oral presentation about drug abuse

Speech on Drug Abuse in English in Simple and easy Words

Table of Contents

Speech on Drug Abuse: Drug abuse has become the most common thing these days and many youth are destroying their lives by getting addicted to drugs. It’s very important to sensitize our youth on the subject of drug abuse. They are ruining the lives of our youth and putting their future in a great darkness. The use of drugs is making their lives vulnerable and prone to destruction. Therefore, it becomes very important to raise awareness about it amongst our youth and prevent them from succumbing to it. The International Day against Drug Abuse and Illicit Trafficking is celebrated annually on June 26th it serves as a significant platform for raising awareness and addressing the critical issue of substance abuse. You can even prepare a speech on drug abuse and deliver it on various occasions and platforms.

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Long and Short Speeches on Drug Abuse in English

For your help, we have posted below some short speech on drug abuse as well as long speech on drug abuse, which will give you a comprehensive understanding of the subject matter and help you create an impressive brief to impress upon your audience and bring a change in society.

Speech on Drug Abuse – Speech 1

Dear Students – Warm Greetings to all of you! I welcome everyone to the school seminar hall.

Today, we are here to discuss about the fatal consumption of drugs and how it is destroying the lives of our youth. But before the discussion begins, I would like to deliver a short speech on drug abuse and would like to enlighten our students on this sensitive subject matter.

Drugs, as we all know, are an illegal matter which some people drink, smoke, inject or eat for the mental as well as physical effects that it leaves. There are several students who consume drugs out of fun or for various other reasons. People who deal in the selling of drugs create a network and mainly target students in order to make them addicted to drugs. Initially, the drugs are sold to the students for free and gradually when they get addicted to it, they start buying and consuming it. In fact, the students also eventually become a part of their network and start dealing in it.

It is observed that students start consuming drugs out of stress or unfair expectations of their teachers as well as parents. Lack of emotional support and disorder in their families make them vulnerable and increase their dependency on drugs. They use it in order to calm down their state of mental agitation. Other than this, it is poverty that compels some students to become a part of the selling and dealing network of drugs and derive their pocket money. Therefore, it becomes like a vicious circle of the drug addicted students from which they seem to find no escape unless the society comes for their rescue.

Sadly, the students fail to realize that the consumption of drugs has a severe impact on their physical and mental health, such as they start experiencing mental disorder, their intelligence level decreases, experience deadly diseases and untimely death. When one completely succumbs to the temptation of drugs, it gets very difficult for him/her to recover from its impact except in the centers for drug rehabilitation where they gain a new life, but which involves a high cost. In fact, there are many cases too where even rehabilitation centers fail because of the worst condition of the patients.

I, therefore, request all the students to refrain themselves completely from the consumption of drugs before it destroys their health, future and takes away their lives. Don’t even try to touch or come close to them. Drugs can even destroy a complete generation. So think wise and act smart. Shape your future which seems bright and full of achievements. The drugs that doctor prescribes to his/her patients must only be taken in order to combat a specific disease otherwise the government must take strict measures to ban its illegal trade in the market and save our youth from destruction.

I want to conclude by saying that drug abuse should be an absolute ‘No’ for all and I sincerely hope that our students will never ever try to consume drugs and will completely stay away from its use. Remember that our country needs you as you are its future and harbinger of progress.

Also Read: Essay on Drug Abuse

Speech on Drug Abuse – Speech 2

Good Morning Friends – Welcome to the 77 th campaign for drug addiction ban.

It feels extremely great to see how the members of our organization are working hard in order to make every day count and reach out to the masses for spreading awareness about the drug addiction or drug abuse. Since day one and today it’s the 77 th campaign of our organization – we haven’t really ever thought that we will grow this big, i.e. currently we have more than 200 people working for us and have gained a mass appeal. The response so far has been really good and we have been able to transform the life of the people for good, who earlier have been living under the influence of drugs.

So today I would further like to appeal to the masses to refrain themselves from using drugs and live a healthy life. Drug addiction or drug abuse is described as an excessive dependency on a substance, which inevitably becomes the compulsive need of the person using it. This need becomes so compulsive that without that substance the person cannot live his life like a normal person does. And, when such a substance is stopped being available in the market then that person is believed to be suffering from substance withdrawal.

