15 Steps to Good Research

  • Define and articulate a research question (formulate a research hypothesis). How to Write a Thesis Statement (Indiana University)
  • Identify possible sources of information in many types and formats. Georgetown University Library's Research & Course Guides
  • Judge the scope of the project.
  • Reevaluate the research question based on the nature and extent of information available and the parameters of the research project.
  • Select the most appropriate investigative methods (surveys, interviews, experiments) and research tools (periodical indexes, databases, websites).
  • Plan the research project. Writing Anxiety (UNC-Chapel Hill) Strategies for Academic Writing (SUNY Empire State College)
  • Retrieve information using a variety of methods (draw on a repertoire of skills).
  • Refine the search strategy as necessary.
  • Write and organize useful notes and keep track of sources. Taking Notes from Research Reading (University of Toronto) Use a citation manager: Zotero or Refworks
  • Evaluate sources using appropriate criteria. Evaluating Internet Sources
  • Synthesize, analyze and integrate information sources and prior knowledge. Georgetown University Writing Center
  • Revise hypothesis as necessary.
  • Use information effectively for a specific purpose.
  • Understand such issues as plagiarism, ownership of information (implications of copyright to some extent), and costs of information. Georgetown University Honor Council Copyright Basics (Purdue University) How to Recognize Plagiarism: Tutorials and Tests from Indiana University
  • Cite properly and give credit for sources of ideas. MLA Bibliographic Form (7th edition, 2009) MLA Bibliographic Form (8th edition, 2016) Turabian Bibliographic Form: Footnote/Endnote Turabian Bibliographic Form: Parenthetical Reference Use a citation manager: Zotero or Refworks

Adapted from the Association of Colleges and Research Libraries "Objectives for Information Literacy Instruction" , which are more complete and include outcomes. See also the broader "Information Literacy Competency Standards for Higher Education."

Enago Academy

What Constitutes a Good Research?

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The Declining Art of Good Research

We seem to be compromising our commitment to good research in favor of publishable research, and there are a combination of trends that are accountable for this.

The first is the continued pressure of “publish or perish” for young academics seeking to move forward on the track for fewer and fewer tenured positions (or increasingly draconian renewable contracts).

Secondly, the open access model of research publication has created a booming population of academic journals with pages to fill and new researchers willing to pay article publication fees (APFs).

Thirdly, budget-strapped institutions have been aggressively targeting doctoral research candidates and the higher fees they bring to the table.

When these three trends are combined, the resulting onslaught of quantity over quality leads us to question what “good” research looks like anymore.

Is it the institution from which the research originated, or the debatable rank of the journal that published it?

Good Research as a Methodological Question

When looking to learn how to recognize what “good” research looks like, it makes sense to start at the beginning with the basic scope of the project:

  • Does the research have a solid hypothesis?
  • Is there evidence of a comprehensive literature review from reputable sources that clearly defines a target area for valuable research?
  • Is the research team allocating sufficient time/resources to do the job properly, or were compromises made in order to accommodate the available funding?
  • Is there evidence of a willingness to refine the hypothesis and research strategy if needed?
  • Are the expectations of the implications of the research realistic?

Characteristics of a Good Research

For conducting a systematic research, it is important understand the characteristics of a good research.

  • Its relevance to existing research conducted by other researchers.
  • A good research is doable and replicable in future.
  • It must be based on a logical rationale and tied to theory.
  • It must generate new questions or hypotheses for incremental work in future.
  • It must directly or indirectly address some real world problem.
  • It must clearly state the variables of the experiment.
  • It must conclude with valid and verifiable findings.

Good Research as an Ethical Question

The question as to whether or not the research is worth conducting at all could generate an extended and heated debate. Researchers are expected to publish, and research budgets are there to be spent.

We can hope that there was some degree of discussion and oversight before the research project was given the green light by a Principal Investigator or Research Supervisor, but those decisions are often made in a context of simple obligation rather than perceived need.

Consider the example of a less than proactive doctoral student with limited time and resources to complete a dissertation topic. A suggestion is made by the departmental Research Supervisor to pick a dissertation from a decade ago and simply repeat it. The suggestion meets the need for expediency and simplicity, but raises as many questions as it answers:

  • What is the validity of the study – just because it can be repeated, should it?
  • What was the contribution of the original study to the general body of knowledge? Will this additional data be an improvement?
  • Given the lack of interest among academic journals in replicated studies, is the suggestion denying the student the opportunity to get published?
  • Is directing a student to replication in the interests of expediency meeting a broader academic goal of graduating proficient researchers?

The Building Blocks of “Good” Research

There is no shortage of reputable, peer-reviewed journals that publish first-rate research material for new researchers to model.

That doesn’t mean you should copy the research topic or the methodology, but it wouldn’t hurt to examine the protocol in detail and make note of the specific decisions made and criteria put in place when that protocol was developed and implemented.

The challenge lies in sticking to those tried-and-true methodologies when your research data doesn’t prove to be as rich and fruitful as you had hoped.

Have you ever been stuck while in the middle of conducting a research? How did you cope with that? Let us know your approach while conducting a good research in the comments section below!

You can also visit our  Q&A forum  for frequently asked questions related to different aspects of research writing and publishing answered by our team that comprises subject-matter experts, eminent researchers, and publication experts.

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Research Basics

  • What Is Research?
  • Types of Research
  • Secondary Research | Literature Review
  • Developing Your Topic
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Research is formalized curiosity. It is poking and prying with a purpose. - Zora Neale Hurston

A good working definition of research might be:

Research is the deliberate, purposeful, and systematic gathering of data, information, facts, and/or opinions for the advancement of personal, societal, or overall human knowledge.

Based on this definition, we all do research all the time. Most of this research is casual research. Asking friends what they think of different restaurants, looking up reviews of various products online, learning more about celebrities; these are all research.

Formal research includes the type of research most people think of when they hear the term “research”: scientists in white coats working in a fully equipped laboratory. But formal research is a much broader category that just this. Most people will never do laboratory research after graduating from college, but almost everybody will have to do some sort of formal research at some point in their careers.

So What Do We Mean By “Formal Research?”

Casual research is inward facing: it’s done to satisfy our own curiosity or meet our own needs, whether that’s choosing a reliable car or figuring out what to watch on TV. Formal research is outward facing. While it may satisfy our own curiosity, it’s primarily intended to be shared in order to achieve some purpose. That purpose could be anything: finding a cure for cancer, securing funding for a new business, improving some process at your workplace, proving the latest theory in quantum physics, or even just getting a good grade in your Humanities 200 class.

What sets formal research apart from casual research is the documentation of where you gathered your information from. This is done in the form of “citations” and “bibliographies.” Citing sources is covered in the section "Citing Your Sources."

Formal research also follows certain common patterns depending on what the research is trying to show or prove. These are covered in the section “Types of Research.”

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Definition of research

 (Entry 1 of 2)

Definition of research  (Entry 2 of 2)

transitive verb

intransitive verb

  • disquisition
  • examination
  • exploration
  • inquisition
  • investigation
  • delve (into)
  • inquire (into)
  • investigate
  • look (into)

Examples of research in a Sentence

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'research.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History

Middle French recerche , from recercher to go about seeking, from Old French recerchier , from re- + cerchier, sercher to search — more at search

1577, in the meaning defined at sense 3

1588, in the meaning defined at transitive sense 1

Phrases Containing research

  • marketing research
  • market research
  • operations research
  • oppo research

research and development

  • research park
  • translational research

Dictionary Entries Near research

Cite this entry.

“Research.” Merriam-Webster.com Dictionary , Merriam-Webster, https://www.merriam-webster.com/dictionary/research. Accessed 19 May. 2024.

Kids Definition

Kids definition of research.

Kids Definition of research  (Entry 2 of 2)

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Home Market Research

What is Research: Definition, Methods, Types & Examples

What is Research

The search for knowledge is closely linked to the object of study; that is, to the reconstruction of the facts that will provide an explanation to an observed event and that at first sight can be considered as a problem. It is very human to seek answers and satisfy our curiosity. Let’s talk about research.

Content Index

What is Research?

What are the characteristics of research.

  • Comparative analysis chart

Qualitative methods

Quantitative methods, 8 tips for conducting accurate research.

Research is the careful consideration of study regarding a particular concern or research problem using scientific methods. According to the American sociologist Earl Robert Babbie, “research is a systematic inquiry to describe, explain, predict, and control the observed phenomenon. It involves inductive and deductive methods.”

Inductive methods analyze an observed event, while deductive methods verify the observed event. Inductive approaches are associated with qualitative research , and deductive methods are more commonly associated with quantitative analysis .

Research is conducted with a purpose to:

  • Identify potential and new customers
  • Understand existing customers
  • Set pragmatic goals
  • Develop productive market strategies
  • Address business challenges
  • Put together a business expansion plan
  • Identify new business opportunities
  • Good research follows a systematic approach to capture accurate data. Researchers need to practice ethics and a code of conduct while making observations or drawing conclusions.
  • The analysis is based on logical reasoning and involves both inductive and deductive methods.
  • Real-time data and knowledge is derived from actual observations in natural settings.
  • There is an in-depth analysis of all data collected so that there are no anomalies associated with it.
  • It creates a path for generating new questions. Existing data helps create more research opportunities.
  • It is analytical and uses all the available data so that there is no ambiguity in inference.
  • Accuracy is one of the most critical aspects of research. The information must be accurate and correct. For example, laboratories provide a controlled environment to collect data. Accuracy is measured in the instruments used, the calibrations of instruments or tools, and the experiment’s final result.

What is the purpose of research?

There are three main purposes:

  • Exploratory: As the name suggests, researchers conduct exploratory studies to explore a group of questions. The answers and analytics may not offer a conclusion to the perceived problem. It is undertaken to handle new problem areas that haven’t been explored before. This exploratory data analysis process lays the foundation for more conclusive data collection and analysis.

LEARN ABOUT: Descriptive Analysis

  • Descriptive: It focuses on expanding knowledge on current issues through a process of data collection. Descriptive research describe the behavior of a sample population. Only one variable is required to conduct the study. The three primary purposes of descriptive studies are describing, explaining, and validating the findings. For example, a study conducted to know if top-level management leaders in the 21st century possess the moral right to receive a considerable sum of money from the company profit.

LEARN ABOUT: Best Data Collection Tools

  • Explanatory: Causal research or explanatory research is conducted to understand the impact of specific changes in existing standard procedures. Running experiments is the most popular form. For example, a study that is conducted to understand the effect of rebranding on customer loyalty.

Here is a comparative analysis chart for a better understanding:

It begins by asking the right questions and choosing an appropriate method to investigate the problem. After collecting answers to your questions, you can analyze the findings or observations to draw reasonable conclusions.

When it comes to customers and market studies, the more thorough your questions, the better the analysis. You get essential insights into brand perception and product needs by thoroughly collecting customer data through surveys and questionnaires . You can use this data to make smart decisions about your marketing strategies to position your business effectively.

To make sense of your study and get insights faster, it helps to use a research repository as a single source of truth in your organization and manage your research data in one centralized data repository .

Types of research methods and Examples

what is research

Research methods are broadly classified as Qualitative and Quantitative .

Both methods have distinctive properties and data collection methods .

Qualitative research is a method that collects data using conversational methods, usually open-ended questions . The responses collected are essentially non-numerical. This method helps a researcher understand what participants think and why they think in a particular way.

Types of qualitative methods include:

  • One-to-one Interview
  • Focus Groups
  • Ethnographic studies
  • Text Analysis

Quantitative methods deal with numbers and measurable forms . It uses a systematic way of investigating events or data. It answers questions to justify relationships with measurable variables to either explain, predict, or control a phenomenon.

Types of quantitative methods include:

  • Survey research
  • Descriptive research
  • Correlational research

LEARN MORE: Descriptive Research vs Correlational Research

Remember, it is only valuable and useful when it is valid, accurate, and reliable. Incorrect results can lead to customer churn and a decrease in sales.

It is essential to ensure that your data is:

  • Valid – founded, logical, rigorous, and impartial.
  • Accurate – free of errors and including required details.
  • Reliable – other people who investigate in the same way can produce similar results.
  • Timely – current and collected within an appropriate time frame.
  • Complete – includes all the data you need to support your business decisions.

Gather insights

What is a research - tips

  • Identify the main trends and issues, opportunities, and problems you observe. Write a sentence describing each one.
  • Keep track of the frequency with which each of the main findings appears.
  • Make a list of your findings from the most common to the least common.
  • Evaluate a list of the strengths, weaknesses, opportunities, and threats identified in a SWOT analysis .
  • Prepare conclusions and recommendations about your study.
  • Act on your strategies
  • Look for gaps in the information, and consider doing additional inquiry if necessary
  • Plan to review the results and consider efficient methods to analyze and interpret results.

Review your goals before making any conclusions about your study. Remember how the process you have completed and the data you have gathered help answer your questions. Ask yourself if what your analysis revealed facilitates the identification of your conclusions and recommendations.

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What is Scientific Research and How Can it be Done?

Scientific researches are studies that should be systematically planned before performing them. In this review, classification and description of scientific studies, planning stage randomisation and bias are explained.

Research conducted for the purpose of contributing towards science by the systematic collection, interpretation and evaluation of data and that, too, in a planned manner is called scientific research: a researcher is the one who conducts this research. The results obtained from a small group through scientific studies are socialised, and new information is revealed with respect to diagnosis, treatment and reliability of applications. The purpose of this review is to provide information about the definition, classification and methodology of scientific research.

Before beginning the scientific research, the researcher should determine the subject, do planning and specify the methodology. In the Declaration of Helsinki, it is stated that ‘the primary purpose of medical researches on volunteers is to understand the reasons, development and effects of diseases and develop protective, diagnostic and therapeutic interventions (method, operation and therapies). Even the best proven interventions should be evaluated continuously by investigations with regard to reliability, effectiveness, efficiency, accessibility and quality’ ( 1 ).

The questions, methods of response to questions and difficulties in scientific research may vary, but the design and structure are generally the same ( 2 ).

Classification of Scientific Research

Scientific research can be classified in several ways. Classification can be made according to the data collection techniques based on causality, relationship with time and the medium through which they are applied.

  • Observational
  • Experimental
  • Descriptive
  • Retrospective
  • Prospective
  • Cross-sectional
  • Social descriptive research ( 3 )

Another method is to classify the research according to its descriptive or analytical features. This review is written according to this classification method.

I. Descriptive research

  • Case series
  • Surveillance studies

II. Analytical research

  • Observational studies: cohort, case control and cross- sectional research
  • Interventional research: quasi-experimental and clinical research
  • Case Report: it is the most common type of descriptive study. It is the examination of a single case having a different quality in the society, e.g. conducting general anaesthesia in a pregnant patient with mucopolysaccharidosis.
  • Case Series: it is the description of repetitive cases having common features. For instance; case series involving interscapular pain related to neuraxial labour analgesia. Interestingly, malignant hyperthermia cases are not accepted as case series since they are rarely seen during historical development.
  • Surveillance Studies: these are the results obtained from the databases that follow and record a health problem for a certain time, e.g. the surveillance of cross-infections during anaesthesia in the intensive care unit.

Moreover, some studies may be experimental. After the researcher intervenes, the researcher waits for the result, observes and obtains data. Experimental studies are, more often, in the form of clinical trials or laboratory animal trials ( 2 ).

Analytical observational research can be classified as cohort, case-control and cross-sectional studies.

Firstly, the participants are controlled with regard to the disease under investigation. Patients are excluded from the study. Healthy participants are evaluated with regard to the exposure to the effect. Then, the group (cohort) is followed-up for a sufficient period of time with respect to the occurrence of disease, and the progress of disease is studied. The risk of the healthy participants getting sick is considered an incident. In cohort studies, the risk of disease between the groups exposed and not exposed to the effect is calculated and rated. This rate is called relative risk. Relative risk indicates the strength of exposure to the effect on the disease.

Cohort research may be observational and experimental. The follow-up of patients prospectively is called a prospective cohort study . The results are obtained after the research starts. The researcher’s following-up of cohort subjects from a certain point towards the past is called a retrospective cohort study . Prospective cohort studies are more valuable than retrospective cohort studies: this is because in the former, the researcher observes and records the data. The researcher plans the study before the research and determines what data will be used. On the other hand, in retrospective studies, the research is made on recorded data: no new data can be added.

In fact, retrospective and prospective studies are not observational. They determine the relationship between the date on which the researcher has begun the study and the disease development period. The most critical disadvantage of this type of research is that if the follow-up period is long, participants may leave the study at their own behest or due to physical conditions. Cohort studies that begin after exposure and before disease development are called ambidirectional studies . Public healthcare studies generally fall within this group, e.g. lung cancer development in smokers.

