly used in engineering and operational research for learning purposes and sometimes as a tool to estimate possible outcomes of real research. Some common situation software are Simulink, MATLAB, and Simul8.

Not all kinds of experimental research can be carried out using simulation as a data collection tool . It is very impractical for a lot of laboratory-based research that involves chemical processes.

A survey is a tool used to gather relevant data about the characteristics of a population and is one of the most common data collection tools. A survey consists of a group of questions prepared by the researcher, to be answered by the research subject.

Surveys can be shared with the respondents both physically and electronically. When collecting data through surveys, the kind of data collected depends on the respondent, and researchers have limited control over it.

Formplus is the best tool for collecting experimental data using survey s. It has relevant features that will aid the data collection process and can also be used in other aspects of experimental research.

Differences between Experimental and Non-Experimental Research 

1. In experimental research, the researcher can control and manipulate the environment of the research, including the predictor variable which can be changed. On the other hand, non-experimental research cannot be controlled or manipulated by the researcher at will.

This is because it takes place in a real-life setting, where extraneous variables cannot be eliminated. Therefore, it is more difficult to conclude non-experimental studies, even though they are much more flexible and allow for a greater range of study fields.

2. The relationship between cause and effect cannot be established in non-experimental research, while it can be established in experimental research. This may be because many extraneous variables also influence the changes in the research subject, making it difficult to point at a particular variable as the cause of a particular change

3. Independent variables are not introduced, withdrawn, or manipulated in non-experimental designs, but the same may not be said about experimental research.

Conclusion  

Experimental research designs are often considered to be the standard in research designs. This is partly due to the common misconception that research is equivalent to scientific experiments—a component of experimental research design.

In this research design, one or more subjects or dependent variables are randomly assigned to different treatments (i.e. independent variables manipulated by the researcher) and the results are observed to conclude. One of the uniqueness of experimental research is in its ability to control the effect of extraneous variables.

Experimental research is suitable for research whose goal is to examine cause-effect relationships, e.g. explanatory research. It can be conducted in the laboratory or field settings, depending on the aim of the research that is being carried out. 

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5.2 Experimental Design

Learning objectives.

  • Explain the difference between between-subjects and within-subjects experiments, list some of the pros and cons of each approach, and decide which approach to use to answer a particular research question.
  • Define random assignment, distinguish it from random sampling, explain its purpose in experimental research, and use some simple strategies to implement it
  • Define several types of carryover effect, give examples of each, and explain how counterbalancing helps to deal with them.

In this section, we look at some different ways to design an experiment. The primary distinction we will make is between approaches in which each participant experiences one level of the independent variable and approaches in which each participant experiences all levels of the independent variable. The former are called between-subjects experiments and the latter are called within-subjects experiments.

Between-Subjects Experiments

In a  between-subjects experiment , each participant is tested in only one condition. For example, a researcher with a sample of 100 university  students might assign half of them to write about a traumatic event and the other half write about a neutral event. Or a researcher with a sample of 60 people with severe agoraphobia (fear of open spaces) might assign 20 of them to receive each of three different treatments for that disorder. It is essential in a between-subjects experiment that the researcher assigns participants to conditions so that the different groups are, on average, highly similar to each other. Those in a trauma condition and a neutral condition, for example, should include a similar proportion of men and women, and they should have similar average intelligence quotients (IQs), similar average levels of motivation, similar average numbers of health problems, and so on. This matching is a matter of controlling these extraneous participant variables across conditions so that they do not become confounding variables.

Random Assignment

The primary way that researchers accomplish this kind of control of extraneous variables across conditions is called  random assignment , which means using a random process to decide which participants are tested in which conditions. Do not confuse random assignment with random sampling. Random sampling is a method for selecting a sample from a population, and it is rarely used in psychological research. Random assignment is a method for assigning participants in a sample to the different conditions, and it is an important element of all experimental research in psychology and other fields too.

In its strictest sense, random assignment should meet two criteria. One is that each participant has an equal chance of being assigned to each condition (e.g., a 50% chance of being assigned to each of two conditions). The second is that each participant is assigned to a condition independently of other participants. Thus one way to assign participants to two conditions would be to flip a coin for each one. If the coin lands heads, the participant is assigned to Condition A, and if it lands tails, the participant is assigned to Condition B. For three conditions, one could use a computer to generate a random integer from 1 to 3 for each participant. If the integer is 1, the participant is assigned to Condition A; if it is 2, the participant is assigned to Condition B; and if it is 3, the participant is assigned to Condition C. In practice, a full sequence of conditions—one for each participant expected to be in the experiment—is usually created ahead of time, and each new participant is assigned to the next condition in the sequence as he or she is tested. When the procedure is computerized, the computer program often handles the random assignment.

One problem with coin flipping and other strict procedures for random assignment is that they are likely to result in unequal sample sizes in the different conditions. Unequal sample sizes are generally not a serious problem, and you should never throw away data you have already collected to achieve equal sample sizes. However, for a fixed number of participants, it is statistically most efficient to divide them into equal-sized groups. It is standard practice, therefore, to use a kind of modified random assignment that keeps the number of participants in each group as similar as possible. One approach is block randomization . In block randomization, all the conditions occur once in the sequence before any of them is repeated. Then they all occur again before any of them is repeated again. Within each of these “blocks,” the conditions occur in a random order. Again, the sequence of conditions is usually generated before any participants are tested, and each new participant is assigned to the next condition in the sequence.  Table 5.2  shows such a sequence for assigning nine participants to three conditions. The Research Randomizer website ( http://www.randomizer.org ) will generate block randomization sequences for any number of participants and conditions. Again, when the procedure is computerized, the computer program often handles the block randomization.

Random assignment is not guaranteed to control all extraneous variables across conditions. The process is random, so it is always possible that just by chance, the participants in one condition might turn out to be substantially older, less tired, more motivated, or less depressed on average than the participants in another condition. However, there are some reasons that this possibility is not a major concern. One is that random assignment works better than one might expect, especially for large samples. Another is that the inferential statistics that researchers use to decide whether a difference between groups reflects a difference in the population takes the “fallibility” of random assignment into account. Yet another reason is that even if random assignment does result in a confounding variable and therefore produces misleading results, this confound is likely to be detected when the experiment is replicated. The upshot is that random assignment to conditions—although not infallible in terms of controlling extraneous variables—is always considered a strength of a research design.

Matched Groups

An alternative to simple random assignment of participants to conditions is the use of a matched-groups design . Using this design, participants in the various conditions are matched on the dependent variable or on some extraneous variable(s) prior the manipulation of the independent variable. This guarantees that these variables will not be confounded across the experimental conditions. For instance, if we want to determine whether expressive writing affects people’s health then we could start by measuring various health-related variables in our prospective research participants. We could then use that information to rank-order participants according to how healthy or unhealthy they are. Next, the two healthiest participants would be randomly assigned to complete different conditions (one would be randomly assigned to the traumatic experiences writing condition and the other to the neutral writing condition). The next two healthiest participants would then be randomly assigned to complete different conditions, and so on until the two least healthy participants. This method would ensure that participants in the traumatic experiences writing condition are matched to participants in the neutral writing condition with respect to health at the beginning of the study. If at the end of the experiment, a difference in health was detected across the two conditions, then we would know that it is due to the writing manipulation and not to pre-existing differences in health.

Within-Subjects Experiments

In a  within-subjects experiment , each participant is tested under all conditions. Consider an experiment on the effect of a defendant’s physical attractiveness on judgments of his guilt. Again, in a between-subjects experiment, one group of participants would be shown an attractive defendant and asked to judge his guilt, and another group of participants would be shown an unattractive defendant and asked to judge his guilt. In a within-subjects experiment, however, the same group of participants would judge the guilt of both an attractive  and  an unattractive defendant.

The primary advantage of this approach is that it provides maximum control of extraneous participant variables. Participants in all conditions have the same mean IQ, same socioeconomic status, same number of siblings, and so on—because they are the very same people. Within-subjects experiments also make it possible to use statistical procedures that remove the effect of these extraneous participant variables on the dependent variable and therefore make the data less “noisy” and the effect of the independent variable easier to detect. We will look more closely at this idea later in the book .  However, not all experiments can use a within-subjects design nor would it be desirable to do so.

One disadvantage of within-subjects experiments is that they make it easier for participants to guess the hypothesis. For example, a participant who is asked to judge the guilt of an attractive defendant and then is asked to judge the guilt of an unattractive defendant is likely to guess that the hypothesis is that defendant attractiveness affects judgments of guilt. This  knowledge could  lead the participant to judge the unattractive defendant more harshly because he thinks this is what he is expected to do. Or it could make participants judge the two defendants similarly in an effort to be “fair.”

Carryover Effects and Counterbalancing

The primary disadvantage of within-subjects designs is that they can result in order effects. An order effect  occurs when participants’ responses in the various conditions are affected by the order of conditions to which they were exposed. One type of order effect is a carryover effect. A  carryover effect  is an effect of being tested in one condition on participants’ behavior in later conditions. One type of carryover effect is a  practice effect , where participants perform a task better in later conditions because they have had a chance to practice it. Another type is a fatigue effect , where participants perform a task worse in later conditions because they become tired or bored. Being tested in one condition can also change how participants perceive stimuli or interpret their task in later conditions. This  type of effect is called a  context effect (or contrast effect) . For example, an average-looking defendant might be judged more harshly when participants have just judged an attractive defendant than when they have just judged an unattractive defendant. Within-subjects experiments also make it easier for participants to guess the hypothesis. For example, a participant who is asked to judge the guilt of an attractive defendant and then is asked to judge the guilt of an unattractive defendant is likely to guess that the hypothesis is that defendant attractiveness affects judgments of guilt. 

Carryover effects can be interesting in their own right. (Does the attractiveness of one person depend on the attractiveness of other people that we have seen recently?) But when they are not the focus of the research, carryover effects can be problematic. Imagine, for example, that participants judge the guilt of an attractive defendant and then judge the guilt of an unattractive defendant. If they judge the unattractive defendant more harshly, this might be because of his unattractiveness. But it could be instead that they judge him more harshly because they are becoming bored or tired. In other words, the order of the conditions is a confounding variable. The attractive condition is always the first condition and the unattractive condition the second. Thus any difference between the conditions in terms of the dependent variable could be caused by the order of the conditions and not the independent variable itself.

There is a solution to the problem of order effects, however, that can be used in many situations. It is  counterbalancing , which means testing different participants in different orders. The best method of counterbalancing is complete counterbalancing  in which an equal number of participants complete each possible order of conditions. For example, half of the participants would be tested in the attractive defendant condition followed by the unattractive defendant condition, and others half would be tested in the unattractive condition followed by the attractive condition. With three conditions, there would be six different orders (ABC, ACB, BAC, BCA, CAB, and CBA), so some participants would be tested in each of the six orders. With four conditions, there would be 24 different orders; with five conditions there would be 120 possible orders. With counterbalancing, participants are assigned to orders randomly, using the techniques we have already discussed. Thus, random assignment plays an important role in within-subjects designs just as in between-subjects designs. Here, instead of randomly assigning to conditions, they are randomly assigned to different orders of conditions. In fact, it can safely be said that if a study does not involve random assignment in one form or another, it is not an experiment.

A more efficient way of counterbalancing is through a Latin square design which randomizes through having equal rows and columns. For example, if you have four treatments, you must have four versions. Like a Sudoku puzzle, no treatment can repeat in a row or column. For four versions of four treatments, the Latin square design would look like:

You can see in the diagram above that the square has been constructed to ensure that each condition appears at each ordinal position (A appears first once, second once, third once, and fourth once) and each condition preceded and follows each other condition one time. A Latin square for an experiment with 6 conditions would by 6 x 6 in dimension, one for an experiment with 8 conditions would be 8 x 8 in dimension, and so on. So while complete counterbalancing of 6 conditions would require 720 orders, a Latin square would only require 6 orders.

Finally, when the number of conditions is large experiments can use  random counterbalancing  in which the order of the conditions is randomly determined for each participant. Using this technique every possible order of conditions is determined and then one of these orders is randomly selected for each participant. This is not as powerful a technique as complete counterbalancing or partial counterbalancing using a Latin squares design. Use of random counterbalancing will result in more random error, but if order effects are likely to be small and the number of conditions is large, this is an option available to researchers.

There are two ways to think about what counterbalancing accomplishes. One is that it controls the order of conditions so that it is no longer a confounding variable. Instead of the attractive condition always being first and the unattractive condition always being second, the attractive condition comes first for some participants and second for others. Likewise, the unattractive condition comes first for some participants and second for others. Thus any overall difference in the dependent variable between the two conditions cannot have been caused by the order of conditions. A second way to think about what counterbalancing accomplishes is that if there are carryover effects, it makes it possible to detect them. One can analyze the data separately for each order to see whether it had an effect.

When 9 Is “Larger” Than 221

Researcher Michael Birnbaum has argued that the  lack  of context provided by between-subjects designs is often a bigger problem than the context effects created by within-subjects designs. To demonstrate this problem, he asked participants to rate two numbers on how large they were on a scale of 1-to-10 where 1 was “very very small” and 10 was “very very large”.  One group of participants were asked to rate the number 9 and another group was asked to rate the number 221 (Birnbaum, 1999) [1] . Participants in this between-subjects design gave the number 9 a mean rating of 5.13 and the number 221 a mean rating of 3.10. In other words, they rated 9 as larger than 221! According to Birnbaum, this  difference  is because participants spontaneously compared 9 with other one-digit numbers (in which case it is  relatively large) and compared 221 with other three-digit numbers (in which case it is relatively  small).

Simultaneous Within-Subjects Designs

So far, we have discussed an approach to within-subjects designs in which participants are tested in one condition at a time. There is another approach, however, that is often used when participants make multiple responses in each condition. Imagine, for example, that participants judge the guilt of 10 attractive defendants and 10 unattractive defendants. Instead of having people make judgments about all 10 defendants of one type followed by all 10 defendants of the other type, the researcher could present all 20 defendants in a sequence that mixed the two types. The researcher could then compute each participant’s mean rating for each type of defendant. Or imagine an experiment designed to see whether people with social anxiety disorder remember negative adjectives (e.g., “stupid,” “incompetent”) better than positive ones (e.g., “happy,” “productive”). The researcher could have participants study a single list that includes both kinds of words and then have them try to recall as many words as possible. The researcher could then count the number of each type of word that was recalled. 

Between-Subjects or Within-Subjects?

Almost every experiment can be conducted using either a between-subjects design or a within-subjects design. This possibility means that researchers must choose between the two approaches based on their relative merits for the particular situation.

Between-subjects experiments have the advantage of being conceptually simpler and requiring less testing time per participant. They also avoid carryover effects without the need for counterbalancing. Within-subjects experiments have the advantage of controlling extraneous participant variables, which generally reduces noise in the data and makes it easier to detect a relationship between the independent and dependent variables.

A good rule of thumb, then, is that if it is possible to conduct a within-subjects experiment (with proper counterbalancing) in the time that is available per participant—and you have no serious concerns about carryover effects—this design is probably the best option. If a within-subjects design would be difficult or impossible to carry out, then you should consider a between-subjects design instead. For example, if you were testing participants in a doctor’s waiting room or shoppers in line at a grocery store, you might not have enough time to test each participant in all conditions and therefore would opt for a between-subjects design. Or imagine you were trying to reduce people’s level of prejudice by having them interact with someone of another race. A within-subjects design with counterbalancing would require testing some participants in the treatment condition first and then in a control condition. But if the treatment works and reduces people’s level of prejudice, then they would no longer be suitable for testing in the control condition. This difficulty is true for many designs that involve a treatment meant to produce long-term change in participants’ behavior (e.g., studies testing the effectiveness of psychotherapy). Clearly, a between-subjects design would be necessary here.

Remember also that using one type of design does not preclude using the other type in a different study. There is no reason that a researcher could not use both a between-subjects design and a within-subjects design to answer the same research question. In fact, professional researchers often take exactly this type of mixed methods approach.

Key Takeaways

  • Experiments can be conducted using either between-subjects or within-subjects designs. Deciding which to use in a particular situation requires careful consideration of the pros and cons of each approach.
  • Random assignment to conditions in between-subjects experiments or counterbalancing of orders of conditions in within-subjects experiments is a fundamental element of experimental research. The purpose of these techniques is to control extraneous variables so that they do not become confounding variables.
  • You want to test the relative effectiveness of two training programs for running a marathon.
  • Using photographs of people as stimuli, you want to see if smiling people are perceived as more intelligent than people who are not smiling.
  • In a field experiment, you want to see if the way a panhandler is dressed (neatly vs. sloppily) affects whether or not passersby give him any money.
  • You want to see if concrete nouns (e.g.,  dog ) are recalled better than abstract nouns (e.g.,  truth).
  • Birnbaum, M.H. (1999). How to show that 9>221: Collect judgments in a between-subjects design. Psychological Methods, 4 (3), 243-249. ↵

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Home » Experimental Design – Types, Methods, Guide

Experimental Design – Types, Methods, Guide

Table of Contents

Experimental Research Design

Experimental Design

Experimental design is a process of planning and conducting scientific experiments to investigate a hypothesis or research question. It involves carefully designing an experiment that can test the hypothesis, and controlling for other variables that may influence the results.