The addiction of drugs has become one of the serious social problems in many developing as well as developed countries and it undeniably proves to be the principal obstruction in the all-round development of the people, society, country and the world at a large. Our country is a progressing country and it is already afflicted with so many other grave problems, such as unemployment, poverty and illiteracy that the problem of Adolescence and Drug abuse makes the situation even worse here as it further makes our economy regressive by destroying the lives of its youth.

Even sadder is the fact that several drug addicts cannot afford to make a purchase of expensive drugs so much so that in the end they have to resort to such activities as theft in their homes. These people are not born thieves, but their addiction to drugs makes them heinous and propels them to commit crimes in order to feed their body with drugs.

People can become addicted to drugs because of various reasons, some of which are mentioned below:

1. In order to de-stress themselves

When a person is under the influence of drugs, he/she forgets everything and enters into a trance-like state. However, it is only later that people realize that the use of drugs is only aggravating the problem and not really helping them in getting rid of the stress.

2. Out of peer pressure

Many times, people start taking drugs because their friends are addicted to them. However, once they start taking it, it becomes really difficult for them to get rid of this habit.

3. Style Statement

Many teenagers these days think that the habit of drinking, smoking and even drug addiction is what helps them look cool and create a style statement in the front of others. However, it’s only when these people get trapped in its vicious circle that they realize the irreparable they have caused to their lives.

Teenagers and every person for that matter must understand that the habit of drug abuse not only greatly affects their body and mind, but also finishes their bright future. So we should strictly say ‘No’ to drugs and save our lives as well the lives of our loved ones by spreading awareness in our surroundings.

Also Read: Speech on Adult Education

Speech on Drug Abuse – Speech 3

Respected Principal, Vice Principal, Teachers and My Dear Fellow Students – Warm Welcome to all of you! Today, standing in the prayer hall I would like to take this opportunity to deliver a brief speech on Drug Abuse.

I request our principal and teachers to kindly allow me to speak on this subject as it is a high time to enlighten our youth about the dangerous habit of drug abuse. In the present times, there are many factors that push a man to resort to drug addiction and make his/her life miserable. The most glaring factors are rapid industrialization and urbanization, which have given birth to a new kind of behavior among the youth of today, i.e. individualism and permissiveness. People these days prefer nuclear families and in many cases both parents are working, as a consequence of which they become less forbearing in comparison to their previous generations. People are living their lives in isolation and avoid getting social because the stress in the modern times has become way too much to make them withdrawn figures in their personal lives.

In the end, such people become involved in the habit of drinking, smoking, drug addiction, etc. Besides, when a child doesn’t feel satisfied at home or when he/she is deprived of love, affection and care of his/her parents, a feeling of discontentment comes in and such children become prone to drug addiction and ruin their lives completely. What is more painful to see that if the drug addicted people are not allowed the use of drugs, then he/she suffers from bouts of depression, painful and uncontrollable convulsions as well as vomiting!

It is an obvious fact that the addiction of drugs is ruining the path of progress of many individuals and our nation as a whole so much so that proactive measures need to be taken in order to keep a check on this destructive habit of our youth. The most significant step in this direction would be about spreading awareness amongst the people on a national scale.

Our Indian government has in fact formulated various campaigns and even has been able to gain success in this direction. The individuals whose family and friends suffer from the addiction of drugs are requested to approach the rehabilitation institutions and camps in order to provide treatment to the addicts.

Drug abuse should not be tolerated and be completely banned as a taboo. However, it is not advised to torture the addict or treat him/her inhumanely for this habit because if you try and convince the person about its treatment then he/she may willingly choose to opt for it and get rid of this addiction by admitting himself/herself at the rehabilitation centers.

A person who has become the victim of drug abuse is forced by his/her bodily conditions to carry on with the addiction, but sooner they realize the bad impact of this habit. All that these people need is a helping hand and therefore we should provide encouragement as well as support to these people in making these addicts come back to their normal lives and lead a healthy life.

