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Pharmacology and Toxicology Theses and Dissertations

This collection contains theses and dissertations from the Department of Pharmacology and Toxicology, collected from the Scholarship@Western Electronic Thesis and Dissertation Repository

Theses/Dissertations from 2017 2017

The Effects of Acetylenic Tricyclic Bis-(Cyano Enone) on Cell Migration , Eddie Chan

Regulation of Cardiac Hypertrophy and Metabolism by Regulator of G Protein Signalling 2 (RGS2) , Katherine N. Lee

Theses/Dissertations from 2016 2016

Effects of Prenatal Exposure to Bisphenol A on Fetal Lung Development , Ayten Hijazi

Regulation of E2F1 in Keratinocytes During UV-Damage and Differentiation , Randeep K. Singh

Theses/Dissertations from 2015 2015

Quantitative Estimation of P-glycorptein-Mediated Drug Transport by Mechanistically Modeled Intrinsic Clearance , Alex D. Morgan

Epidermal Growth Factor Receptor in Joint Health and Osteoarthritis , Michael A. Pest

Regulation of Hepatic Drug Metabolizing Enzymes in Chronic Kidney Disease , Thomas J. Velenosi

Theses/Dissertations from 2014 2014

American Ginseng Modulation of Immune Function and Phytochemical Analysis , Chike G. Azike

Analysis of the Vascular Phenotype of the ENT1-null mouse , Keisha A. Best

Cortisol and Testosterone in Hair as Biological Markers of Systolic Heart Failure , Justin Chan

Regulation of the High-Affinity Choline Transporter Activity and Trafficking in Alzheimer’s Disease-Related Pathological Conditions , Leah K. Cuddy

Erythropoietin and Chronic Kidney Disease Alter Hepatic Expression of Cytochrome P450 Enzymes and Drug Transport Proteins , David A. Feere

The Role of c-Kit Receptor Tyrosine Kinase in Beta-Cell Proliferation, Function and Survival , Zhi Chao Feng

The Effects of Atypical Protein Kinase C on TGFβ Signalling , Adrian D. Gunaratne

Investigating Risk Factors for Pediatric Opioid Morbidity and Mortality , Lauren E. Kelly

Role Of Nitric Oxide In Embryonic Heart Development And Adult Aortic Valve Disease , Yin Liu

The ATP2C2 Gene as Transcribed from a Novel Transcriptional Start Site in Pancreatic Acinar Cells , Caitlin M. Sullivan

Effect of Ascorbate on Coagulation and Fibrinolytic Factors in the Septic Microvasculature , Scott Swarbreck

In Vitro Functional Analysis Of Novel Single Nucleotide Polymorphisms In OATP1B1 And Potential Clinical Relevance , Zhiyuan P. Yin

Theses/Dissertations from 2013 2013

Role of iNOS in septic pulmonary microvascular endothelial cell activation , Zahra Asad

ER stress coupled pannexin channel activation via STIM proteins , Ankur Bodalia

Pharmacogenetics of Oral Anticoagulants and Antiplatelets , Inna Gong

N-acetylcysteine as a chemoprotectant against ifosfamide nephrotoxicity; from mechanism to prevention , Lauren Hanly

Fetal and Neonatal Exposure to Nicotine Augments Hepatic Fatty Acid Synthesis in Rat Offspring Long-Term , Noelle L. Ma

Reorganization of inhibitory synapses in experimental epilepsy , Emily J. Pollock

Mechanism of Ascorbate Protection Against Sepsis-Induced Capillary Blood Flow Impairment , Dan Secor

Theses/Dissertations from 2012 2012

Statin Transport by Hepatic Organic Anion-Transporting Polypeptides (OATPs) , Marianne K. DeGorter

The Role of Drug Transporters in Statin-Induced Myopathy , Michael J. Knauer

The role of GRK2 in hypertension and regulation of GPR30 , Bonan Liu

Human Equilibrative Nucleoside Transporter Subtype 1: Structure-Function Analysis Using Cysteine Mutagenesis and Thiol Modifying Techniques , Jamie Park

Methodological Challenges and Clinical Applications of Hair Cortisol Analysis , Evan W. Russell