Experimental design typically includes identifying the variables that will be manipulated or measured, defining the sample or population to be studied, selecting an appropriate method of sampling, choosing a method for data collection and analysis, and determining the appropriate statistical tests to use.

Types of Experimental Design

Here are the different types of experimental design:

Completely Randomized Design

In this design, participants are randomly assigned to one of two or more groups, and each group is exposed to a different treatment or condition.

Randomized Block Design

This design involves dividing participants into blocks based on a specific characteristic, such as age or gender, and then randomly assigning participants within each block to one of two or more treatment groups.

Factorial Design

In a factorial design, participants are randomly assigned to one of several groups, each of which receives a different combination of two or more independent variables.

Repeated Measures Design

In this design, each participant is exposed to all of the different treatments or conditions, either in a random order or in a predetermined order.

Crossover Design

This design involves randomly assigning participants to one of two or more treatment groups, with each group receiving one treatment during the first phase of the study and then switching to a different treatment during the second phase.

Split-plot Design

In this design, the researcher manipulates one or more variables at different levels and uses a randomized block design to control for other variables.

Nested Design

This design involves grouping participants within larger units, such as schools or households, and then randomly assigning these units to different treatment groups.

Laboratory Experiment

Laboratory experiments are conducted under controlled conditions, which allows for greater precision and accuracy. However, because laboratory conditions are not always representative of real-world conditions, the results of these experiments may not be generalizable to the population at large.

Field Experiment

Field experiments are conducted in naturalistic settings and allow for more realistic observations. However, because field experiments are not as controlled as laboratory experiments, they may be subject to more sources of error.

Experimental Design Methods

Experimental design methods refer to the techniques and procedures used to design and conduct experiments in scientific research. Here are some common experimental design methods:

Randomization

This involves randomly assigning participants to different groups or treatments to ensure that any observed differences between groups are due to the treatment and not to other factors.

Control Group

The use of a control group is an important experimental design method that involves having a group of participants that do not receive the treatment or intervention being studied. The control group is used as a baseline to compare the effects of the treatment group.

Blinding involves keeping participants, researchers, or both unaware of which treatment group participants are in, in order to reduce the risk of bias in the results.

Counterbalancing

This involves systematically varying the order in which participants receive treatments or interventions in order to control for order effects.

Replication

Replication involves conducting the same experiment with different samples or under different conditions to increase the reliability and validity of the results.

This experimental design method involves manipulating multiple independent variables simultaneously to investigate their combined effects on the dependent variable.

This involves dividing participants into subgroups or blocks based on specific characteristics, such as age or gender, in order to reduce the risk of confounding variables.

Data Collection Method

Experimental design data collection methods are techniques and procedures used to collect data in experimental research. Here are some common experimental design data collection methods:

Direct Observation

This method involves observing and recording the behavior or phenomenon of interest in real time. It may involve the use of structured or unstructured observation, and may be conducted in a laboratory or naturalistic setting.

Self-report Measures

Self-report measures involve asking participants to report their thoughts, feelings, or behaviors using questionnaires, surveys, or interviews. These measures may be administered in person or online.

Behavioral Measures

Behavioral measures involve measuring participants’ behavior directly, such as through reaction time tasks or performance tests. These measures may be administered using specialized equipment or software.

Physiological Measures

Physiological measures involve measuring participants’ physiological responses, such as heart rate, blood pressure, or brain activity, using specialized equipment. These measures may be invasive or non-invasive, and may be administered in a laboratory or clinical setting.

Archival Data

Archival data involves using existing records or data, such as medical records, administrative records, or historical documents, as a source of information. These data may be collected from public or private sources.

Computerized Measures

Computerized measures involve using software or computer programs to collect data on participants’ behavior or responses. These measures may include reaction time tasks, cognitive tests, or other types of computer-based assessments.

Video Recording

Video recording involves recording participants’ behavior or interactions using cameras or other recording equipment. This method can be used to capture detailed information about participants’ behavior or to analyze social interactions.

Data Analysis Method

Experimental design data analysis methods refer to the statistical techniques and procedures used to analyze data collected in experimental research. Here are some common experimental design data analysis methods:

Descriptive Statistics

Descriptive statistics are used to summarize and describe the data collected in the study. This includes measures such as mean, median, mode, range, and standard deviation.

Inferential Statistics

Inferential statistics are used to make inferences or generalizations about a larger population based on the data collected in the study. This includes hypothesis testing and estimation.

Analysis of Variance (ANOVA)

ANOVA is a statistical technique used to compare means across two or more groups in order to determine whether there are significant differences between the groups. There are several types of ANOVA, including one-way ANOVA, two-way ANOVA, and repeated measures ANOVA.

Regression Analysis

Regression analysis is used to model the relationship between two or more variables in order to determine the strength and direction of the relationship. There are several types of regression analysis, including linear regression, logistic regression, and multiple regression.

Factor Analysis

Factor analysis is used to identify underlying factors or dimensions in a set of variables. This can be used to reduce the complexity of the data and identify patterns in the data.

Structural Equation Modeling (SEM)

SEM is a statistical technique used to model complex relationships between variables. It can be used to test complex theories and models of causality.

Cluster Analysis

Cluster analysis is used to group similar cases or observations together based on similarities or differences in their characteristics.

Time Series Analysis

Time series analysis is used to analyze data collected over time in order to identify trends, patterns, or changes in the data.

Multilevel Modeling

Multilevel modeling is used to analyze data that is nested within multiple levels, such as students nested within schools or employees nested within companies.

Applications of Experimental Design 

Experimental design is a versatile research methodology that can be applied in many fields. Here are some applications of experimental design:

  • Medical Research: Experimental design is commonly used to test new treatments or medications for various medical conditions. This includes clinical trials to evaluate the safety and effectiveness of new drugs or medical devices.
  • Agriculture : Experimental design is used to test new crop varieties, fertilizers, and other agricultural practices. This includes randomized field trials to evaluate the effects of different treatments on crop yield, quality, and pest resistance.
  • Environmental science: Experimental design is used to study the effects of environmental factors, such as pollution or climate change, on ecosystems and wildlife. This includes controlled experiments to study the effects of pollutants on plant growth or animal behavior.
  • Psychology : Experimental design is used to study human behavior and cognitive processes. This includes experiments to test the effects of different interventions, such as therapy or medication, on mental health outcomes.
  • Engineering : Experimental design is used to test new materials, designs, and manufacturing processes in engineering applications. This includes laboratory experiments to test the strength and durability of new materials, or field experiments to test the performance of new technologies.
  • Education : Experimental design is used to evaluate the effectiveness of teaching methods, educational interventions, and programs. This includes randomized controlled trials to compare different teaching methods or evaluate the impact of educational programs on student outcomes.
  • Marketing : Experimental design is used to test the effectiveness of marketing campaigns, pricing strategies, and product designs. This includes experiments to test the impact of different marketing messages or pricing schemes on consumer behavior.

Examples of Experimental Design 

Here are some examples of experimental design in different fields:

  • Example in Medical research : A study that investigates the effectiveness of a new drug treatment for a particular condition. Patients are randomly assigned to either a treatment group or a control group, with the treatment group receiving the new drug and the control group receiving a placebo. The outcomes, such as improvement in symptoms or side effects, are measured and compared between the two groups.
  • Example in Education research: A study that examines the impact of a new teaching method on student learning outcomes. Students are randomly assigned to either a group that receives the new teaching method or a group that receives the traditional teaching method. Student achievement is measured before and after the intervention, and the results are compared between the two groups.
  • Example in Environmental science: A study that tests the effectiveness of a new method for reducing pollution in a river. Two sections of the river are selected, with one section treated with the new method and the other section left untreated. The water quality is measured before and after the intervention, and the results are compared between the two sections.
  • Example in Marketing research: A study that investigates the impact of a new advertising campaign on consumer behavior. Participants are randomly assigned to either a group that is exposed to the new campaign or a group that is not. Their behavior, such as purchasing or product awareness, is measured and compared between the two groups.
  • Example in Social psychology: A study that examines the effect of a new social intervention on reducing prejudice towards a marginalized group. Participants are randomly assigned to either a group that receives the intervention or a control group that does not. Their attitudes and behavior towards the marginalized group are measured before and after the intervention, and the results are compared between the two groups.

When to use Experimental Research Design 

Experimental research design should be used when a researcher wants to establish a cause-and-effect relationship between variables. It is particularly useful when studying the impact of an intervention or treatment on a particular outcome.

Here are some situations where experimental research design may be appropriate:

  • When studying the effects of a new drug or medical treatment: Experimental research design is commonly used in medical research to test the effectiveness and safety of new drugs or medical treatments. By randomly assigning patients to treatment and control groups, researchers can determine whether the treatment is effective in improving health outcomes.
  • When evaluating the effectiveness of an educational intervention: An experimental research design can be used to evaluate the impact of a new teaching method or educational program on student learning outcomes. By randomly assigning students to treatment and control groups, researchers can determine whether the intervention is effective in improving academic performance.
  • When testing the effectiveness of a marketing campaign: An experimental research design can be used to test the effectiveness of different marketing messages or strategies. By randomly assigning participants to treatment and control groups, researchers can determine whether the marketing campaign is effective in changing consumer behavior.
  • When studying the effects of an environmental intervention: Experimental research design can be used to study the impact of environmental interventions, such as pollution reduction programs or conservation efforts. By randomly assigning locations or areas to treatment and control groups, researchers can determine whether the intervention is effective in improving environmental outcomes.
  • When testing the effects of a new technology: An experimental research design can be used to test the effectiveness and safety of new technologies or engineering designs. By randomly assigning participants or locations to treatment and control groups, researchers can determine whether the new technology is effective in achieving its intended purpose.

How to Conduct Experimental Research

Here are the steps to conduct Experimental Research:

  • Identify a Research Question : Start by identifying a research question that you want to answer through the experiment. The question should be clear, specific, and testable.
  • Develop a Hypothesis: Based on your research question, develop a hypothesis that predicts the relationship between the independent and dependent variables. The hypothesis should be clear and testable.
  • Design the Experiment : Determine the type of experimental design you will use, such as a between-subjects design or a within-subjects design. Also, decide on the experimental conditions, such as the number of independent variables, the levels of the independent variable, and the dependent variable to be measured.
  • Select Participants: Select the participants who will take part in the experiment. They should be representative of the population you are interested in studying.
  • Randomly Assign Participants to Groups: If you are using a between-subjects design, randomly assign participants to groups to control for individual differences.
  • Conduct the Experiment : Conduct the experiment by manipulating the independent variable(s) and measuring the dependent variable(s) across the different conditions.
  • Analyze the Data: Analyze the data using appropriate statistical methods to determine if there is a significant effect of the independent variable(s) on the dependent variable(s).
  • Draw Conclusions: Based on the data analysis, draw conclusions about the relationship between the independent and dependent variables. If the results support the hypothesis, then it is accepted. If the results do not support the hypothesis, then it is rejected.
  • Communicate the Results: Finally, communicate the results of the experiment through a research report or presentation. Include the purpose of the study, the methods used, the results obtained, and the conclusions drawn.

Purpose of Experimental Design 

The purpose of experimental design is to control and manipulate one or more independent variables to determine their effect on a dependent variable. Experimental design allows researchers to systematically investigate causal relationships between variables, and to establish cause-and-effect relationships between the independent and dependent variables. Through experimental design, researchers can test hypotheses and make inferences about the population from which the sample was drawn.

Experimental design provides a structured approach to designing and conducting experiments, ensuring that the results are reliable and valid. By carefully controlling for extraneous variables that may affect the outcome of the study, experimental design allows researchers to isolate the effect of the independent variable(s) on the dependent variable(s), and to minimize the influence of other factors that may confound the results.

Experimental design also allows researchers to generalize their findings to the larger population from which the sample was drawn. By randomly selecting participants and using statistical techniques to analyze the data, researchers can make inferences about the larger population with a high degree of confidence.

Overall, the purpose of experimental design is to provide a rigorous, systematic, and scientific method for testing hypotheses and establishing cause-and-effect relationships between variables. Experimental design is a powerful tool for advancing scientific knowledge and informing evidence-based practice in various fields, including psychology, biology, medicine, engineering, and social sciences.

Advantages of Experimental Design 

Experimental design offers several advantages in research. Here are some of the main advantages:

  • Control over extraneous variables: Experimental design allows researchers to control for extraneous variables that may affect the outcome of the study. By manipulating the independent variable and holding all other variables constant, researchers can isolate the effect of the independent variable on the dependent variable.
  • Establishing causality: Experimental design allows researchers to establish causality by manipulating the independent variable and observing its effect on the dependent variable. This allows researchers to determine whether changes in the independent variable cause changes in the dependent variable.
  • Replication : Experimental design allows researchers to replicate their experiments to ensure that the findings are consistent and reliable. Replication is important for establishing the validity and generalizability of the findings.
  • Random assignment: Experimental design often involves randomly assigning participants to conditions. This helps to ensure that individual differences between participants are evenly distributed across conditions, which increases the internal validity of the study.
  • Precision : Experimental design allows researchers to measure variables with precision, which can increase the accuracy and reliability of the data.
  • Generalizability : If the study is well-designed, experimental design can increase the generalizability of the findings. By controlling for extraneous variables and using random assignment, researchers can increase the likelihood that the findings will apply to other populations and contexts.

Limitations of Experimental Design

Experimental design has some limitations that researchers should be aware of. Here are some of the main limitations:

  • Artificiality : Experimental design often involves creating artificial situations that may not reflect real-world situations. This can limit the external validity of the findings, or the extent to which the findings can be generalized to real-world settings.
  • Ethical concerns: Some experimental designs may raise ethical concerns, particularly if they involve manipulating variables that could cause harm to participants or if they involve deception.
  • Participant bias : Participants in experimental studies may modify their behavior in response to the experiment, which can lead to participant bias.
  • Limited generalizability: The conditions of the experiment may not reflect the complexities of real-world situations. As a result, the findings may not be applicable to all populations and contexts.
  • Cost and time : Experimental design can be expensive and time-consuming, particularly if the experiment requires specialized equipment or if the sample size is large.
  • Researcher bias : Researchers may unintentionally bias the results of the experiment if they have expectations or preferences for certain outcomes.
  • Lack of feasibility : Experimental design may not be feasible in some cases, particularly if the research question involves variables that cannot be manipulated or controlled.

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Methodology

Research Methods | Definitions, Types, Examples

Research methods are specific procedures for collecting and analyzing data. Developing your research methods is an integral part of your research design . When planning your methods, there are two key decisions you will make.

First, decide how you will collect data . Your methods depend on what type of data you need to answer your research question :

  • Qualitative vs. quantitative : Will your data take the form of words or numbers?
  • Primary vs. secondary : Will you collect original data yourself, or will you use data that has already been collected by someone else?
  • Descriptive vs. experimental : Will you take measurements of something as it is, or will you perform an experiment?

Second, decide how you will analyze the data .

  • For quantitative data, you can use statistical analysis methods to test relationships between variables.
  • For qualitative data, you can use methods such as thematic analysis to interpret patterns and meanings in the data.

Table of contents

Methods for collecting data, examples of data collection methods, methods for analyzing data, examples of data analysis methods, other interesting articles, frequently asked questions about research methods.

Data is the information that you collect for the purposes of answering your research question . The type of data you need depends on the aims of your research.

Qualitative vs. quantitative data

Your choice of qualitative or quantitative data collection depends on the type of knowledge you want to develop.

For questions about ideas, experiences and meanings, or to study something that can’t be described numerically, collect qualitative data .

If you want to develop a more mechanistic understanding of a topic, or your research involves hypothesis testing , collect quantitative data .

You can also take a mixed methods approach , where you use both qualitative and quantitative research methods.

Primary vs. secondary research

Primary research is any original data that you collect yourself for the purposes of answering your research question (e.g. through surveys , observations and experiments ). Secondary research is data that has already been collected by other researchers (e.g. in a government census or previous scientific studies).

If you are exploring a novel research question, you’ll probably need to collect primary data . But if you want to synthesize existing knowledge, analyze historical trends, or identify patterns on a large scale, secondary data might be a better choice.