Speech on Drug Abuse – Speech 4

Hon’ble Principal, Vice Principal, Fellow Colleagues and My Dear Students – Warm Greetings to one and all!

Firstly, I would like to extend a note of thank you to our respected Principal and Vice Principal for gracing this speech ceremony with their presence and giving their approval too. And, to all the fellow teachers – as without your support this event wouldn’t have been possible. I would also like to congratulate our dear students for making the desired arrangement on a short notice.

The topic for today’s speech is Drug Abuse! I have chosen to speak on this topic because these days I observe many campaigns being run on Drug Abuse in order to teach the people about its ill effects. As a teacher, it also becomes my responsibility to help them spread the message wherever we can and most importantly beginning from our very own school.

Drug abuse is considered one of the banes of our so called civilized society. It has affected all the sections and regions of our society. People with the illicit use of drug are found everywhere, i.e. in urban and rural regions, among men and women, among rich and poor. But it is exceedingly practiced by our young girls and boys living in hostels in nearly all technical and educational institutions.

The grave situation of drug abuse is prevalent across the world and unfortunately our very country India is more strongly affected by it. Our country is a transit country because it is placed between the Golden Triangle consisting of Burma, Thailand and Cambodia, including Golden Crescent consisting of Afghanistan, Pakistan and Iran – the places where most of the drugs, chiefly heroin and opium are produced. Pakistan is undeniably the nucleus of the world when it comes to any unlawful activity and as far as the drug production is concerned – it is the hub. In fact, a big proportion of drugs go by India in order that it can be exported to other countries.

This happens through the network of drug mafia who further has connections with formidable smugglers as well as terrorists. In the process, unfortunately several young men as well as women become victims to this diabolic activity. Pakistan with the help of ISI is involving itself in a proxy war in the region of Kashmir against India through money earned with the help of drug mafia. Thus, terrorism and drugs share very strong connections.

This addiction to drug is so deadly that people fall prey to its use and become almost a slave. If a person doesn’t get its regular dose, then that person starts feeling a lack of it and becomes depressed with severe pain which even leads to a lack of sensation in arms and legs. Drugs are of various kinds, such as heroin, opium, charas, ganja, etc.

There are some injections too which lead to a state of severe drowsiness. In case, a drug-addict is not able to receive the required dose of drug when needed, then he/she would be ready to do anything for it even by resorting to unfair means, such as theft or may be hurting someone physically, etc.

I therefore request everyone to strictly say ‘No’ to drugs and get such people admitted to rehabilitation centers where their conditions can be improved before it gets horrible and proves fatal for that person.

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Speech on Drug Abuse Faq’s

What is the topic of drug abuse day.

Drug Abuse Day focuses on raising awareness about the harmful effects of drug misuse and addiction.

What is drug abuse in the English language?

Drug abuse in English refers to the harmful and improper use of drugs, often leading to health and social problems.

How can we say no to drugs?

We can say no to drugs by staying informed, making healthy choices, and seeking support from friends and family when faced with drug temptations.

How to write an essay about drugs?

To write an essay about drugs, start with an introduction, discuss the impacts, causes, and solutions, and conclude with your viewpoint on the topic.

What is drugs summary?

A drugs summary is a brief overview of key information about drugs, including their effects, risks, and uses.

What is drug abuse in a short introduction?

Drug abuse is when people misuse drugs, causing harm to themselves and society. It's a serious problem that needs attention.

What are a few lines on addiction?

Addiction is a strong, harmful craving for something, like drugs, that can be very difficult to control. It can lead to serious problems.

We can say no to drugs by being strong, confident, and making choices that keep us safe and healthy.

Addiction is a powerful need for something that can be harmful, like drugs or alcohol. It can affect a person's life in many negative ways.

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• v.10(3); 2018 Jul

Route of Drug Abuse and its Impact on Oral Health-Related Quality of Life among Drug Addicts

Aditi sharma.