Intestinal and hepatic drug transporters and their role in the disposition of lipid-lowering drugs , Ute I. Schwarz

Molecular Mechanisms of Cell Migration Inhibition by Synthetic Triterpenoids , Ciric Chi Wing To

Characterization of EIF2Be and Its Interaction with RGS2 , William H. Xue

Theses/Dissertations from 2011 2011

Purine Transport and Metabolism in Microvascular Endothelial Cells , Derek B J Bone

Predicting Drug Hypersensitivity Reactions: Mechanistic and Clinical Implications , Abdelbaset A. Elzagallaai

Regulation of G Protein Signaling by GoLoco Motif Containing Proteins , Peishen Zhao

Theses/Dissertations from 2010 2010

Pharmacokinetics and Therapeutic Uses of Mesna , Murray J. Cutler

Regulation of DNA Damage Processing by Covalent Modification of Thymine DNA Glycosylase , Ryan D. Mohan

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Pharmacology & Toxicology Department Theses and Dissertations

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About the programs

The advanced degree programs at the Indiana University of Medicine Department of Pharmacology and Toxicology prepare scientists for careers across the spectrum of biomedical research. The Master of Science (M.S.) degree is a thesis research degree that gives a student the intellectual background to understand and participate in ongoing research projects. The Doctor of Philosophy (Ph.D.) degree is offered for the student who wants to pursue an independent career in research. Students with the Ph.D. degree are prepared for an academic career combining research with teaching or for a career in industrial pharmaceutical research. A combined M.D./Ph.D. degree is open to qualified individuals who ultimately seek to direct biomedical research with a clinical emphasis.

For more information visit http://medicine.iu.edu/body.cfm?id=4418&oTopID=4418

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UKnowledge > College of Medicine > Pharmacology and Nutritional Sciences > Theses & Dissertations

Theses and Dissertations--Pharmacology and Nutritional Sciences

Theses/dissertations from 2023 2023.

THE ROLE OF RENAL-DERIVED HUMAN SOLUBLE PRORENIN RECEPTOR IN BLOOD PRESSURE REGULATION AND KIDNEY FUNCTION , Gertrude Arthur

AGE- AND SEX-DEPENDENT ALTERATIONS IN PRIMARY SOMATOSENSORY NEURONAL CALCIUM NETWORK DYNAMICS DURING LOCOMOTION , Sami L. Case

RELATIVE ADRENAL INSUFFICIENCY IN SEPSIS , Dan Hao

Exploring the Efficacy of miR-33 Antagonism in Promoting Regression of Intracranial Atherosclerosis in a Nonhuman Primate Model , Peter Hecker

HIGH CHOLESTEROL DIET INDUCES SUDDEN DEATH IN MICE WITH IMPAIRED REVERSE CHOLESTEROL TRANSPORT , Misa Ito

ROLE OF AUTOPHAGY IN AORTIC ANEURYSMS , Aida Javidan

MITOCHONDRIA AS CAUSES OF AND THERAPEUTIC TARGETS IN CHRONIC POST-SEPSIS SKELETAL MUSCLE WEAKNESS , Meagan Scott Kingren

THE ROLE OF HIGH MOBILITY GROUP BOX-1 PATHOBIOLOGY IN ANGIOTENSIN II-INDUCED ABDOMINAL AORTIC ANEURYSMS , Shayan Mohammadmoradi

AGE-ASSOCIATED INCREASE OF GAMMA DELTA T CELLS IN VISCERAL ADIPOSE TISSUE AND MECHANISMS OF THEIR ACCUMULATION , Sujata Mukherjee

SEX DIMORPHISMS OF ALDOSTERONE AND HIGH SALT INDUCED AORTIC ANEURYSMS IN MICE , Xufang Mu

EFFECTS OF ELEVATED EXTRACELLULAR DOPAMINE ON ASTROCYTES IN THE NUCLEUS ACCUMBENS , Mengfan Xia

Theses/Dissertations from 2022 2022

A STUDY OF THE ANALYSIS OF HEMP-DERIVED OIL PRODUCTS: DEVELOPMENT OF A METHOD FOR THE ANALYSIS OF PHYTOCANNABINOIDS IN MEDICINAL PRODUCTS , Erin Johnson