Descriptive vs. experimental data

In descriptive research , you collect data about your study subject without intervening. The validity of your research will depend on your sampling method .

In experimental research , you systematically intervene in a process and measure the outcome. The validity of your research will depend on your experimental design .

To conduct an experiment, you need to be able to vary your independent variable , precisely measure your dependent variable, and control for confounding variables . If it’s practically and ethically possible, this method is the best choice for answering questions about cause and effect.

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Your data analysis methods will depend on the type of data you collect and how you prepare it for analysis.

Data can often be analyzed both quantitatively and qualitatively. For example, survey responses could be analyzed qualitatively by studying the meanings of responses or quantitatively by studying the frequencies of responses.

Qualitative analysis methods

Qualitative analysis is used to understand words, ideas, and experiences. You can use it to interpret data that was collected:

  • From open-ended surveys and interviews , literature reviews , case studies , ethnographies , and other sources that use text rather than numbers.
  • Using non-probability sampling methods .

Qualitative analysis tends to be quite flexible and relies on the researcher’s judgement, so you have to reflect carefully on your choices and assumptions and be careful to avoid research bias .

Quantitative analysis methods

Quantitative analysis uses numbers and statistics to understand frequencies, averages and correlations (in descriptive studies) or cause-and-effect relationships (in experiments).

You can use quantitative analysis to interpret data that was collected either:

  • During an experiment .
  • Using probability sampling methods .

Because the data is collected and analyzed in a statistically valid way, the results of quantitative analysis can be easily standardized and shared among researchers.

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research subjects of experimental

If you want to know more about statistics , methodology , or research bias , make sure to check out some of our other articles with explanations and examples.

  • Chi square test of independence
  • Statistical power
  • Descriptive statistics
  • Degrees of freedom
  • Pearson correlation
  • Null hypothesis
  • Double-blind study
  • Case-control study
  • Research ethics
  • Data collection
  • Hypothesis testing
  • Structured interviews

Research bias

  • Hawthorne effect
  • Unconscious bias
  • Recall bias
  • Halo effect
  • Self-serving bias
  • Information bias

Quantitative research deals with numbers and statistics, while qualitative research deals with words and meanings.

Quantitative methods allow you to systematically measure variables and test hypotheses . Qualitative methods allow you to explore concepts and experiences in more detail.

In mixed methods research , you use both qualitative and quantitative data collection and analysis methods to answer your research question .

A sample is a subset of individuals from a larger population . Sampling means selecting the group that you will actually collect data from in your research. For example, if you are researching the opinions of students in your university, you could survey a sample of 100 students.

In statistics, sampling allows you to test a hypothesis about the characteristics of a population.

The research methods you use depend on the type of data you need to answer your research question .

  • If you want to measure something or test a hypothesis , use quantitative methods . If you want to explore ideas, thoughts and meanings, use qualitative methods .
  • If you want to analyze a large amount of readily-available data, use secondary data. If you want data specific to your purposes with control over how it is generated, collect primary data.
  • If you want to establish cause-and-effect relationships between variables , use experimental methods. If you want to understand the characteristics of a research subject, use descriptive methods.

Methodology refers to the overarching strategy and rationale of your research project . It involves studying the methods used in your field and the theories or principles behind them, in order to develop an approach that matches your objectives.

Methods are the specific tools and procedures you use to collect and analyze data (for example, experiments, surveys , and statistical tests ).

In shorter scientific papers, where the aim is to report the findings of a specific study, you might simply describe what you did in a methods section .

In a longer or more complex research project, such as a thesis or dissertation , you will probably include a methodology section , where you explain your approach to answering the research questions and cite relevant sources to support your choice of methods.

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Mastering Research: The Principles of Experimental Design

David Costello

In a world overflowing with information and data, how do we differentiate between mere observation and genuine knowledge? The answer lies in the realm of experimental design. At its core, experimental design is a structured method used to investigate the relationships between different variables. It's not merely about collecting data, but about ensuring that this data is reliable, valid, and can lead to meaningful conclusions.

The significance of a well-structured research process cannot be understated. From medical studies determining the efficacy of a new drug, to businesses testing a new marketing strategy, or environmental scientists assessing the impact of climate change on a specific ecosystem – a robust experimental design serves as the backbone. Without it, we run the risk of drawing flawed conclusions or making decisions based on erroneous or biased information.

The beauty of experimental design is its universality. It's a tool that transcends disciplines, bringing rigor and credibility to investigations across fields. Whether you're in the world of biotechnology, finance, psychology, or countless other domains, understanding the tenets of experimental design will ensure that your inquiries are grounded in sound methodology, paving the way for discoveries that can shape industries and change lives.

Core principles

Types of experimental designs, steps in designing an experiment, pitfalls and challenges, case studies, tools and software, future progress, how experimental design has evolved over time.

Delving into the annals of scientific history, we find that experimental design, as a formalized discipline, is relatively young. However, the spirit of experimentation is ancient, sewn deeply into the fabric of human curiosity. As early as Ancient Greece, rudimentary experimental methods were employed to understand natural phenomena . Yet, the structured approach we recognize today took centuries to develop.

The Renaissance era witnessed a surge in scientific curiosity and methodical investigation . This period marked a shift from reliance on anecdotal evidence and dogmatic beliefs to empirical observation. Notably, Sir Francis Bacon , during the early 17th century, championed the empirical method, emphasizing the need for systematic data collection and analysis.

But it was during the late 19th and early 20th centuries that the discipline truly began to crystallize. The burgeoning fields of psychology, agriculture, and biology demanded rigorous methods to validate their findings. The introduction of statistical methods and controlled experiments in agricultural research set a benchmark for research methodologies across various disciplines.

From its embryonic stages of simple observation to the sophisticated, statistically driven methodologies of today, experimental design has been shaped by the demands of the times and the relentless pursuit of truth by generations of researchers. It has evolved from mere intuition-based inquiries to a framework of control, randomization, and replication, ensuring that our conclusions stand up to the strictest scrutiny.

Key figures and their contributions

When charting the evolution of experimental design, certain luminaries stand tall, casting long shadows of influence that still shape the field today. Let's delve into a few of these groundbreaking figures:

  • Contribution: Often heralded as the father of modern statistics, Fisher introduced many concepts that form the backbone of experimental design. His work in the 1920s and 1930s laid the groundwork for the design of experiments.
  • Legacy: Fisher's introduction of the randomized controlled trial, analysis of variance ( ANOVA ), and the principle of maximum likelihood estimation revolutionized statistics and experimental methodology. His book, The Design of Experiments , remains a classic reference in the field.
  • Contribution: A prolific figure in the world of statistics, Pearson developed the method of moments , laying the foundation for many statistical tests.
  • Legacy: Pearson's chi-squared test is one of the many techniques he introduced, which researchers still widely use today to test the independence of categorical variables.
  • Contribution: Together, they conceptualized the framework for the theory of hypothesis testing , which is a staple in modern experimental design.
  • Legacy: Their delineation of Type I and Type II errors and the introduction of confidence intervals have become fundamental concepts in statistical inference.
  • Contribution: While better known as a nursing pioneer, Nightingale was also a gifted statistician. She employed statistics and well-designed charts to advocate for better medical practices and hygiene during the Crimean War .
  • Legacy: Nightingale's application of statistical methods to health underscores the importance of data in decision-making processes and set a precedent for evidence-based health policies.
  • Contribution: Box made significant strides in the areas of quality control and time series analysis.
  • Legacy: The Box-Jenkins (or ARIMA) model for time series forecasting and the Box-Behnken designs for response surface methodology are testaments to his lasting influence in both experimental design and statistical forecasting.

These trailblazers, among many others, transformed experimental design from a nascent field of inquiry into a robust and mature discipline. Their innovations continue to guide researchers and inform methodologies, bridging the gap between curiosity and concrete understanding.

Randomization: ensuring each subject has an equal chance of being in any group

Randomization is the practice of allocating subjects or experimental units to different groups or conditions entirely by chance. This means each participant, or experimental unit, has an equal likelihood of being assigned to any specific group or condition.

Why is this method of assignment held in such high regard, and why is it so fundamental to the research process? Let's delve into the pivotal role randomization plays and its overarching importance in maintaining the rigor of experimental endeavors.

  • Eliminating Bias: By allocating subjects randomly, we prevent any unintentional bias in group assignments. This ensures that the groups are more likely to be comparable in all major respects. Without randomization, researchers might, even inadvertently, assign certain types of participants to one group over another, leading to skewed results.
  • Balancing Unknown Factors: There are always lurking variables that researchers might be unaware of or unable to control. Randomization helps in ensuring that these unobserved or uncontrolled variables are equally distributed across groups, thereby ensuring that the groups are comparable in all major respects.
  • Foundation for Statistical Analysis: Randomization is the bedrock upon which much of statistical inference is built. It allows researchers to make probabilistic statements about the outcomes of their studies. Without randomization, many of the statistical tools employed in analyzing experimental results would be inappropriate or invalid.
  • Enhancing External Validity: A randomized study increases the chances that the results are generalizable to a broader population. Because participants are randomly selected, the findings can often be extrapolated to similar groups outside the study.

While randomization is a powerful tool, it's not without its challenges. For instance, in smaller samples, randomization might not always guarantee perfectly balanced groups. Moreover, in some contexts, like when studying the effects of a surgical technique, randomization might be ethically challenging.

Nevertheless, in the grand scheme of experimental design, randomization remains a gold standard. It's a bulwark against biases, both known and unknown, ensuring that research conclusions are drawn from a foundation of fairness and rigor.

Replication: repeating the experiment to ensure results are consistent

At its essence, replication involves conducting an experiment again, under the same conditions, to verify its results. It's like double-checking your math on a complex equation—reassuring yourself and others that the outcome is consistent and not just a random occurrence or due to unforeseen errors.

So, what makes this practice of repetition so indispensable to the research realm? Let's delve deeper into the role replication plays in solidifying and authenticating scientific insights.

  • Verifying Results: Even with the most rigorous experimental designs, errors can creep in, or unusual random events can skew results. Replicating an experiment helps confirm that the findings are genuine and not a result of such anomalies.
  • Reducing Uncertainty: Every experiment comes with a degree of uncertainty. By replicating the study, this uncertainty can be reduced, providing a clearer picture of the phenomenon under investigation.
  • Uncovering Variability: Results can vary due to numerous reasons—slight differences in conditions, experimental materials, or even the subjects themselves. Replication can help identify and quantify this variability, lending more depth to the understanding of results.
  • Building Scientific Consensus: Replication is fundamental in building trust within the scientific community. When multiple researchers, possibly across different labs or even countries, reproduce the same results, it strengthens the validity of the findings.
  • Enhancing Generalizability: Repeated experiments, especially when performed in different locations or with diverse groups, can ensure that the results apply more broadly and are not confined to specific conditions or populations.

While replication is a robust tool in the researcher's arsenal, it isn't always straightforward. Sometimes, especially in fields like psychology or medicine, replicating the exact conditions of the original study can be challenging. Furthermore, in our age of rapid publication, there might be a bias towards novel findings rather than repeated studies, potentially undervaluing the importance of replication.

In conclusion, replication stands as a sentinel of validity in experimental design. While one experiment can shed light on a phenomenon, it's the repeated and consistent results that truly illuminate our understanding, ensuring that what we believe is based not on fleeting chance but on reliable and consistent evidence.

Control: keeping other variables constant while testing the variable of interest

In its simplest form, control means keeping all factors and conditions, save for the variable being studied, consistent and unchanged. It's akin to setting a stage where everything remains static, allowing the spotlight to shine solely on the lead actor: our variable of interest.

What exactly elevates this principle to such a paramount position in the scientific realm? Let's unpack the fundamental reasons that underscore the indispensability of control in experimental design.

  • Isolating the Variable of Interest: With numerous factors potentially influencing an experiment, it's crucial to ensure that the observed effects result solely from the variable being studied. Control aids in achieving this isolation, ensuring that extraneous variables don't cloud the results.
  • Eliminating Confounding Effects: Without proper control, other variables might interact with the variable of interest, leading to misleading or confounded outcomes. By keeping everything else constant, control ensures the purity of results.
  • Enhancing the Credibility of Results: When an experiment is well-controlled, its results become more trustworthy. It demonstrates that the researcher has accounted for potential disturbances, leading to a more precise understanding of the relationship between variables.
  • Facilitating Replication: A well-controlled experiment provides a consistent framework, making it easier for other researchers to replicate the study and validate its findings.
  • Aiding in Comparisons: By ensuring that all other variables remain constant, control allows for a clearer comparison between different experimental groups or conditions.

Maintaining strict control is not always feasible, especially in field experiments or when dealing with complex systems. In such cases, researchers often rely on statistical controls or randomization to account for the influence of extraneous variables.

In the grand tapestry of experimental research, control serves as the stabilizing thread, ensuring that the patterns we observe are genuine reflections of the variable under scrutiny. It's a testament to the meticulous nature of scientific inquiry, underscoring the need for precision and care in every step of the experimental journey.

Completely randomized design

The Completely Randomized Design (CRD) is an experimental setup where all the experimental units (e.g., participants, plants, animals) are allocated to different groups entirely by chance. There's no stratification, clustering, or blocking. In essence, every unit has an equal opportunity to be assigned to any group.

Here are the advantages that make it a favored choice for many researchers:

  • Simplicity: CRD is easy to understand and implement, making it suitable for experiments where the primary goal is to compare the effects of different conditions or interventions without considering other complicating factors.
  • Flexibility: Since the only criterion is random assignment, CRD can be employed in various experimental scenarios, irrespective of the number of conditions or experimental units.
  • Statistical Robustness: Due to its random nature, the CRD is amenable to many statistical analyses. When the assumptions of independence, normality, and equal variances are met, CRD allows for straightforward application of techniques like ANOVA to discern the effects of different conditions.

However, like any tool in the research toolkit, the Completely Randomized Design doesn't come without its caveats. It's crucial to acknowledge the limitations and considerations that accompany CRD, ensuring that its application is both judicious and informed.

  • Efficiency: In situations where there are recognizable subgroups or blocks within the experimental units, a CRD might not be the most efficient design. Variability within blocks could overshadow the effects of different conditions.
  • Environmental Factors: If the experimental units are spread across different environments or conditions, these uncontrolled variations might confound the effects being studied, leading to less precise or even misleading conclusions.
  • Size: In cases where the sample size is small, the sheer randomness of CRD might result in uneven group sizes, potentially reducing the power of the study.

The Completely Randomized Design stands as a testament to the power of randomness in experimental research. While it might not be the best fit for every scenario, especially when there are known sources of variability, it offers a robust and straightforward approach for many research questions. As with all experimental designs, the key is to understand its strengths and limitations, applying it judiciously based on the specifics of the research at hand.

Randomized block design

The Randomized Block Design (RBD) is an experimental configuration where units are first divided into blocks or groups based on some inherent characteristic or source of variability. Within these blocks, units are then randomly assigned to different conditions or categories. Essentially, it's a two-step process: first, grouping similar units, and then, randomizing assignments within these groups.

Here are the positive attributes of the Randomized Block Design that underscore its value in experimental research:

  • Control Over Variability: By grouping similar experimental units into blocks, RBD effectively reduces the variability that might otherwise confound the results. This enhances the experiment's power and precision.
  • More Accurate Comparisons: Since conditions are randomized within blocks of similar units, comparisons between different effects become more accurate and meaningful.
  • Flexibility: RBD can be employed in scenarios with any number of conditions and blocks. Its flexible nature makes it suitable for diverse experimental needs.

While the merits of the Randomized Block Design are widely recognized, understanding its potential limitations and considerations is paramount to ensure that research outcomes are both insightful and grounded in reality:

  • Complexity: Designing and analyzing an RBD can be more complex than simpler designs like CRD. It requires careful consideration of how to define blocks and how to randomize conditions within them.
  • Assumption of Homogeneity: RBD assumes that the variability within blocks is less than the variability between them. If this assumption is violated, the design might lose its efficiency.
  • Increased Sample Size: To maintain power, RBD might necessitate a larger sample size, especially if there are numerous blocks.

The Randomized Block Design stands as an exemplary method to combine the best of both worlds: the robustness of randomization and the sensitivity to inherent variability. While it might demand more meticulous planning and design, its capacity to deliver more refined insights makes it a valuable tool in the realm of experimental research.

Factorial design

A factorial design is an experimental setup where two or more independent variables, or factors, are simultaneously tested, not only for their individual effects but also for their combined or interactive effects. If you imagine an experiment where two factors are varied at two levels each, you would have a 2x2 factorial design, resulting in four unique experimental conditions.

