Clinical presentation and initial evaluation of non-Hodgkin lymphoma
INTRODUCTION. Non-Hodgkin lymphomas (NHL) comprise a diverse group of hematologic malignancies that are variously derived from B cell progenitors, T cell progenitors, mature B cells, mature T cells, or (rarely) natural killer cells. NHL is seen in patients of all ages, races, and socioeconomic status. Diagnosis and classification of NHL ...
Lymphoma: Diagnosis and Treatment
Learn about the epidemiology, risk factors, clinical presentation, diagnosis, and treatment of lymphoma, a group of malignant neoplasms of lymphocytes. Find out how to stage, monitor, and vaccinate patients with lymphoma.
Lymphoma
For clinical purposes, lymphoma is termed as aggressive (high grade) and indolent (low grade). ... Follicular Lymphoma. The most common presentation is subacute, or chronic asymptomatic peripheral lymphadenopathy, which sometimes persists or waxes and wanes over a period of years. Abdominal, pelvic, or retroperitoneal lymphadenopathy can be ...
Non-Hodgkin Lymphoma
Introduction. Non-Hodgkin lymphoma (NHL) is a neoplasm of the lymphoid tissues originating from B cell precursors, mature B cells, T cell precursors, and mature T cells. Non-Hodgkin lymphoma comprises various subtypes, each with different epidemiologies, etiologies, immunophenotypic, genetic, clinical features, and response to therapy. It can ...
Non-Hodgkin Lymphoma (NHL) Clinical Presentation
The clinical manifestations of non-Hodgkin lymphoma (NHL) vary with such factors as the location of the lymphomatous process, the rate of tumor growth, and the function of the organ being compromised or displaced by the malignant process. The Working Formulation classification groups the subtypes of NHL by clinical behavior—that is, low-grade ...
Lymphoma
Lymphoma is a cancer of the lymphatic system, which is part of the body's germ-fighting network. The lymphatic system includes the lymph nodes (lymph glands), spleen, thymus gland and bone marrow. Lymphoma can affect all those areas as well as other organs throughout the body. Many types of lymphoma exist.
Lymphoma
Nodular lymphocyte-predominant Hodgkin lymphoma: Clinical manifestations, diagnosis, and staging. View in. Overview of Hodgkin lymphoma in children and adolescents. ... Clinical presentation, pathologic features, and diagnosis of Sézary syndrome. View in. Initial treatment of peripheral T cell lymphoma.
Hodgkin Lymphoma Clinical Presentation
Features of Hodgkin lymphoma include the following: Hodgkin lymphoma (formerly, Hodgkin disease) is a potentially curable lymphoma with distinct histology, biologic behavior, and clinical characteristics. The disease is defined in terms of its microscopic appearance (histology) (see the image below) and the expression of cell surface markers ...
The diagnosis and management of suspected lymphoma in general practice
1 INTRODUCTION. Lymphoma is a heterogenous group of lymphoid neoplasms with marked differences in clinical course and response to treatment. 1 Lymphomas are grouped by their postulated normal cell type of origin (B-cell vs. T-cell), and morphology (Hodgkin vs. non-Hodgkin) as well as the degree of cellular differentiation. 2 With advancements in molecular medicine, more than 100 discrete ...
Hodgkin Lymphoma
Hodgkin lymphoma (HL), formerly called Hodgkin disease, is a rare monoclonal lymphoid neoplasm with high cure rates. Biological and clinical studies have divided this disease entity into two distinct categories: classical Hodgkin lymphoma and nodular lymphocyte-predominant Hodgkin lymphoma (NLP-HL). These two disease entities show differences in the clinical picture and pathology.
The Clinical Presentation of Lymphomas
The Clinical Presentation of Lymphomas. From Miguel Islas-Ohlmayer, M.D. Lymphomas, blood cell tumors that usually originate in lymphatic tissues (and can spread to other organs), are among the most diverse and most curable of all malignancies. There are two major groups of lymphomas: About 90 percent are non-Hodgkin lymphomas (NHLs) and about ...
Lymphomas: pathogenesis, clinical features and diagnosis
Presentation. Hodgkin lymphoma commonly presents with painless swollen lymph nodes (lymphadenopathy), often affecting the cervical or supraclavicular nodes in the neck. About 25% of patients present with the three 'B symptoms': night sweats, unexplained fever and weight loss of more than 10% over six months.
B-Cell Lymphoma Clinical Presentation
Shortness of breath, chest pain, cough. Abdominal pain and distention. Bone pain. Central nervous system (CNS) symptoms. Typical physical examination findings include the following: Pallor (suggesting anemia) Purpura, petechiae, or ecchymoses (suggesting thrombocytopenia) Findings in patients with an advanced high-grade lymphoma may include the ...