MODELING THE EFFECTS OF ADVERSE CHILDHOOD EXPERIENCES USING A MOUSE MODEL OF NEGLECT: MECHANISMS OF ADIPOSITY EXPANSION IN FEMALES , Jacqueline Leachman

EFFICACY OF PREBIOTIC DIETARY INTERVENTION TO MITIGATE RISKS FOR DEMENTIA VIA THE GUT-BRAIN AXIS , Lucille M. Yanckello

Theses/Dissertations from 2021 2021

Robust RNA Integrity-to-Neuronal Gene Expression Association in Autopsy Brain Tissue Not Explained by Post-Mortem Variables; and Acute Behavioral Stress Does Not Alter RNA Quality, While Progesterone Protects Against Effects of Stress Exposure , Eleanor S. Johnson

THE GESTATION OF HEALTH: ENVIRONMENTAL INSULTS, BEHAVIORAL INTERVENTIONS, AND PROTECTIVE MECHANISMS , Brittany Breon Rice

Genetic Mouse Models of Liver Disease: Potential Roles of Zhx2 (Afr1) and Afr2 in Damage and Regeneration , Courtney P. Turpin

Theses/Dissertations from 2020 2020

The Effects of Dietary Nitrate and Vitamin C on Endothelial Function and Oxidative Stress Biomarkers , Reem Basaqr

Divergence in Neuronal Calcium Dysregulation in Brain Aging and Animal Models of AD , Adam Ghoweri

ROLE OF PANCREATIC AMYLIN IN ALZHEIMER’S AND BRAIN MICROVASCULAR PATHOLOGIES , Han Gia Ly

FUNCTIONAL IMPACT OF ANGIOTENSINOGEN SPECIFIC DOMAINS ON ANGIOTENSIN II-MEDIATED FUNCTIONS , Chia-Hua Wu

Theses/Dissertations from 2019 2019

AZITHROMYCIN THERAPY REDUCES CARDIAC INFLAMMATION AND MITIGATES ADVERSE CARDIAC REMODELING AFTER MYOCARDIAL INFARCTION , Ahmed Hamish Neamah Al-Darraji

RESIDUAL NEXT-DAY EFFECTS OF ALPRAZOLAM ON PSYCHOMOTOR PERFORMANCE AND SIMULATED DRIVING IN HEALTHY NORMAL VOLUNTEERS , Marion A. Coe

Exploring the Role of Insulin Receptor Signaling in Hippocampal Learning and Memory, Neuronal Calcium Dysregulation, and Glucose Metabolism , Hilaree N. Frazier

PYOCYANIN, A VIRULENCE FACTOR PRODUCED BY SEPSIS-CAUSING PSEUDOMONAS AERUGINOSA, PROMOTES ADIPOSE WASTING AND CACHEXIA , Nika Larian

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Home > Eppley Institute > Theses & Dissertations

Theses & Dissertations: Cancer Research

Theses/dissertations from 2023 2023.

Development of Combination Therapy Strategies to Treat Cancer Using Dihydroorotate Dehydrogenase Inhibitors , Nicholas Mullen

Overcoming Resistance Mechanisms to CDK4/6 Inhibitor Treatment Using CDK6-Selective PROTAC , Sarah Truong

Theses/Dissertations from 2022 2022

Omics Analysis in Cancer and Development , Emalie J. Clement

Investigating the Role of Splenic Macrophages in Pancreatic Cancer , Daisy V. Gonzalez

Polymeric Chloroquine in Metastatic Pancreatic Cancer Therapy , Rubayat Islam Khan

Evaluating Targets and Therapeutics for the Treatment of Pancreatic Cancer , Shelby M. Knoche

Characterization of 1,1-Diarylethylene FOXM1 Inhibitors Against High-Grade Serous Ovarian Carcinoma Cells , Cassie Liu

Novel Mechanisms of Protein Kinase C α Regulation and Function , Xinyue Li

SOX2 Dosage Governs Tumor Cell Identity and Proliferation , Ethan P. Metz

Post-Transcriptional Control of the Epithelial-to-Mesenchymal Transition (EMT) in Ras-Driven Colorectal Cancers , Chaitra Rao