Here are the advantages you should consider regarding this methodology:

  • Efficiency: Instead of conducting separate experiments for each factor, researchers can study multiple factors in a single experiment, conserving resources and time.
  • Comprehensive Insights: Factorial designs allow for the exploration of interactions between factors. This is crucial because in real-world situations, factors often don't operate in isolation.
  • Generalizability: By varying multiple factors simultaneously, the results tend to be more generalizable across a broader range of conditions.
  • Optimization: By revealing how factors interact, factorial designs can guide practitioners in optimizing conditions for desired outcomes.

No methodology is without its nuances, and while factorial designs boast numerous strengths, they come with their own set of limitations and considerations:

  • Complexity: As the number of factors or levels increases, the design can become complex, demanding more experimental units and potentially complicating data analysis.
  • Potential for Confounding: If not carefully designed, there's a risk that effects from one factor might be mistakenly attributed to another, especially in higher-order factorial designs.
  • Resource Intensive: While factorial designs can be efficient, they can also become resource-intensive as the number of conditions grows.

The factorial design stands out as an essential tool for researchers aiming to delve deep into the intricacies of multiple factors and their interactions. While it requires meticulous planning and interpretation, its capacity to provide a holistic understanding of complex scenarios renders it invaluable in experimental research.

Matched pair design

A Matched Pair Design , also known simply as a paired design, is an experimental setup where participants are grouped into pairs based on one or more matching criteria, often a specific characteristic or trait. Once matched, one member of each pair is subjected to one condition while the other experiences a different condition or control. This design is particularly powerful when comparing just two conditions, as it reduces the variability between subjects.

As we explore the advantages of this design, it becomes evident why it's often the methodology of choice for certain investigative contexts:

  • Control Over Variability: By matching participants based on certain criteria, this design controls for variability due to those criteria, thereby increasing the experiment's sensitivity and reducing error.
  • Efficiency: With a paired approach, fewer subjects may be required compared to completely randomized designs, potentially making the study more time and resource-efficient.
  • Direct Comparisons: The design facilitates direct comparisons between conditions, as each pair acts as its own control.

As with any research methodology, the Matched Pair Design, despite its distinct advantages, comes with inherent limitations and critical considerations:

  • Matching Complexity: The process of matching participants can be complicated, demanding meticulous planning and potentially excluding subjects who don't fit pairing criteria.
  • Not Suitable for Multiple Conditions: This design is most effective when comparing two conditions. When there are more than two conditions to compare, other designs might be more appropriate.
  • Potential Dependency Issues: Since participants are paired, statistical analyses must account for potential dependencies between paired observations.

The Matched Pair Design stands as a great tool for experiments where controlling for specific characteristics is crucial. Its emphasis on paired precision can lead to more reliable results, but its effective implementation requires careful consideration of the matching criteria and statistical analyses. As with all designs, understanding its nuances is key to leveraging its strengths and mitigating potential challenges.

Covariate design

A Covariate Design , also known as Analysis of Covariance (ANCOVA), is an experimental approach wherein the main effects of certain independent variables, as well as the effect of one or more covariates, are considered. Covariates are typically variables that are not of primary interest to the researcher but may influence the outcome variable. By including these covariates in the analysis, researchers can control for their effect, providing a clearer picture of the relationship between the primary independent variables and the outcome.

While many designs aim for clarity by isolating variables, the Covariate Design embraces and controls for the intricacies, presenting a series of compelling advantages. As we unpack these benefits, the appeal of incorporating covariates into experimental research becomes increasingly evident:

  • Increased Precision: By controlling for covariates, this design can lead to more precise estimates of the main effects of interest.
  • Efficiency: Including covariates can help explain more of the variability in the outcome, potentially leading to more statistically powerful results with smaller sample sizes.
  • Flexibility: The design offers the flexibility to account for and control multiple extraneous factors, allowing for more comprehensive analyses.

Every research approach, no matter how robust, comes with its own set of challenges and nuances. The Covariate Design is no exception to this rule:

  • Assumption Testing: Covariate Design requires certain assumptions to be met, such as linearity and homogeneity of regression slopes, which, if violated, can lead to misleading results.
  • Complexity: Incorporating covariates adds complexity to the experimental setup and the subsequent statistical analysis.
  • Risk of Overadjustment: If not chosen judiciously, covariates can lead to overadjustment, potentially masking true effects or leading to spurious findings.

The Covariate Design stands out for its ability to refine experimental results by accounting for potential confounding factors. This heightened precision, however, demands a keen understanding of the design's assumptions and the intricacies involved in its implementation. It serves as a powerful option in the researcher's arsenal, provided its complexities are navigated with knowledge and care.

Designing an experiment requires careful planning, an understanding of the underlying scientific principles, and a keen attention to detail. The essence of a well-designed experiment lies in ensuring both the integrity of the research and the validity of the results it yields. The experimental design acts as the backbone of the research, laying the foundation upon which meaningful conclusions can be drawn. Given the importance of this phase, it's paramount for researchers to approach it methodically. To assist in this experimental setup, here's a step-by-step guide to help you navigate this crucial task with precision and clarity.

  • Identify the Research Question or Hypothesis: Before delving into the experimental process, it's crucial to have a clear understanding of what you're trying to investigate. This begins with defining a specific research question or formulating a hypothesis that predicts the outcome of your study. A well-defined research question or hypothesis serves as the foundation for the entire experimental process.
  • Choose the Appropriate Experimental Design: Depending on the nature of your research question and the specifics of your study, you'll need to choose the most suitable experimental design. Whether it's a Completely Randomized Design, a Randomized Block Design, or any other setup, your choice will influence how you conduct the experiment and analyze the data.
  • Select the Subjects/Participants: Determine who or what will be the subjects of your study. This could range from human participants to animal models or even plants, depending on your field of study. It's vital to ensure that the selected subjects are representative of the larger population you aim to generalize to.
  • Allocate Subjects to Different Groups: Once you've chosen your participants, you'll need to decide how to allocate them to different experimental groups. This could involve random assignment or other methodologies, ensuring that each group is comparable and that the effects of confounding variables are minimized.
  • Implement the Experiment and Gather Data: With everything in place, conduct the experiment according to your chosen design. This involves exposing each group to the relevant conditions and then gathering data based on the outcomes you're measuring.
  • Analyze the Data: Once you've collected your data, it's time to dive into the numbers. Using statistical tools and techniques, analyze the data to determine whether there are significant differences between your groups, and if your hypothesis is supported.
  • Interpret the Results and Draw Conclusions: Data analysis will provide you with statistical outcomes, but it's up to you to interpret what these numbers mean in the context of your research question. Draw conclusions based on your findings, and consider their implications for your field and future research endeavors.

By following these steps, you can ensure a structured and systematic approach to your experimental research, paving the way for insightful and valid results.

Confounding variables: external factors that might influence the outcome

One of the most common challenges faced in experimental design is the presence of confounding variables. These are external factors that unintentionally vary along with the factor you are investigating, potentially influencing the outcome of the experiment. The danger of confounding variables lies in their ability to provide alternative explanations for any observed effect, thereby muddying the waters of your results.

For instance, if you were investigating the effect of a new drug on blood pressure and failed to control for factors like caffeine intake or stress levels, you might mistakenly attribute changes in blood pressure to the drug when they were actually caused by these other uncontrolled factors.

Properly identifying and controlling for confounding variables is essential. Failure to do so can lead to false conclusions and misinterpretations of data. Addressing them either through the experimental design itself, like by using randomization or matched groups, or in the analysis phase, such as through statistical controls, ensures that the observed effects can be confidently attributed to the variable or condition being studied rather than to extraneous influences.

External validity: making sure results can be generalized to broader contexts

A paramount challenge in experimental design is guaranteeing external validity. This concept refers to the degree to which the findings of a study can be generalized to settings, populations, times, and measures different from those specifically used in the study.

The dilemma often arises in highly controlled environments, such as laboratories. While these settings allow for precise conditions and minimized confounding variables, they might not always reflect real-world scenarios. For instance, a study might find a specific teaching method effective in a quiet, one-on-one setting. However, if that same method doesn't perform as well in a busy classroom with 30 students, the study's external validity becomes questionable.

For researchers, the challenge is to strike a balance. While controlling for potential confounding variables is paramount, it's equally crucial to ensure the experimental conditions maintain a certain degree of real-world relevance. To enhance external validity, researchers may use strategies such as diversifying participant pools, varying experimental conditions, or even conducting field experiments. Regardless of the approach, the ultimate goal remains: to ensure the experiment's findings can be meaningfully applied in broader, real-world contexts.

Ethical considerations: ensuring the safety and rights of participants

Any experimental design undertaking must prioritize the well-being, dignity, and rights of participants. Upholding these values not only ensures the moral integrity of any study but also is crucial in ensuring the reliability and validity of the research .

All participants, whether human or animal, are entitled to respect and their safety should never be placed in jeopardy. For human subjects, it's imperative that they are adequately briefed about the research aims, potential risks, and benefits. This highlights the significance of informed consent, a process where participants acknowledge their comprehension of the study and willingly agree to participate.

Beyond the initiation of the experiment, ethical considerations continue to play a pivotal role. It's vital to maintain the privacy and confidentiality of the participants, ensuring that the collected data doesn't lead to harm or stigmatization. Extra caution is needed when experiments involve vulnerable groups, such as children or the elderly. Furthermore, researchers should be equipped to offer necessary support or point towards professional help should participants experience distress because of the experimental procedures. It's worth noting that many research institutions have ethical review boards to ensure all experiments uphold these principles, fortifying the credibility and authenticity of the research process.

The Stanford Prison Experiment (1971)

The Stanford Prison Experiment , conducted in 1971 by psychologist Philip Zimbardo at Stanford University, stands as one of the most infamous studies in the annals of psychology. The primary objective of the experiment was to investigate the inherent psychological mechanisms and behaviors that emerge when individuals are placed in positions of power and subordination. To this end, volunteer participants were randomly assigned to roles of either prison guards or inmates in a simulated prison environment.

Zimbardo's design sought to create an immersive environment, ensuring that participants genuinely felt the dynamics of their assigned roles. The mock prison was set up in the basement of Stanford's psychology building, complete with cells and guard quarters. Participants assigned to the role of guards were provided with uniforms, batons, and mirrored sunglasses to prevent eye contact. Those assigned as prisoners wore smocks and stocking caps, emphasizing their status. To enhance the realism, an unannounced "arrest" was made for the "prisoners" at their homes by the local police department. Throughout the experiment, no physical violence was permitted; however, the guards were allowed to establish their own rules to maintain order and ensure the prisoners attended the daily counts.

Scheduled to run for two weeks, the experiment was terminated after only six days due to the extreme behavioral transformations observed. The guards rapidly became authoritarian, implementing degrading and abusive strategies to maintain control. In contrast, the prisoners exhibited signs of intense emotional distress, and some even demonstrated symptoms of depression. Zimbardo himself became deeply involved, initially overlooking the adverse effects on the participants. The study's findings highlighted the profound impact that situational dynamics and perceived roles can have on behavior. While it was severely criticized for ethical concerns, it underscored the depths to which human behavior could conform to assigned roles, leading to significant discussions on the ethics of research and the power dynamics inherent in institutional settings.

The Stanford Prison Experiment is particularly relevant to experimental design for these reasons:

  • Control vs. Realism: One of the challenging dilemmas in experimental design is striking a balance between controlling variables and maintaining ecological validity (how experimental conditions mimic real-world situations). Zimbardo's study attempted to create a highly controlled environment with the mock prison but also sought to maintain a sense of realism by arresting participants at their homes and immersing them in their roles. The consequences of this design, however, were unforeseen and extreme behavioral transformations.
  • Ethical Considerations: A cornerstone of experimental design involves ensuring the safety, rights, and well-being of participants. The Stanford Prison Experiment is often cited as an example of what can go wrong when these principles are not rigorously adhered to. The psychological distress faced by participants wasn't anticipated in the original design and wasn't adequately addressed during its execution. This oversight emphasizes the critical importance of periodic assessment of participants' well-being and the flexibility to adapt or terminate the study if adverse effects arise.
  • Role of the Researcher: Zimbardo's involvement and the manner in which he became part of the experiment highlight the potential biases and impacts a researcher can have on an experiment's outcome. In experimental design, it's crucial to consider the researcher's role and minimize any potential interference or influence they might have on the study's results.
  • Interpretation of Results: The aftermath of the experiment brought forth critical discussions on how results are interpreted and presented. It emphasized the importance of considering external influences, participant expectations, and other confounding variables when deriving conclusions from experimental data.

In essence, the Stanford Prison Experiment serves as a cautionary tale in experimental design. It underscores the importance of ethical considerations, participant safety, the potential pitfalls of high realism without safeguards, and the unintended consequences that can emerge even in well-planned experiments.

Meselson-Stahl Experiment (1958)

The Meselson-Stahl Experiment , conducted in 1958 by biologists Matthew Meselson and Franklin Stahl , holds a significant place in molecular biology. The duo set out to determine the mechanism by which DNA replicates, aiming to understand if it follows a conservative, semi-conservative, or dispersive model.

Utilizing Escherichia coli (E. coli) bacteria, Meselson and Stahl grew cultures in a medium containing a heavy isotope of nitrogen, 15 N, allowing the bacteria's DNA to incorporate this heavy isotope. Subsequently, they transferred the bacteria to a medium with the more common 14 N isotope and allowed it to replicate. By using ultracentrifugation, they separated DNA based on density, expecting distinct bands on a gradient depending on the replication model.

The observed patterns over successive bacterial generations revealed a single band that shifted from the heavy to light position, supporting the semi-conservative replication model. This meant that during DNA replication, each of the two strands of a DNA molecule serves as a template for a new strand, leading to two identical daughter molecules. The experiment's elegant design and conclusive results provided pivotal evidence for the molecular mechanism of DNA replication, reshaping our understanding of genetic continuity.

The Meselson-Stahl Experiment is particularly relevant to experimental design for these reasons:

  • Innovative Techniques: The use of isotopic labeling and density gradient ultracentrifugation was pioneering, showcasing the importance of utilizing and even developing novel techniques tailored to address specific scientific questions.
  • Controlled Variables: By methodically controlling the growth environment and the nitrogen sources, Meselson and Stahl ensured that any observed differences in DNA density were due to the replication mechanism itself, and not extraneous factors.
  • Direct Comparison: The experiment design allowed for direct comparison between the expected results of different replication models and the actual observed outcomes, facilitating a clear and decisive conclusion.
  • Clarity in Hypothesis: The researchers had clear expectations for the results of each potential replication model, which helped in accurately interpreting the outcomes.

Reflecting on the Meselson-Stahl Experiment, it serves as an exemplar in experimental biology. Their meticulous approach, combined with innovative techniques, answered a fundamental biological question with clarity. This experiment not only resolved a significant debate in molecular biology but also showcased the power of well-designed experimental methods in revealing nature's intricate processes.

The Hawthorne Studies (1920s-1930s)

The Hawthorne Studies , conducted between the 1920s and 1930s at Western Electric's Hawthorne plant in Chicago, represent a pivotal shift in organizational and industrial psychology. Initially intended to study the relationship between lighting conditions and worker productivity, the research evolved into a broader investigation of the various factors influencing worker output and morale. These studies have since shaped our understanding of human relations and the socio-psychological aspects of the workplace.

The Hawthorne Studies comprised several experiments, but the most notable were the "relay assembly tests" and the "bank wiring room studies." In the relay assembly tests, researchers made various manipulations to the working conditions of a small group of female workers, such as altering light levels, giving rest breaks, and changing the length of the workday. The intent was to identify which conditions led to the highest levels of productivity. Conversely, the bank wiring room studies were observational in nature. Here, the researchers aimed to understand the group dynamics and social structures that emerged among male workers, without any experimental manipulations.

Surprisingly, in the relay assembly tests, almost every change—whether it was an improvement or a return to original conditions—led to increased worker productivity. Even when conditions were reverted to their initial state, worker output remained higher than before. This puzzling phenomenon led researchers to speculate that the mere act of being observed and the knowledge that one's performance was being monitored led to increased effort and productivity, a phenomenon now referred to as the Hawthorne Effect . The bank wiring room studies, on the other hand, shed light on how informal group norms and social relations could influence individual productivity, often more significantly than monetary incentives.

These studies challenged the then-dominant scientific management approach, which viewed workers primarily as mechanical entities whose productivity could be optimized through physical and environmental adjustments. Instead, the Hawthorne Studies highlighted the importance of psychological and social factors in the workplace, laying the foundation for the human relations movement in organizational management.