1 Senior Lecturer, Department of Public Health Dentistry, Swami Devi Dyal Hospital and Dental College, Barwala, India

Simarpreet Singh

2 Professor, Department of Public Health Dentistry, Surendera Dental College and Research Institute, Sri Ganganagar, India

Anmol Mathur

3 Associate Professor, Department of Public Health Dentistry, Dr. D.Y Patil Vidyapeeth, Pune, India

Vikram Pal Aggarwal

4 Senior Lecturer, Department of Public Health Dentistry, Surendera Dental College and Research Institute, Sri Ganganagar, India

5 Reader, Department of Public Health Dentistry, Surendera Dental College and Research Institute, Sri Ganganagar, India

Diljot Kaur Makkar

6 Reader, Department of Public Health Dentistry, Institue of Dental Sciences, Sephora, J&K, India

Deeksha Gijwani

Various studies have tested quality of life (QOL) among drug addicts, however very few have reported any association between oral health-related quality of life (OHRQOL) and mode of drug administration among drug addicts. Hence, the present study was conducted aiming to evaluate the impact of mode of administration of drugs on OHRQOL among drug addicts.

Data was collected using respondent-driven sampling (RDS) method among 313 male drug addicts in Sri Ganganagar, Rajasthan, India, using self-administered questionnaires on oral hygiene aids and drug addiction history. OHRQOL was recorded using Oral Health Impact Profile (OHIP-14) questionnaire. The chi-square test, t-test, and Kruskal-Wallis test were used for statistical analysis.

In this study, 56.2% of the drug addicts reported practicing oral hygiene aids. The main drugs abused were heroin, cocaine, and amphetamines as 51.4%, 35.1%, and 13.4%, respectively. Most of the drug addicts were employed (82.4%) and studied up to primary education (46.3%). The highest mean values of community periodontal index (CPI) and decayed, missing, filled surface (DMFS) were found among the cocaine addicts and amphetamine abusers with rates of 3.11 ± 0.98 and 6.69 ± 8.52, respectively. Poor OHRQOL was observed among addicts who consumed drugs in inhalation since a long time irrespective of the type of the drug, but among them heroin addicted subjects had the poorest OHRQOL.

OHRQOL was poor among the drug addicts in comparison to general population. Preventive strategies on oral health and other health promotion programs for this vulnerable group can be unified.

Introduction

Drug addiction is a prolonged, deteriorating disorder characterized by compulsion to take a drug and lack of self-control in limiting drug intake. It is defined as physical and psychological dependence on psychotic substances (e.g., alcohol, tobacco, heroine, etc.). These substances, when cross the blood-brain barrier on ingestion, temporarily alter the chemical milieu of the brain. 1 These substances or drugs may be natural or synthetic, the use of which has a psychoactive effect and amends or alters the functions of a living organism. These drugs can be consumed either by inhalation, injection, or by ingestion. Globally, the numbers of drug addicts in 2013 were 246 million 2 among whom 11.35 million lived in India. 3 Alcohol, cannabis, and raw opium consumption has been traditionally accepted in India, however an increase in methamphetamines use has been reported recently in some regions of South East Asia. 2

Consistent drug use results in social or economic burden is often associated with medical as well as oral health problems. Drug addiction is along with both direct and indirect concerns for oral health and can exaggerate oral problems indirectly through its hostile effects on the users’ behavior as well as life style. Oral health diseases are greatly associated with drug misuse as oral tissues are directly exposed to them during the drug consumption. This can be understood as drug’s biologic interaction with normal functioning of oral cavity.

It is a well-known fact that oral diseases impact the quality of life (QOL). QOL is a multidimensional concept with interrelated domains such as social, physical, psychological, and living environments. Similarly, oral health may impact a person functionally, psychologically, and socially in addition to causing pain and discomfort. Oral health has a demonstrable effect on QOL, despite the fact that psychological and social aspects of a person’s life are not habitually associated with their oral health status.

There are various studies like the ones conducted by Maremmani et al. 4 and De Maeyer et al. 5 on examining QOL among drug addicts, but to the best of our knowledge, very few studies have reported the association between OHRQOL and mode of administration among drug addicts until now. The results will definitely be of great importance in definition, allocation, and prioritization of resources towards this vulnerable population. Therefore, measuring OHRQOL along with the mode of consumption of these drugs should definitely provide insight towards the association of these unaddressed factors with oral health status among this group.