  • Case-Control Studies: these studies are retrospective cohort studies. They examine the cause and effect relationship from the effect to the cause. The detection or determination of data depends on the information recorded in the past. The researcher has no control over the data ( 2 ).

Cross-sectional studies are advantageous since they can be concluded relatively quickly. It may be difficult to obtain a reliable result from such studies for rare diseases ( 2 ).

Cross-sectional studies are characterised by timing. In such studies, the exposure and result are simultaneously evaluated. While cross-sectional studies are restrictedly used in studies involving anaesthesia (since the process of exposure is limited), they can be used in studies conducted in intensive care units.

  • Quasi-Experimental Research: they are conducted in cases in which a quick result is requested and the participants or research areas cannot be randomised, e.g. giving hand-wash training and comparing the frequency of nosocomial infections before and after hand wash.
  • Clinical Research: they are prospective studies carried out with a control group for the purpose of comparing the effect and value of an intervention in a clinical case. Clinical study and research have the same meaning. Drugs, invasive interventions, medical devices and operations, diets, physical therapy and diagnostic tools are relevant in this context ( 6 ).

Clinical studies are conducted by a responsible researcher, generally a physician. In the research team, there may be other healthcare staff besides physicians. Clinical studies may be financed by healthcare institutes, drug companies, academic medical centres, volunteer groups, physicians, healthcare service providers and other individuals. They may be conducted in several places including hospitals, universities, physicians’ offices and community clinics based on the researcher’s requirements. The participants are made aware of the duration of the study before their inclusion. Clinical studies should include the evaluation of recommendations (drug, device and surgical) for the treatment of a disease, syndrome or a comparison of one or more applications; finding different ways for recognition of a disease or case and prevention of their recurrence ( 7 ).

Clinical Research

In this review, clinical research is explained in more detail since it is the most valuable study in scientific research.

Clinical research starts with forming a hypothesis. A hypothesis can be defined as a claim put forward about the value of a population parameter based on sampling. There are two types of hypotheses in statistics.

  • H 0 hypothesis is called a control or null hypothesis. It is the hypothesis put forward in research, which implies that there is no difference between the groups under consideration. If this hypothesis is rejected at the end of the study, it indicates that a difference exists between the two treatments under consideration.
  • H 1 hypothesis is called an alternative hypothesis. It is hypothesised against a null hypothesis, which implies that a difference exists between the groups under consideration. For example, consider the following hypothesis: drug A has an analgesic effect. Control or null hypothesis (H 0 ): there is no difference between drug A and placebo with regard to the analgesic effect. The alternative hypothesis (H 1 ) is applicable if a difference exists between drug A and placebo with regard to the analgesic effect.

The planning phase comes after the determination of a hypothesis. A clinical research plan is called a protocol . In a protocol, the reasons for research, number and qualities of participants, tests to be applied, study duration and what information to be gathered from the participants should be found and conformity criteria should be developed.

The selection of participant groups to be included in the study is important. Inclusion and exclusion criteria of the study for the participants should be determined. Inclusion criteria should be defined in the form of demographic characteristics (age, gender, etc.) of the participant group and the exclusion criteria as the diseases that may influence the study, age ranges, cases involving pregnancy and lactation, continuously used drugs and participants’ cooperation.

The next stage is methodology. Methodology can be grouped under subheadings, namely, the calculation of number of subjects, blinding (masking), randomisation, selection of operation to be applied, use of placebo and criteria for stopping and changing the treatment.

I. Calculation of the Number of Subjects

The entire source from which the data are obtained is called a universe or population . A small group selected from a certain universe based on certain rules and which is accepted to highly represent the universe from which it is selected is called a sample and the characteristics of the population from which the data are collected are called variables. If data is collected from the entire population, such an instance is called a parameter . Conducting a study on the sample rather than the entire population is easier and less costly. Many factors influence the determination of the sample size. Firstly, the type of variable should be determined. Variables are classified as categorical (qualitative, non-numerical) or numerical (quantitative). Individuals in categorical variables are classified according to their characteristics. Categorical variables are indicated as nominal and ordinal (ordered). In nominal variables, the application of a category depends on the researcher’s preference. For instance, a female participant can be considered first and then the male participant, or vice versa. An ordinal (ordered) variable is ordered from small to large or vice versa (e.g. ordering obese patients based on their weights-from the lightest to the heaviest or vice versa). A categorical variable may have more than one characteristic: such variables are called binary or dichotomous (e.g. a participant may be both female and obese).

If the variable has numerical (quantitative) characteristics and these characteristics cannot be categorised, then it is called a numerical variable. Numerical variables are either discrete or continuous. For example, the number of operations with spinal anaesthesia represents a discrete variable. The haemoglobin value or height represents a continuous variable.

Statistical analyses that need to be employed depend on the type of variable. The determination of variables is necessary for selecting the statistical method as well as software in SPSS. While categorical variables are presented as numbers and percentages, numerical variables are represented using measures such as mean and standard deviation. It may be necessary to use mean in categorising some cases such as the following: even though the variable is categorical (qualitative, non-numerical) when Visual Analogue Scale (VAS) is used (since a numerical value is obtained), it is classified as a numerical variable: such variables are averaged.

Clinical research is carried out on the sample and generalised to the population. Accordingly, the number of samples should be correctly determined. Different sample size formulas are used on the basis of the statistical method to be used. When the sample size increases, error probability decreases. The sample size is calculated based on the primary hypothesis. The determination of a sample size before beginning the research specifies the power of the study. Power analysis enables the acquisition of realistic results in the research, and it is used for comparing two or more clinical research methods.

Because of the difference in the formulas used in calculating power analysis and number of samples for clinical research, it facilitates the use of computer programs for making calculations.

It is necessary to know certain parameters in order to calculate the number of samples by power analysis.

  • Type-I (α) and type-II (β) error levels
  • Difference between groups (d-difference) and effect size (ES)
  • Distribution ratio of groups
  • Direction of research hypothesis (H1)

a. Type-I (α) and Type-II (β) Error (β) Levels

Two types of errors can be made while accepting or rejecting H 0 hypothesis in a hypothesis test. Type-I error (α) level is the probability of finding a difference at the end of the research when there is no difference between the two applications. In other words, it is the rejection of the hypothesis when H 0 is actually correct and it is known as α error or p value. For instance, when the size is determined, type-I error level is accepted as 0.05 or 0.01.

Another error that can be made during a hypothesis test is a type-II error. It is the acceptance of a wrongly hypothesised H 0 hypothesis. In fact, it is the probability of failing to find a difference when there is a difference between the two applications. The power of a test is the ability of that test to find a difference that actually exists. Therefore, it is related to the type-II error level.

Since the type-II error risk is expressed as β, the power of the test is defined as 1–β. When a type-II error is 0.20, the power of the test is 0.80. Type-I (α) and type-II (β) errors can be intentional. The reason to intentionally make such an error is the necessity to look at the events from the opposite perspective.

b. Difference between Groups and ES

ES is defined as the state in which statistical difference also has clinically significance: ES≥0.5 is desirable. The difference between groups is the absolute difference between the groups compared in clinical research.

c. Allocation Ratio of Groups

The allocation ratio of groups is effective in determining the number of samples. If the number of samples is desired to be determined at the lowest level, the rate should be kept as 1/1.

d. Direction of Hypothesis (H1)

The direction of hypothesis in clinical research may be one-sided or two-sided. While one-sided hypotheses hypothesis test differences in the direction of size, two-sided hypotheses hypothesis test differences without direction. The power of the test in two-sided hypotheses is lower than one-sided hypotheses.

After these four variables are determined, they are entered in the appropriate computer program and the number of samples is calculated. Statistical packaged software programs such as Statistica, NCSS and G-Power may be used for power analysis and calculating the number of samples. When the samples size is calculated, if there is a decrease in α, difference between groups, ES and number of samples, then the standard deviation increases and power decreases. The power in two-sided hypothesis is lower. It is ethically appropriate to consider the determination of sample size, particularly in animal experiments, at the beginning of the study. The phase of the study is also important in the determination of number of subjects to be included in drug studies. Usually, phase-I studies are used to determine the safety profile of a drug or product, and they are generally conducted on a few healthy volunteers. If no unacceptable toxicity is detected during phase-I studies, phase-II studies may be carried out. Phase-II studies are proof-of-concept studies conducted on a larger number (100–500) of volunteer patients. When the effectiveness of the drug or product is evident in phase-II studies, phase-III studies can be initiated. These are randomised, double-blinded, placebo or standard treatment-controlled studies. Volunteer patients are periodically followed-up with respect to the effectiveness and side effects of the drug. It can generally last 1–4 years and is valuable during licensing and releasing the drug to the general market. Then, phase-IV studies begin in which long-term safety is investigated (indication, dose, mode of application, safety, effectiveness, etc.) on thousands of volunteer patients.

II. Blinding (Masking) and Randomisation Methods

When the methodology of clinical research is prepared, precautions should be taken to prevent taking sides. For this reason, techniques such as randomisation and blinding (masking) are used. Comparative studies are the most ideal ones in clinical research.

Blinding Method

A case in which the treatments applied to participants of clinical research should be kept unknown is called the blinding method . If the participant does not know what it receives, it is called a single-blind study; if even the researcher does not know, it is called a double-blind study. When there is a probability of knowing which drug is given in the order of application, when uninformed staff administers the drug, it is called in-house blinding. In case the study drug is known in its pharmaceutical form, a double-dummy blinding test is conducted. Intravenous drug is given to one group and a placebo tablet is given to the comparison group; then, the placebo tablet is given to the group that received the intravenous drug and intravenous drug in addition to placebo tablet is given to the comparison group. In this manner, each group receives both the intravenous and tablet forms of the drug. In case a third party interested in the study is involved and it also does not know about the drug (along with the statistician), it is called third-party blinding.

Randomisation Method

The selection of patients for the study groups should be random. Randomisation methods are used for such selection, which prevent conscious or unconscious manipulations in the selection of patients ( 8 ).

No factor pertaining to the patient should provide preference of one treatment to the other during randomisation. This characteristic is the most important difference separating randomised clinical studies from prospective and synchronous studies with experimental groups. Randomisation strengthens the study design and enables the determination of reliable scientific knowledge ( 2 ).

The easiest method is simple randomisation, e.g. determination of the type of anaesthesia to be administered to a patient by tossing a coin. In this method, when the number of samples is kept high, a balanced distribution is created. When the number of samples is low, there will be an imbalance between the groups. In this case, stratification and blocking have to be added to randomisation. Stratification is the classification of patients one or more times according to prognostic features determined by the researcher and blocking is the selection of a certain number of patients for each stratification process. The number of stratification processes should be determined at the beginning of the study.

As the number of stratification processes increases, performing the study and balancing the groups become difficult. For this reason, stratification characteristics and limitations should be effectively determined at the beginning of the study. It is not mandatory for the stratifications to have equal intervals. Despite all the precautions, an imbalance might occur between the groups before beginning the research. In such circumstances, post-stratification or restandardisation may be conducted according to the prognostic factors.

The main characteristic of applying blinding (masking) and randomisation is the prevention of bias. Therefore, it is worthwhile to comprehensively examine bias at this stage.

Bias and Chicanery

While conducting clinical research, errors can be introduced voluntarily or involuntarily at a number of stages, such as design, population selection, calculating the number of samples, non-compliance with study protocol, data entry and selection of statistical method. Bias is taking sides of individuals in line with their own decisions, views and ideological preferences ( 9 ). In order for an error to lead to bias, it has to be a systematic error. Systematic errors in controlled studies generally cause the results of one group to move in a different direction as compared to the other. It has to be understood that scientific research is generally prone to errors. However, random errors (or, in other words, ‘the luck factor’-in which bias is unintended-do not lead to bias ( 10 ).

Another issue, which is different from bias, is chicanery. It is defined as voluntarily changing the interventions, results and data of patients in an unethical manner or copying data from other studies. Comparatively, bias may not be done consciously.

In case unexpected results or outliers are found while the study is analysed, if possible, such data should be re-included into the study since the complete exclusion of data from a study endangers its reliability. In such a case, evaluation needs to be made with and without outliers. It is insignificant if no difference is found. However, if there is a difference, the results with outliers are re-evaluated. If there is no error, then the outlier is included in the study (as the outlier may be a result). It should be noted that re-evaluation of data in anaesthesiology is not possible.

Statistical evaluation methods should be determined at the design stage so as not to encounter unexpected results in clinical research. The data should be evaluated before the end of the study and without entering into details in research that are time-consuming and involve several samples. This is called an interim analysis . The date of interim analysis should be determined at the beginning of the study. The purpose of making interim analysis is to prevent unnecessary cost and effort since it may be necessary to conclude the research after the interim analysis, e.g. studies in which there is no possibility to validate the hypothesis at the end or the occurrence of different side effects of the drug to be used. The accuracy of the hypothesis and number of samples are compared. Statistical significance levels in interim analysis are very important. If the data level is significant, the hypothesis is validated even if the result turns out to be insignificant after the date of the analysis.

Another important point to be considered is the necessity to conclude the participants’ treatment within the period specified in the study protocol. When the result of the study is achieved earlier and unexpected situations develop, the treatment is concluded earlier. Moreover, the participant may quit the study at its own behest, may die or unpredictable situations (e.g. pregnancy) may develop. The participant can also quit the study whenever it wants, even if the study has not ended ( 7 ).

In case the results of a study are contrary to already known or expected results, the expected quality level of the study suggesting the contradiction may be higher than the studies supporting what is known in that subject. This type of bias is called confirmation bias. The presence of well-known mechanisms and logical inference from them may create problems in the evaluation of data. This is called plausibility bias.

Another type of bias is expectation bias. If a result different from the known results has been achieved and it is against the editor’s will, it can be challenged. Bias may be introduced during the publication of studies, such as publishing only positive results, selection of study results in a way to support a view or prevention of their publication. Some editors may only publish research that extols only the positive results or results that they desire.

Bias may be introduced for advertisement or economic reasons. Economic pressure may be applied on the editor, particularly in the cases of studies involving drugs and new medical devices. This is called commercial bias.

In recent years, before beginning a study, it has been recommended to record it on the Web site www.clinicaltrials.gov for the purpose of facilitating systematic interpretation and analysis in scientific research, informing other researchers, preventing bias, provision of writing in a standard format, enhancing contribution of research results to the general literature and enabling early intervention of an institution for support. This Web site is a service of the US National Institutes of Health.

The last stage in the methodology of clinical studies is the selection of intervention to be conducted. Placebo use assumes an important place in interventions. In Latin, placebo means ‘I will be fine’. In medical literature, it refers to substances that are not curative, do not have active ingredients and have various pharmaceutical forms. Although placebos do not have active drug characteristic, they have shown effective analgesic characteristics, particularly in algology applications; further, its use prevents bias in comparative studies. If a placebo has a positive impact on a participant, it is called the placebo effect ; on the contrary, if it has a negative impact, it is called the nocebo effect . Another type of therapy that can be used in clinical research is sham application. Although a researcher does not cure the patient, the researcher may compare those who receive therapy and undergo sham. It has been seen that sham therapies also exhibit a placebo effect. In particular, sham therapies are used in acupuncture applications ( 11 ). While placebo is a substance, sham is a type of clinical application.

Ethically, the patient has to receive appropriate therapy. For this reason, if its use prevents effective treatment, it causes great problem with regard to patient health and legalities.

Before medical research is conducted with human subjects, predictable risks, drawbacks and benefits must be evaluated for individuals or groups participating in the study. Precautions must be taken for reducing the risk to a minimum level. The risks during the study should be followed, evaluated and recorded by the researcher ( 1 ).

After the methodology for a clinical study is determined, dealing with the ‘Ethics Committee’ forms the next stage. The purpose of the ethics committee is to protect the rights, safety and well-being of volunteers taking part in the clinical research, considering the scientific method and concerns of society. The ethics committee examines the studies presented in time, comprehensively and independently, with regard to ethics and science; in line with the Declaration of Helsinki and following national and international standards concerning ‘Good Clinical Practice’. The method to be followed in the formation of the ethics committee should be developed without any kind of prejudice and to examine the applications with regard to ethics and science within the framework of the ethics committee, Regulation on Clinical Trials and Good Clinical Practice ( www.iku.com ). The necessary documents to be presented to the ethics committee are research protocol, volunteer consent form, budget contract, Declaration of Helsinki, curriculum vitae of researchers, similar or explanatory literature samples, supporting institution approval certificate and patient follow-up form.