The Hawthorne Studies are particularly relevant to experimental design for these reasons:

  • Observer Effect: The Hawthorne Studies introduced the idea that the mere act of observation could alter participants' behavior. This has significant implications for experimental design, emphasizing the need to account for and minimize observer-induced changes in behavior.
  • Complexity of Human Behavior: While the initial focus was on physical conditions (like lighting), the results demonstrated that human behavior and performance are influenced by a myriad of interrelated factors. This underscores the importance of considering psychological, social, and environmental variables when designing experiments.
  • Unintended Outcomes: The unintended discovery of the Hawthorne Effect exemplifies that experimental outcomes can sometimes diverge from initial expectations. Researchers should remain open to such unexpected findings, as they can lead to new insights and directions.
  • Evolution of Experimental Focus: The shift from purely environmental manipulations to observational studies in the Hawthorne research highlights the flexibility required in experimental design. As new findings emerge, it's crucial for researchers to adapt their methodologies to better address evolving research questions.

In summary, the Hawthorne Studies serve as a testament to the evolving nature of experimental research and the profound effects that observation, social dynamics, and psychological factors can have on outcomes. They highlight the importance of adaptability, holistic understanding, and the acknowledgment of unexpected results in the realm of experimental design.

Michelson-Morley Experiment (1887)

The Michelson-Morley Experiment , conducted in 1887 by physicists Albert A. Michelson and Edward W. Morley , is considered one of the foundational experiments in the world of physics. The primary aim was to detect the relative motion of matter through the hypothetical luminiferous aether, a medium through which light was believed to propagate.

Michelson and Morley designed an apparatus known as the interferometer . This device split a beam of light so that it traveled in two perpendicular directions. After reflecting off mirrors, the two beams would recombine, and any interference patterns observed would indicate differences in their travel times. If the aether wind existed, the Earth's motion through the aether would cause such an interference pattern. The experiment was conducted at different times of the year, considering Earth's motion around the sun might influence the results.

Contrary to expectations, the experiment found no significant difference in the speed of light regardless of the direction of measurement or the time of year. This null result was groundbreaking. It effectively disproved the existence of the luminiferous aether and paved the way for the theory of relativity introduced by Albert Einstein in 1905 , which fundamentally changed our understanding of time and space.

The Michelson-Morley Experiment is particularly relevant to experimental design for these reasons:

  • Methodological Rigor: The precision and care with which the experiment was designed and conducted set a new standard for experimental physics.
  • Dealing with Null Results: Rather than being discarded, the absence of the expected result became the main discovery, emphasizing the importance of unexpected outcomes in scientific research.
  • Impact on Theoretical Foundations: The experiment's findings had profound implications, showing that experiments can challenge and even overturn prevailing theoretical frameworks.
  • Iterative Testing: The experiment was not just a one-off. Its repeated tests at different times underscore the value of replication and varied conditions in experimental design.

Through their meticulous approach and openness to unexpected results, Michelson and Morley didn't merely answer a question; they reshaped the very framework of understanding within physics. Their work underscores the essence of scientific inquiry: that true discovery often lies not just in confirming our hypotheses, but in uncovering the deeper truths that challenge our prevailing notions. As researchers and scientists continue to push the boundaries of knowledge, the lessons from this experiment serve as a beacon, reminding us of the potential that rigorous, well-designed experiments have in illuminating the mysteries of our universe.

Borlaug's Green Revolution (1940s-1960s)

The Green Revolution , spearheaded by agronomist Norman Borlaug between the 1940s and 1960s, represents a transformative period in agricultural history. Borlaug's work focused on addressing the pressing food shortages in developing countries. By implementing advanced breeding techniques, he aimed to produce high-yield, disease-resistant, and dwarf wheat varieties that would boost agricultural productivity substantially.

To achieve this, Borlaug and his team undertook extensive crossbreeding of wheat varieties. They employed shuttle breeding —a technique where crops are grown in two distinct locations with different planting seasons. This not only accelerated the breeding process but also ensured the new varieties were adaptable to varied conditions. Another innovation was to develop strains of wheat that were "dwarf," ensuring that the plants, when loaded with grains, didn't become too tall and topple over—a common problem with high-yielding varieties.

The resulting high-yield, semi-dwarf, disease-resistant wheat varieties revolutionized global agriculture. Countries like India and Pakistan, which were on the brink of mass famine, witnessed a dramatic increase in wheat production. This Green Revolution saved millions from starvation, earned Borlaug the Nobel Peace Prize in 1970, and altered the course of agricultural research and policy worldwide.

The Green Revolution is particularly relevant to experimental design for these reasons:

  • Iterative Testing: Borlaug's approach highlighted the significance of continual testing and refining. By iterating breeding processes, he was able to perfect the wheat varieties more efficiently.
  • Adaptability: The use of shuttle breeding showcased the importance of ensuring that experimental designs account for diverse real-world conditions, enhancing the global applicability of results.
  • Anticipating Challenges: By focusing on dwarf varieties, Borlaug preempted potential problems, demonstrating that foresight in experimental design can lead to more effective solutions.
  • Scalability: The work wasn't just about creating a solution, but one that could be scaled up to meet global demands, emphasizing the necessity of scalability considerations in design.

The Green Revolution exemplifies the profound impact well-designed experiments can have on society. Borlaug's strategies, which combined foresight with rigorous testing, reshaped global agriculture, underscoring the potential of scientific endeavors to address pressing global challenges when thoughtfully and innovatively approached.

Experimental design has undergone a transformation over the years. Modern technology plays an indispensable role in refining and streamlining experimental processes. Gone are the days when researchers solely depended on manual calculations, paper-based data recording, and rudimentary statistical tools. Today, advanced software and tools provide accurate, quick, and efficient means to design experiments, collect data, perform statistical analysis, and interpret results.

Several tools and software are at the forefront of this technological shift in experimental design:

  • Minitab: A popular statistical software offering tools for various experimental designs including factorials, response surface methodologies, and optimization techniques.
  • R: An open-source programming language and environment tailored for statistical computing and graphics. Its extensibility and comprehensive suite of statistical techniques make it a favorite among researchers.
  • JMP: Developed by SAS , it is known for its interactive and dynamic graphics. It provides a powerful suite for design of experiments and statistical modeling.
  • Design-Expert: A software dedicated to experimental design and product optimization. It's particularly useful for response surface methods.
  • SPSS: A software package used for statistical analysis, it provides advanced statistics, machine learning algorithms, and text analysis for researchers of all levels.
  • Python (with libraries like SciPy and statsmodels): Python is a versatile programming language and, when combined with specific libraries, becomes a potent tool for statistical analysis and experimental design.

One of the primary advantages of using these software tools is their capability for advanced statistical analysis. They enable researchers to perform complex computations within seconds, something that would take hours or even days manually. Furthermore, the visual representation features in these tools assist in understanding intricate data patterns, correlations, and other crucial aspects of data. By aiding in statistical analysis and interpretation, software tools eliminate human errors, provide insights that might be overlooked in manual analysis, and significantly speed up the research process, allowing scientists and researchers to focus on drawing accurate conclusions and making informed decisions based on the data.

The world of experimental research is continually evolving, with each new development promising to reshape how we approach, conduct, and interpret experiments. The central tenets of experimental design—control, randomization, replication—though fundamental, are being complemented by sophisticated techniques that ensure richer insights and more robust conclusions.

One of the most transformative forces in experimental design's future landscape is the surge of artificial intelligence (AI) and machine learning (ML) technologies . Historically, the design and analysis of experiments have depended on human expertise for selecting factors to study, setting the levels of these factors, and deciding on the number and order of experimental runs. With AI and ML's advent, many of these tasks can be automated, leading to optimized experimental designs that might be too complex for manual formulation. For instance, machine learning algorithms can predict potential outcomes based on vast datasets, guiding researchers in choosing the most promising experimental conditions.

Moreover, AI-driven experimental platforms can dynamically adapt during the course of the experiment, tweaking conditions based on real-time results, thereby leading to adaptive experimental designs. These adaptive designs promise to be more efficient, as they can identify and focus on the most relevant regions of the experimental space, often requiring fewer experimental runs than traditional designs. By harnessing the power of AI and ML, researchers can uncover complex interactions and nonlinearities in their data that might have otherwise gone unnoticed.

Furthermore, the convergence of AI and experimental design holds tremendous potential for areas like drug development and personalized medicine. By analyzing vast genetic datasets, AI algorithms can help design experiments that target very specific biological pathways or predict individual patients' responses to particular treatments. Such personalized experimental designs could dramatically reduce the time and cost of bringing new treatments to market and ensuring that they are effective for the intended patient populations.

In conclusion, the future of experimental design is bright, marked by rapid advancements and a fusion of traditional methods with cutting-edge technologies. As AI and machine learning continue to permeate this field, we can expect experimental research to become more efficient, accurate, and personalized, heralding a new era of discovery and innovation.

In the ever-evolving landscape of research and innovation, experimental design remains a cornerstone, guiding scholars and professionals towards meaningful insights and discoveries. As we reflect on its past and envision its future, it's clear that experimental design will continue to play an instrumental role in shaping the trajectory of numerous disciplines. It will be instrumental in harnessing the full potential of emerging technologies, driving forward scientific understanding, and solving some of the most pressing challenges of our time. With a rich history behind it and a promising horizon ahead, experimental design stands as a testament to the human spirit's quest for knowledge, understanding, and innovation.

Header image by Gorodenkoff .

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Experimental Research: Meaning And Examples Of Experimental Research

Ever wondered why scientists across the world are being lauded for discovering the Covid-19 vaccine so early? It’s because every…

What Is Experimental Research

Ever wondered why scientists across the world are being lauded for discovering the Covid-19 vaccine so early? It’s because every government knows that vaccines are a result of experimental research design and it takes years of collected data to make one. It takes a lot of time to compare formulas and combinations with an array of possibilities across different age groups, genders and physical conditions. With their efficiency and meticulousness, scientists redefined the meaning of experimental research when they discovered a vaccine in less than a year.

What Is Experimental Research?

Characteristics of experimental research design, types of experimental research design, advantages and disadvantages of experimental research, examples of experimental research.

Experimental research is a scientific method of conducting research using two variables: independent and dependent. Independent variables can be manipulated to apply to dependent variables and the effect is measured. This measurement usually happens over a significant period of time to establish conditions and conclusions about the relationship between these two variables.

Experimental research is widely implemented in education, psychology, social sciences and physical sciences. Experimental research is based on observation, calculation, comparison and logic. Researchers collect quantitative data and perform statistical analyses of two sets of variables. This method collects necessary data to focus on facts and support sound decisions. It’s a helpful approach when time is a factor in establishing cause-and-effect relationships or when an invariable behavior is seen between the two.  

Now that we know the meaning of experimental research, let’s look at its characteristics, types and advantages.

The hypothesis is at the core of an experimental research design. Researchers propose a tentative answer after defining the problem and then test the hypothesis to either confirm or disregard it. Here are a few characteristics of experimental research:

  • Dependent variables are manipulated or treated while independent variables are exerted on dependent variables as an experimental treatment. Extraneous variables are variables generated from other factors that can affect the experiment and contribute to change. Researchers have to exercise control to reduce the influence of these variables by randomization, making homogeneous groups and applying statistical analysis techniques.
  • Researchers deliberately operate independent variables on the subject of the experiment. This is known as manipulation.
  • Once a variable is manipulated, researchers observe the effect an independent variable has on a dependent variable. This is key for interpreting results.
  • A researcher may want multiple comparisons between different groups with equivalent subjects. They may replicate the process by conducting sub-experiments within the framework of the experimental design.

Experimental research is equally effective in non-laboratory settings as it is in labs. It helps in predicting events in an experimental setting. It generalizes variable relationships so that they can be implemented outside the experiment and applied to a wider interest group.

The way a researcher assigns subjects to different groups determines the types of experimental research design .

Pre-experimental Research Design

In a pre-experimental research design, researchers observe a group or various groups to see the effect an independent variable has on the dependent variable to cause change. There is no control group as it is a simple form of experimental research . It’s further divided into three categories:

  • A one-shot case study research design is a study where one dependent variable is considered. It’s a posttest study as it’s carried out after treating what presumably caused the change.
  • One-group pretest-posttest design is a study that combines both pretest and posttest studies by testing a single group before and after administering the treatment.
  • Static-group comparison involves studying two groups by subjecting one to treatment while the other remains static. After post-testing all groups the differences are observed.

This design is practical but lacks in certain areas of true experimental criteria.

True Experimental Research Design

This design depends on statistical analysis to approve or disregard a hypothesis. It’s an accurate design that can be conducted with or without a pretest on a minimum of two dependent variables assigned randomly. It is further classified into three types:

  • The posttest-only control group design involves randomly selecting and assigning subjects to two groups: experimental and control. Only the experimental group is treated, while both groups are observed and post-tested to draw a conclusion from the difference between the groups.
  • In a pretest-posttest control group design, two groups are randomly assigned subjects. Both groups are presented, the experimental group is treated and both groups are post-tested to measure how much change happened in each group.
  • Solomon four-group design is a combination of the previous two methods. Subjects are randomly selected and assigned to four groups. Two groups are tested using each of the previous methods.

True experimental research design should have a variable to manipulate, a control group and random distribution.

With experimental research, we can test ideas in a controlled environment before marketing. It acts as the best method to test a theory as it can help in making predictions about a subject and drawing conclusions. Let’s look at some of the advantages that make experimental research useful:

  • It allows researchers to have a stronghold over variables and collect desired results.
  • Results are usually specific.
  • The effectiveness of the research isn’t affected by the subject.
  • Findings from the results usually apply to similar situations and ideas.
  • Cause and effect of a hypothesis can be identified, which can be further analyzed for in-depth ideas.
  • It’s the ideal starting point to collect data and lay a foundation for conducting further research and building more ideas.
  • Medical researchers can develop medicines and vaccines to treat diseases by collecting samples from patients and testing them under multiple conditions.
  • It can be used to improve the standard of academics across institutions by testing student knowledge and teaching methods before analyzing the result to implement programs.
  • Social scientists often use experimental research design to study and test behavior in humans and animals.
  • Software development and testing heavily depend on experimental research to test programs by letting subjects use a beta version and analyzing their feedback.

Even though it’s a scientific method, it has a few drawbacks. Here are a few disadvantages of this research method:

  • Human error is a concern because the method depends on controlling variables. Improper implementation nullifies the validity of the research and conclusion.
  • Eliminating extraneous variables (real-life scenarios) produces inaccurate conclusions.
  • The process is time-consuming and expensive
  • In medical research, it can have ethical implications by affecting patients’ well-being.
  • Results are not descriptive and subjects can contribute to response bias.

Experimental research design is a sophisticated method that investigates relationships or occurrences among people or phenomena under a controlled environment and identifies the conditions responsible for such relationships or occurrences

Experimental research can be used in any industry to anticipate responses, changes, causes and effects. Here are some examples of experimental research :

  • This research method can be used to evaluate employees’ skills. Organizations ask candidates to take tests before filling a post. It is used to screen qualified candidates from a pool of applicants. This allows organizations to identify skills at the time of employment. After training employees on the job, organizations further evaluate them to test impact and improvement. This is a pretest-posttest control group research example where employees are ‘subjects’ and the training is ‘treatment’.
  • Educational institutions follow the pre-experimental research design to administer exams and evaluate students at the end of a semester. Students are the dependent variables and lectures are independent. Since exams are conducted at the end and not the beginning of a semester, it’s easy to conclude that it’s a one-shot case study research.
  • To evaluate the teaching methods of two teachers, they can be assigned two student groups. After teaching their respective groups on the same topic, a posttest can determine which group scored better and who is better at teaching. This method can have its drawbacks as certain human factors, such as attitudes of students and effectiveness to grasp a subject, may negatively influence results. 

Experimental research is considered a standard method that uses observations, simulations and surveys to collect data. One of its unique features is the ability to control extraneous variables and their effects. It’s a suitable method for those looking to examine the relationship between cause and effect in a field setting or in a laboratory. Although experimental research design is a scientific approach, research is not entirely a scientific process. As much as managers need to know what is experimental research , they have to apply the correct research method, depending on the aim of the study.

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Explore Harappa Diaries to learn more about topics such as Main Objective Of Research , Definition Of Qualitative Research , Examples Of Experiential Learning and Collaborative Learning Strategies to upgrade your knowledge and skills.

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  • 10 April 2024

How to supercharge cancer-fighting cells: give them stem-cell skills

  • Sara Reardon 0

Sara Reardon is a freelance journalist based in Bozeman, Montana.

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A CAR T cell (orange; artificially coloured) attacks a cancer cell (green). Credit: Eye Of Science/Science Photo Library

Bioengineered immune cells have been shown to attack and even cure cancer , but they tend to get exhausted if the fight goes on for a long time. Now, two separate research teams have found a way to rejuvenate these cells: make them more like stem cells .