The study group consisted of 324 male drug addicts examined over a period of 6 months from October 2015 to March 2016. All the subjects in the study used their desired drug at least twice a week in the same mode of administration and should had features of forbearance and continued use despite social, economic, and medical problems. The drug addicts who misused more than one drug and occasional users were excluded from the study. The data of the participants was kept confidential and anonymous. 11 participants refused to give informed consent so the final sample included 313 participants. The study was sanctioned by the ethical committee of Surendera Dental College and Research Institute, Sri Ganganagar, Rajasthan, India.

Respondent-driven sampling (RDS) was used to gather a sample of drug addicts. Such a sampling technique was administered to reach unseen populations. The method accounted for non-random selection of initial respondents. In all de-addiction centers, 4 initial respondents were selected. Those respondents were the first “flow” of participants, who recruited the second. The number of surfs was five in order to reduce selection bias and to reach deeper into the population of drug addicts and provide generalizability of the results. Respondents were allowed to enroll a maximum of three new participants. This technique allowed the recruitment of active addicts and was not similar to other studies drawing the data from institutionalized settings where the HRQOL is definitely affected and the recruits are not actually addicts but rather being affected by withdrawal symptoms.

The data was recorded through face-to-face interviews using a self-prepared questionnaire which included questions regarding socio-demographic factors, oral hygiene practices (brushing material; mode; frequency), history of alcohol use, smoking, and detailed history of drug (heroin, cocaine, and amphetamines) consumption. The questionnaire was piloted on a group of 15 addicts, and few adjustments were made in the instrument before its application. The clinical examination was done by a single calibrated examiner for whom kappa statistic was determined 0.8, 2 days prior to study.

A standard instrument was needed in order to evaluate the impact of oral health problems on OHRQOL among drug addicts. The Indian version of the Oral Health Impact Profile (OHIP-14) proposed by Deshpande and Nawathe 6 was the best among the questionnaires to evaluate OHRQOL among the adult populations as it represented both an individual as well as a group of individuals, while measuring the extent with which poor oral health could affect daily life. The period of interview and examination lasted for 20 minutes.

The community periodontal index (CPI) and decayed, missing, filled surface (DMFS) indexes were recorded to evaluate the periodontal status and caries prevalence among the drug addicts respectively according to the criteria proposed by the World Health Organization (WHO). 7 WHO type III examination was carried using the WHO probe natural light, mouth mirror, and explorer whereas patients were seated on ordinary chairs.

The SPSS software (version 20, IBM Corporation, Armonk, NY, USA) was used for the statistical analysis. The statistical significance was determined by the chi-square test, unpaired t-test, and Kruskal-Wallis test with level of significance set at P < 0.05.

In the present study, most of the drug addicts were in 25-34 year age group. The main drugs of misuse were heroin (n = 161), cocaine (n = 110), and amphetamines (n = 42), and the duration of addiction was more than five years in almost half of the drug addicts. Most of the drug addicts were employed (n = 258). Almost half of the drug addicts had undergone primary education (n = 145) and oral hygiene practices were seen in more than half (n = 176) of the drug addicts ( Table 1 ).

Characteristics of addicts

The most affected domain of OHRQOL was social disability followed by psychological disability and the least affected domain was physical disability reported among addicted population. People consuming drugs in inhalation form reported higher impact towards social disability domain of OHRQOL ( Table 2 ).

Oral health-related quality of life (OHRQOL) of drug addicts according to type and mode of consumption

OHRQOL: Oral health-related quality of life

Table 3 shows the OHRQOL of drug addicts according to type and duration of addiction. As the duration of addiction of these drugs increased, the OHRQOL also deteriorated.