Only one sister/brother, mother, father, son/daughter and wife/husband can take charge in the same ethics committee. A rector, vice rector, dean, deputy dean, provincial healthcare director and chief physician cannot be members of the ethics committee.

Members of the ethics committee can work as researchers or coordinators in clinical research. However, during research meetings in which members of the ethics committee are researchers or coordinators, they must leave the session and they cannot sign-off on decisions. If the number of members in the ethics committee for a particular research is so high that it is impossible to take a decision, the clinical research is presented to another ethics committee in the same province. If there is no ethics committee in the same province, an ethics committee in the closest settlement is found.

Thereafter, researchers need to inform the participants using an informed consent form. This form should explain the content of clinical study, potential benefits of the study, alternatives and risks (if any). It should be easy, comprehensible, conforming to spelling rules and written in plain language understandable by the participant.

This form assists the participants in taking a decision regarding participation in the study. It should aim to protect the participants. The participant should be included in the study only after it signs the informed consent form; the participant can quit the study whenever required, even when the study has not ended ( 7 ).

Peer-review: Externally peer-reviewed.

Author Contributions: Concept - C.Ö.Ç., A.D.; Design - C.Ö.Ç.; Supervision - A.D.; Resource - C.Ö.Ç., A.D.; Materials - C.Ö.Ç., A.D.; Analysis and/or Interpretation - C.Ö.Ç., A.D.; Literature Search - C.Ö.Ç.; Writing Manuscript - C.Ö.Ç.; Critical Review - A.D.; Other - C.Ö.Ç., A.D.

Conflict of Interest: No conflict of interest was declared by the authors.

Financial Disclosure: The authors declared that this study has received no financial support.

Research: Definition, Characteristics, Goals, Approaches

research definition

Research is an original and systematic investigation undertaken to increase existing knowledge and understanding of the unknown to establish facts and principles.

Let’s understand research:

What is Research?

Research is a voyage of discovery of new knowledge. It comprises creating ideas and generating new knowledge that leads to new and improved insights and the development of new materials, devices, products, and processes.

It should have the potential to produce sufficiently relevant results to increase and synthesize existing knowledge or correct and integrate previous knowledge.

Good reflective research produces theories and hypotheses and benefits any intellectual attempt to analyze facts and phenomena.

Where did the word Research Come from?

The word ‘research’ perhaps originates from the old French word “recerchier” which meant to ‘ search again.’ It implicitly assumes that the earlier search was not exhaustive and complete; hence, a repeated search is called for.

In practice, ‘research’ refers to a scientific process of generating an unexplored horizon of knowledge, aiming at discovering or establishing facts, solving a problem, and reaching a decision. Keeping the above points in view, we arrive at the following definition of research:

Research Definition

Research is a scientific approach to answering a research question, solving a research problem, or generating new knowledge through a systematic and orderly collection, organization, and analysis of data to make research findings useful in decision-making.

When do we call research scientific? Any research endeavor is said to be scientific if

  • It is based on empirical and measurable evidence subject to specific principles of reasoning;
  • It consists of systematic observations, measurement, and experimentation;
  • It relies on the application of scientific methods and harnessing of curiosity;
  • It provides scientific information and theories for the explanation of nature;
  • It makes practical applications possible, and
  • It ensures adequate analysis of data employing rigorous statistical techniques.

The chief characteristic that distinguishes the scientific method from other methods of acquiring knowledge is that scientists seek to let reality speak for itself, supporting a theory when a theory’s predictions are confirmed and challenging a theory when its predictions prove false.

Scientific research has multidimensional functions, characteristics, and objectives.

Keeping these issues in view, we assert that research in any field or discipline:

  • Attempts to solve a research problem;
  • Involves gathering new data from primary or first-hand sources or using existing data for a new purpose;
  • is based upon observable experiences or empirical evidence;
  • Demands accurate observation and description;
  • Employs carefully designed procedures and rigorous analysis;
  • attempts to find an objective, unbiased solution to the problem and takes great pains to validate the methods employed;
  • is a deliberate and unhurried activity that is directional but often refines the problem or questions as the research progresses.

Characteristics of Research

Keeping this in mind that research in any field of inquiry is undertaken to provide information to support decision-making in its respective area, we summarize some desirable characteristics of research:

  • The research should focus on priority problems.
  • The research should be systematic. It emphasizes that a researcher should employ a structured procedure.
  • The research should be logical. Without manipulating ideas logically, the scientific researcher cannot make much progress in any investigation.
  • The research should be reductive. This means that one researcher’s findings should be made available to other researchers to prevent them from repeating the same research.
  • The research should be replicable. This asserts that there should be scope to confirm previous research findings in a new environment and different settings with a new group of subjects or at a different point in time.
  • The research should be generative. This is one of the valuable characteristics of research because answering one question leads to generating many other new questions.
  • The research should be action-oriented. In other words, it should be aimed at solving to implement its findings.
  • The research should follow an integrated multidisciplinary approach, i.e., research approaches from more than one discipline are needed.
  • The research should be participatory, involving all parties concerned (from policymakers down to community members) at all stages of the study.
  • The research must be relatively simple, timely, and time-bound, employing a comparatively simple design.
  • The research must be as much cost-effective as possible.
  • The research results should be presented in formats most useful for administrators, decision-makers, business managers, or community members.

3 Basic Operations of Research

Scientific research in any field of inquiry involves three basic operations:

  • Data collection;
  • Data analysis;
  • Report writing .

3 basic operations of research

  • Data collection refers to observing, measuring, and recording data or information.
  • Data analysis, on the other hand, refers to arranging and organizing the collected data so that we may be able to find out what their significance is and generalize about them.
  • Report writing is the ultimate step of the study . Its purpose is to convey the information contained in it to the readers or audience.

If you note down, for example, the reading habit of newspapers of a group of residents in a community, that would be your data collection.

If you then divide these residents into three categories, ‘regular,’ ‘occasional,’ and ‘never,’ you have performed a simple data analysis. Your findings may now be presented in a report form.

A reader of your report knows what percentage of the community people never read any newspaper and so on.

Here are some examples that demonstrate what research is:

  • A farmer is planting two varieties of jute side by side to compare yields;
  • A sociologist examines the causes and consequences of divorce;
  • An economist is looking at the interdependence of inflation and foreign direct investment;
  • A physician is experimenting with the effects of multiple uses of disposable insulin syringes in a hospital;
  • A business enterprise is examining the effects of advertisement of their products on the volume of sales;
  • An economist is doing a cost-benefit analysis of reducing the sales tax on essential commodities;
  • The Bangladesh Bank is closely observing and monitoring the performance of nationalized and private banks;
  • Based on some prior information, Bank Management plans to open new counters for female customers.
  • Supermarket Management is assessing the satisfaction level of the customers with their products.

The above examples are all researching whether the instrument is an electronic microscope, hospital records, a microcomputer, a questionnaire, or a checklist.

Research Motivation – What makes one motivated to do research?

A person may be motivated to undertake research activities because

  • He might have genuine interest and curiosity in the existing body of knowledge and understanding of the problem;
  • He is looking for answers to questions that have remained unanswered so far and trying to unfold the truth;
  • The existing tools and techniques are accessible to him, and others may need modification and change to suit the current needs.

One might research ensuring.

  • Better livelihood;
  • Better career development;
  • Higher position, prestige, and dignity in society;
  • Academic achievement leading to higher degrees;
  • Self-gratification.

At the individual level, the results of the research are used by many:

  • A villager is drinking water from an arsenic-free tube well;
  • A rural woman is giving more green vegetables to her child than before;
  • A cigarette smoker is actively considering quitting smoking;
  • An old man is jogging for cardiovascular fitness;
  • A sociologist is using newly suggested tools and techniques in poverty measurement.

The above activities are all outcomes of the research.

All involved in the above processes will benefit from the research results. There is hardly any action in everyday life that does not depend upon previous research.

Research in any field of inquiry provides us with the knowledge and skills to solve problems and meet the challenges of a fast-paced decision-making environment.

9 Qualities of Research

Good research generates dependable data. It is conducted by professionals and can be used reliably for decision-making. It is thus of crucial importance that research should be made acceptable to the audience for which research should possess some desirable qualities in terms of.

9 qualities of research are;

Purpose clearly defined

Research process detailed, research design planner, ethical issues considered, limitations revealed, adequate analysis ensured, findings unambiguously presented, conclusions and recommendations justified..

We enumerate below a few qualities that good research should possess.

Good research must have its purposes clearly and unambiguously defined.

The problem involved or the decision to be made should be sharply delineated as clearly as possible to demonstrate the credibility of the research.

The research procedures should be described in sufficient detail to permit other researchers to repeat the research later.

Failure to do so makes it difficult or impossible to estimate the validity and reliability of the results. This weakens the confidence of the readers.

Any recommendations from such research justifiably get little attention from the policymakers and implementation.

The procedural design of the research should be carefully planned to yield results that are as objective as possible.

In doing so, care must be taken so that the sample’s representativeness is ensured, relevant literature has been thoroughly searched, experimental controls, whenever necessary, have been followed, and the personal bias in selecting and recording data has been minimized.

A research design should always safeguard against causing mental and physical harm not only to the participants but also those who belong to their organizations.

Careful consideration must also be given to research situations when there is a possibility for exploitation, invasion of privacy, and loss of dignity of all those involved in the study.

The researcher should report with complete honesty and frankness any flaws in procedural design; he followed and provided estimates of their effects on the findings.

This enhances the readers’ confidence and makes the report acceptable to the audience. One can legitimately question the value of research where no limitations are reported.

Adequate analysis reveals the significance of the data and helps the researcher to check the reliability and validity of his estimates.

Data should, therefore, be analyzed with proper statistical rigor to assist the researcher in reaching firm conclusions.

When statistical methods have been employed, the probability of error should be estimated, and criteria of statistical significance applied.

The presentation of the results should be comprehensive, easily understood by the readers, and organized so that the readers can readily locate the critical and central findings.

Proper research always specifies the conditions under which the research conclusions seem valid.

Therefore, it is important that any conclusions drawn and recommendations made should be solely based on the findings of the study.

No inferences or generalizations should be made beyond the data. If this were not followed, the objectivity of the research would tend to decrease, resulting in confidence in the findings.

The researcher’s experiences were reflected.

The research report should contain information about the qualifications of the researchers .

If the researcher is experienced, has a good reputation in research, and is a person of integrity, his report is likely to be highly valued. The policymakers feel confident in implementing the recommendations made in such reports.

4 Goals of Research

goals of research

The primary goal or purpose of research in any field of inquiry; is to add to what is known about the phenomenon under investigation by applying scientific methods. Though each research has its own specific goals, we may enumerate the following 4 broad goals of scientific research:

Exploration and Explorative Research

Description and descriptive research, causal explanation and causal research, prediction and predictive research.

The link between the 4 goals of research and the questions raised in reaching these goals.

Let’s try to understand the 4 goals of the research.

Exploration is finding out about some previously unexamined phenomenon. In other words, an explorative study structures and identifies new problems.

The explorative study aims to gain familiarity with a phenomenon or gain new insights into it.

Exploration is particularly useful when researchers lack a clear idea of the problems they meet during their study.

Through exploration, researchers attempt to

  • Develop concepts more clearly;
  • Establish priorities among several alternatives;
  • Develop operational definitions of variables;
  • Formulate research hypotheses and sharpen research objectives;
  • Improve the methodology and modify (if needed) the research design .

Exploration is achieved through what we call exploratory research.

The end of an explorative study comes when the researchers are convinced that they have established the major dimensions of the research task.

Many research activities consist of gathering information on some topic of interest. The description refers to these data-based information-gathering activities. Descriptive studies portray precisely the characteristics of a particular individual, situation, or group.

Here, we attempt to describe situations and events through studies, which we refer to as descriptive research.

Such research is undertaken when much is known about the problem under investigation.

Descriptive studies try to discover answers to the questions of who, what, when, where, and sometimes how.

Such research studies may involve the collection of data and the creation of distribution of the number of times the researcher observes a single event or characteristic, known as a research variable.

A descriptive study may also involve the interaction of two or more variables and attempts to observe if there is any relationship between the variables under investigation .

Research that examines such a relationship is sometimes called a correlational study. It is correlational because it attempts to relate (i.e., co-relate) two or more variables.

A descriptive study may be feasible to answer the questions of the following types:

  • What are the characteristics of the people who are involved in city crime? Are they young? Middle-aged? Poor? Muslim? Educated?
  • Who are the potential buyers of the new product? Men or women? Urban people or rural people?
  • Are rural women more likely to marry earlier than their urban counterparts?
  • Does previous experience help an employee to get a higher initial salary?

Although the data description in descriptive research is factual, accurate, and systematic, the research cannot describe what caused a situation.

Thus, descriptive research cannot be used to create a causal relationship where one variable affects another.

In other words, descriptive research can be said to have a low requirement for internal validity. In sum, descriptive research deals with everything that can be counted and studied.

But there are always restrictions on that. All research must impact the lives of the people around us.

For example, finding the most frequent disease that affects the people of a community falls under descriptive research.

But the research readers will have the hunch to know why this has happened and what to do to prevent that disease so that more people will live healthy lives.

It dictates that we need a causal explanation of the situation under reference and a causal study vis-a-vis causal research .

Explanation reveals why and how something happens.

An explanatory study goes beyond description and attempts to establish a cause-and-effect relationship between variables. It explains the reason for the phenomenon that the descriptive study observed.

Thus, if a researcher finds that communities with larger family sizes have higher child deaths or that smoking correlates with lung cancer, he is performing a descriptive study.

If he explains why it is so and tries to establish a cause-and-effect relationship, he is performing explanatory or causal research . The researcher uses theories or at-least hypotheses to account for the factors that caused a certain phenomenon.

Look at the following examples that fit causal studies:

  • Why are people involved in crime? Can we explain this as a consequence of the present job market crisis or lack of parental care?
  • Will the buyers be motivated to purchase the new product in a new container ? Can an attractive advertisement motivate them to buy a new product?
  • Why has the share market shown the steepest-ever fall in stock prices? Is it because of the IMF’s warnings and prescriptions on the commercial banks’ exposure to the stock market or because of an abundant increase in the supply of new shares?

Prediction seeks to answer when and in what situations will occur if we can provide a plausible explanation for the event in question.

However, the precise nature of the relationship between explanation and prediction has been a subject of debate.

One view is that explanation and prediction are the same phenomena, except that prediction precedes the event while the explanation takes place after the event has occurred.

Another view is that explanation and prediction are fundamentally different processes.

We need not be concerned with this debate here but can simply state that in addition to being able to explain an event after it has occurred, we would also be able to predict when it will occur.

Research Approaches

4 research approaches

There are two main approaches to doing research.

The first is the basic approach, which mostly pertains to academic research. Many people view this as pure research or fundamental research.

The research implemented through the second approach is variously known as applied research, action research, operations research, or contract research.

Also, the third category of research, evaluative research, is important in many applications. All these approaches have different purposes influencing the nature of the respective research.

Lastly, precautions in research are required for thorough research.

So, 4 research approaches are;

  • Basic Research .
  • Applied Research .
  • Evaluative Research .
  • Precautions in Research.

Areas of Research

The most important fields or areas of research, among others, are;

  • Social Research .
  • Health Research .
  • Population Research .
  • Business Research .
  • Marketing Research .
  • Agricultural Research .
  • Biomedical Research.
  • Clinical Research .
  • Outcomes Research.
  • Internet Research.
  • Archival Research.
  • Empirical Research.
  • Legal Research .
  • Education Research .
  • Engineering Research .
  • Historical Research.

Check out our article describing all 16 areas of research .

Precautions in Research

Whether a researcher is doing applied or basic research or research of any other form, he or she must take necessary precautions to ensure that the research he or she is doing is relevant, timely, efficient, accurate, and ethical .

The research is considered relevant if it anticipates the kinds of information that decision-makers, scientists, or policymakers will require.

Timely research is completed in time to influence decisions.

  • Research is efficient when it is of the best quality for the minimum expenditure and the study is appropriate to the research context.
  • Research is considered accurate or valid when the interpretation can account for both consistencies and inconsistencies in the data.
  • Research is ethical when it can promote trust, exercise care, ensure standards, and protect the rights of the participants in the research process.

What is the definition of research?

What are the characteristics of good research, what are the three basic operations involved in scientific research, what are the four broad goals of scientific research, what distinguishes the scientific method from other methods of acquiring knowledge, what is the origin of the word ‘research’, how is “research methodology” defined, how does research methodology ensure the appropriateness of a research method.