Use of Machine Learning Algorithms and Highly Multiplexed Immunohistochemistry to Perform In-Depth Characterization of Primary Pancreatic Tumors and Metastatic Sites , Krysten Vance

Characterization of Metastatic Cutaneous Squamous Cell Carcinoma in the Immunosuppressed Patient , Megan E. Wackel

Visceral adipose tissue remodeling in pancreatic ductal adenocarcinoma cachexia: the role of activin A signaling , Pauline Xu

Phos-Tag-Based Screens Identify Novel Therapeutic Targets in Ovarian Cancer and Pancreatic Cancer , Renya Zeng

Theses/Dissertations from 2021 2021

Functional Characterization of Cancer-Associated DNA Polymerase ε Variants , Stephanie R. Barbari

Pancreatic Cancer: Novel Therapy, Research Tools, and Educational Outreach , Ayrianne J. Crawford

Apixaban to Prevent Thrombosis in Adult Patients Treated With Asparaginase , Krishna Gundabolu

Molecular Investigation into the Biologic and Prognostic Elements of Peripheral T-cell Lymphoma with Regulators of Tumor Microenvironment Signaling Explored in Model Systems , Tyler Herek

Utilizing Proteolysis-Targeting Chimeras to Target the Transcriptional Cyclin-Dependent Kinases 9 and 12 , Hannah King

Insights into Cutaneous Squamous Cell Carcinoma Pathogenesis and Metastasis Using a Bedside-to-Bench Approach , Marissa Lobl

Development of a MUC16-Targeted Near-Infrared Antibody Probe for Fluorescence-Guided Surgery of Pancreatic Cancer , Madeline T. Olson

FGFR4 glycosylation and processing in cholangiocarcinoma promote cancer signaling , Andrew J. Phillips

Theses/Dissertations from 2020 2020

Cooperativity of CCNE1 and FOXM1 in High-Grade Serous Ovarian Cancer , Lucy Elge

Characterizing the critical role of metabolic and redox homeostasis in colorectal cancer , Danielle Frodyma

Genomic and Transcriptomic Alterations in Metabolic Regulators and Implications for Anti-tumoral Immune Response , Ryan J. King

Dimers of Isatin Derived Spirocyclic NF-κB Inhibitor Exhibit Potent Anticancer Activity by Inducing UPR Mediated Apoptosis , Smit Kour

From Development to Therapy: A Panoramic Approach to Further Our Understanding of Cancer , Brittany Poelaert

The Cellular Origin and Molecular Drivers of Claudin-Low Mammary Cancer , Patrick D. Raedler

Mitochondrial Metabolism as a Therapeutic Target for Pancreatic Cancer , Simon Shin

Development of Fluorescent Hyaluronic Acid Nanoparticles for Intraoperative Tumor Detection , Nicholas E. Wojtynek

Theses/Dissertations from 2019 2019

The role of E3 ubiquitin ligase FBXO9 in normal and malignant hematopoiesis , R. Willow Hynes-Smith

BRCA1 & CTDP1 BRCT Domainomics in the DNA Damage Response , Kimiko L. Krieger

Targeted Inhibition of Histone Deacetyltransferases for Pancreatic Cancer Therapy , Richard Laschanzky

Human Leukocyte Antigen (HLA) Class I Molecule Components and Amyloid Precursor-Like Protein 2 (APLP2): Roles in Pancreatic Cancer Cell Migration , Bailee Sliker

Theses/Dissertations from 2018 2018

FOXM1 Expression and Contribution to Genomic Instability and Chemoresistance in High-Grade Serous Ovarian Cancer , Carter J. Barger

Overcoming TCF4-Driven BCR Signaling in Diffuse Large B-Cell Lymphoma , Keenan Hartert

Functional Role of Protein Kinase C Alpha in Endometrial Carcinogenesis , Alice Hsu

Functional Signature Ontology-Based Identification and Validation of Novel Therapeutic Targets and Natural Products for the Treatment of Cancer , Beth Neilsen

Elucidating the Roles of Lunatic Fringe in Pancreatic Ductal Adenocarcinoma , Prathamesh Patil

