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Postdoctoral Research Associate

• Job Description 13548.pdf (PDF , 346.15kb)

Role Description

Department of biology.

Our laboratories provide a supportive and collaborative environment in which the PDRA can contribute fully, flourish and expand their range and learn new techniques. The Department of Biology is renowned internationally for its research, and the successful applicant will join a team of researchers in the York Biomedical Research Institute investigating cellular processes in parasites that cause African trypanosomiasis.

Applications are invited for a postdoctoral researcher for 36 months to characterise the signalling pathways that regulate autophagy, lysosome exocytosis and biomolecular condensates during the lifecycle differentiations and host adaptation of the African trypanosome T. brucei. The position is funded by a MRC CDA to Dr. Mathieu Cayla who will manage the post.

The project will require the use of a wide range of different techniques such as high−throughput live imaging, gene silencing screens, mass spectrometry and murine infection, giving plenty of opportunity to develop transferable skills. 

The position requires you to have a PhD in Molecular Biology, Cell Biology or Microbiology. For this multidisciplinary project, you will bring knowledge and expertise in standard molecular biology, -omics studies and imaging techniques. It would be highly desirable to have previous experience in one or more of the following: handling murine models and pathogens of class 2, in protein kinases  and signalling, in -omics data analysis, super resolution microscopy and/or live imaging, and CRISPR/Cas9 mediated precision editing.

Key responsibilities

The post must cover the following responsibilities:

• Validate of high−throughput live imaging system combined with gene silencing screen of protein kinases
• Autophagy-related proximity labelling, phospho-proteomic and mass spectrometry analysis
• Assays of protein interaction and enzyme activity using biophysical and biochemical approaches
• Generation of mutated cell lines by CRISPR/Cas9 mediated precision editing and phenotypic validation in vitro and in murine model
• Biomolecular condensate purification and component analysis by mass spectrometry and sequencing

Skills, Experience & Qualification needed

• A PhD in Molecular Biology, Cell Biology or Microbiology
• Knowledge in molecular biology, parasitology, and a range of modern techniques, to engage in high quality research
• Skills and experiences in cell culture, handling of class 2 pathogens, murine infection, and gene editing is desirable
• Excellent track record of research publications and highly developed communication skills
• Attention to detail, collaborative ethos with interest in and enthusiasm for co-supervising students
• Positive attitude to colleagues and students and a willingness to work proactively
• Commitment to personal development and understanding of equality and diversity issues

Interview date : 28/10/2024 (TBC)

For informal enquiries : please contact Dr. Mathieu Cayla on [email protected]

The University strives to be diverse and inclusive  – a place where we can ALL be ourselves.

We particularly encourage applications from people who identify as Black, Asian or from a Minority Ethnic background, who are underrepresented at the University. 

We offer family friendly, flexible working arrangements, with forums and inclusive facilities to support our staff. #EqualityatYork

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Labcorp Drug Development Salary for Senior Research Associate BETA

What is the average salary for a Senior Research Associate at Labcorp Drug Development in the United States? Based on our data, it appears that the optimal compensation range for a Senior Research Associate at Labcorp Drug Development is between $85,401 and $104,158, with an average salary of $95,079. Salaries can vary widely depending on the region, the department and many other important factors such as the employee’s level of education, certifications and additional skills.

DISCLAIMER: The salary range presented here is an estimation that has been derived from our proprietary algorithm. It should be noted that this range does not originate from the company's factual payroll records or survey data.

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Labcorp Drug Development Overview

Labcorp is a leading global life sciences company that provides vital information to help doctors, hospitals, pharmaceutical companies, researchers, and patients make clear and confident decisions. Through their unparalleled diagnostics and drug development capabilities, they provide insights and accelerate innovations to improve health and improve lives.

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What skills does a person need at labcorp drug development.

At Labcorp Drug Development, specify the abilities and skills that a person needs in order to carry out the specified job duties. Each competency has five to ten behavioral assertions that can be observed, each with a corresponding performance level (from one to five) that is required for a particular job.

• Analysis: Analysis is the process of considering something carefully or using statistical methods in order to understand it or explain it.
• Fundraising: Fundraising or fund-raising (also known as "development" or "advancement") is the process of seeking and gathering voluntary financial contributions by engaging individuals, businesses, charitable foundations, or governmental agencies. Although fundraising typically refers to efforts to gather money for non-profit organizations, it is sometimes used to refer to the identification and solicitation of investors or other sources of capital for for-profit enterprises. Traditionally, fundraising consisted mostly of asking for donations on the street or at people's doors, and this is experiencing very strong growth in the form of face-to-face fundraising, but new forms of fundraising, such as online fundraising, have emerged in recent years, though these are often based on older methods such as grassroots fundraising.
• Molecular Biology: Molecular biology /məˈlɛkjʊlər/ is a branch of biology that concerns the molecular basis of biological activity between biomolecules in the various systems of a cell, including the interactions between DNA, RNA, proteins and their biosynthesis, as well as the regulation of these interactions. Writing in Nature in 1961, William Astbury described molecular biology as:
• Cell Culture: Cell culture or Tissue culture is the process by which cells are grown under controlled conditions, generally outside their natural environment.
• Presentation: Presentation conveys information from a speaker to an audience. Presentations are typically demonstrations, introduction, lecture, or speech meant to inform, persuade, inspire, motivate, build goodwill, or present a new idea/product.

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