After discussing the research definition and knowing the characteristics, goals, and approaches, it’s time to delve into the research fundamentals. For a comprehensive understanding, refer to our detailed research and methodology concepts guide .

Research should be relevant, timely, efficient, accurate, and ethical. It should anticipate the information required by decision-makers, be completed in time to influence decisions, be of the best quality for the minimum expenditure, and protect the rights of participants in the research process.

The two main approaches to research are the basic approach, often viewed as pure or fundamental research, and the applied approach, which includes action research, operations research, and contract research.

30 Accounting Research Paper Topics and Ideas for Writing

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Literature Reviews

  • 1. Define your research question
  • Getting started
  • Types of reviews

Define topic

Brainstorming, limit scope, how ai can help, helpful resources.

  • 2. Plan your search
  • 3. Search the literature
  • 4. Organize your results
  • 5. Synthesize your findings
  • 6. Write the review
  • Artificial intelligence (AI) tools
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define good research

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For example, the following research question is too broad.

Does social media affect mental health in college students?

A more focused research question could be:

Does social media play a role in the number of eating disorder diagnoses in college-aged women?

Need some guidance? Contact your subject librarian for a research consultation or reach out to [email protected] .

Start the brainstorming process:

  • Begin by identifying a broad topic of research interest (the more you're personally interested in it, the better!). Write it down to clarify your focus.
  • Narrow down your scope  by considering specific areas within this topic that you want to explore.
  • Identify key themes and elements  related to these specific areas. These will be the building blocks of your investigation.
  • Finally,  integrate these key areas and elements  into a well-crafted research question.

One way to brainstorm is to use a flowchart.

define good research

The scope of a topic  encompasses the boundaries and constraints you set for your research. The more precise your research question, the smoother the research process becomes.

Feeling stuck? Here are some ways you can narrow down your topic:

  • geographic location
  • time period
  • discipline/field of study
  • age group, etc.

define good research

You:  I need to conduct a literature review about social media, mental health, and college students. What are some example research questions within this topic?

ChatGPT: 

  • How does the frequency and nature of social media use impact the mental health of college students?
  • What role do specific social media platforms play in influencing the mental well-being of college students?
  • How do online social interactions on platforms like Facebook, Instagram, or Twitter relate to the mental health outcomes of college students?
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Cultural Relativity and Acceptance of Embryonic Stem Cell Research

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There is a debate about the ethical implications of using human embryos in stem cell research, which can be influenced by cultural, moral, and social values. This paper argues for an adaptable framework to accommodate diverse cultural and religious perspectives. By using an adaptive ethics model, research protections can reflect various populations and foster growth in stem cell research possibilities.

INTRODUCTION

Stem cell research combines biology, medicine, and technology, promising to alter health care and the understanding of human development. Yet, ethical contention exists because of individuals’ perceptions of using human embryos based on their various cultural, moral, and social values. While these disagreements concerning policy, use, and general acceptance have prompted the development of an international ethics policy, such a uniform approach can overlook the nuanced ethical landscapes between cultures. With diverse viewpoints in public health, a single global policy, especially one reflecting Western ethics or the ethics prevalent in high-income countries, is impractical. This paper argues for a culturally sensitive, adaptable framework for the use of embryonic stem cells. Stem cell policy should accommodate varying ethical viewpoints and promote an effective global dialogue. With an extension of an ethics model that can adapt to various cultures, we recommend localized guidelines that reflect the moral views of the people those guidelines serve.

Stem cells, characterized by their unique ability to differentiate into various cell types, enable the repair or replacement of damaged tissues. Two primary types of stem cells are somatic stem cells (adult stem cells) and embryonic stem cells. Adult stem cells exist in developed tissues and maintain the body’s repair processes. [1] Embryonic stem cells (ESC) are remarkably pluripotent or versatile, making them valuable in research. [2] However, the use of ESCs has sparked ethics debates. Considering the potential of embryonic stem cells, research guidelines are essential. The International Society for Stem Cell Research (ISSCR) provides international stem cell research guidelines. They call for “public conversations touching on the scientific significance as well as the societal and ethical issues raised by ESC research.” [3] The ISSCR also publishes updates about culturing human embryos 14 days post fertilization, suggesting local policies and regulations should continue to evolve as ESC research develops. [4]  Like the ISSCR, which calls for local law and policy to adapt to developing stem cell research given cultural acceptance, this paper highlights the importance of local social factors such as religion and culture.

I.     Global Cultural Perspective of Embryonic Stem Cells

Views on ESCs vary throughout the world. Some countries readily embrace stem cell research and therapies, while others have stricter regulations due to ethical concerns surrounding embryonic stem cells and when an embryo becomes entitled to moral consideration. The philosophical issue of when the “someone” begins to be a human after fertilization, in the morally relevant sense, [5] impacts when an embryo becomes not just worthy of protection but morally entitled to it. The process of creating embryonic stem cell lines involves the destruction of the embryos for research. [6] Consequently, global engagement in ESC research depends on social-cultural acceptability.

a.     US and Rights-Based Cultures

In the United States, attitudes toward stem cell therapies are diverse. The ethics and social approaches, which value individualism, [7] trigger debates regarding the destruction of human embryos, creating a complex regulatory environment. For example, the 1996 Dickey-Wicker Amendment prohibited federal funding for the creation of embryos for research and the destruction of embryos for “more than allowed for research on fetuses in utero.” [8] Following suit, in 2001, the Bush Administration heavily restricted stem cell lines for research. However, the Stem Cell Research Enhancement Act of 2005 was proposed to help develop ESC research but was ultimately vetoed. [9] Under the Obama administration, in 2009, an executive order lifted restrictions allowing for more development in this field. [10] The flux of research capacity and funding parallels the different cultural perceptions of human dignity of the embryo and how it is socially presented within the country’s research culture. [11]

b.     Ubuntu and Collective Cultures

African bioethics differs from Western individualism because of the different traditions and values. African traditions, as described by individuals from South Africa and supported by some studies in other African countries, including Ghana and Kenya, follow the African moral philosophies of Ubuntu or Botho and Ukama , which “advocates for a form of wholeness that comes through one’s relationship and connectedness with other people in the society,” [12] making autonomy a socially collective concept. In this context, for the community to act autonomously, individuals would come together to decide what is best for the collective. Thus, stem cell research would require examining the value of the research to society as a whole and the use of the embryos as a collective societal resource. If society views the source as part of the collective whole, and opposes using stem cells, compromising the cultural values to pursue research may cause social detachment and stunt research growth. [13] Based on local culture and moral philosophy, the permissibility of stem cell research depends on how embryo, stem cell, and cell line therapies relate to the community as a whole . Ubuntu is the expression of humanness, with the person’s identity drawn from the “’I am because we are’” value. [14] The decision in a collectivistic culture becomes one born of cultural context, and individual decisions give deference to others in the society.

Consent differs in cultures where thought and moral philosophy are based on a collective paradigm. So, applying Western bioethical concepts is unrealistic. For one, Africa is a diverse continent with many countries with different belief systems, access to health care, and reliance on traditional or Western medicines. Where traditional medicine is the primary treatment, the “’restrictive focus on biomedically-related bioethics’” [is] problematic in African contexts because it neglects bioethical issues raised by traditional systems.” [15] No single approach applies in all areas or contexts. Rather than evaluating the permissibility of ESC research according to Western concepts such as the four principles approach, different ethics approaches should prevail.

Another consideration is the socio-economic standing of countries. In parts of South Africa, researchers have not focused heavily on contributing to the stem cell discourse, either because it is not considered health care or a health science priority or because resources are unavailable. [16] Each country’s priorities differ given different social, political, and economic factors. In South Africa, for instance, areas such as maternal mortality, non-communicable diseases, telemedicine, and the strength of health systems need improvement and require more focus. [17] Stem cell research could benefit the population, but it also could divert resources from basic medical care. Researchers in South Africa adhere to the National Health Act and Medicines Control Act in South Africa and international guidelines; however, the Act is not strictly enforced, and there is no clear legislation for research conduct or ethical guidelines. [18]

Some parts of Africa condemn stem cell research. For example, 98.2 percent of the Tunisian population is Muslim. [19] Tunisia does not permit stem cell research because of moral conflict with a Fatwa. Religion heavily saturates the regulation and direction of research. [20] Stem cell use became permissible for reproductive purposes only recently, with tight restrictions preventing cells from being used in any research other than procedures concerning ART/IVF.  Their use is conditioned on consent, and available only to married couples. [21] The community's receptiveness to stem cell research depends on including communitarian African ethics.

c.     Asia

Some Asian countries also have a collective model of ethics and decision making. [22] In China, the ethics model promotes a sincere respect for life or human dignity, [23] based on protective medicine. This model, influenced by Traditional Chinese Medicine (TCM), [24] recognizes Qi as the vital energy delivered via the meridians of the body; it connects illness to body systems, the body’s entire constitution, and the universe for a holistic bond of nature, health, and quality of life. [25] Following a protective ethics model, and traditional customs of wholeness, investment in stem cell research is heavily desired for its applications in regenerative therapies, disease modeling, and protective medicines. In a survey of medical students and healthcare practitioners, 30.8 percent considered stem cell research morally unacceptable while 63.5 percent accepted medical research using human embryonic stem cells. Of these individuals, 89.9 percent supported increased funding for stem cell research. [26] The scientific community might not reflect the overall population. From 1997 to 2019, China spent a total of $576 million (USD) on stem cell research at 8,050 stem cell programs, increased published presence from 0.6 percent to 14.01 percent of total global stem cell publications as of 2014, and made significant strides in cell-based therapies for various medical conditions. [27] However, while China has made substantial investments in stem cell research and achieved notable progress in clinical applications, concerns linger regarding ethical oversight and transparency. [28] For example, the China Biosecurity Law, promoted by the National Health Commission and China Hospital Association, attempted to mitigate risks by introducing an institutional review board (IRB) in the regulatory bodies. 5800 IRBs registered with the Chinese Clinical Trial Registry since 2021. [29] However, issues still need to be addressed in implementing effective IRB review and approval procedures.

The substantial government funding and focus on scientific advancement have sometimes overshadowed considerations of regional cultures, ethnic minorities, and individual perspectives, particularly evident during the one-child policy era. As government policy adapts to promote public stability, such as the change from the one-child to the two-child policy, [30] research ethics should also adapt to ensure respect for the values of its represented peoples.

Japan is also relatively supportive of stem cell research and therapies. Japan has a more transparent regulatory framework, allowing for faster approval of regenerative medicine products, which has led to several advanced clinical trials and therapies. [31] South Korea is also actively engaged in stem cell research and has a history of breakthroughs in cloning and embryonic stem cells. [32] However, the field is controversial, and there are issues of scientific integrity. For example, the Korean FDA fast-tracked products for approval, [33] and in another instance, the oocyte source was unclear and possibly violated ethical standards. [34] Trust is important in research, as it builds collaborative foundations between colleagues, trial participant comfort, open-mindedness for complicated and sensitive discussions, and supports regulatory procedures for stakeholders. There is a need to respect the culture’s interest, engagement, and for research and clinical trials to be transparent and have ethical oversight to promote global research discourse and trust.

d.     Middle East

Countries in the Middle East have varying degrees of acceptance of or restrictions to policies related to using embryonic stem cells due to cultural and religious influences. Saudi Arabia has made significant contributions to stem cell research, and conducts research based on international guidelines for ethical conduct and under strict adherence to guidelines in accordance with Islamic principles. Specifically, the Saudi government and people require ESC research to adhere to Sharia law. In addition to umbilical and placental stem cells, [35] Saudi Arabia permits the use of embryonic stem cells as long as they come from miscarriages, therapeutic abortions permissible by Sharia law, or are left over from in vitro fertilization and donated to research. [36] Laws and ethical guidelines for stem cell research allow the development of research institutions such as the King Abdullah International Medical Research Center, which has a cord blood bank and a stem cell registry with nearly 10,000 donors. [37] Such volume and acceptance are due to the ethical ‘permissibility’ of the donor sources, which do not conflict with religious pillars. However, some researchers err on the side of caution, choosing not to use embryos or fetal tissue as they feel it is unethical to do so. [38]

Jordan has a positive research ethics culture. [39] However, there is a significant issue of lack of trust in researchers, with 45.23 percent (38.66 percent agreeing and 6.57 percent strongly agreeing) of Jordanians holding a low level of trust in researchers, compared to 81.34 percent of Jordanians agreeing that they feel safe to participate in a research trial. [40] Safety testifies to the feeling of confidence that adequate measures are in place to protect participants from harm, whereas trust in researchers could represent the confidence in researchers to act in the participants’ best interests, adhere to ethical guidelines, provide accurate information, and respect participants’ rights and dignity. One method to improve trust would be to address communication issues relevant to ESC. Legislation surrounding stem cell research has adopted specific language, especially concerning clarification “between ‘stem cells’ and ‘embryonic stem cells’” in translation. [41] Furthermore, legislation “mandates the creation of a national committee… laying out specific regulations for stem-cell banking in accordance with international standards.” [42] This broad regulation opens the door for future global engagement and maintains transparency. However, these regulations may also constrain the influence of research direction, pace, and accessibility of research outcomes.

e.     Europe

In the European Union (EU), ethics is also principle-based, but the principles of autonomy, dignity, integrity, and vulnerability are interconnected. [43] As such, the opportunity for cohesion and concessions between individuals’ thoughts and ideals allows for a more adaptable ethics model due to the flexible principles that relate to the human experience The EU has put forth a framework in its Convention for the Protection of Human Rights and Dignity of the Human Being allowing member states to take different approaches. Each European state applies these principles to its specific conventions, leading to or reflecting different acceptance levels of stem cell research. [44]

For example, in Germany, Lebenzusammenhang , or the coherence of life, references integrity in the unity of human culture. Namely, the personal sphere “should not be subject to external intervention.” [45]  Stem cell interventions could affect this concept of bodily completeness, leading to heavy restrictions. Under the Grundgesetz, human dignity and the right to life with physical integrity are paramount. [46] The Embryo Protection Act of 1991 made producing cell lines illegal. Cell lines can be imported if approved by the Central Ethics Commission for Stem Cell Research only if they were derived before May 2007. [47] Stem cell research respects the integrity of life for the embryo with heavy specifications and intense oversight. This is vastly different in Finland, where the regulatory bodies find research more permissible in IVF excess, but only up to 14 days after fertilization. [48] Spain’s approach differs still, with a comprehensive regulatory framework. [49] Thus, research regulation can be culture-specific due to variations in applied principles. Diverse cultures call for various approaches to ethical permissibility. [50] Only an adaptive-deliberative model can address the cultural constructions of self and achieve positive, culturally sensitive stem cell research practices. [51]

II.     Religious Perspectives on ESC

Embryonic stem cell sources are the main consideration within religious contexts. While individuals may not regard their own religious texts as authoritative or factual, religion can shape their foundations or perspectives.

The Qur'an states:

“And indeed We created man from a quintessence of clay. Then We placed within him a small quantity of nutfa (sperm to fertilize) in a safe place. Then We have fashioned the nutfa into an ‘alaqa (clinging clot or cell cluster), then We developed the ‘alaqa into mudgha (a lump of flesh), and We made mudgha into bones, and clothed the bones with flesh, then We brought it into being as a new creation. So Blessed is Allah, the Best of Creators.” [52]

Many scholars of Islam estimate the time of soul installment, marked by the angel breathing in the soul to bring the individual into creation, as 120 days from conception. [53] Personhood begins at this point, and the value of life would prohibit research or experimentation that could harm the individual. If the fetus is more than 120 days old, the time ensoulment is interpreted to occur according to Islamic law, abortion is no longer permissible. [54] There are a few opposing opinions about early embryos in Islamic traditions. According to some Islamic theologians, there is no ensoulment of the early embryo, which is the source of stem cells for ESC research. [55]

In Buddhism, the stance on stem cell research is not settled. The main tenets, the prohibition against harming or destroying others (ahimsa) and the pursuit of knowledge (prajña) and compassion (karuna), leave Buddhist scholars and communities divided. [56] Some scholars argue stem cell research is in accordance with the Buddhist tenet of seeking knowledge and ending human suffering. Others feel it violates the principle of not harming others. Finding the balance between these two points relies on the karmic burden of Buddhist morality. In trying to prevent ahimsa towards the embryo, Buddhist scholars suggest that to comply with Buddhist tenets, research cannot be done as the embryo has personhood at the moment of conception and would reincarnate immediately, harming the individual's ability to build their karmic burden. [57] On the other hand, the Bodhisattvas, those considered to be on the path to enlightenment or Nirvana, have given organs and flesh to others to help alleviate grieving and to benefit all. [58] Acceptance varies on applied beliefs and interpretations.