Theses/Dissertations from 2017 2017

Metabolic Reprogramming of Pancreatic Ductal Adenocarcinoma Cells in Response to Chronic Low pH Stress , Jaime Abrego

Understanding the Relationship between TGF-Beta and IGF-1R Signaling in Colorectal Cancer , Katie L. Bailey

The Role of EHD2 in Triple-Negative Breast Cancer Tumorigenesis and Progression , Timothy A. Bielecki

Perturbing anti-apoptotic proteins to develop novel cancer therapies , Jacob Contreras

Role of Ezrin in Colorectal Cancer Cell Survival Regulation , Premila Leiphrakpam

Evaluation of Aminopyrazole Analogs as Cyclin-Dependent Kinase Inhibitors for Colorectal Cancer Therapy , Caroline Robb

Identifying the Role of Janus Kinase 1 in Mammary Gland Development and Breast Cancer , Barbara Swenson

DNMT3A Haploinsufficiency Provokes Hematologic Malignancy of B-Lymphoid, T-Lymphoid, and Myeloid Lineage in Mice , Garland Michael Upchurch

Theses/Dissertations from 2016 2016

EHD1 As a Positive Regulator of Macrophage Colony-Stimulating Factor-1 Receptor , Luke R. Cypher

Inflammation- and Cancer-Associated Neurolymphatic Remodeling and Cachexia in Pancreatic Ductal Adenocarcinoma , Darci M. Fink

Role of CBL-family Ubiquitin Ligases as Critical Negative Regulators of T Cell Activation and Functions , Benjamin Goetz

Exploration into the Functional Impact of MUC1 on the Formation and Regulation of Transcriptional Complexes Containing AP-1 and p53 , Ryan L. Hanson

DNA Polymerase Zeta-Dependent Mutagenesis: Molecular Specificity, Extent of Error-Prone Synthesis, and the Role of dNTP Pools , Olga V. Kochenova

Defining the Role of Phosphorylation and Dephosphorylation in the Regulation of Gap Junction Proteins , Hanjun Li

Molecular Mechanisms Regulating MYC and PGC1β Expression in Colon Cancer , Jamie L. McCall

Pancreatic Cancer Invasion of the Lymphatic Vasculature and Contributions of the Tumor Microenvironment: Roles for E-selectin and CXCR4 , Maria M. Steele

Altered Levels of SOX2, and Its Associated Protein Musashi2, Disrupt Critical Cell Functions in Cancer and Embryonic Stem Cells , Erin L. Wuebben

Theses/Dissertations from 2015 2015

Characterization and target identification of non-toxic IKKβ inhibitors for anticancer therapy , Elizabeth Blowers

Effectors of Ras and KSR1 dependent colon tumorigenesis , Binita Das

Characterization of cancer-associated DNA polymerase delta variants , Tony M. Mertz

A Role for EHD Family Endocytic Regulators in Endothelial Biology , Alexandra E. J. Moffitt

Biochemical pathways regulating mammary epithelial cell homeostasis and differentiation , Chandrani Mukhopadhyay

EPACs: epigenetic regulators that affect cell survival in cancer. , Catherine Murari

Role of the C-terminus of the Catalytic Subunit of Translesion Synthesis Polymerase ζ (Zeta) in UV-induced Mutagensis , Hollie M. Siebler

LGR5 Activates TGFbeta Signaling and Suppresses Metastasis in Colon Cancer , Xiaolin Zhou

LGR5 Activates TGFβ Signaling and Suppresses Metastasis in Colon Cancer , Xiaolin Zhou

Theses/Dissertations from 2014 2014

Genetic dissection of the role of CBL-family ubiquitin ligases and their associated adapters in epidermal growth factor receptor endocytosis , Gulzar Ahmad

Strategies for the identification of chemical probes to study signaling pathways , Jamie Leigh Arnst

Defining the mechanism of signaling through the C-terminus of MUC1 , Roger B. Brown

Targeting telomerase in human pancreatic cancer cells , Katrina Burchett

The identification of KSR1-like molecules in ras-addicted colorectal cancer cells , Drew Gehring