Oral health-related quality of life (OHRQOL) of drug addicts according to type and duration of addiction

Table 4 shows oral health status of drug addicts according to type, mode of administration, and duration of addiction of drugs. The highest and lowest mean CPI scores were obtained for cocaine and amphetamine drug addicts, respectively. In addition, the highest and lowest mean decayed surfaces were obtained respectively among amphetamines and cocaine drug addicts. The remarkable outcome of the study was that those who consumed drugs and advocated oral hygiene practices had better oral health status in comparison to those who consumed drugs and were not advocating oral hygiene practices. Comparatively, mean score for CPI and decayed surfaces was more in individuals who injected these drugs than those who inhaled them. Mean difference score for CPI was found more in individuals who brushed and those who didn’t brush among the subjects in the inhalation category when compared with injection category subjects. There was significant relationship between the type of drug, mode of administration, and duration of addiction with CPI and mean decayed surfaces.

Oral health status according to drug, mode, and duration of addiction

SD: Standard deviation; CPI: Community periodontal index

Different symbols indicate statistical significance.

This study was an attempt to evaluate the impact of mode of consumption of drugs on the oral health related QOL among drug addicts. Most of the participants (37%) were in 25-34 year age group, which was similar to various studies including the studies performed by Shekarchizadeh et al. 8 and Ray and Chopra. 9 Other studies were also concerned with the similar age group for drug dependency. 10 , 11 According to the studies, the cause for this age pattern could be due to the fact that at this age, individuals are perceived as adults and become monetarily liberated.

Most of the participants had undergone primary education (46.3%) and were employed (82.4%), which was in contrast with the study by Supic et al. 12 This variation in results could be due the fact that the participants were less educated and belonged to labor class; working on daily wages hence can be considered as employed.

This kind of employment pattern was pretty common in this part of the country where people were working more as laborers to meet their daily needs. This physically tedious work drives them to consume alcohol, tobacco, and various illicit drugs relieving their stress and deteriorating their oral health. 13 - 15

The outcome of the current study reveals that the subjects practicing oral hygiene were more in number as compared to the addicts practicing irregular/no oral hygiene practices; this was similar to the previous studies. 8 , 12 This distribution could be due to easy availability of oral hygiene aids nowadays.

The OHRQOL was worsened more among those drug addicts who consumed drugs for more than five years in the present study. Similarly, Shekarchizadeh et al. 8 reported that the drug addicts’ OHRQOL was worsened as the duration of practicing illicit drugs increased.

The findings of the study reports that the most exaggerated domain was social disability which was dissimilar with the study carried out on general population in which the most commonly reported impacts was seen within the domains of physical disability 16 and physical pain. 17 The least affected domain in the present study was physical disability whereas in other studies, the it was handicap16 and functional limitation. 17 The high reporting of social disability domain among the study population could be due to the fact that the drug addict population is usually isolated from the general population, especially their family and tendency to report irritable episodes. Drug use is a response to social breakdown which offers users a mirage of escape from adversity and stress, but only makes their problems worse. People turn to drugs to numb the pain of harsh economic and social conditions, which in turn leads to downward social mobility.

The overall oral health status of the drug addicts seems to be in poor state as it can be clearly appreciated from the results of the mean CPI and DMFS scores among drug addicts who brushed and those who did not brush were 1.94, 3.39 and 2.48, 5.01, respectively. It had been well documented in the studies by Brand et al. 18 and Van Zyl 19 that among cocaine addicts, the gingivae are being coated with white slough, which when removed show sign of inflammation and erythema. The outcomes of the present study are in accordance with above mentioned studies and present high CPI scores among cocaine users. These complications on periodontal health were related to strong vasoconstriction properties of cocaine. In addition, gingival laceration may be aggravated among drug users due to excessively vigorous tooth brushing during high period. This reason was being supported by Saini et al. 1 and Brand et al. 18 Moreover, inflammation at the site of repeated injections may also lead to limited motor activity leading to poor oral hygiene skills among injection drug users.

Studies done by Saini et al. 1 and Robinson et al. 20 reported high caries experience among heroin drug addicts, whereas results of the present study indicated predominance of caries experience among amphetamines drug users. This high caries experience must be due to the Xerostomia caused by the use of opiates 1 , 20 and amphetamines. 1 , 19 , 21

The present study was a pioneer attempt to check the OHRQOL in relation to mode of administration and its effect on oral health status among drug addicts who had not been tested before; hence the comparison with other studies could not be made. According to authors, the results could have been appreciated better in a longitudinal design. Hence, new study with longitudinal design must be conducted to test the effect of mode of consumption on oral health and its QOL.