Catholicism does not support embryonic stem cell research, as it entails creation or destruction of human embryos. This destruction conflicts with the belief in the sanctity of life. For example, in the Old Testament, Genesis describes humanity as being created in God’s image and multiplying on the Earth, referencing the sacred rights to human conception and the purpose of development and life. In the Ten Commandments, the tenet that one should not kill has numerous interpretations where killing could mean murder or shedding of the sanctity of life, demonstrating the high value of human personhood. In other books, the theological conception of when life begins is interpreted as in utero, [59] highlighting the inviolability of life and its formation in vivo to make a religious point for accepting such research as relatively limited, if at all. [60] The Vatican has released ethical directives to help apply a theological basis to modern-day conflicts. The Magisterium of the Church states that “unless there is a moral certainty of not causing harm,” experimentation on fetuses, fertilized cells, stem cells, or embryos constitutes a crime. [61] Such procedures would not respect the human person who exists at these stages, according to Catholicism. Damages to the embryo are considered gravely immoral and illicit. [62] Although the Catholic Church officially opposes abortion, surveys demonstrate that many Catholic people hold pro-choice views, whether due to the context of conception, stage of pregnancy, threat to the mother’s life, or for other reasons, demonstrating that practicing members can also accept some but not all tenets. [63]

Some major Jewish denominations, such as the Reform, Conservative, and Reconstructionist movements, are open to supporting ESC use or research as long as it is for saving a life. [64] Within Judaism, the Talmud, or study, gives personhood to the child at birth and emphasizes that life does not begin at conception: [65]

“If she is found pregnant, until the fortieth day it is mere fluid,” [66]

Whereas most religions prioritize the status of human embryos, the Halakah (Jewish religious law) states that to save one life, most other religious laws can be ignored because it is in pursuit of preservation. [67] Stem cell research is accepted due to application of these religious laws.

We recognize that all religions contain subsets and sects. The variety of environmental and cultural differences within religious groups requires further analysis to respect the flexibility of religious thoughts and practices. We make no presumptions that all cultures require notions of autonomy or morality as under the common morality theory , which asserts a set of universal moral norms that all individuals share provides moral reasoning and guides ethical decisions. [68] We only wish to show that the interaction with morality varies between cultures and countries.

III.     A Flexible Ethical Approach

The plurality of different moral approaches described above demonstrates that there can be no universally acceptable uniform law for ESC on a global scale. Instead of developing one standard, flexible ethical applications must be continued. We recommend local guidelines that incorporate important cultural and ethical priorities.

While the Declaration of Helsinki is more relevant to people in clinical trials receiving ESC products, in keeping with the tradition of protections for research subjects, consent of the donor is an ethical requirement for ESC donation in many jurisdictions including the US, Canada, and Europe. [69] The Declaration of Helsinki provides a reference point for regulatory standards and could potentially be used as a universal baseline for obtaining consent prior to gamete or embryo donation.

For instance, in Columbia University’s egg donor program for stem cell research, donors followed standard screening protocols and “underwent counseling sessions that included information as to the purpose of oocyte donation for research, what the oocytes would be used for, the risks and benefits of donation, and process of oocyte stimulation” to ensure transparency for consent. [70] The program helped advance stem cell research and provided clear and safe research methods with paid participants. Though paid participation or covering costs of incidental expenses may not be socially acceptable in every culture or context, [71] and creating embryos for ESC research is illegal in many jurisdictions, Columbia’s program was effective because of the clear and honest communications with donors, IRBs, and related stakeholders.  This example demonstrates that cultural acceptance of scientific research and of the idea that an egg or embryo does not have personhood is likely behind societal acceptance of donating eggs for ESC research. As noted, many countries do not permit the creation of embryos for research.

Proper communication and education regarding the process and purpose of stem cell research may bolster comprehension and garner more acceptance. “Given the sensitive subject material, a complete consent process can support voluntary participation through trust, understanding, and ethical norms from the cultures and morals participants value. This can be hard for researchers entering countries of different socioeconomic stability, with different languages and different societal values. [72]

An adequate moral foundation in medical ethics is derived from the cultural and religious basis that informs knowledge and actions. [73] Understanding local cultural and religious values and their impact on research could help researchers develop humility and promote inclusion.

IV.     Concerns

Some may argue that if researchers all adhere to one ethics standard, protection will be satisfied across all borders, and the global public will trust researchers. However, defining what needs to be protected and how to define such research standards is very specific to the people to which standards are applied. We suggest that applying one uniform guide cannot accurately protect each individual because we all possess our own perceptions and interpretations of social values. [74] Therefore, the issue of not adjusting to the moral pluralism between peoples in applying one standard of ethics can be resolved by building out ethics models that can be adapted to different cultures and religions.

Other concerns include medical tourism, which may promote health inequities. [75] Some countries may develop and approve products derived from ESC research before others, compromising research ethics or drug approval processes. There are also concerns about the sale of unauthorized stem cell treatments, for example, those without FDA approval in the United States. Countries with robust research infrastructures may be tempted to attract medical tourists, and some customers will have false hopes based on aggressive publicity of unproven treatments. [76]

For example, in China, stem cell clinics can market to foreign clients who are not protected under the regulatory regimes. Companies employ a marketing strategy of “ethically friendly” therapies. Specifically, in the case of Beike, China’s leading stem cell tourism company and sprouting network, ethical oversight of administrators or health bureaus at one site has “the unintended consequence of shifting questionable activities to another node in Beike's diffuse network.” [77] In contrast, Jordan is aware of stem cell research’s potential abuse and its own status as a “health-care hub.” Jordan’s expanded regulations include preserving the interests of individuals in clinical trials and banning private companies from ESC research to preserve transparency and the integrity of research practices. [78]

The social priorities of the community are also a concern. The ISSCR explicitly states that guidelines “should be periodically revised to accommodate scientific advances, new challenges, and evolving social priorities.” [79] The adaptable ethics model extends this consideration further by addressing whether research is warranted given the varying degrees of socioeconomic conditions, political stability, and healthcare accessibilities and limitations. An ethical approach would require discussion about resource allocation and appropriate distribution of funds. [80]

While some religions emphasize the sanctity of life from conception, which may lead to public opposition to ESC research, others encourage ESC research due to its potential for healing and alleviating human pain. Many countries have special regulations that balance local views on embryonic personhood, the benefits of research as individual or societal goods, and the protection of human research subjects. To foster understanding and constructive dialogue, global policy frameworks should prioritize the protection of universal human rights, transparency, and informed consent. In addition to these foundational global policies, we recommend tailoring local guidelines to reflect the diverse cultural and religious perspectives of the populations they govern. Ethics models should be adapted to local populations to effectively establish research protections, growth, and possibilities of stem cell research.

For example, in countries with strong beliefs in the moral sanctity of embryos or heavy religious restrictions, an adaptive model can allow for discussion instead of immediate rejection. In countries with limited individual rights and voice in science policy, an adaptive model ensures cultural, moral, and religious views are taken into consideration, thereby building social inclusion. While this ethical consideration by the government may not give a complete voice to every individual, it will help balance policies and maintain the diverse perspectives of those it affects. Embracing an adaptive ethics model of ESC research promotes open-minded dialogue and respect for the importance of human belief and tradition. By actively engaging with cultural and religious values, researchers can better handle disagreements and promote ethical research practices that benefit each society.

This brief exploration of the religious and cultural differences that impact ESC research reveals the nuances of relative ethics and highlights a need for local policymakers to apply a more intense adaptive model.

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[3] International Society for Stem Cell Research. (2023). Laboratory-based human embryonic stem cell research, embryo research, and related research activities . International Society for Stem Cell Research. https://www.isscr.org/guidelines/blog-post-title-one-ed2td-6fcdk ; Kimmelman, J., Hyun, I., Benvenisty, N.  et al.  Policy: Global standards for stem-cell research.  Nature   533 , 311–313 (2016). https://doi.org/10.1038/533311a

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[5] Concerning the moral philosophies of stem cell research, our paper does not posit a personal moral stance nor delve into the “when” of human life begins. To read further about the philosophical debate, consider the following sources:

Sandel M. J. (2004). Embryo ethics--the moral logic of stem-cell research.  The New England journal of medicine ,  351 (3), 207–209. https://doi.org/10.1056/NEJMp048145 ; George, R. P., & Lee, P. (2020, September 26). Acorns and Embryos . The New Atlantis. https://www.thenewatlantis.com/publications/acorns-and-embryos ; Sagan, A., & Singer, P. (2007). The moral status of stem cells. Metaphilosophy , 38 (2/3), 264–284. http://www.jstor.org/stable/24439776 ; McHugh P. R. (2004). Zygote and "clonote"--the ethical use of embryonic stem cells.  The New England journal of medicine ,  351 (3), 209–211. https://doi.org/10.1056/NEJMp048147 ; Kurjak, A., & Tripalo, A. (2004). The facts and doubts about beginning of the human life and personality.  Bosnian journal of basic medical sciences ,  4 (1), 5–14. https://doi.org/10.17305/bjbms.2004.3453

[6] Vazin, T., & Freed, W. J. (2010). Human embryonic stem cells: derivation, culture, and differentiation: a review.  Restorative neurology and neuroscience ,  28 (4), 589–603. https://doi.org/10.3233/RNN-2010-0543

[7] Socially, at its core, the Western approach to ethics is widely principle-based, autonomy being one of the key factors to ensure a fundamental respect for persons within research. For information regarding autonomy in research, see: Department of Health, Education, and Welfare, & National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research (1978). The Belmont Report. Ethical principles and guidelines for the protection of human subjects of research.; For a more in-depth review of autonomy within the US, see: Beauchamp, T. L., & Childress, J. F. (1994). Principles of Biomedical Ethics . Oxford University Press.

[8] Sherley v. Sebelius , 644 F.3d 388 (D.C. Cir. 2011), citing 45 C.F.R. 46.204(b) and [42 U.S.C. § 289g(b)]. https://www.cadc.uscourts.gov/internet/opinions.nsf/6c690438a9b43dd685257a64004ebf99/$file/11-5241-1391178.pdf

[9] Stem Cell Research Enhancement Act of 2005, H. R. 810, 109 th Cong. (2001). https://www.govtrack.us/congress/bills/109/hr810/text ; Bush, G. W. (2006, July 19). Message to the House of Representatives . National Archives and Records Administration. https://georgewbush-whitehouse.archives.gov/news/releases/2006/07/20060719-5.html

[10] National Archives and Records Administration. (2009, March 9). Executive order 13505 -- removing barriers to responsible scientific research involving human stem cells . National Archives and Records Administration. https://obamawhitehouse.archives.gov/the-press-office/removing-barriers-responsible-scientific-research-involving-human-stem-cells

[11] Hurlbut, W. B. (2006). Science, Religion, and the Politics of Stem Cells.  Social Research ,  73 (3), 819–834. http://www.jstor.org/stable/40971854

[12] Akpa-Inyang, Francis & Chima, Sylvester. (2021). South African traditional values and beliefs regarding informed consent and limitations of the principle of respect for autonomy in African communities: a cross-cultural qualitative study. BMC Medical Ethics . 22. 10.1186/s12910-021-00678-4.

[13] Source for further reading: Tangwa G. B. (2007). Moral status of embryonic stem cells: perspective of an African villager. Bioethics , 21(8), 449–457. https://doi.org/10.1111/j.1467-8519.2007.00582.x , see also Mnisi, F. M. (2020). An African analysis based on ethics of Ubuntu - are human embryonic stem cell patents morally justifiable? African Insight , 49 (4).

[14] Jecker, N. S., & Atuire, C. (2021). Bioethics in Africa: A contextually enlightened analysis of three cases. Developing World Bioethics , 22 (2), 112–122. https://doi.org/10.1111/dewb.12324

[15] Jecker, N. S., & Atuire, C. (2021). Bioethics in Africa: A contextually enlightened analysis of three cases. Developing World Bioethics, 22(2), 112–122. https://doi.org/10.1111/dewb.12324

[16] Jackson, C.S., Pepper, M.S. Opportunities and barriers to establishing a cell therapy programme in South Africa.  Stem Cell Res Ther   4 , 54 (2013). https://doi.org/10.1186/scrt204 ; Pew Research Center. (2014, May 1). Public health a major priority in African nations . Pew Research Center’s Global Attitudes Project. https://www.pewresearch.org/global/2014/05/01/public-health-a-major-priority-in-african-nations/

[17] Department of Health Republic of South Africa. (2021). Health Research Priorities (revised) for South Africa 2021-2024 . National Health Research Strategy. https://www.health.gov.za/wp-content/uploads/2022/05/National-Health-Research-Priorities-2021-2024.pdf

[18] Oosthuizen, H. (2013). Legal and Ethical Issues in Stem Cell Research in South Africa. In: Beran, R. (eds) Legal and Forensic Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-32338-6_80 , see also: Gaobotse G (2018) Stem Cell Research in Africa: Legislation and Challenges. J Regen Med 7:1. doi: 10.4172/2325-9620.1000142

[19] United States Bureau of Citizenship and Immigration Services. (1998). Tunisia: Information on the status of Christian conversions in Tunisia . UNHCR Web Archive. https://webarchive.archive.unhcr.org/20230522142618/https://www.refworld.org/docid/3df0be9a2.html

[20] Gaobotse, G. (2018) Stem Cell Research in Africa: Legislation and Challenges. J Regen Med 7:1. doi: 10.4172/2325-9620.1000142

[21] Kooli, C. Review of assisted reproduction techniques, laws, and regulations in Muslim countries.  Middle East Fertil Soc J   24 , 8 (2020). https://doi.org/10.1186/s43043-019-0011-0 ; Gaobotse, G. (2018) Stem Cell Research in Africa: Legislation and Challenges. J Regen Med 7:1. doi: 10.4172/2325-9620.1000142

[22] Pang M. C. (1999). Protective truthfulness: the Chinese way of safeguarding patients in informed treatment decisions. Journal of medical ethics , 25(3), 247–253. https://doi.org/10.1136/jme.25.3.247

[23] Wang, L., Wang, F., & Zhang, W. (2021). Bioethics in China’s biosecurity law: Forms, effects, and unsettled issues. Journal of law and the biosciences , 8(1).  https://doi.org/10.1093/jlb/lsab019 https://academic.oup.com/jlb/article/8/1/lsab019/6299199

[24] Wang, Y., Xue, Y., & Guo, H. D. (2022). Intervention effects of traditional Chinese medicine on stem cell therapy of myocardial infarction.  Frontiers in pharmacology ,  13 , 1013740. https://doi.org/10.3389/fphar.2022.1013740

[25] Li, X.-T., & Zhao, J. (2012). Chapter 4: An Approach to the Nature of Qi in TCM- Qi and Bioenergy. In Recent Advances in Theories and Practice of Chinese Medicine (p. 79). InTech.

[26] Luo, D., Xu, Z., Wang, Z., & Ran, W. (2021). China's Stem Cell Research and Knowledge Levels of Medical Practitioners and Students.  Stem cells international ,  2021 , 6667743. https://doi.org/10.1155/2021/6667743

[27] Luo, D., Xu, Z., Wang, Z., & Ran, W. (2021). China's Stem Cell Research and Knowledge Levels of Medical Practitioners and Students.  Stem cells international ,  2021 , 6667743. https://doi.org/10.1155/2021/6667743

[28] Zhang, J. Y. (2017). Lost in translation? accountability and governance of Clinical Stem Cell Research in China. Regenerative Medicine , 12 (6), 647–656. https://doi.org/10.2217/rme-2017-0035

[29] Wang, L., Wang, F., & Zhang, W. (2021). Bioethics in China’s biosecurity law: Forms, effects, and unsettled issues. Journal of law and the biosciences , 8(1).  https://doi.org/10.1093/jlb/lsab019 https://academic.oup.com/jlb/article/8/1/lsab019/6299199

[30] Chen, H., Wei, T., Wang, H.  et al.  Association of China’s two-child policy with changes in number of births and birth defects rate, 2008–2017.  BMC Public Health   22 , 434 (2022). https://doi.org/10.1186/s12889-022-12839-0

[31] Azuma, K. Regulatory Landscape of Regenerative Medicine in Japan.  Curr Stem Cell Rep   1 , 118–128 (2015). https://doi.org/10.1007/s40778-015-0012-6

[32] Harris, R. (2005, May 19). Researchers Report Advance in Stem Cell Production . NPR. https://www.npr.org/2005/05/19/4658967/researchers-report-advance-in-stem-cell-production

[33] Park, S. (2012). South Korea steps up stem-cell work.  Nature . https://doi.org/10.1038/nature.2012.10565

[34] Resnik, D. B., Shamoo, A. E., & Krimsky, S. (2006). Fraudulent human embryonic stem cell research in South Korea: lessons learned.  Accountability in research ,  13 (1), 101–109. https://doi.org/10.1080/08989620600634193 .