Mechanisms of regulation of AID APOBEC deaminases activity and protection of the genome from promiscuous deamination , Artem Georgievich Lada

Characterization of the DNA-biding properties of human telomeric proteins , Amanda Lakamp-Hawley

Studies on MUC1, p120-catenin, Kaiso: coordinate role of mucins, cell adhesion molecules and cell cycle players in pancreatic cancer , Xiang Liu

Epac interaction with the TGFbeta PKA pathway to regulate cell survival in colon cancer , Meghan Lynn Mendick

Theses/Dissertations from 2013 2013

Deconvolution of the phosphorylation patterns of replication protein A by the DNA damage response to breaks , Kerry D. Brader

Modeling malignant breast cancer occurrence and survival in black and white women , Michael Gleason

The role of dna methyltransferases in myc-induced lymphomagenesis , Ryan A. Hlady

Design and development of inhibitors of CBL (TKB)-protein interactions , Eric A. Kumar

Pancreatic cancer-associated miRNAs : expression, regulation and function , Ashley M. Mohr

Mechanistic studies of mitochondrial outer membrane permeabilization (MOMP) , Xiaming Pang

Novel roles for JAK2/STAT5 signaling in mammary gland development, cancer, and immune dysregulation , Jeffrey Wayne Schmidt

Optimization of therapeutics against lethal pancreatic cancer , Joshua J. Souchek

Theses/Dissertations from 2012 2012

Immune-based novel diagnostic mechanisms for pancreatic cancer , Michael J. Baine

Sox2 associated proteins are essential for cell fate , Jesse Lee Cox

KSR2 regulates cellular proliferation, transformation, and metabolism , Mario R. Fernandez

Discovery of a novel signaling cross-talk between TPX2 and the aurora kinases during mitosis , Jyoti Iyer

Regulation of metabolism by KSR proteins , Paula Jean Klutho

The role of ERK 1/2 signaling in the dna damage-induced G2 , Ryan Kolb

Regulation of the Bcl-2 family network during apoptosis induced by different stimuli , Hernando Lopez

Studies on the role of cullin3 in mitosis , Saili Moghe

Characteristics of amyloid precursor-like protein 2 (APLP2) in pancreatic cancer and Ewing's sarcoma , Haley Louise Capek Peters

Structural and biophysical analysis of a human inosine triphosphate pyrophosphatase polymorphism , Peter David Simone

Functions and regulation of Ron receptor tyrosine kinase in human pancreatic cancer and its therapeutic applications , Yi Zou

Theses/Dissertations from 2011 2011

Coordinate detection of new targets and small molecules for cancer therapy , Kurt Fisher

The role of c-Myc in pancreatic cancer initiation and progression , Wan-Chi Lin

The role of inosine triphosphate pyrophosphatase (ITPA) in maintanence [sic] of genomic stability in human cells , Miriam-Rose Menezes

Molecular insights into major histocompatibility complex class I folding and assembly , Laura Christina Simone

The role of bcl-2 in colon cancer metastatic progression , Wang Wang

A rational peptidomimetic approach towards generation of high affinity BRCT (BRCA1) inhibitors , Ziyan Yuan

D-type cyclins and breast cancer , Quian Zhang

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• Thesis Research
• PhD in Pharmacology & Physiology

The most important aspect of the PhD program is the dissertation research. From the second to the fifth year of the program, the students devote the bulk of their time to original research and to the preparation of the doctoral thesis. 

Identification of the Mentor & Research Area

Mentors are typically chosen at the beginning of the second year, but no later than the middle of the second year. Once a thesis mentor is identified, research toward the thesis begins. In the second year and thereafter, the student is engaged in full-time laboratory research in the mentor’s laboratory. If a fellowship grant is not obtained, students are supported by the mentor’s funding from third year onward. 

Thesis Advisory Committee

This is formed in the second year and includes at least three faculty members from Pharmacology & Physiology with expertise in areas relevant to the student’s research and an established scientist from outside the Program. The thesis mentor is not part of the Thesis Advisory Committee, but attends the meetings and helps the student. The student’s committee members must be approved by the Program Director. After approval, the members of the thesis committee designate a chair of the committee who helps the student facilitate the meeting. The student meets with his/her Advisory Committee at least once a year to discuss and evaluate research progress. The meetings should take place immediately following the annual Seminar talk by the student. The student should download and print the thesis committee report form  and bring it to the annual meeting. The chair of the committee should fill out and turn in the thesis committee report form. 