Clinical presentation and staging of Hodgkin lymphoma
In the present chapter the authors present a brief overview of the diagnostic methods proposed over time for Hodgkin lymphoma (HL) spread detection, moving from surgical procedures, through standard radiological and functional imaging techniques to the present state of the art for HL staging. ... Clinical presentation and staging of Hodgkin ...
Clinical presentation and characteristics of lymphoma in the head and
The variable clinical presentation of lymphoma is a challenge for the ENT specialist. Fast diagnosis is crucial for rapid treatment, especially in highly aggressive NHL like the Burkitt-lymphoma and HL. A standardized medical history, clinical examination and imaging evaluations paired with patient' …
Follicular Lymphoma
Follicular lymphoma (FL) is the second most common type of non-Hodgkin lymphoma (NHL), accounting for almost 30% of all lymphomas, and the most common subtype of clinically indolent NHL. FL is a slow-growing B-cell lymphoproliferative disorder, with survival calculated in years. Based on histology, FL is graded from 1 to 3 (low grade to high grade).[1][2]
Patient/Physician Teamwork: Treating a Rare Oral Presentation of DLBCL
Hindocha N, Nilsson J. Oral presentation of diffuse large B-cell lymphoma: a rare entity. Oral Surgery . 2019;12(4):332-334. doi:10.1111/ors.12430 Related Videos
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A Rare Case of Laryngeal Mantle Cell Lymphoma
Mantle cell lymphoma (MCL) is a rare subtype of non-Hodgkin lymphoma with an annual incidence of 1 case per 200 000 people. MCL composes 5% of all non-Hodgkin lymphoma cases and occurs predominantly in men (3 men to 1 woman) with a median age of 60 to 70 years at the time of diagnosis. 1 Most often, MCL is treated with a combination of chemotherapy and immunotherapy.
Burkitt Lymphoma and Burkitt-like Lymphoma Clinical Presentation
The 3 different clinical variants of Burkitt lymphoma (BL) described (endemic, sporadic, and immunodeficiency related) may have varied clinical presentations. [ 2 , 6 , 39 ] The endemic form of Burkitt lymphoma (eBL) is most commonly seen in patients in equatorial Africa, with jaw and facial bone (orbit) involvement occurring in more than 50% ...
Myositis as a prominent manifestation of primary skeletal muscle
Lymphoma is a heterogeneous group of malignancies, primarily consisting of T-cell and B-cell neoplasms. ... Taking into account the patient's clinical presentation, imaging results, muscle biopsy pathology, and response to treatment, we arrived at the final diagnosis: primary skeletal muscle peripheral T-cell lymphoma, not otherwise specified ...
Prolonged remission with ibrutinib maintenance therapy following
The patient was then enrolled in a clinical trial (NCT02483858), 'Study of Oral PQR309 Patients with Advanced Tumors', in November 2017 [Citation 25]. Unfortunately, she experienced a rapid decline in mental function, speech, strength, and gait. Her CNS lymphoma was significantly larger on brain MRI (fourth progression) (Figure 5). Because ...
Kite Data at EHA 2024 Demonstrate Positive Patient Outcomes and
- Analysis Comparing Real-World and Clinical Trial Data Show Yescarta ® Has Higher Manufacturing Success Rates and Improved T-Cell Performance, Respectively, in Second-Line vs. Third-Line+ Treatment of Large B-cell Lymphoma - - Encore Oral Presentation from the Phase 1 Study of Anitocabtagene autoleucel (anito-cel) in Relapsed/Refractory Multiple Myeloma (R/R MM); Trial Design for Phase ...
Clinical Signs and Symptoms of Hepatitis C
If symptoms of acute HCV infection do occur, they can include: Abdominal pain, nausea, and/or vomiting. Dark urine or clay-colored stools. Fatigue. Fever. Jaundice. Joint pain. Loss of appetite. For those who do develop symptoms, they typically appear 2-12 weeks after exposure, but the window can range from 2-26 weeks. 1 2.
PDF 2024 American Society of Clinical Oncology (ASCO)
Clinical presentation and characteristics of lymphoma in the head and
The variable clinical presentation of lymphoma is a challenge for the ENT specialist. Fast diagnosis is crucial for rapid treatment, especially in highly aggressive NHL like the Burkitt-lymphoma and HL. A standardized medical history, clinical examination and imaging evaluations paired with patient's signs, symptoms and demographic knowledge ...
Genmab to Present New and Updated Results From Multiple Clinical Trials
Sixteen abstracts accepted for presentation and publication demonstrate depth and breadth of comprehensive epcoritamab development program Three oral presentations highlight novel data evaluating epcoritamab in patients with relapsed/refractory (R/R) follicular lymphoma (FL), in combination for first-line treatment of diffuse large B-cell ...