This study brings new information from a public health perspective. Predictably, the periodontal and dental caries status of this population was measured to be significantly higher than the general population and the OHRQOL was deprived. Moreover, this type of study is relevant to planning of public health programs, and may contribute to the definition of groups with higher levels of need. Rather than cutting access to care among this vulnerable population, more effective public health policy would be instigated to increase preventive and treatment services.

Acknowledgments

Conflicts of Interest

The Authors have no conflict of interest.

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Asco 2024 | ascentage pharma to present four studies, including an oral report featuring the latest data of olverembatinib in sdh-deficient gist.

SUZHOU, China and ROCKVILLE, Md. , April 24, 2024 /PRNewswire/ -- Ascentage Pharma (6855.HK), a global biopharmaceutical company engaged in developing novel therapies for cancer, chronic hepatitis B (CHB), and age-related diseases, announced today that results from four clinical studies of the company's three key drug candidates have been selected for presentations, including an Oral Report, at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting. The three drugs are olverembatinib (HQP1351), the first and only China -approved third-generation BCR-ABL inhibitor; lisaftoclax (APG-2575), a Bcl-2-selective inhibitor; and APG-2449, a FAK/ALK/ROS1 inhibitor.

The ASCO Annual Meeting showcases the most cutting-edge research in clinical oncology and state-of-the-art advanced cancer therapies and is the world's most influential and prominent scientific gathering of the clinical oncology community. This year's ASCO Annual Meeting will take place both online and in-person at the McCormick Place, Chicago, IL , the United States , on May 31–June 4, 2024 (local time).

"Entering the seventh consecutive year for our studies to be selected for presentations at the ASCO Annual Meeting, we are honored to have the opportunity to once again showcase our capabilities in global innovation and clinical development at this top international scientific meeting," said Dr. Yifan Zhai , Chief Medical Officer of Ascentage Pharma . "Our presentations this year include an Oral Report featuring updated data of olverembatinib in patients with succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumor (GIST), an indication that currently has no effective treatment. Furthermore, we will release detailed data of lisaftoclax in patients with acute myeloid leukemia (AML) and in patients with Waldenstrom macroglobulinemia (WM), as well as those of APG-2449 in patients with non-small cell lung cancer (NSCLC). We look forward to sharing the detailed results from those studies with our colleagues at the meeting. Moving forward, we will remain dedicated to those global clinical development programs of key candidates to hopefully bring more treatment options to patients in need."

These four clinical studies to be presented at this year's ASCO Annual Meeting are as follows:

Olverembatinib Updated efficacy results of olverembatinib (HQP1351) in patients with tyrosine kinase inhibitor (TKI)-resistant succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumor (GIST) and paraganglioma Abstract#: 11502 Format: Oral Report Session Title: Sarcoma Date and Time: June 3, 2024 , Monday, 3:00 PM – 6:00 PM (Central Time) First Author:  Haibo Qiu, MD, PhD, Sun Yat -sen University Cancer Center, Guangzhou , Guangdong, China .

APG-2575 (Lisaftoclax) Safety and efficacy of lisaftoclax, a novel BCL-2 inhibitor, in combination with azacitidine in patients with treatment-naïve or relapsed or refractory acute myeloid leukemia Abstract#: 6541 Format: Poster Presentation Session Title: Hematologic Malignancies—Leukemia, Myelodysplastic Syndromes, and Allotransplant Date and Time: June 3, 2024 , Monday, 9:00 AM – 12:00 PM (Central Time) First Author: Huafeng Wang , MD, PhD, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou , Zhejiang, China .

Updated efficacy and safety results of BCL-2 inhibitor lisaftoclax (APG-2575) alone or combined with ibrutinib or rituximab in patients (pts) with Waldenstr ö m macroglobulinemia (WM) Abstract#: 7078 Format:  Poster Presentati on Se ssion Title: Hematologic Malignancies—Lymphoma and Chronic Lymphocytic Leukemia Date and Time: June 3, 2024 , Monday, 9:00 AM– 12:00 PM (Central Time) First Author: Masa Lasica, MBBS, FRACP, FRCPA, St Vincent's Hospital, Melbourne , Victoria, Australia .