Both teams found that the bespoke immune cells called CAR T cells gain new vigour if engineered to have high levels of a particular protein. These boosted CAR T cells have gene activity similar to that of stem cells and a renewed ability to fend off cancer . Both papers were published today in Nature 1 , 2 .

The papers “open a new avenue for engineering therapeutic T cells for cancer patients”, says Tuoqi Wu, an immunologist at the University of Texas Southwestern in Dallas who was not involved in the research.

Reviving exhausted cells

CAR T cells are made from the immune cells called T cells, which are isolated from the blood of person who is going to receive treatment for cancer or another disease. The cells are genetically modified to recognize and attack specific proteins — called chimeric antigen receptors (CARs) — on the surface of disease-causing cells and reinfused into the person being treated.

But keeping the cells active for long enough to eliminate cancer has proved challenging, especially in solid tumours such as those of the breast and lung. (CAR T cells have been more effective in treating leukaemia and other blood cancers.) So scientists are searching for better ways to help CAR T cells to multiply more quickly and last longer in the body.

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Cutting-edge CAR-T cancer therapy is now made in India — at one-tenth the cost

With this goal in mind, a team led by immunologist Crystal Mackall at Stanford University in California and cell and gene therapy researcher Evan Weber at the University of Pennsylvania in Philadelphia compared samples of CAR T cells used to treat people with leukaemia 1 . In some of the recipients, the cancer had responded well to treatment; in others, it had not.

The researchers analysed the role of cellular proteins that regulate gene activity and serve as master switches in the T cells. They found a set of 41 genes that were more active in the CAR T cells associated with a good response to treatment than in cells associated with a poor response. All 41 genes seemed to be regulated by a master-switch protein called FOXO1.

The researchers then altered CAR T cells to make them produce more FOXO1 than usual. Gene activity in these cells began to look like that of T memory stem cells, which recognize cancer and respond to it quickly.

The researchers then injected the engineered cells into mice with various types of cancer. Extra FOXO1 made the CAR T cells better at reducing both solid tumours and blood cancers. The stem-cell-like cells shrank a mouse’s tumour more completely and lasted longer in the body than did standard CAR T cells.

Master-switch molecule

A separate team led by immunologists Phillip Darcy, Junyun Lai and Paul Beavis at Peter MacCallum Cancer Centre in Melbourne, Australia, reached the same conclusion with different methods 2 . Their team was examining the effect of IL-15, an immune-signalling molecule that is administered alongside CAR T cells in some clinical trials. IL-15 helps to switch T cells to a stem-like state, but the cells can get stuck there instead of maturing to fight cancer.

The team analysed gene activity in CAR T cells and found that IL-15 turned on genes associated with FOXO1. The researchers engineered CAR T cells to produce extra-high levels of FOXO1 and showed that they became more stem-like, but also reached maturity and fought cancer without becoming exhausted. “It’s the ideal situation,” Darcy says.

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Stem-cell and genetic therapies make a healthy marriage

The team also found that extra-high levels of FOXO1 improved the CAR T cells’ metabolism, allowing them to last much longer when infused into mice. “We were surprised by the magnitude of the effect,” says Beavis.

Mackall says she was excited to see that FOXO1 worked the same way in mice and humans. “It means this is pretty fundamental,” she says.

Engineering CAR T cells that overexpress FOXO1 might be fairly simple to test in people with cancer, although Mackall says researchers will need to determine which people and types of cancer are most likely to respond well to rejuvenated cells. Darcy says that his team is already speaking to clinical researchers about testing FOXO1 in CAR T cells — trials that could start within two years.

And Weber points to an ongoing clinical trial in which people with leukaemia are receiving CAR T cells genetically engineered to produce unusually high levels of another master-switch protein called c-Jun, which also helps T cells avoid exhaustion. The trial’s results have not been released yet, but Mackall says she suspects the same system could be applied to FOXO1 and that overexpressing both proteins might make the cells even more powerful.

doi: https://doi.org/10.1038/d41586-024-01043-2

Doan, A. et al. Nature https://doi.org/10.1038/s41586-024-07300-8 (2024).

Article   Google Scholar  

Chan, J. D. et al. Nature https://doi.org/10.1038/s41586-024-07242-1 (2024).

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Single-shot measurement of photonic topological invariant

Nathan roberts, guido baardink, anton souslov, and peter j. mosley, phys. rev. research 6 , l022010 – published 11 april 2024.

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  • ACKNOWLEDGMENTS

Topological design enables robustness to be engineered into a system. However, a general challenge remains to experimentally characterize topological properties. In this work, we demonstrate a technique for directly observing a winding-number invariant using a single measurement. By propagating light with a sufficiently broad spectrum along a topological photonic crystal fiber, we calculate the winding number invariant from the output intensity pattern. We quantify the capabilities of this single-shot method, which works even for surprisingly narrow and asymmetric spectral distributions. We demonstrate our approach using topological fiber, but our method is generalizable to other platforms. Our method is experimentally straightforward: we use only a broadband input excitation and a single output to measure the topological invariant.

Figure

  • Received 19 July 2023
  • Revised 23 January 2024
  • Accepted 29 February 2024

DOI: https://doi.org/10.1103/PhysRevResearch.6.L022010

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Published by the American Physical Society under the terms of the Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI.

Published by the American Physical Society

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  • Physical Systems

Authors & Affiliations

  • 1 Department of Physics, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
  • 2 Centre for Photonics and Photonic Materials, University of Bath, Bath BA2 7AY, United Kingdom
  • 3 TCM Group, Cavendish Laboratory, JJ Thomson Avenue, Cambridge, CB3 0HE, United Kingdom
  • * [email protected]
  • [email protected]

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Vol. 6, Iss. 2 — April - June 2024

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  • Condensed Matter Physics

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Schematic of the single-shot measurement. (a) Cross section of the 12-core topological photonic crystal fiber based on the SSH chain (left). The different air hole sizes (see right zoom) give rise to alternating weak-strong intercore couplings. (b) A narrow spectrum of light is coupled into a bulk core (left). The resultant intensity profile (right) is used to calculate a weighted intensity difference I d , which is then wavelength averaged to measure the system's topological invariant. (c) Our method uses a broadband spectrum, allowing the invariant to be calculated in a single shot.

(a) Heuristic explanation of the connection between the output intensity profile and the topological invariant. A broad spectrum excites a single core and the output intensity profiles are considered for two extreme cases, C 1 = 0 and C 2 = 0 . For the topologically trivial case C 2 = 0 , light stays within a single unit cell and the average intensity difference is zero. For the nontrivial case C 1 = 0 , light cannot couple to the other core within the same unit cell. On average, half the light intensity ends up in the neighboring unit cell, making the weighted intensity difference 2 〈 I d 〉 λ = 1 . (b) Schematic explanation of our experiment. The intensity distributions per unit wavelength for both the narrowest spectrum (purple) and the widest spectrum (dashed teal) are shown in the plot. The intensity distributions are used to excite core six of the topological fiber before the output is imaged onto a camera. The two intensity plots shown correspond to the two spectra shown in the plot. (c) Experimental data showing the effects of changing the spectral width on the winding-number measurement ( ν ). The black crosses are experimental averages of three measurements, with the error bars being their standard deviation. The observed winding numbers stay around the expected value of one, but the uncertainty associated with the measurements (gray shaded region) grows as the root mean square (RMS) spectral width decreases. The green diamonds and red triangles show the theoretical predictions of our measurement when the experimental spectra are propagated. The diamonds correspond to the system's topological state with the same couplings as in our experiment, while for the triangles, the C 1 and C 2 couplings are flipped, leaving the system in a topologically trivial phase.

(a) Four example distributions of the input spectrum. We vary the root mean square (RMS) width of the input spectrum from 27.8 nm (turquoise) to 5.8 nm (dark green) by reducing the standard deviation of the distribution. (b) shows the calculated winding number ( ν ) for each of these input spectra as a function of the RMS width of the distribution. (c) Response of the weighted intensity difference to changing wavelength (red) and changing distance (blue) in the topologically nontrivial case. Both plots show twice the weighted intensity difference oscillating around one, the expected value of the winding number that characterizes the system. (d) Winding numbers calculated by averaging the wavelength and distance curves plotted in (c). (e) Product of the distribution density and 2 I d [which approaches the winding number as shown in Eq. ( 2 )], for the distributions shown in (a). We show graphically that the mean of this function becomes closer to the winding number, ν = 1 as the RMS width of the exciting spectrum increases.

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Chapter 10 Experimental Research

Experimental research, often considered to be the “gold standard” in research designs, is one of the most rigorous of all research designs. In this design, one or more independent variables are manipulated by the researcher (as treatments), subjects are randomly assigned to different treatment levels (random assignment), and the results of the treatments on outcomes (dependent variables) are observed. The unique strength of experimental research is its internal validity (causality) due to its ability to link cause and effect through treatment manipulation, while controlling for the spurious effect of extraneous variable.

Experimental research is best suited for explanatory research (rather than for descriptive or exploratory research), where the goal of the study is to examine cause-effect relationships. It also works well for research that involves a relatively limited and well-defined set of independent variables that can either be manipulated or controlled. Experimental research can be conducted in laboratory or field settings. Laboratory experiments , conducted in laboratory (artificial) settings, tend to be high in internal validity, but this comes at the cost of low external validity (generalizability), because the artificial (laboratory) setting in which the study is conducted may not reflect the real world. Field experiments , conducted in field settings such as in a real organization, and high in both internal and external validity. But such experiments are relatively rare, because of the difficulties associated with manipulating treatments and controlling for extraneous effects in a field setting.

Experimental research can be grouped into two broad categories: true experimental designs and quasi-experimental designs. Both designs require treatment manipulation, but while true experiments also require random assignment, quasi-experiments do not. Sometimes, we also refer to non-experimental research, which is not really a research design, but an all-inclusive term that includes all types of research that do not employ treatment manipulation or random assignment, such as survey research, observational research, and correlational studies.

Basic Concepts

Treatment and control groups. In experimental research, some subjects are administered one or more experimental stimulus called a treatment (the treatment group ) while other subjects are not given such a stimulus (the control group ). The treatment may be considered successful if subjects in the treatment group rate more favorably on outcome variables than control group subjects. Multiple levels of experimental stimulus may be administered, in which case, there may be more than one treatment group. For example, in order to test the effects of a new drug intended to treat a certain medical condition like dementia, if a sample of dementia patients is randomly divided into three groups, with the first group receiving a high dosage of the drug, the second group receiving a low dosage, and the third group receives a placebo such as a sugar pill (control group), then the first two groups are experimental groups and the third group is a control group. After administering the drug for a period of time, if the condition of the experimental group subjects improved significantly more than the control group subjects, we can say that the drug is effective. We can also compare the conditions of the high and low dosage experimental groups to determine if the high dose is more effective than the low dose.

Treatment manipulation. Treatments are the unique feature of experimental research that sets this design apart from all other research methods. Treatment manipulation helps control for the “cause” in cause-effect relationships. Naturally, the validity of experimental research depends on how well the treatment was manipulated. Treatment manipulation must be checked using pretests and pilot tests prior to the experimental study. Any measurements conducted before the treatment is administered are called pretest measures , while those conducted after the treatment are posttest measures .

Random selection and assignment. Random selection is the process of randomly drawing a sample from a population or a sampling frame. This approach is typically employed in survey research, and assures that each unit in the population has a positive chance of being selected into the sample. Random assignment is however a process of randomly assigning subjects to experimental or control groups. This is a standard practice in true experimental research to ensure that treatment groups are similar (equivalent) to each other and to the control group, prior to treatment administration. Random selection is related to sampling, and is therefore, more closely related to the external validity (generalizability) of findings. However, random assignment is related to design, and is therefore most related to internal validity. It is possible to have both random selection and random assignment in well-designed experimental research, but quasi-experimental research involves neither random selection nor random assignment.

Threats to internal validity. Although experimental designs are considered more rigorous than other research methods in terms of the internal validity of their inferences (by virtue of their ability to control causes through treatment manipulation), they are not immune to internal validity threats. Some of these threats to internal validity are described below, within the context of a study of the impact of a special remedial math tutoring program for improving the math abilities of high school students.

  • History threat is the possibility that the observed effects (dependent variables) are caused by extraneous or historical events rather than by the experimental treatment. For instance, students’ post-remedial math score improvement may have been caused by their preparation for a math exam at their school, rather than the remedial math program.
  • Maturation threat refers to the possibility that observed effects are caused by natural maturation of subjects (e.g., a general improvement in their intellectual ability to understand complex concepts) rather than the experimental treatment.
  • Testing threat is a threat in pre-post designs where subjects’ posttest responses are conditioned by their pretest responses. For instance, if students remember their answers from the pretest evaluation, they may tend to repeat them in the posttest exam. Not conducting a pretest can help avoid this threat.
  • Instrumentation threat , which also occurs in pre-post designs, refers to the possibility that the difference between pretest and posttest scores is not due to the remedial math program, but due to changes in the administered test, such as the posttest having a higher or lower degree of difficulty than the pretest.
  • Mortality threat refers to the possibility that subjects may be dropping out of the study at differential rates between the treatment and control groups due to a systematic reason, such that the dropouts were mostly students who scored low on the pretest. If the low-performing students drop out, the results of the posttest will be artificially inflated by the preponderance of high-performing students.
  • Regression threat , also called a regression to the mean, refers to the statistical tendency of a group’s overall performance on a measure during a posttest to regress toward the mean of that measure rather than in the anticipated direction. For instance, if subjects scored high on a pretest, they will have a tendency to score lower on the posttest (closer to the mean) because their high scores (away from the mean) during the pretest was possibly a statistical aberration. This problem tends to be more prevalent in non-random samples and when the two measures are imperfectly correlated.

Two-Group Experimental Designs

The simplest true experimental designs are two group designs involving one treatment group and one control group, and are ideally suited for testing the effects of a single independent variable that can be manipulated as a treatment. The two basic two-group designs are the pretest-posttest control group design and the posttest-only control group design, while variations may include covariance designs. These designs are often depicted using a standardized design notation, where R represents random assignment of subjects to groups, X represents the treatment administered to the treatment group, and O represents pretest or posttest observations of the dependent variable (with different subscripts to distinguish between pretest and posttest observations of treatment and control groups).

Pretest-posttest control group design . In this design, subjects are randomly assigned to treatment and control groups, subjected to an initial (pretest) measurement of the dependent variables of interest, the treatment group is administered a treatment (representing the independent variable of interest), and the dependent variables measured again (posttest). The notation of this design is shown in Figure 10.1.

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Figure 10.1. Pretest-posttest control group design

The effect E of the experimental treatment in the pretest posttest design is measured as the difference in the posttest and pretest scores between the treatment and control groups:

E = (O 2 – O 1 ) – (O 4 – O 3 )

Statistical analysis of this design involves a simple analysis of variance (ANOVA) between the treatment and control groups. The pretest posttest design handles several threats to internal validity, such as maturation, testing, and regression, since these threats can be expected to influence both treatment and control groups in a similar (random) manner. The selection threat is controlled via random assignment. However, additional threats to internal validity may exist. For instance, mortality can be a problem if there are differential dropout rates between the two groups, and the pretest measurement may bias the posttest measurement (especially if the pretest introduces unusual topics or content).

Posttest-only control group design . This design is a simpler version of the pretest-posttest design where pretest measurements are omitted. The design notation is shown in Figure 10.2.

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Figure 10.2. Posttest only control group design.

The treatment effect is measured simply as the difference in the posttest scores between the two groups:

E = (O 1 – O 2 )

The appropriate statistical analysis of this design is also a two- group analysis of variance (ANOVA). The simplicity of this design makes it more attractive than the pretest-posttest design in terms of internal validity. This design controls for maturation, testing, regression, selection, and pretest-posttest interaction, though the mortality threat may continue to exist.

Covariance designs . Sometimes, measures of dependent variables may be influenced by extraneous variables called covariates . Covariates are those variables that are not of central interest to an experimental study, but should nevertheless be controlled in an experimental design in order to eliminate their potential effect on the dependent variable and therefore allow for a more accurate detection of the effects of the independent variables of interest. The experimental designs discussed earlier did not control for such covariates. A covariance design (also called a concomitant variable design) is a special type of pretest posttest control group design where the pretest measure is essentially a measurement of the covariates of interest rather than that of the dependent variables. The design notation is shown in Figure 10.3, where C represents the covariates:

research subjects of experimental

Figure 10.3. Covariance design

Because the pretest measure is not a measurement of the dependent variable, but rather a covariate, the treatment effect is measured as the difference in the posttest scores between the treatment and control groups as:

research subjects of experimental

Figure 10.4. 2 x 2 factorial design

Factorial designs can also be depicted using a design notation, such as that shown on the right panel of Figure 10.4. R represents random assignment of subjects to treatment groups, X represents the treatment groups themselves (the subscripts of X represents the level of each factor), and O represent observations of the dependent variable. Notice that the 2 x 2 factorial design will have four treatment groups, corresponding to the four combinations of the two levels of each factor. Correspondingly, the 2 x 3 design will have six treatment groups, and the 2 x 2 x 2 design will have eight treatment groups. As a rule of thumb, each cell in a factorial design should have a minimum sample size of 20 (this estimate is derived from Cohen’s power calculations based on medium effect sizes). So a 2 x 2 x 2 factorial design requires a minimum total sample size of 160 subjects, with at least 20 subjects in each cell. As you can see, the cost of data collection can increase substantially with more levels or factors in your factorial design. Sometimes, due to resource constraints, some cells in such factorial designs may not receive any treatment at all, which are called incomplete factorial designs . Such incomplete designs hurt our ability to draw inferences about the incomplete factors.