Thesis Proposal

A thesis proposal is prepared no later than the third year. The proposal defines an original and significant research problem, assesses the research literature critically, suggests feasible experimental approaches to the problem and presents any available preliminary data in support of the approach. The thesis proposal should be presented to the thesis advisory committee at the annual meeting in the spring of either the second or third year, typically coinciding with the Seminar talk in the spring. A form for the thesis proposal, signed by the thesis committee, needs to be turned into the Graduate School. Thereafter, the student meets with his/her Advisory Committee at least once a year to discuss and evaluate research progress and modify the initial proposal if required. It is highly recommended that meetings are held just after the student’s annual Seminar. These meetings are an opportunity to present data and get feedback from the committee with regard to the direction and progress of the project. The student is encouraged to prepare an agenda and a short handout. The only role of the committee chair is to aid the student in efficiently running the meeting.

Thesis Committee Report

Complete the report and bring it to the Annual Seminar Presentations.

Thesis Forms

Go to the Graduate School of Arts & Sciences website to find all the thesis forms.

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Pharmacology, PhD

School of medicine.

The Department of Pharmacology and Molecular Sciences hosts the Pharmacology Graduate Program, which offers a program of study and research leading to the Ph.D. degree. Research training opportunities within the program cover a broad spectrum of biomedical sciences including chemical biology, immunology, virology, cancer, and neuroscience. The mission of departmental research is to understand the molecular processes underlying physiology and pathology, and to apply this knowledge to discovering new drug targets and developing novel therapeutics. Within the program, students may choose to focus their efforts in any of a large number of specific research areas including signal transduction, structural biology and drug design, NMR spectroscopy, molecular genetics, cancer chemoprevention, viral immunosuppression, cancer immunology, cell-mediated immunity, mechanisms of HIV infection, vaccine development, glycobiology, biomedical mass spectrometry, clinical pharmacology, drug delivery, anti-parasite drug development, histone acetylation and gene regulation, melatonin and circadian rhythm, drug metabolism, Vitamin D pharmacology, natural product biosynthesis, telomerase and chromosome stability, T cell activation and tolerance, DNA repair, DNA topoisomerases, molecular imaging, and the clinical pharmacology of cardiovascular agents. The department is also pleased to host students and award doctoral degrees to M.D./Ph.D. degree candidates and students in other Ph.D. graduate programs in which Pharmacology faculty participate (Biochemistry, Cellular and Molecular Biology, Cellular and Molecular Medicine, Immunology, Neuroscience, and Pathobiology).

Financial Support

Financial support covering normal living costs, individual medical insurance, and tuition is provided.

Admission Requirements

Applicants should have a B.A. or B.S. degree with a major in any of the biological or physical sciences. Entering students are expected to have completed college-level courses in chemistry (inorganic, organic, and physical), calculus, and physics; a strong background in biochemistry is particularly desirable. A completed application form, at least three letters of recommendation, undergraduate transcripts, and a statement of interest must be received by December 8th.

Program Requirements

Students in the Pharmacology program must successfully complete the following courses:

Students must also take two advanced elective courses selected from those offered by this or other departments. Students are able to select a course of studies uniquely suited to their own career goals.

During their first year of study, students will complete ~10-week research rotations in addition to their coursework. They will initiate dissertation research by the end of their first year and complete elective courses relevant to their developing interests in subsequent years of training.

During the second year of study, students will be required to pass a qualifying examination conducted as prescribed by the Doctor of Philosophy Board of the University. This examination will probe the depth and breadth of the student’s knowledge of the biomedical subjects taught in the core courses.

The candidate is required to present a written dissertation based on original research undertaken while in residence as a graduate student and to present a departmental seminar describing the thesis research.

Combined M.D.-Ph.D. Degrees

Students seeking admission to or who are already participating in the M.D. program in the School of Medicine may participate in a program leading to both the M.D. and the Ph.D. degrees.