APG-2449 Updated study results of novel FAK/ALK/ROS1 inhibitor APG-2449 in patients (pts) with non-small-cell lung cancer (NSCLC) resistant to second-generation ALK inhibitors. Abstract#: 3124 Format: Poster Presentation Session Title: Developmental Therapeutics—Molecularly Targeted Agents and Tumor Biology Date and Time: June 1, 2024 , Saturday, 9:00 AM – 12:00 PM (Central Time) First Author:  Yuxiang Ma, MD, PhD, Sun Yat -sen University Cancer Center, Guangzhou , Guangdong, China .

About Ascentage Pharma

Ascentage Pharma (6855.HK) is a globally focused biopharmaceutical company engaged in developing novel therapies for cancers, chronic hepatitis B, and age-related diseases. On October 28, 2019 , Ascentage Pharma was listed on the Main Board of the Stock Exchange of Hong Kong Limited with the stock code 6855.HK.

Ascentage Pharma focuses on developing therapeutics that inhibit protein-protein interactions to restore apoptosis, or programmed cell death. The company has built a pipeline of 9 clinical drug candidates, including novel, highly potent Bcl-2, and dual Bcl-2/Bcl-xL inhibitors, as well as candidates aimed at IAP and MDM2-p53 pathways, and next-generation tyrosine kinase inhibitors (TKIs). Ascentage Pharma is also the only company in the world with active clinical programs targeting all three known classes of key apoptosis regulators. The company is conducting more than 40 Phase I/II clinical trials, including 5 global registrational phase III studies, in the US, Australia , Europe , and China . Ascentage Pharma has been designated for multiple Major National R&D Projects, including five Major New Drug Projects, one New Drug Incubator status, four Innovative Drug Programs, and one Major Project for the Prevention and Treatment of Infectious Diseases.

Olverembatinib, the company's core drug candidate developed for the treatment of drug-resistant chronic myeloid leukemia (CML) and the company's first approved product, has been granted Priority Review Designations and Breakthrough Therapy Designations by the Center for Drug Evaluation (CDE) of China National Medical Products Administration (NMPA). To date, the drug had been included into the China 2022 National Reimbursement Drug List (NRDL). Furthermore, olverembatinib has been granted an Orphan Drug Designation (ODD) and a Fast Track Designation (FTD) by the US FDA, and an Orphan Designation by the EMA of the EU. To date, Ascentage Pharma has obtained a total of 16 ODDs from the US FDA and 1 Orphan Designation from the EMA of the EU for 4 of the company's investigational drug candidates.

Leveraging its robust R&D capabilities, Ascentage Pharma has built a portfolio of global intellectual property rights and entered into global partnerships with numerous renowned biotechnology and pharmaceutical companies and research institutes such as UNITY Biotechnology, MD Anderson Cancer Center, Mayo Clinic, Dana-Farber Cancer Institute, MSD, and AstraZeneca. The company has built a talented team with global experience in the discovery and development of innovative drugs and is setting up its world-class commercial manufacturing and Sales & Marketing teams. One pivotal aim of Ascentage Pharma is to continuously strengthen its R&D capabilities and accelerate its clinical development programs, in order to fulfil its mission of addressing unmet clinical needs in China and around the world for the benefit of more patients.

Forward-Looking Statements

The forward-looking statements made in this article relate only to the events or information as of the date on which the statements are made in this article. Except as required by law, Ascentage Pharma undertakes no obligation to update or revise publicly any forward-looking statements, whether as a result of new information, future events, or otherwise, after the date on which the statements are made or to reflect the occurrence of unanticipated events. You should read this article completely and with the understanding that our actual future results or performance may be materially different from what we expect. In this article, statements of, or references to, our intentions or those of any of our Directors or our Company are made as of the date of this article. Any of these intentions may alter in light of future development.

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