[35] Alahmad, G., Aljohani, S., & Najjar, M. F. (2020). Ethical challenges regarding the use of stem cells: interviews with researchers from Saudi Arabia. BMC medical ethics, 21(1), 35. https://doi.org/10.1186/s12910-020-00482-6

[36] Association for the Advancement of Blood and Biotherapies.  https://www.aabb.org/regulatory-and-advocacy/regulatory-affairs/regulatory-for-cellular-therapies/international-competent-authorities/saudi-arabia

[37] Alahmad, G., Aljohani, S., & Najjar, M. F. (2020). Ethical challenges regarding the use of stem cells: Interviews with researchers from Saudi Arabia.  BMC medical ethics ,  21 (1), 35. https://doi.org/10.1186/s12910-020-00482-6

[38] Alahmad, G., Aljohani, S., & Najjar, M. F. (2020). Ethical challenges regarding the use of stem cells: Interviews with researchers from Saudi Arabia. BMC medical ethics , 21(1), 35. https://doi.org/10.1186/s12910-020-00482-6

Culturally, autonomy practices follow a relational autonomy approach based on a paternalistic deontological health care model. The adherence to strict international research policies and religious pillars within the regulatory environment is a great foundation for research ethics. However, there is a need to develop locally targeted ethics approaches for research (as called for in Alahmad, G., Aljohani, S., & Najjar, M. F. (2020). Ethical challenges regarding the use of stem cells: interviews with researchers from Saudi Arabia. BMC medical ethics, 21(1), 35. https://doi.org/10.1186/s12910-020-00482-6), this decision-making approach may help advise a research decision model. For more on the clinical cultural autonomy approaches, see: Alabdullah, Y. Y., Alzaid, E., Alsaad, S., Alamri, T., Alolayan, S. W., Bah, S., & Aljoudi, A. S. (2022). Autonomy and paternalism in Shared decision‐making in a Saudi Arabian tertiary hospital: A cross‐sectional study. Developing World Bioethics , 23 (3), 260–268. https://doi.org/10.1111/dewb.12355 ; Bukhari, A. A. (2017). Universal Principles of Bioethics and Patient Rights in Saudi Arabia (Doctoral dissertation, Duquesne University). https://dsc.duq.edu/etd/124; Ladha, S., Nakshawani, S. A., Alzaidy, A., & Tarab, B. (2023, October 26). Islam and Bioethics: What We All Need to Know . Columbia University School of Professional Studies. https://sps.columbia.edu/events/islam-and-bioethics-what-we-all-need-know

[39] Ababneh, M. A., Al-Azzam, S. I., Alzoubi, K., Rababa’h, A., & Al Demour, S. (2021). Understanding and attitudes of the Jordanian public about clinical research ethics.  Research Ethics ,  17 (2), 228-241.  https://doi.org/10.1177/1747016120966779

[40] Ababneh, M. A., Al-Azzam, S. I., Alzoubi, K., Rababa’h, A., & Al Demour, S. (2021). Understanding and attitudes of the Jordanian public about clinical research ethics.  Research Ethics ,  17 (2), 228-241.  https://doi.org/10.1177/1747016120966779

[41] Dajani, R. (2014). Jordan’s stem-cell law can guide the Middle East.  Nature  510, 189. https://doi.org/10.1038/510189a

[42] Dajani, R. (2014). Jordan’s stem-cell law can guide the Middle East.  Nature  510, 189. https://doi.org/10.1038/510189a

[43] The EU’s definition of autonomy relates to the capacity for creating ideas, moral insight, decisions, and actions without constraint, personal responsibility, and informed consent. However, the EU views autonomy as not completely able to protect individuals and depends on other principles, such as dignity, which “expresses the intrinsic worth and fundamental equality of all human beings.” Rendtorff, J.D., Kemp, P. (2019). Four Ethical Principles in European Bioethics and Biolaw: Autonomy, Dignity, Integrity and Vulnerability. In: Valdés, E., Lecaros, J. (eds) Biolaw and Policy in the Twenty-First Century. International Library of Ethics, Law, and the New Medicine, vol 78. Springer, Cham. https://doi.org/10.1007/978-3-030-05903-3_3

[44] Council of Europe. Convention for the protection of Human Rights and Dignity of the Human Being with regard to the Application of Biology and Medicine: Convention on Human Rights and Biomedicine (ETS No. 164) https://www.coe.int/en/web/conventions/full-list?module=treaty-detail&treatynum=164 (forbidding the creation of embryos for research purposes only, and suggests embryos in vitro have protections.); Also see Drabiak-Syed B. K. (2013). New President, New Human Embryonic Stem Cell Research Policy: Comparative International Perspectives and Embryonic Stem Cell Research Laws in France.  Biotechnology Law Report ,  32 (6), 349–356. https://doi.org/10.1089/blr.2013.9865

[45] Rendtorff, J.D., Kemp, P. (2019). Four Ethical Principles in European Bioethics and Biolaw: Autonomy, Dignity, Integrity and Vulnerability. In: Valdés, E., Lecaros, J. (eds) Biolaw and Policy in the Twenty-First Century. International Library of Ethics, Law, and the New Medicine, vol 78. Springer, Cham. https://doi.org/10.1007/978-3-030-05903-3_3

[46] Tomuschat, C., Currie, D. P., Kommers, D. P., & Kerr, R. (Trans.). (1949, May 23). Basic law for the Federal Republic of Germany. https://www.btg-bestellservice.de/pdf/80201000.pdf

[47] Regulation of Stem Cell Research in Germany . Eurostemcell. (2017, April 26). https://www.eurostemcell.org/regulation-stem-cell-research-germany

[48] Regulation of Stem Cell Research in Finland . Eurostemcell. (2017, April 26). https://www.eurostemcell.org/regulation-stem-cell-research-finland

[49] Regulation of Stem Cell Research in Spain . Eurostemcell. (2017, April 26). https://www.eurostemcell.org/regulation-stem-cell-research-spain

[50] Some sources to consider regarding ethics models or regulatory oversights of other cultures not covered:

Kara MA. Applicability of the principle of respect for autonomy: the perspective of Turkey. J Med Ethics. 2007 Nov;33(11):627-30. doi: 10.1136/jme.2006.017400. PMID: 17971462; PMCID: PMC2598110.

Ugarte, O. N., & Acioly, M. A. (2014). The principle of autonomy in Brazil: one needs to discuss it ...  Revista do Colegio Brasileiro de Cirurgioes ,  41 (5), 374–377. https://doi.org/10.1590/0100-69912014005013

Bharadwaj, A., & Glasner, P. E. (2012). Local cells, global science: The rise of embryonic stem cell research in India . Routledge.

For further research on specific European countries regarding ethical and regulatory framework, we recommend this database: Regulation of Stem Cell Research in Europe . Eurostemcell. (2017, April 26). https://www.eurostemcell.org/regulation-stem-cell-research-europe   

[51] Klitzman, R. (2006). Complications of culture in obtaining informed consent. The American Journal of Bioethics, 6(1), 20–21. https://doi.org/10.1080/15265160500394671 see also: Ekmekci, P. E., & Arda, B. (2017). Interculturalism and Informed Consent: Respecting Cultural Differences without Breaching Human Rights.  Cultura (Iasi, Romania) ,  14 (2), 159–172.; For why trust is important in research, see also: Gray, B., Hilder, J., Macdonald, L., Tester, R., Dowell, A., & Stubbe, M. (2017). Are research ethics guidelines culturally competent?  Research Ethics ,  13 (1), 23-41.  https://doi.org/10.1177/1747016116650235

[52] The Qur'an  (M. Khattab, Trans.). (1965). Al-Mu’minun, 23: 12-14. https://quran.com/23

[53] Lenfest, Y. (2017, December 8). Islam and the beginning of human life . Bill of Health. https://blog.petrieflom.law.harvard.edu/2017/12/08/islam-and-the-beginning-of-human-life/

[54] Aksoy, S. (2005). Making regulations and drawing up legislation in Islamic countries under conditions of uncertainty, with special reference to embryonic stem cell research. Journal of Medical Ethics , 31: 399-403.; see also: Mahmoud, Azza. "Islamic Bioethics: National Regulations and Guidelines of Human Stem Cell Research in the Muslim World." Master's thesis, Chapman University, 2022. https://doi.org/10.36837/ chapman.000386

[55] Rashid, R. (2022). When does Ensoulment occur in the Human Foetus. Journal of the British Islamic Medical Association , 12 (4). ISSN 2634 8071. https://www.jbima.com/wp-content/uploads/2023/01/2-Ethics-3_-Ensoulment_Rafaqat.pdf.

[56] Sivaraman, M. & Noor, S. (2017). Ethics of embryonic stem cell research according to Buddhist, Hindu, Catholic, and Islamic religions: perspective from Malaysia. Asian Biomedicine,8(1) 43-52.  https://doi.org/10.5372/1905-7415.0801.260

[57] Jafari, M., Elahi, F., Ozyurt, S. & Wrigley, T. (2007). 4. Religious Perspectives on Embryonic Stem Cell Research. In K. Monroe, R. Miller & J. Tobis (Ed.),  Fundamentals of the Stem Cell Debate: The Scientific, Religious, Ethical, and Political Issues  (pp. 79-94). Berkeley: University of California Press.  https://escholarship.org/content/qt9rj0k7s3/qt9rj0k7s3_noSplash_f9aca2e02c3777c7fb76ea768ba458f0.pdf https://doi.org/10.1525/9780520940994-005

[58] Lecso, P. A. (1991). The Bodhisattva Ideal and Organ Transplantation.  Journal of Religion and Health ,  30 (1), 35–41. http://www.jstor.org/stable/27510629 ; Bodhisattva, S. (n.d.). The Key of Becoming a Bodhisattva . A Guide to the Bodhisattva Way of Life. http://www.buddhism.org/Sutras/2/BodhisattvaWay.htm

[59] There is no explicit religious reference to when life begins or how to conduct research that interacts with the concept of life. However, these are relevant verses pertaining to how the fetus is viewed. (( King James Bible . (1999). Oxford University Press. (original work published 1769))

Jerimiah 1: 5 “Before I formed thee in the belly I knew thee; and before thou camest forth out of the womb I sanctified thee…”

In prophet Jerimiah’s insight, God set him apart as a person known before childbirth, a theme carried within the Psalm of David.

Psalm 139: 13-14 “…Thou hast covered me in my mother's womb. I will praise thee; for I am fearfully and wonderfully made…”

These verses demonstrate David’s respect for God as an entity that would know of all man’s thoughts and doings even before birth.

[60] It should be noted that abortion is not supported as well.

[61] The Vatican. (1987, February 22). Instruction on Respect for Human Life in Its Origin and on the Dignity of Procreation Replies to Certain Questions of the Day . Congregation For the Doctrine of the Faith. https://www.vatican.va/roman_curia/congregations/cfaith/documents/rc_con_cfaith_doc_19870222_respect-for-human-life_en.html

[62] The Vatican. (2000, August 25). Declaration On the Production and the Scientific and Therapeutic Use of Human Embryonic Stem Cells . Pontifical Academy for Life. https://www.vatican.va/roman_curia/pontifical_academies/acdlife/documents/rc_pa_acdlife_doc_20000824_cellule-staminali_en.html ; Ohara, N. (2003). Ethical Consideration of Experimentation Using Living Human Embryos: The Catholic Church’s Position on Human Embryonic Stem Cell Research and Human Cloning. Department of Obstetrics and Gynecology . Retrieved from https://article.imrpress.com/journal/CEOG/30/2-3/pii/2003018/77-81.pdf.

[63] Smith, G. A. (2022, May 23). Like Americans overall, Catholics vary in their abortion views, with regular mass attenders most opposed . Pew Research Center. https://www.pewresearch.org/short-reads/2022/05/23/like-americans-overall-catholics-vary-in-their-abortion-views-with-regular-mass-attenders-most-opposed/

[64] Rosner, F., & Reichman, E. (2002). Embryonic stem cell research in Jewish law. Journal of halacha and contemporary society , (43), 49–68.; Jafari, M., Elahi, F., Ozyurt, S. & Wrigley, T. (2007). 4. Religious Perspectives on Embryonic Stem Cell Research. In K. Monroe, R. Miller & J. Tobis (Ed.),  Fundamentals of the Stem Cell Debate: The Scientific, Religious, Ethical, and Political Issues  (pp. 79-94). Berkeley: University of California Press.  https://escholarship.org/content/qt9rj0k7s3/qt9rj0k7s3_noSplash_f9aca2e02c3777c7fb76ea768ba458f0.pdf https://doi.org/10.1525/9780520940994-005

[65] Schenker J. G. (2008). The beginning of human life: status of embryo. Perspectives in Halakha (Jewish Religious Law).  Journal of assisted reproduction and genetics ,  25 (6), 271–276. https://doi.org/10.1007/s10815-008-9221-6

[66] Ruttenberg, D. (2020, May 5). The Torah of Abortion Justice (annotated source sheet) . Sefaria. https://www.sefaria.org/sheets/234926.7?lang=bi&with=all&lang2=en

[67] Jafari, M., Elahi, F., Ozyurt, S. & Wrigley, T. (2007). 4. Religious Perspectives on Embryonic Stem Cell Research. In K. Monroe, R. Miller & J. Tobis (Ed.),  Fundamentals of the Stem Cell Debate: The Scientific, Religious, Ethical, and Political Issues  (pp. 79-94). Berkeley: University of California Press.  https://escholarship.org/content/qt9rj0k7s3/qt9rj0k7s3_noSplash_f9aca2e02c3777c7fb76ea768ba458f0.pdf https://doi.org/10.1525/9780520940994-005

[68] Gert, B. (2007). Common morality: Deciding what to do . Oxford Univ. Press.

[69] World Medical Association (2013). World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA , 310(20), 2191–2194. https://doi.org/10.1001/jama.2013.281053 Declaration of Helsinki – WMA – The World Medical Association .; see also: National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research. (1979).  The Belmont report: Ethical principles and guidelines for the protection of human subjects of research . U.S. Department of Health and Human Services.  https://www.hhs.gov/ohrp/regulations-and-policy/belmont-report/read-the-belmont-report/index.html

[70] Zakarin Safier, L., Gumer, A., Kline, M., Egli, D., & Sauer, M. V. (2018). Compensating human subjects providing oocytes for stem cell research: 9-year experience and outcomes.  Journal of assisted reproduction and genetics ,  35 (7), 1219–1225. https://doi.org/10.1007/s10815-018-1171-z https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063839/ see also: Riordan, N. H., & Paz Rodríguez, J. (2021). Addressing concerns regarding associated costs, transparency, and integrity of research in recent stem cell trial. Stem Cells Translational Medicine , 10 (12), 1715–1716. https://doi.org/10.1002/sctm.21-0234

[71] Klitzman, R., & Sauer, M. V. (2009). Payment of egg donors in stem cell research in the USA.  Reproductive biomedicine online ,  18 (5), 603–608. https://doi.org/10.1016/s1472-6483(10)60002-8

[72] Krosin, M. T., Klitzman, R., Levin, B., Cheng, J., & Ranney, M. L. (2006). Problems in comprehension of informed consent in rural and peri-urban Mali, West Africa.  Clinical trials (London, England) ,  3 (3), 306–313. https://doi.org/10.1191/1740774506cn150oa

[73] Veatch, Robert M.  Hippocratic, Religious, and Secular Medical Ethics: The Points of Conflict . Georgetown University Press, 2012.