In a factorial design, a main effect is said to exist if the dependent variable shows a significant difference between multiple levels of one factor, at all levels of other factors. No change in the dependent variable across factor levels is the null case (baseline), from which main effects are evaluated. In the above example, you may see a main effect of instructional type, instructional time, or both on learning outcomes. An interaction effect exists when the effect of differences in one factor depends upon the level of a second factor. In our example, if the effect of instructional type on learning outcomes is greater for 3 hours/week of instructional time than for 1.5 hours/week, then we can say that there is an interaction effect between instructional type and instructional time on learning outcomes. Note that the presence of interaction effects dominate and make main effects irrelevant, and it is not meaningful to interpret main effects if interaction effects are significant.

Hybrid Experimental Designs

Hybrid designs are those that are formed by combining features of more established designs. Three such hybrid designs are randomized bocks design, Solomon four-group design, and switched replications design.

Randomized block design. This is a variation of the posttest-only or pretest-posttest control group design where the subject population can be grouped into relatively homogeneous subgroups (called blocks ) within which the experiment is replicated. For instance, if you want to replicate the same posttest-only design among university students and full -time working professionals (two homogeneous blocks), subjects in both blocks are randomly split between treatment group (receiving the same treatment) or control group (see Figure 10.5). The purpose of this design is to reduce the “noise” or variance in data that may be attributable to differences between the blocks so that the actual effect of interest can be detected more accurately.

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Figure 10.5. Randomized blocks design.

Solomon four-group design . In this design, the sample is divided into two treatment groups and two control groups. One treatment group and one control group receive the pretest, and the other two groups do not. This design represents a combination of posttest-only and pretest-posttest control group design, and is intended to test for the potential biasing effect of pretest measurement on posttest measures that tends to occur in pretest-posttest designs but not in posttest only designs. The design notation is shown in Figure 10.6.

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Figure 10.6. Solomon four-group design

Switched replication design . This is a two-group design implemented in two phases with three waves of measurement. The treatment group in the first phase serves as the control group in the second phase, and the control group in the first phase becomes the treatment group in the second phase, as illustrated in Figure 10.7. In other words, the original design is repeated or replicated temporally with treatment/control roles switched between the two groups. By the end of the study, all participants will have received the treatment either during the first or the second phase. This design is most feasible in organizational contexts where organizational programs (e.g., employee training) are implemented in a phased manner or are repeated at regular intervals.

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Figure 10.7. Switched replication design.

Quasi-Experimental Designs

Quasi-experimental designs are almost identical to true experimental designs, but lacking one key ingredient: random assignment. For instance, one entire class section or one organization is used as the treatment group, while another section of the same class or a different organization in the same industry is used as the control group. This lack of random assignment potentially results in groups that are non-equivalent, such as one group possessing greater mastery of a certain content than the other group, say by virtue of having a better teacher in a previous semester, which introduces the possibility of selection bias . Quasi-experimental designs are therefore inferior to true experimental designs in interval validity due to the presence of a variety of selection related threats such as selection-maturation threat (the treatment and control groups maturing at different rates), selection-history threat (the treatment and control groups being differentially impact by extraneous or historical events), selection-regression threat (the treatment and control groups regressing toward the mean between pretest and posttest at different rates), selection-instrumentation threat (the treatment and control groups responding differently to the measurement), selection-testing (the treatment and control groups responding differently to the pretest), and selection-mortality (the treatment and control groups demonstrating differential dropout rates). Given these selection threats, it is generally preferable to avoid quasi-experimental designs to the greatest extent possible.

Many true experimental designs can be converted to quasi-experimental designs by omitting random assignment. For instance, the quasi-equivalent version of pretest-posttest control group design is called nonequivalent groups design (NEGD), as shown in Figure 10.8, with random assignment R replaced by non-equivalent (non-random) assignment N . Likewise, the quasi -experimental version of switched replication design is called non-equivalent switched replication design (see Figure 10.9).

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Figure 10.8. NEGD design.

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Figure 10.9. Non-equivalent switched replication design.

In addition, there are quite a few unique non -equivalent designs without corresponding true experimental design cousins. Some of the more useful of these designs are discussed next.

Regression-discontinuity (RD) design . This is a non-equivalent pretest-posttest design where subjects are assigned to treatment or control group based on a cutoff score on a preprogram measure. For instance, patients who are severely ill may be assigned to a treatment group to test the efficacy of a new drug or treatment protocol and those who are mildly ill are assigned to the control group. In another example, students who are lagging behind on standardized test scores may be selected for a remedial curriculum program intended to improve their performance, while those who score high on such tests are not selected from the remedial program. The design notation can be represented as follows, where C represents the cutoff score:

research subjects of experimental

Figure 10.10. RD design.

Because of the use of a cutoff score, it is possible that the observed results may be a function of the cutoff score rather than the treatment, which introduces a new threat to internal validity. However, using the cutoff score also ensures that limited or costly resources are distributed to people who need them the most rather than randomly across a population, while simultaneously allowing a quasi-experimental treatment. The control group scores in the RD design does not serve as a benchmark for comparing treatment group scores, given the systematic non-equivalence between the two groups. Rather, if there is no discontinuity between pretest and posttest scores in the control group, but such a discontinuity persists in the treatment group, then this discontinuity is viewed as evidence of the treatment effect.

Proxy pretest design . This design, shown in Figure 10.11, looks very similar to the standard NEGD (pretest-posttest) design, with one critical difference: the pretest score is collected after the treatment is administered. A typical application of this design is when a researcher is brought in to test the efficacy of a program (e.g., an educational program) after the program has already started and pretest data is not available. Under such circumstances, the best option for the researcher is often to use a different prerecorded measure, such as students’ grade point average before the start of the program, as a proxy for pretest data. A variation of the proxy pretest design is to use subjects’ posttest recollection of pretest data, which may be subject to recall bias, but nevertheless may provide a measure of perceived gain or change in the dependent variable.

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Figure 10.11. Proxy pretest design.

Separate pretest-posttest samples design . This design is useful if it is not possible to collect pretest and posttest data from the same subjects for some reason. As shown in Figure 10.12, there are four groups in this design, but two groups come from a single non-equivalent group, while the other two groups come from a different non-equivalent group. For instance, you want to test customer satisfaction with a new online service that is implemented in one city but not in another. In this case, customers in the first city serve as the treatment group and those in the second city constitute the control group. If it is not possible to obtain pretest and posttest measures from the same customers, you can measure customer satisfaction at one point in time, implement the new service program, and measure customer satisfaction (with a different set of customers) after the program is implemented. Customer satisfaction is also measured in the control group at the same times as in the treatment group, but without the new program implementation. The design is not particularly strong, because you cannot examine the changes in any specific customer’s satisfaction score before and after the implementation, but you can only examine average customer satisfaction scores. Despite the lower internal validity, this design may still be a useful way of collecting quasi-experimental data when pretest and posttest data are not available from the same subjects.

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Figure 10.12. Separate pretest-posttest samples design.

Nonequivalent dependent variable (NEDV) design . This is a single-group pre-post quasi-experimental design with two outcome measures, where one measure is theoretically expected to be influenced by the treatment and the other measure is not. For instance, if you are designing a new calculus curriculum for high school students, this curriculum is likely to influence students’ posttest calculus scores but not algebra scores. However, the posttest algebra scores may still vary due to extraneous factors such as history or maturation. Hence, the pre-post algebra scores can be used as a control measure, while that of pre-post calculus can be treated as the treatment measure. The design notation, shown in Figure 10.13, indicates the single group by a single N , followed by pretest O 1 and posttest O 2 for calculus and algebra for the same group of students. This design is weak in internal validity, but its advantage lies in not having to use a separate control group.

An interesting variation of the NEDV design is a pattern matching NEDV design , which employs multiple outcome variables and a theory that explains how much each variable will be affected by the treatment. The researcher can then examine if the theoretical prediction is matched in actual observations. This pattern-matching technique, based on the degree of correspondence between theoretical and observed patterns is a powerful way of alleviating internal validity concerns in the original NEDV design.

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Figure 10.13. NEDV design.

Perils of Experimental Research

Experimental research is one of the most difficult of research designs, and should not be taken lightly. This type of research is often best with a multitude of methodological problems. First, though experimental research requires theories for framing hypotheses for testing, much of current experimental research is atheoretical. Without theories, the hypotheses being tested tend to be ad hoc, possibly illogical, and meaningless. Second, many of the measurement instruments used in experimental research are not tested for reliability and validity, and are incomparable across studies. Consequently, results generated using such instruments are also incomparable. Third, many experimental research use inappropriate research designs, such as irrelevant dependent variables, no interaction effects, no experimental controls, and non-equivalent stimulus across treatment groups. Findings from such studies tend to lack internal validity and are highly suspect. Fourth, the treatments (tasks) used in experimental research may be diverse, incomparable, and inconsistent across studies and sometimes inappropriate for the subject population. For instance, undergraduate student subjects are often asked to pretend that they are marketing managers and asked to perform a complex budget allocation task in which they have no experience or expertise. The use of such inappropriate tasks, introduces new threats to internal validity (i.e., subject’s performance may be an artifact of the content or difficulty of the task setting), generates findings that are non-interpretable and meaningless, and makes integration of findings across studies impossible.

The design of proper experimental treatments is a very important task in experimental design, because the treatment is the raison d’etre of the experimental method, and must never be rushed or neglected. To design an adequate and appropriate task, researchers should use prevalidated tasks if available, conduct treatment manipulation checks to check for the adequacy of such tasks (by debriefing subjects after performing the assigned task), conduct pilot tests (repeatedly, if necessary), and if doubt, using tasks that are simpler and familiar for the respondent sample than tasks that are complex or unfamiliar.

In summary, this chapter introduced key concepts in the experimental design research method and introduced a variety of true experimental and quasi-experimental designs. Although these designs vary widely in internal validity, designs with less internal validity should not be overlooked and may sometimes be useful under specific circumstances and empirical contingencies.

  • Social Science Research: Principles, Methods, and Practices. Authored by : Anol Bhattacherjee. Provided by : University of South Florida. Located at : http://scholarcommons.usf.edu/oa_textbooks/3/ . License : CC BY-NC-SA: Attribution-NonCommercial-ShareAlike

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PHYS 2210 Exploring Experimental Physics

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In this laboratory course, students will build on the knowledge and skills developed in Physics 1110 (Introduction to Experimental Physics) to conduct semester-long experimental physics projects. Students will work in lab project teams to iteratively develop a research question, write a proposal that is reviewed by their peers and experts, engage for multiple weeks with their project, and present their findings in a public poster session at the end of the semester. Students will learn additional skills in experimental design and data analysis, with broader focuses on how to generate interesting, testable, and feasible research questions, how to provide critical and constructive feedback to others, and how to present research to a broad audience. The course provides an early opportunity for students to get a glimpse of experimental physics research, employ creativity to generate an answer to a novel research question and/or design a unique experimental approach.

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About half of americans say public k-12 education is going in the wrong direction.

School buses arrive at an elementary school in Arlington, Virginia. (Chen Mengtong/China News Service via Getty Images)

About half of U.S. adults (51%) say the country’s public K-12 education system is generally going in the wrong direction. A far smaller share (16%) say it’s going in the right direction, and about a third (32%) are not sure, according to a Pew Research Center survey conducted in November 2023.

Pew Research Center conducted this analysis to understand how Americans view the K-12 public education system. We surveyed 5,029 U.S. adults from Nov. 9 to Nov. 16, 2023.

The survey was conducted by Ipsos for Pew Research Center on the Ipsos KnowledgePanel Omnibus. The KnowledgePanel is a probability-based web panel recruited primarily through national, random sampling of residential addresses. The survey is weighted by gender, age, race, ethnicity, education, income and other categories.

Here are the questions used for this analysis , along with responses, and the survey methodology .

A diverging bar chart showing that only 16% of Americans say public K-12 education is going in the right direction.

A majority of those who say it’s headed in the wrong direction say a major reason is that schools are not spending enough time on core academic subjects.

These findings come amid debates about what is taught in schools , as well as concerns about school budget cuts and students falling behind academically.

Related: Race and LGBTQ Issues in K-12 Schools

Republicans are more likely than Democrats to say the public K-12 education system is going in the wrong direction. About two-thirds of Republicans and Republican-leaning independents (65%) say this, compared with 40% of Democrats and Democratic leaners. In turn, 23% of Democrats and 10% of Republicans say it’s headed in the right direction.

Among Republicans, conservatives are the most likely to say public education is headed in the wrong direction: 75% say this, compared with 52% of moderate or liberal Republicans. There are no significant differences among Democrats by ideology.

Similar shares of K-12 parents and adults who don’t have a child in K-12 schools say the system is going in the wrong direction.

A separate Center survey of public K-12 teachers found that 82% think the overall state of public K-12 education has gotten worse in the past five years. And many teachers are pessimistic about the future.

Related: What’s It Like To Be A Teacher in America Today?

Why do Americans think public K-12 education is going in the wrong direction?

We asked adults who say the public education system is going in the wrong direction why that might be. About half or more say the following are major reasons:

  • Schools not spending enough time on core academic subjects, like reading, math, science and social studies (69%)
  • Teachers bringing their personal political and social views into the classroom (54%)
  • Schools not having the funding and resources they need (52%)

About a quarter (26%) say a major reason is that parents have too much influence in decisions about what schools are teaching.

How views vary by party

A dot plot showing that Democrats and Republicans who say public education is going in the wrong direction give different explanations.

Americans in each party point to different reasons why public education is headed in the wrong direction.

Republicans are more likely than Democrats to say major reasons are:

  • A lack of focus on core academic subjects (79% vs. 55%)
  • Teachers bringing their personal views into the classroom (76% vs. 23%)

A bar chart showing that views on why public education is headed in the wrong direction vary by political ideology.

In turn, Democrats are more likely than Republicans to point to:

  • Insufficient school funding and resources (78% vs. 33%)
  • Parents having too much say in what schools are teaching (46% vs. 13%)

Views also vary within each party by ideology.

Among Republicans, conservatives are particularly likely to cite a lack of focus on core academic subjects and teachers bringing their personal views into the classroom.

Among Democrats, liberals are especially likely to cite schools lacking resources and parents having too much say in the curriculum.

Note: Here are the questions used for this analysis , along with responses, and the survey methodology .

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University of Auckland excels in 2024 QS subject rankings

10 April 2024

University news , Faculty of Science , Faculty of Arts , Faculty of Engineering , Faculty of Education and Social Work

The University's research, reputation and teaching is having a global impact, with ten subjects it teaches ranked in the top 50 subjects of universities worldwide.

QS subject rankings 2024 10 in top 50

Waipapa Taumata Rau, University of Auckland has added to its reputation as a world-leading research, teaching and learning institution, with its results in the QS World University Rankings by Subject 2024.  

Ten of the subjects the University teaches have been ranked in the top 50 subjects worldwide, based on academic and employer reputation as well as research, compared with eight in 2023. In the top 100, the University has 23 ranked subjects.  

Marketing ranks 21-50 in the world, entering the top 50 for the University for the first time. Anatomy and Physiology is also a new entrant to the QS top 50 subjects, ranking 45=.  

Sports related subjects, regularly in the top 50, are equal 28th, up from 32 in 2023. Education, consistently in the top 50, holds firm at 37, while Archaeology ranks 39th equal, up from 46 in 2023.  Anthropology, ranked 48, is up one place from 2023. Rounding out the other ten in the top 50 subjects are Civil Engineering (46) and English (48). Two subjects that had fallen out of the top 50 last year are back in – Psychology (45) and Linguistics (49).

The 2024 QS Subject Rankings comprise a research component but also a strong employer reputation component.

Professor Jason Ingham, who was head of the Department of Civil and Environmental Engineering during the rankings period, says the QS Subject Rankings are important for many reasons.