Pediatric Hodgkin Lymphoma Clinical Presentation
These paraneoplastic syndromes can present before, after, or at the time of presentation of HL. Formally known as Hodgkin disease, Hodgkin lymphoma (HL) is a highly curable malignancy. It is a unique neoplasm in which the malignant cell, the Reed-Stenberg cell (RSC), represents only a small proportion of cells constituting the bulk of the tumor.
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INTRODUCTION. Non-Hodgkin lymphomas (NHL) comprise a diverse group of hematologic malignancies that are variously derived from B cell progenitors, T cell progenitors, mature B cells, mature T cells, or (rarely) natural killer cells. NHL is seen in patients of all ages, races, and socioeconomic status. Diagnosis and classification of NHL ...
Learn about the epidemiology, risk factors, clinical presentation, diagnosis, and treatment of lymphoma, a group of malignant neoplasms of lymphocytes. Find out how to stage, monitor, and vaccinate patients with lymphoma.
For clinical purposes, lymphoma is termed as aggressive (high grade) and indolent (low grade). ... Follicular Lymphoma. The most common presentation is subacute, or chronic asymptomatic peripheral lymphadenopathy, which sometimes persists or waxes and wanes over a period of years. Abdominal, pelvic, or retroperitoneal lymphadenopathy can be ...
Introduction. Non-Hodgkin lymphoma (NHL) is a neoplasm of the lymphoid tissues originating from B cell precursors, mature B cells, T cell precursors, and mature T cells. Non-Hodgkin lymphoma comprises various subtypes, each with different epidemiologies, etiologies, immunophenotypic, genetic, clinical features, and response to therapy. It can ...
The clinical manifestations of non-Hodgkin lymphoma (NHL) vary with such factors as the location of the lymphomatous process, the rate of tumor growth, and the function of the organ being compromised or displaced by the malignant process. The Working Formulation classification groups the subtypes of NHL by clinical behavior—that is, low-grade ...
Lymphoma is a cancer of the lymphatic system, which is part of the body's germ-fighting network. The lymphatic system includes the lymph nodes (lymph glands), spleen, thymus gland and bone marrow. Lymphoma can affect all those areas as well as other organs throughout the body. Many types of lymphoma exist.
Nodular lymphocyte-predominant Hodgkin lymphoma: Clinical manifestations, diagnosis, and staging. View in. Overview of Hodgkin lymphoma in children and adolescents. ... Clinical presentation, pathologic features, and diagnosis of Sézary syndrome. View in. Initial treatment of peripheral T cell lymphoma.
Features of Hodgkin lymphoma include the following: Hodgkin lymphoma (formerly, Hodgkin disease) is a potentially curable lymphoma with distinct histology, biologic behavior, and clinical characteristics. The disease is defined in terms of its microscopic appearance (histology) (see the image below) and the expression of cell surface markers ...
1 INTRODUCTION. Lymphoma is a heterogenous group of lymphoid neoplasms with marked differences in clinical course and response to treatment. 1 Lymphomas are grouped by their postulated normal cell type of origin (B-cell vs. T-cell), and morphology (Hodgkin vs. non-Hodgkin) as well as the degree of cellular differentiation. 2 With advancements in molecular medicine, more than 100 discrete ...
Hodgkin lymphoma (HL), formerly called Hodgkin disease, is a rare monoclonal lymphoid neoplasm with high cure rates. Biological and clinical studies have divided this disease entity into two distinct categories: classical Hodgkin lymphoma and nodular lymphocyte-predominant Hodgkin lymphoma (NLP-HL). These two disease entities show differences in the clinical picture and pathology.
The Clinical Presentation of Lymphomas. From Miguel Islas-Ohlmayer, M.D. Lymphomas, blood cell tumors that usually originate in lymphatic tissues (and can spread to other organs), are among the most diverse and most curable of all malignancies. There are two major groups of lymphomas: About 90 percent are non-Hodgkin lymphomas (NHLs) and about ...
Presentation. Hodgkin lymphoma commonly presents with painless swollen lymph nodes (lymphadenopathy), often affecting the cervical or supraclavicular nodes in the neck. About 25% of patients present with the three 'B symptoms': night sweats, unexplained fever and weight loss of more than 10% over six months.
Shortness of breath, chest pain, cough. Abdominal pain and distention. Bone pain. Central nervous system (CNS) symptoms. Typical physical examination findings include the following: Pallor (suggesting anemia) Purpura, petechiae, or ecchymoses (suggesting thrombocytopenia) Findings in patients with an advanced high-grade lymphoma may include the ...