[74] Msoroka, M. S., & Amundsen, D. (2018). One size fits not quite all: Universal research ethics with diversity.  Research Ethics ,  14 (3), 1-17.  https://doi.org/10.1177/1747016117739939

[75] Pirzada, N. (2022). The Expansion of Turkey’s Medical Tourism Industry.  Voices in Bioethics ,  8 . https://doi.org/10.52214/vib.v8i.9894

[76] Stem Cell Tourism: False Hope for Real Money . Harvard Stem Cell Institute (HSCI). (2023). https://hsci.harvard.edu/stem-cell-tourism , See also: Bissassar, M. (2017). Transnational Stem Cell Tourism: An ethical analysis.  Voices in Bioethics ,  3 . https://doi.org/10.7916/vib.v3i.6027

[77] Song, P. (2011) The proliferation of stem cell therapies in post-Mao China: problematizing ethical regulation,  New Genetics and Society , 30:2, 141-153, DOI:  10.1080/14636778.2011.574375

[78] Dajani, R. (2014). Jordan’s stem-cell law can guide the Middle East.  Nature  510, 189. https://doi.org/10.1038/510189a

[79] International Society for Stem Cell Research. (2024). Standards in stem cell research . International Society for Stem Cell Research. https://www.isscr.org/guidelines/5-standards-in-stem-cell-research

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Mifrah Hayath

SM Candidate Harvard Medical School, MS Biotechnology Johns Hopkins University

Olivia Bowers

MS Bioethics Columbia University (Disclosure: affiliated with Voices in Bioethics)

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Leveraging collective action and environmental literacy to address complex sustainability challenges

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  • Volume 52 , pages 30–44, ( 2023 )

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  • Nicole M. Ardoin   ORCID: orcid.org/0000-0002-3290-8211 1 ,
  • Alison W. Bowers 2 &
  • Mele Wheaton 3  

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Developing and enhancing societal capacity to understand, debate elements of, and take actionable steps toward a sustainable future at a scale beyond the individual are critical when addressing sustainability challenges such as climate change, resource scarcity, biodiversity loss, and zoonotic disease. Although mounting evidence exists for how to facilitate individual action to address sustainability challenges, there is less understanding of how to foster collective action in this realm. To support research and practice promoting collective action to address sustainability issues, we define the term “collective environmental literacy” by delineating four key potent aspects: scale, dynamic processes, shared resources, and synergy. Building on existing collective constructs and thought, we highlight areas where researchers, practitioners, and policymakers can support individuals and communities as they come together to identify, develop, and implement solutions to wicked problems. We close by discussing limitations of this work and future directions in studying collective environmental literacy.

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Introduction

For socio-ecologically intertwined issues—such as climate change, land conversion, biodiversity loss, resource scarcity, and zoonotic diseases—and their associated multi-decadal timeframes, individual action is necessary, yet not sufficient, for systemic, sustained change (Amel et al. 2017 ; Bodin 2017 ; Niemiec et al. 2020 ; Spitzer and Fraser 2020 ). Instead, collective action, or individuals working together toward a common good, is essential for achieving the scope and scale of solutions to current sustainability challenges. To support communities as they engage in policy and action for socio-environmental change, communicators, land managers, policymakers, and other practitioners need an understanding of how communities coalesce and leverage their shared knowledge, skills, connections, and experiences.

Engagement efforts, such as those grounded in behavior-change approaches or community-based social marketing initiatives, that address socio-environmental issues have often emphasized individuals as the pathway to change. Such efforts address a range of domains including, but not limited to, residential energy use, personal transportation choices, and workplace recycling efforts, often doing so in a stepwise fashion, envisioning each setting or suite of behaviors as discrete spheres of action and influence (Heimlich and Ardoin 2008 ; McKenzie-Mohr 2011 ). In this way, specific actions are treated incrementally and linearly, considering first the individual barriers to be removed and then the motivations to be activated (and, sometimes, sustained; Monroe 2003 ; Gifford et al. 2011 ). Once each behavior is successfully instantiated, the next barrier is then addressed. Proceeding methodically from one action to the next, such initiatives often quite successfully alter a series of actions or group of related behaviors (at least initially) by addressing them incrementally, one at a time (Byerly et al. 2018 ). Following this aspirational logic chain, many resources have been channeled into such programs under the assumption that, by raising awareness and knowledge, such information, communication, and educational outreach efforts will shift attitudes and behaviors to an extent that, ultimately, mass-scale change will follow. (See discussion in Wals et al. 2014 .)

Numerous studies have demonstrated, however, that challenges arise with these stepwise approaches, particularly with regard to their ability to address complex issues and persist over time (Heimlich and Ardoin 2008 ; Wals et al. 2014 ). Such approaches place a tremendous—and unrealistic—burden on individuals, ignoring key aspects not only of behavioral science but also of social science more broadly, including the view that humans exist nested within socio-ecological systems and, thus, are most successful at achieving lasting change when it is meaningful, relevant, and undertaken within a supportive context (Swim et al. 2011 ; Feola 2015 ). Individualized approaches often require multiple steps or nudges (Byerly et al. 2018 ), or ongoing reminders to retain their salience (Stern et al. 2008 ). Because of the emphasis on decontextualized action, such approaches can miss, ignore, obfuscate, or minimize the importance of the bigger picture, which includes the sociocultural, biophysical, and political economic contexts (Ardoin 2006 ; Amel et al. 2017 ). Although the tightly trained focus on small, actionable steps and reliance on individual willpower may help in initially achieving success with initial habit formation (Carden and Wood 2018 ), it becomes questionable in terms of bringing about a wave of transformation on larger scales in the longer term. For those decontextualized actions to persist, they require continued prompting, constancy, and support in the social and biophysical context (Schultz 2014 ; Manfredo et al. 2016 ; Wood and Rünger 2016 ).

Less common in practice are theoretically based initiatives that embrace the holistic nature of the human experience, which occurs within complex systems spanning time and space in a multidimensional, weblike fashion (Bronfenbrenner 1979 ; Rogoff 2003 ; Barron 2006 ; DeCaro and Stokes 2008 ; Gould et al. 2019 ; Hovardas 2020 ). These systems-thinking approaches, while varying across disciplines and epistemological perspectives, envision human experiences, including learning and behavior, as occurring within a milieu that include the social, political, cultural, and historical contexts (Rogoff 2003 ; Roth and Lee 2007 ; Swim et al. 2011 ; Gordon 2019 ). In such a view, people’s everyday practices continuously reflect and grow out of past learning and experiences, not only at the individual, but also at the collective level (Lave 1991 ; Gutiérrez and Rogoff 2003 ; Nasir et al. 2020 ; Ardoin and Heimlich 2021 ). The multidimensional context in which we exist—including the broader temporal and spatial ecosystem—both facilitates and constrains our actions.

Scholars across diverse areas of study discuss the need for and power of collective thought and action, using various conceptual frames, models, and terms, such as collective action, behavior, impact, and intelligence; collaborative governance; communities of practice; crowdsourcing; and social movement theory; among many others (Table 1 ). These scholars acknowledge and explore the influence of our multidimensional context on collective thought and action. In this paper, we explore the elements and processes that constitute collective environmental literacy . We draw on the vast, relevant literature and, in so doing, we attempt to invoke the power of the collective: by reviewing and synthesizing ideas from a variety of fields, we strive to leverage existing constructs and perspectives that explore notions of the “collective” (see Table 1 for a summary of constructs and theories reviewed to develop our working definition of collective environmental literacy). A primary goal of this paper is to dialogue with other researchers and practitioners working in this arena who are eager to uncover and further explore related avenues.

First, we present a formal definition of collective environmental literacy. Next, we briefly review the dominant view of environmental literacy at the individual level and, in support of a collective take on environmental literacy, we examine various collective constructs. We then delve more deeply into the definition of collective environmental literacy by outlining four key aspects: scale, dynamic processes, shared resources, and synergy. We conclude by providing suggestions for future directions in studying collective environmental literacy.

Defining collective environmental literacy

Decades of research in political science, economics, anthropology, sociology, psychology, and the learning sciences, among other fields (Chawla and Cushing 2007 ; Ostrom 2009 ; Sawyer 2014 ; Bamberg et al. 2015 ; Chan 2016 ; Jost et al. 2017 ) repeatedly demonstrates the effectiveness, and indeed necessity of, collective action when addressing problems that are inherently social in nature. Yet theoretical frameworks and empirical documentation emphasize that such collective activities rarely arise spontaneously and, when they do, are a result of preconditions that have sown fertile ground (van Zomeren et al. 2008 ; Duncan 2018 ). Persistent and effective collective action then requires scaffolding in the form of institutional, sociocultural, and political economic structure that provides ongoing support. To facilitate discussions of how to effectively support collective action around sustainability issues, we suggest the concept of “collective environmental literacy.” We conceptualize collective environmental literacy as more than collective action; rather, we suggest that the term encapsulates action along with its various supporting structures and resources. Additionally, we employ the word “literacy” as it connotes learning, intention, and the idea that knowledge, skills, attitudes, and behaviors can be enhanced iteratively over time. By using “literacy,” we strive to highlight the efforts, often unseen, that lead to effective collective action in communities. We draw on scholarship in science and health education, areas that have begun over the past two decades to theorize about related areas of collective science literacy (Roth and Lee 2002 , 2004 ; Lee and Roth 2003 ; Feinstein 2018 ) and health literacy (Freedman et al. 2009 ; Papen 2009 ; Chinn 2011 ; Guzys et al. 2015 ). Although these evolving constructs lack consensus definitions, they illuminate affordances and constraints that exist when conceptualizing collective environmental literacy (National Academies of Sciences, Engineering, and Medicine [NASEM] 2016 ).

Some of the key necessary—but not sufficient—conditions that facilitate aligned, collective actions include a common body of decision-making information; shared attitudes, values, and beliefs toward a motivating issue or concern; and efficacy skills that facilitate change-making (Sturmer and Simon 2004 ; van Zomeren et al. 2008 ; Jagers et al. 2020 ). In addition, other contextual factors are essential, such as trust, reciprocity, collective efficacy, and communication among group members and societal-level facilitators, such as social norms, institutions, and technology (Bandura 2000 ; Ostrom 2010 ; McAdam and Boudet 2012 ; Jagers et al. 2020 ). Taken together, we term this body of knowledge, dispositions, skills, and the context in which they flourish collective environmental literacy . More formally, we define collective environmental literacy as: a dynamic, synergistic process that occurs as group members develop and leverage shared resources to undertake individual and aggregate actions over time to address sustainability issues within the multi-scalar context of a socio-environmental system (Fig.  1 ).

figure 1

Key elements of collective environmental literacy

Environmental literacy: Historically individual, increasingly collective

Over the past five decades, the term “environmental literacy” has come into increasingly frequent use. Breaking from the traditional association of “literacy” with reading and writing in formal school contexts, environmental literacy emphasizes associations with character and behavior, often in the form of responsible environmental stewardship (Roth 1992 ). Footnote 1 Such perspectives define the concept as including affective (attitudinal), cognitive (knowledge-based), and behavioral domains, emphasizing that environmental literacy is both a process and outcome that develops, builds, and morphs over time (Hollweg et al. 2011 ; Wheaton et al. 2018 ; Clark et al. 2020 ).

The emphasis on defining, measuring, and developing interventions to bring about environmental literacy has primarily remained at the individual scale, as evidenced by frequent descriptions of an environmentally literate person (Roth 1992 ; Hollweg et al. 2011 among others) rather than community or community member. In most understandings, discussions, and manifestations of environmental literacy, the implicit assumption remains that the unit of action, intervention, and therefore analysis occurs at the individual level. Yet instinctively and perhaps by nature, community members often seek information and, as a result, take action collectively, sharing what some scholars call “the hive mind” or “group mind,” relying on each other for distributed knowledge, expertise, motivation, and support (Surowiecki 2005 ; Sunstein 2008 ; Sloman and Fernbach 2017 ; Paul 2021 ).

As with the proverbial elephant (Saxe, n.d.), each person, household, or neighborhood group may understand or “see” a different part of an issue or challenge, bring a novel understanding to the table, and have a certain perspective or skill to contribute. Although some environmental literacy discussions allude to a collective lens (e.g., Hollweg et al. 2011 ; Ardoin et al. 2013 ; Wheaton et al. 2018 ; Bey et al. 2020 ), defining, developing frameworks, and creating measures to assess the efficacy of such collective-scale sustainability-related endeavors has remained elusive. Footnote 2 Looking to related fields and disciplines—such as ecosystem theory, epidemiology and public health, sociology, network theory, and urban planning, among others—can provide insight, theoretical frames, and empirical examples to assist in such conceptualizations (McAdam and Boudet 2012 ; National Research Council 2015 ) (See Table 1 for an overview of some of the many areas of study that informed our conceptualization of collective environmental literacy).

Seeking the essence of the collective: Looking to and learning from others

The social sciences have long focused on “the kinds of activities engaged in by sizable but loosely organized groups of people” (Turner et al. 2020 , para. 1) and addressed various collective constructs, such as collective behavior, action, intelligence, and memory (Table 1 ). Although related constructs in both the social and natural sciences—such as communities of practice (Wenger and Snyder 2000 ), collaborative governance (Ansell and Gash 2008 ; Emerson et al. 2012 ), and the collaboration–coordination continuum (Sadoff and Grey 2005 ; Prager 2015 ), as well as those from social movement theory and related areas (McAdam and Boudet 2012 ; de Moor and Wahlström 2019 )—lack the word “collective” in name, they too leverage the benefits of collectivity. A central tenet connects all of these areas: powerful processes, actions, and outcomes can arise when individuals coalesce around a common purpose or cause. This notion of a dynamic, potent force transcending the individual to enhance the efficacy of outcomes motivates the application of a collective lens to the environmental literacy concept.

Dating to the 1800s, discussions of collective behavior have explored connections to social order, structures, and norms (Park 1927 ; Smelser 2011 /1962; Turner and Killian 1987 ). Initially, the focus emphasized spontaneous, often violent crowd behaviors, such as riots, mobs, and rebellions. More contemporarily, sociologists, political scientists, and others who study social movements and collective behaviors acknowledge that such phenomena may take many forms, including those occurring in natural ecosystems, such as ant colonies, bird flocks, and even the human brain (Gordon 2019 ). In sociology, collective action represents a paradigm shift highlighting coordinated, purposeful pro-social movements, while de-emphasizing aroused emotions and crowd behavior (Miller 2014 ). In political science, Ostrom’s ( 1990 , 2000 , 2010 ) theory of collective action in the context of the management of shared resources extends the concept’s reach to economics and other fields. In education and the learning sciences, social learning and sociocultural theories tap into the idea of learning as a social-cognitive-cultural endeavor (Vygotsky 1980 ; Lave and Wenger 1991 ; Tudge and Winterhoff 1993 ; Rogoff 2003 ; Reed et al. 2010 ).

Collective action, specifically, and collective constructs, generally, have found their way into the research and practice in the fields of conservation, natural resources, and environmental management. Collective action theory has been applied in a range of settings and scenarios, including agriculture (Mills et al. 2011 ), invasive species management (Marshall et al. 2016 ; Sullivan et al. 2017 ; Lubeck et al. 2019 ; Clarke et al. 2021 ), fire management (Canadas et al. 2016 ; Charnley et al. 2020 ), habitat conservation (Raymond 2006 ; Niemiec et al. 2020 ), and water governance (Lopez-Gunn 2003 ; Baldwin et al. 2018 ), among others. Frameworks and methods that emphasize other collective-related ideas—like collaboration, co-production, and group learning—are also ubiquitous in natural resource and environmental management. These constructs include community-based conservation (DeCaro and Stokes 2008 ; Niemiec et al. 2016 ), community natural resource management (Kellert et al. 2000 ; Dale et al. 2020 ), collaboration/coordination (Sadoff and Grey 2005 ; Prager 2015 ), polycentricity (Galaz et al. 2012 ; Heikkila et al. 2018 ), knowledge co-production (Armitage et al. 2011 ; Singh et al. 2021 ), and social learning (Reed et al. 2010 ; Hovardas 2020 ). Many writings on collective efforts in the social sciences broadly, and applied in the area of environment specifically, provide insights into collective action’s necessary preconditions, which prove invaluable to further defining and later operationalizing collective environmental literacy.

Unpacking the definition of collective environmental literacy: Anchoring principles

As described, we propose the following working definition of collective environmental literacy drawing on our analysis of related literatures and informed by scholarly and professional experience in the sustainability and conservation fields: a dynamic, synergistic process that occurs as group members develop and leverage shared resources to undertake individual and aggregate actions over time to address sustainability issues within the multi-scalar context of a socio-environmental system (Fig.  1 ). This definition centers on four core, intertwined ideas: the scale of the group involved; the dynamic nature of the process; shared resources brought by, available to, and needed by the group; and the synergy that arises from group interaction.

Multi-scalar

When transitioning from the focus on individual to collective actions—and, herein, principles of environmental literacy—the most obvious and primary requisite shift is one of scale. Yet, moving to a collective scale does not mean abandoning action at the individual scale; rather, success at the collective level is intrinsically tied to what occurs at an individual level. Such collective-scale impacts leverage the power of the hive, harnessing people’s willingness, ability, and motivation to take action alongside others, share their ideas and resources to build collective ideas and resources, contribute to making a difference in an impactful way, and participate communally in pro-social activities.