“When we advertise to fill vacant academic appointments, they help us to receive the strongest applicants – people who recognise the reputation of the University of Auckland. They’re also important to attract high-calibre doctoral students from around the world.”

He says being able to say a subject offering is ‘among the best in the world’ is invaluable.

Professor Frank Bloomfield, Deputy Vice-Chancellor Research, says it’s heartening to know that people recognise the University as being a leading university globally.

“For staff to know that the research and research-led teaching they do is highly valued by their international peers is empowering. Having ten subjects ranked in the top 50 in the world reflects the quality of our research and teaching and contributes to University of Auckland degrees being recognised globally.”

He says in research, academics and students are making significant strides in addressing some of the world's most pressing challenges, from climate change to healthcare disparities.

“Our interdisciplinary approach fosters collaboration and innovation and we’re developing solutions that resonate globally. Our students know the importance of this kind of work."

Professor Frank Bloomfield, Deputy Vice-Chancellor Research

For staff to know that the research and research-led teaching they do is highly valued by their international peers is empowering.

Professor Frank Bloomfield Deputy Vice-Chancellor Research

Vice-Chancellor Professor Dawn Freshwater said the results emphasised the University’s commitment to excellence and innovation, and the role staff play in showcasing research and best practice in teaching and learning.

“The University is dedicated to providing students with a world-class education that prepares them for success in an ever-changing world,” she said. “Our goal is to foster a culture of curiosity, creativity and critical inquiry to empower students to become lifelong learners and leaders in their respective fields. We’re doing that really well.”

The methodology for the QS subject rankings used saw 45 of the University’s subjects meet the criteria to be ranked, and 23 of those were ranked in the top 100 in the world.

In November 2023, eight University of Auckland-affiliated researchers were named in the prestigious Clarivate Highly Cited Researchers List , and this month, six of the University’s researchers were elected Fellows by the Royal Society Te Apārangi .

About the QS Subject Rankings 

The 2024 edition of the QS World University Rankings by Subject , released on 10 April by global higher education analyst QS Quacquarelli Symonds, provides independent comparative analysis on the performance of more than 16,400 individual university programmes, taken by students at more than 1,500 universities in 96 locations around the world, across 55 academic disciplines and five broad faculty areas. 

Other current rankings

The University of Auckland was ranked 68th in the world in the overarching QS World University Rankings 2024, making it New Zealand’s highest-ranked university. It was also ranked fifth in the world in the  2024 QS World University Sustainability Rankings. The University was ranked No. 1 in New Zealand and 68th worldwide in the QS Graduate Employability Rankings in 2023. 

For more information: 

University of Auckland Media Manager Denise Montgomery denise.montgomery@auckland.ac.nz

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  • New Zealand's world-ranked University
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1.10: Chapter 10 Experimental Research

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  • William Pelz
  • Herkimer College via Lumen Learning

Experimental research, often considered to be the “gold standard” in research designs, is one of the most rigorous of all research designs. In this design, one or more independent variables are manipulated by the researcher (as treatments), subjects are randomly assigned to different treatment levels (random assignment), and the results of the treatments on outcomes (dependent variables) are observed. The unique strength of experimental research is its internal validity (causality) due to its ability to link cause and effect through treatment manipulation, while controlling for the spurious effect of extraneous variable.

Experimental research is best suited for explanatory research (rather than for descriptive or exploratory research), where the goal of the study is to examine cause-effect relationships. It also works well for research that involves a relatively limited and well-defined set of independent variables that can either be manipulated or controlled. Experimental research can be conducted in laboratory or field settings. Laboratory experiments , conducted in laboratory (artificial) settings, tend to be high in internal validity, but this comes at the cost of low external validity (generalizability), because the artificial (laboratory) setting in which the study is conducted may not reflect the real world. Field experiments , conducted in field settings such as in a real organization, and high in both internal and external validity. But such experiments are relatively rare, because of the difficulties associated with manipulating treatments and controlling for extraneous effects in a field setting.

Experimental research can be grouped into two broad categories: true experimental designs and quasi-experimental designs. Both designs require treatment manipulation, but while true experiments also require random assignment, quasi-experiments do not. Sometimes, we also refer to non-experimental research, which is not really a research design, but an all-inclusive term that includes all types of research that do not employ treatment manipulation or random assignment, such as survey research, observational research, and correlational studies.

Basic Concepts

Treatment and control groups. In experimental research, some subjects are administered one or more experimental stimulus called a treatment (the treatment group ) while other subjects are not given such a stimulus (the control group ). The treatment may be considered successful if subjects in the treatment group rate more favorably on outcome variables than control group subjects. Multiple levels of experimental stimulus may be administered, in which case, there may be more than one treatment group. For example, in order to test the effects of a new drug intended to treat a certain medical condition like dementia, if a sample of dementia patients is randomly divided into three groups, with the first group receiving a high dosage of the drug, the second group receiving a low dosage, and the third group receives a placebo such as a sugar pill (control group), then the first two groups are experimental groups and the third group is a control group. After administering the drug for a period of time, if the condition of the experimental group subjects improved significantly more than the control group subjects, we can say that the drug is effective. We can also compare the conditions of the high and low dosage experimental groups to determine if the high dose is more effective than the low dose.

Treatment manipulation. Treatments are the unique feature of experimental research that sets this design apart from all other research methods. Treatment manipulation helps control for the “cause” in cause-effect relationships. Naturally, the validity of experimental research depends on how well the treatment was manipulated. Treatment manipulation must be checked using pretests and pilot tests prior to the experimental study. Any measurements conducted before the treatment is administered are called pretest measures , while those conducted after the treatment are posttest measures.

Random selection and assignment. Random selection is the process of randomly drawing a sample from a population or a sampling frame. This approach is typically employed in survey research, and assures that each unit in the population has a positive chance of being selected into the sample. Random assignment is however a process of randomly assigning subjects to experimental or control groups. This is a standard practice in true experimental research to ensure that treatment groups are similar (equivalent) to each other and to the control group, prior to treatment administration. Random selection is related to sampling, and is therefore, more closely related to the external validity (generalizability) of findings. However, random assignment is related to design, and is therefore most related to internal validity. It is possible to have both random selection and random assignment in well-designed experimental research, but quasi-experimental research involves neither random selection nor random assignment.

Threats to internal validity. Although experimental designs are considered more rigorous than other research methods in terms of the internal validity of their inferences (by virtue of their ability to control causes through treatment manipulation), they are not immune to internal validity threats. Some of these threats to internal validity are described below, within the context of a study of the impact of a special remedial math tutoring program for improving the math abilities of high school students.

  • History threat is the possibility that the observed effects (dependent variables) are caused by extraneous or historical events rather than by the experimental treatment. For instance, students’ post-remedial math score improvement may have been caused by their preparation for a math exam at their school, rather than the remedial math program.
  • Maturation threat refers to the possibility that observed effects are caused by natural maturation of subjects (e.g., a general improvement in their intellectual ability to understand complex concepts) rather than the experimental treatment.
  • Testing threat is a threat in pre-post designs where subjects’ posttest responses are conditioned by their pretest responses. For instance, if students remember their answers from the pretest evaluation, they may tend to repeat them in the posttest exam. Not conducting a pretest can help avoid this threat.
  • Instrumentation threat , which also occurs in pre-post designs, refers to the possibility that the difference between pretest and posttest scores is not due to the remedial math program, but due to changes in the administered test, such as the posttest having a higher or lower degree of difficulty than the pretest.
  • Mortality threat refers to the possibility that subjects may be dropping out of the study at differential rates between the treatment and control groups due to a systematic reason, such that the dropouts were mostly students who scored low on the pretest. If the low-performing students drop out, the results of the posttest will be artificially inflated by the preponderance of high-performing students.
  • Regression threat , also called a regression to the mean, refers to the statistical tendency of a group’s overall performance on a measure during a posttest to regress toward the mean of that measure rather than in the anticipated direction. For instance, if subjects scored high on a pretest, they will have a tendency to score lower on the posttest (closer to the mean) because their high scores (away from the mean) during the pretest was possibly a statistical aberration. This problem tends to be more prevalent in non-random samples and when the two measures are imperfectly correlated.

Two-Group Experimental Designs

The simplest true experimental designs are two group designs involving one treatment group and one control group, and are ideally suited for testing the effects of a single independent variable that can be manipulated as a treatment. The two basic two-group designs are the pretest-posttest control group design and the posttest-only control group design, while variations may include covariance designs. These designs are often depicted using a standardized design notation, where R represents random assignment of subjects to groups, X represents the treatment administered to the treatment group, and O represents pretest or posttest observations of the dependent variable (with different subscripts to distinguish between pretest and posttest observations of treatment and control groups).

Pretest-posttest control group design. In this design, subjects are randomly assigned to treatment and control groups, subjected to an initial (pretest) measurement of the dependent variables of interest, the treatment group is administered a treatment (representing the independent variable of interest), and the dependent variables measured again (posttest). The notation of this design is shown in Figure 10.1.

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COMMENTS

  1. Experimental research

    10 Experimental research. 10. Experimental research. Experimental research—often considered to be the 'gold standard' in research designs—is one of the most rigorous of all research designs. In this design, one or more independent variables are manipulated by the researcher (as treatments), subjects are randomly assigned to different ...

  2. A Complete Guide to Experimental Research

    Experimental research refers to the experiments conducted in the laboratory or observation under controlled conditions. Researchers try to find out the cause-and-effect relationship between two or more variables. The subjects/participants in the experiment are selected and observed. They receive treatments such as changes in room temperature ...

  3. Exploring Experimental Research: Methodologies, Designs, and

    Experimental research serves as a fundamental scientific method aimed at unraveling. cause-and-effect relationships between variables across various disciplines. This. paper delineates the key ...

  4. Guide to Experimental Design

    An experimental design where treatments aren't randomly assigned is called a quasi-experimental design. Between-subjects vs. within-subjects. In a between-subjects design (also known as an independent measures design or classic ANOVA design), individuals receive only one of the possible levels of an experimental treatment.

  5. A Quick Guide to Experimental Design

    An experimental design where treatments aren't randomly assigned is called a quasi-experimental design. Between-subjects vs within-subjects. In a between-subjects design (also known as an independent measures design or classic ANOVA design), individuals receive only one of the possible levels of an experimental treatment.

  6. Experimental Research

    In true experimental research, the researcher not only manipulates the independent variable, he or she also randomly assigned individuals to the various treatment categories (i.e., control and treatment). In quasi experimental research, the researcher does not randomly assign subjects to treatment and control groups. In other words, the ...

  7. Experimental Research

    Experimental science is the queen of sciences and the goal of all speculation. Roger Bacon (1214-1294) Download chapter PDF. Experiments are part of the scientific method that helps to decide the fate of two or more competing hypotheses or explanations on a phenomenon. The term 'experiment' arises from Latin, Experiri, which means, 'to ...

  8. 5.6: Experimental Research (Summary)

    Experimental treatments can also be compared with the best available alternative. Experiments can be conducted using either between-subjects or within-subjects designs. Deciding which to use in a particular situation requires careful consideration of the pros and cons of each approach.

  9. Experimental Research Design

    The use of randomized experimental research designs ensures that the research subjects in each of the experimental conditions are equal in expectation before the administration of the experimental treatment. However, the use of randomized experimental designs does not ensure that the experiment will remain bias-free after randomization ...

  10. Experimental Research: What it is + Types of designs

    The classic experimental design definition is: "The methods used to collect data in experimental studies.". There are three primary types of experimental design: The way you classify research subjects based on conditions or groups determines the type of research design you should use. 01. Pre-Experimental Design.

  11. Guide to experimental research design

    Experimental research is an option when the project includes an independent variable and a desire to understand the relationship between cause and effect. ... This structure divides subjects into two groups, with two as control groups. Researchers assign the first control group a posttest only and the second control group a pretest and a posttest.

  12. Experimental Research Designs: Types, Examples & Advantages

    Experimental research design is a framework of protocols and procedures created to conduct experimental research with a scientific approach using two sets of variables. Herein, the first set of variables acts as a constant, used to measure the differences of the second set. ... The classification of the research subjects, conditions, or groups ...

  13. Experimental Research Designs: Types, Examples & Methods

    Experimental research examples are different, depending on the type of experimental research design that is being considered. The most basic example of experimental research is laboratory experiments, which may differ in nature depending on the subject of research.

  14. 5.2 Experimental Design

    Random assignment is a method for assigning participants in a sample to the different conditions, and it is an important element of all experimental research in psychology and other fields too. In its strictest sense, random assignment should meet two criteria. One is that each participant has an equal chance of being assigned to each condition ...

  15. Experimental Design

    Medical Research: Experimental design is commonly used to test new treatments or medications for various medical conditions. This includes clinical trials to evaluate the safety and effectiveness of new drugs or medical devices. ... If you are using a between-subjects design, randomly assign participants to groups to control for individual ...

  16. Research Methods

    Descriptive vs. experimental data. In descriptive research, you collect data about your study subject without intervening. The validity of your research will depend on your sampling method. In experimental research, you systematically intervene in a process and measure the outcome. The validity of your research will depend on your experimental ...

  17. Mastering Research: The Principles of Experimental Design

    Randomization: ensuring each subject has an equal chance of being in any group. Randomization is the practice of allocating subjects or experimental units to different groups or conditions entirely by chance. This means each participant, or experimental unit, has an equal likelihood of being assigned to any specific group or condition.

  18. Experimental Research: Meaning And Examples Of Experimental ...

    The way a researcher assigns subjects to different groups determines the types of experimental research design. Pre-experimental Research Design; In a pre-experimental research design, researchers observe a group or various groups to see the effect an independent variable has on the dependent variable to cause change.

  19. Experimental Research: Definition, Types and Examples

    It's the most basic style of experimental research. Free experimental research can occur in one of these design structures: One-shot case study research design: In this form of experimental research, experimenters subject a single group to a stimulus and test them at the end of the application. This allows researchers to gather results for ...

  20. How to supercharge cancer-fighting cells: give them stem-cell skills

    Bioengineered immune cells have been shown to attack and even cure cancer, but they tend to get exhausted if the fight goes on for a long time. Now, two separate research teams have found a way to ...

  21. Phys. Rev. Research 6, L022010 (2024)

    The green diamonds and red triangles show the theoretical predictions of our measurement when the experimental spectra are propagated. The diamonds correspond to the system's topological state with the same couplings as in our experiment, while for the triangles, the C 1 and C 2 couplings are flipped, leaving the system in a topologically ...

  22. MindBridge: A Cross-Subject Brain Decoding Framework

    View PDF HTML (experimental) Abstract: Brain decoding, a pivotal field in neuroscience, aims to reconstruct stimuli from acquired brain signals, primarily utilizing functional magnetic resonance imaging (fMRI). Currently, brain decoding is confined to a per-subject-per-model paradigm, limiting its applicability to the same individual for whom the decoding model is trained.

  23. Chapter 10 Experimental Research

    Chapter 10 Experimental Research. Experimental research, often considered to be the "gold standard" in research designs, is one of the most rigorous of all research designs. In this design, one or more independent variables are manipulated by the researcher (as treatments), subjects are randomly assigned to different treatment levels ...

  24. Class Roster

    Fall 2024 - PHYS 2210 - In this laboratory course, students will build on the knowledge and skills developed in Physics 1110 (Introduction to Experimental Physics) to conduct semester-long experimental physics projects. Students will work in lab project teams to iteratively develop a research question, write a proposal that is reviewed by their ...

  25. About half of Americans say public K-12 education ...

    About Pew Research Center Pew Research Center is a nonpartisan fact tank that informs the public about the issues, attitudes and trends shaping the world. It conducts public opinion polling, demographic research, media content analysis and other empirical social science research. Pew Research Center does not take policy positions.

  26. University of Auckland excels in 2024 QS subject rankings

    Ten of the subjects the University teaches have been ranked in the top 50 subjects worldwide, based on academic and employer reputation as well as research, compared with eight in 2023. In the top 100, the University has 23 ranked subjects. Marketing ranks 21-50 in the world, entering the top 50 for the University for the first time.

  27. 1.10: Chapter 10 Experimental Research

    Experimental research, often considered to be the "gold standard" in research designs, is one of the most rigorous of all research designs. In this design, one or more independent variables are manipulated by the researcher (as treatments), subjects are randomly assigned to different treatment levels (random assignment), and the results of ...

  28. [2403.19887] Jamba: A Hybrid Transformer-Mamba Language Model

    View PDF HTML (experimental) Abstract: We present Jamba, a new base large language model based on a novel hybrid Transformer-Mamba mixture-of-experts (MoE) architecture. Specifically, Jamba interleaves blocks of Transformer and Mamba layers, enjoying the benefits of both model families. MoE is added in some of these layers to increase model capacity while keeping active parameter usage manageable.