In the present chapter the authors present a brief overview of the diagnostic methods proposed over time for Hodgkin lymphoma (HL) spread detection, moving from surgical procedures, through standard radiological and functional imaging techniques to the present state of the art for HL staging. ... Clinical presentation and staging of Hodgkin ...
The variable clinical presentation of lymphoma is a challenge for the ENT specialist. Fast diagnosis is crucial for rapid treatment, especially in highly aggressive NHL like the Burkitt-lymphoma and HL. A standardized medical history, clinical examination and imaging evaluations paired with patient' …
Follicular lymphoma (FL) is the second most common type of non-Hodgkin lymphoma (NHL), accounting for almost 30% of all lymphomas, and the most common subtype of clinically indolent NHL. FL is a slow-growing B-cell lymphoproliferative disorder, with survival calculated in years. Based on histology, FL is graded from 1 to 3 (low grade to high grade).[1][2]
Hindocha N, Nilsson J. Oral presentation of diffuse large B-cell lymphoma: a rare entity. Oral Surgery . 2019;12(4):332-334. doi:10.1111/ors.12430 Related Videos
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Mantle cell lymphoma (MCL) is a rare subtype of non-Hodgkin lymphoma with an annual incidence of 1 case per 200 000 people. MCL composes 5% of all non-Hodgkin lymphoma cases and occurs predominantly in men (3 men to 1 woman) with a median age of 60 to 70 years at the time of diagnosis. 1 Most often, MCL is treated with a combination of chemotherapy and immunotherapy.
The 3 different clinical variants of Burkitt lymphoma (BL) described (endemic, sporadic, and immunodeficiency related) may have varied clinical presentations. [ 2 , 6 , 39 ] The endemic form of Burkitt lymphoma (eBL) is most commonly seen in patients in equatorial Africa, with jaw and facial bone (orbit) involvement occurring in more than 50% ...
Lymphoma is a heterogeneous group of malignancies, primarily consisting of T-cell and B-cell neoplasms. ... Taking into account the patient's clinical presentation, imaging results, muscle biopsy pathology, and response to treatment, we arrived at the final diagnosis: primary skeletal muscle peripheral T-cell lymphoma, not otherwise specified ...
The patient was then enrolled in a clinical trial (NCT02483858), 'Study of Oral PQR309 Patients with Advanced Tumors', in November 2017 [Citation 25]. Unfortunately, she experienced a rapid decline in mental function, speech, strength, and gait. Her CNS lymphoma was significantly larger on brain MRI (fourth progression) (Figure 5). Because ...
- Analysis Comparing Real-World and Clinical Trial Data Show Yescarta ® Has Higher Manufacturing Success Rates and Improved T-Cell Performance, Respectively, in Second-Line vs. Third-Line+ Treatment of Large B-cell Lymphoma - - Encore Oral Presentation from the Phase 1 Study of Anitocabtagene autoleucel (anito-cel) in Relapsed/Refractory Multiple Myeloma (R/R MM); Trial Design for Phase ...
If symptoms of acute HCV infection do occur, they can include: Abdominal pain, nausea, and/or vomiting. Dark urine or clay-colored stools. Fatigue. Fever. Jaundice. Joint pain. Loss of appetite. For those who do develop symptoms, they typically appear 2-12 weeks after exposure, but the window can range from 2-26 weeks. 1 2.
Society of Clinical Oncology (ASCO) Annual Meeting TAKEDA ONCOLOGY SPONSORED ABSTRACTS ©2024 Takeda Pharmaceuticals U.S.A., Inc. Learn more at TakedaOncology.com ... untreated stage III/IV classical Hodgkin lymphoma POSTER PRESENTATION Hematologic Malignancies— Lymphoma and Chronic Lymphocytic Leukemia Monday, June 3, 2024 9:00 AM-12:00 PM ...
The variable clinical presentation of lymphoma is a challenge for the ENT specialist. Fast diagnosis is crucial for rapid treatment, especially in highly aggressive NHL like the Burkitt-lymphoma and HL. A standardized medical history, clinical examination and imaging evaluations paired with patient's signs, symptoms and demographic knowledge ...
Sixteen abstracts accepted for presentation and publication demonstrate depth and breadth of comprehensive epcoritamab development program Three oral presentations highlight novel data evaluating epcoritamab in patients with relapsed/refractory (R/R) follicular lymphoma (FL), in combination for first-line treatment of diffuse large B-cell ...
These paraneoplastic syndromes can present before, after, or at the time of presentation of HL. Formally known as Hodgkin disease, Hodgkin lymphoma (HL) is a highly curable malignancy. It is a unique neoplasm in which the malignant cell, the Reed-Stenberg cell (RSC), represents only a small proportion of cells constituting the bulk of the tumor.