Collective environmental literacy is likely dynamic in its orientation to scale, incorporating place-based notions, such as ecoregional or community-level environmental literacy (with an emphasis on geographic boundaries). On the other hand, it may encapsulate environmental literacy of a group or organization united by a common identity (e.g., organizational membership) or cause (e.g., old-growth forests, coastal protection), rather than solely or even primarily by geography. Although shifting scales can make measuring collective environmental literacy more difficult, dynamic levels may be a benefit when addressing planetary boundary issues such as climate change, biodiversity, and ocean acidification (Galaz et al. 2012 ). Some scholars have called for a polycentric approach to these large-scale issues in response to a perceived failure of global-wide, top-down solutions (Ostrom 2010 , 2012 ; Jordan et al. 2018 ). Conceptualizing and consequently supporting collective environmental literacy at multiple scales can facilitate such desired polycentricity.

Rather than representing a static outcome, environmental literacy is a dynamic process that is fluctuating and complex, reflective of iterative interactions among community members, whose discussions and negotiations reflect the changing context of sustainability issues. Footnote 3 Such open-minded processes allow for, and indeed welcome, adaptation in a way that builds social-ecological resilience (Berkes and Jolly 2002 ; Adger et al. 2005 ; Berkes 2007 ). Additionally, this dynamism allows for collective development and maturation, supporting community growth in collective knowledge, attitudes, skills, and actions via new experiences, interactions, and efforts (Berkman et al. 2010 ). With this mindset, and within a sociocultural perspective, collective environmental literacy evolves through drawing on and contributing to the community’s funds of knowledge (González et al. 2006 ). Movement and actions within and among groups impact collective literacy, as members share knowledge and other resources, shifting individuals and the group in the course of their shared practices (Samerski 2019 ).

In a collective mode, effectiveness is heightened as shared resources are streamlined, waste is minimized, and innovation maximized. Rather than each group member developing individual expertise in every matter of concern, the shared knowledge, skills, and behaviors can be distributed, pursued, and amplified among group members efficiently and effectively, with collective literacy emerging from the process of pooling diverse forms of capital and aggregating resources. This perspective builds on ideas of social capital as a collective good (Ostrom 1990 ; Putnam 2020 ), wherein relationships of trust and reciprocity are both inputs and outcomes (Pretty and Ward 2001 ). The shared resources then catalyze and sustain action as they are reassembled and coalesced at the group level for collective impact.

The pooled resources—likely vast—may include, but are not limited to, physical and human resources, funding, time, energy, and space and place (physical or digital). Shared resources may also include forms of theorized capital, such as intellectual and social (Putnam 2020 ). Also of note is the recognition that these resources extend far beyond information and knowledge. Of particular interest when building collective environmental literacy are resources previously ignored or overlooked by those in power in prior sustainability efforts. For example, collective environmental literacy can draw strength from shared resources unique to the community or even subgroups within the larger community. Discussions of Indigenous knowledge (Gadgil et al. 1993 ) and funds of knowledge (González et al. 2006 ; Cruz et al. 2018 ) suggest critical, shared resources that highlight strengths of an individual community and its members. Another dimension of shared resources relates to the strength of institutional connections, such as the benefits that accrue from leveraging the collective knowledge, expertise, and resources of organizational collaborators working in adjacent areas to further and amplify each other’s impact (Wojcik et al. 2021 ).

Synergistic

Finally, given the inherent complexities related to defining, deploying, implementing, and measuring these dynamic, at-times ephemeral processes, resources, and outcomes at a collective scale, working in such a manner must be clearly advantageous to pressing sustainability issues at hand. Numerous related constructs and approaches from a range of fields emphasize the benefits of diverse collaboration to collective thought and action, including improved solutions, more effective and fair processes, and more socioculturally just outcomes (Klein 1990 ; Jörg 2011 ; Wenger and Snyder 2000 ; Djenontin and Meadow 2018 ). These benefits go beyond efficient aggregation and distribution of resources, invoking an almost magical quality that defines synergy, resulting in robust processes and outcomes that are more than the sum of the parts.

This synergy relies on the diversity of a group across various dimensions, bringing power, strength, and insight to a decision-making process (Bear and Woolley 2011 ; Curşeu and Pluut 2013 ; Freeman and Huang 2015 ; Lu et al. 2017 ; Bendor and Page 2019 ). Individuals are limited not only to singular knowledge-perspectives and skillsets, but also to their own experiences, which influence their self-affirming viewpoints and tendencies to seek out confirmatory information for existing beliefs (Kahan et al. 2011 ). Although the coming together of those from different racial, cultural, social, and economic backgrounds facilitates a collective literacy process that draws on a wider range of resources and equips a gestalt, it also sets up the need to consider issues of power, privilege, voice, and representation (Bäckstrand 2006 ) and the role of social capital, leading to questions related to trust and reciprocity in effective collectives (Pretty and Ward 2001 ; Folke et al. 2005 ).

Leveraging the ‘Hive’: Proceeding with collective environmental literacy

This paper presents one conceptualization of collective environmental literacy, with the understanding that numerous ways exist to envision its definition, formation, deployment, and measurement. Characterized by a collective effort, such literacies at scale offer a way to imagine, measure, and support the synergy that occurs when the emphasis moves from an individual to a larger whole. By expanding the scale and focusing on shared responsibility among actors at the systems level, opportunities arise for inspiring and enabling a broader contribution to a sustainable future. These evolving notions serve to invite ongoing conversation, both in research and practice, about how to enact our collective responsibility toward, as well as vision of, a thriving future.

Emerging from the many discussions of shared and collaborative efforts to address socio-environmental issues, our conceptualization of collective environmental literacy is a first step toward supporting communities as they work to identify, address, and solve sustainability problems. We urge continued discussions on this topic, with the goal of understanding the concept of collective environmental literacy, how to measure it, and the implications of this work for practitioners. The conceptual roots of collective environmental literacy reach into countless fields of study and, as such, a transdisciplinary approach, which includes an eye toward practice, is necessary to fully capture and maximize the tremendous amount of knowledge, wisdom, and experience around this topic. Specifically, next steps to evolve the concept include engaging sustainability researchers and practitioners in discussions of the saliency of the presented definition of collective environmental literacy. These discussions include verifying the completeness of the definition and ensuring a thorough review of relevant research: Are parts of the definition missing or unclear? What are the “blank, blind, bald, and bright spots” in the literature (Reid 2019 p. 158)? Additionally, recognizing and leveraging literacy at a collective scale most certainly is not unique to environmental work, nor is adopting literacy-related language to conceptualize and measure process outcomes, although the former has consistently proven more challenging. Moreover, although we (the authors) appreciate the connotations and structures gained by using a literacy framework, we struggle with whether “environmental literacy” is the most appropriate and useful term for the conceptualizations as described herein; we, thus, welcome lively discussions about the need for new terminology.

Even at this early stage of conceptualization, this work has implications for practitioners. For scientists, communicators, policymakers, land managers, and other professionals desiring to work with communities to address sustainability issues, a primary take-away message concerns the holistic nature of what is needed for effective collective action in the environmental realm. Many previous efforts have focused on conveying information and, while a lack of knowledge and awareness may be a barrier to action in some cases, the need for a more holistic lens is increasingly clear. This move beyond an individually focused, information-deficit model is essential for effective impact (Bolderdijk et al. 2013 ; van der Linden 2014 ; Geiger et al. 2019 ). The concept of collective environmental literacy suggests a role for developing shared resources that can foster effective collective action. When working with communities, a critical early step includes some form of needs assessment—a systematic, in-depth process that allows for meaningfully gauging gaps in shared resources required to tackle sustainability issues (Braus 2011). Following this initial, evaluative step, an understanding of the components of collective environmental literacy, as outlined in this paper, can be used to guide the development of interventions to support communities in their efforts to address those issues.

Growing discussion of collective literacy constructs, and related areas, suggests researchers, practitioners, and policymakers working in pro-social areas recognize and value collective efforts, despite the need for clearer definitions and effective measures. This definitional and measurement work, in both research and practice, is not easy. The ever-changing, dynamic contexts in which collective environmental literacy exists make defining the concept a moving target, compounded by a need to draw upon work in countless, often distinct academic fields of study. Furthermore, the hard-to-see, inner workings of collective constructs make measurement difficult. Yet, the “power of the hive” is intriguing, as the synergism that arises from communities working in an aligned manner toward a unified vision suggests a potency and wave of motivated action essential to coalescing and leveraging individual goodwill, harnessing its power and potential toward effective sustainability solutions.

See Stables and Bishop’s ( 2001 ) idea of defining environmental literacy by viewing the environment as “text.”

The climate change education literature also includes a nascent, but growing, discussion of collective-lens thinking and literacy. See, for example, Waldron et al. ( 2019 ), Mochizuki and Bryan ( 2015 ), and Kopnina ( 2016 ).

This conceptualization is similar to how some scholars describe collective health literacy (Berkman et al., 2010 ; Mårtensson and Hensing, 2012 ).

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Acknowledgements

We are grateful to Maria DiGiano, Anna Lee, and Becca Shareff for their feedback and contributions to early drafts of this paper. We appreciate the research and writing assistance supporting this paper provided by various members of the Stanford Social Ecology Lab, especially: Brennecke Gale, Pari Ghorbani, Regina Kong, Naomi Ray, and Austin Stack.

This work was supported by a grant from the Pisces Foundation.

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Alison W. Bowers

Emmett Interdisciplinary Program in Environment and Resources, School of Earth, Energy and Environmental Sciences, Stanford University, 473 Via Ortega, Suite 226, Stanford, CA, 94305, USA

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Ardoin, N.M., Bowers, A.W. & Wheaton, M. Leveraging collective action and environmental literacy to address complex sustainability challenges. Ambio 52 , 30–44 (2023). https://doi.org/10.1007/s13280-022-01764-6

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Received : 11 July 2021

Revised : 11 January 2022

Accepted : 22 June 2022

Published : 09 August 2022

Issue Date : January 2023

DOI : https://doi.org/10.1007/s13280-022-01764-6

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When Online Content Disappears

Methodology, table of contents.

  • Webpages from the last decade
  • Links on government websites
  • Links on news websites
  • Reference links on Wikipedia
  • Posts on Twitter
  • Acknowledgments
  • Collection and analysis of Twitter data
  • Data collection for World Wide Web websites, government websites and news websites
  • Data collection for Wikipedia source links
  • Evaluating the status of pages and links
  • Definition of links

Twitter analysis in this report is based on 4.8 million tweets collected from March 8 to April 27, 2023. This process involved collecting batches of 3,000 new tweets every 30 minutes over the duration of the collection period using the Twitter Streaming API. This resulted in a sample of tweets created at different times and days over a number of weeks. 

We regularly monitored the status of those tweets starting March 15 and ending June 15, 2023. Each day during the monitoring period, we looked up all collected tweets using the Twitter Search API. We collected the most recent engagement metrics for those tweets, as well as a status code indicating whether each tweet was still publicly available on the site or not.

Tweets were classified as unavailable if they returned a status code of “Not Found” (indicating the tweet itself had been deleted) or “Authorization Error” (indicating it was inaccessible because the account itself had been deleted or made private by the user or suspended by Twitter itself). Because we monitored the status of all collected tweets over the duration of the monitoring period, we were able to identify tweets that became visible again after previously being unavailable.

In addition to examining attrition rates using the full sample of 4.8 million tweets, we selected tweets from a random sample of 100,000 users, resulting in a sample of 148,494 tweets from our original collection, and gathered detailed information about those tweets and the users who posted them. These included details such as the language the tweet was written in; whether the bio field or profile picture of the account had been updated from the site defaults; the age of the account; and whether the account is verified. This subsample is used in the analysis of what types of tweets tend to be removed from the site.

To examine attrition on the broader internet, we collected three samples of web crawl data from Common Crawl , a nonprofit organization that collects and maintains a large web archive. This data has been collected monthly starting in 2008. We used this archive to create a historical sample of URLs from the broader internet dating back to 2013, as well as contemporaneous snapshots of pages from government entities and news websites. 

Sample of URLs from the broader internet

This analysis is based on random samples of URLs from crawls conducted from 2013 to 2023, using year as a stratifying variable. We used the March/April crawl where possible and the closest available date range for years in which a March/April crawl was not conducted. This resulted in a full sample of 1 million pages – approximately 91,000 pages each year from 2013 to 2023 – that were known to have existed at the time they were collected by Common Crawl.

We then looked at whether these pages were still available in fall 2023 using the procedure described below. These checks were performed in several stages, running Oct. 12-Nov. 6, 2023.

Sample of government website URLs

This analysis is based on a random sample of 500,000 pages with a .gov domain, stratified by domain and level of government. We collected these pages from the Common Crawl MAIN-2023-14 crawl conducted March/April 2023.

Each page was assigned to a level of government (Federal – Executive; State; City; County; Federal – Legislative; Federal – Judicial; Tribal; Independent Intrastate; and Interstate) using https://get.gov , the official administrator for the .gov top-level domain. We retrieved the dataset used for this analysis Aug. 22, 2023.

This resulted in a sample with the following breakdown of domains and levels of government: 

A table showing a Sample of government website URLs

For each of the 500,000 pages collected, we selected a random sample of 10% of all links (internal as well as external) found on that page. This resulted in a total of 4,179,313 links. We then looked at whether the pages these links point to were still available. 

Sample of news website URLs 

The analysis of news websites is based on a list of 2,063 domains categorized as “News/Information” by the measurement and audience metrics company comScore. We divided these domains into quintiles based on comScore site traffic for Q4 2022 and sampled 500,000 total pages from these domains using site traffic quintiles as a stratifying variable.

This resulted in a sample with the following breakdown of domains: 

A table showing a Sample of news website URLs

We selected a 50% simple random sample of all the 7,089,514 links that appeared on these pages, excluding any internal links (those that point within the same host domain). We then looked at whether the pages these links point to were still available. 

We sampled 50,000 pages from the list of all titles in the English Wikipedia May 20, 2023, snapshot on Sept. 20, 2023. As some pages have multiple titles in the list of all titles, but refer to the same page (for instance, “UK” and “United Kingdom” ), we followed redirects to eliminate duplicate titles for the same page. Between the snapshot and our collection, 50 pages were removed; our analysis is based on the remaining 49,950 pages.

Our analysis evaluated all external links (that is, links pointing to non-Wikipedia domains) from the “References” section of all the pages in the sample as of Oct. 10-11, 2023, using the same definition of link and procedure described above. 

We categorized links as alive or dead using the response code from the page. A page was classified as inaccessible if the domain was not available in a DNS server or if the server returned one of the following error codes indicating the content was not available:

  • 204 No Content
  • 400 Bad Request
  • 404 Not Found
  • 500 Internal Server Error
  • 501 Not Implemented
  • 502 Bad Gateway
  • 503 Service Unavailable
  • 523 Origin Is Unreachable

Pages were considered accessible in all other cases – including ambiguous situations in which we could not guarantee that the content exists, like soft 404 pages or timeouts not caused by the DNS.

We evaluated links in four rounds. In the first round (Oct. 12 to Oct. 15), we evaluated whether links were functional by following them using the requests library in Python, allowing for pages to timeout after one second. In this round, we recorded the initial status code and final status code after redirects, if applicable.

For the pages that did not return a 200 OK status code, we did a second round of evaluations (Oct. 16 to Oct. 17) in which we collected the status code using randomized browser headers from the library fake_headers.

A third round (Oct. 27 to Oct. 28) rechecked pages that did not successfully resolve to any status code and for pages that returned a 429 (“Too many requests”) status code, with an additional timeout of three seconds.

In the final round (Nov. 6), we looked up the pages that did not return any result in a DNS server using the dnspython module in Python allowing for a three-second timeout. 

We identified hyperlinks from the HTML code of the websites by looking at all <a> tags that included a href attribute. We limited our attention to hyperlinks that used the HTTP or HTTPS protocol. Pages frequently use relative links that do not include the specification of the scheme and domain of the site in the definition. In those cases, we restricted our attention to those that referred to subdomains or paths (i.e., that started with a backslash /) and discarded hyperlinks defined by anchors (i.e., that started with a pound sign #). 

Whenever a page used a relative link, we tried reconstructing the absolute URL by prepending the domain information. In our analyses, these reconstructed URL were treated as any other URL during our analyses.  

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