recent research topics in cell biology

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Collection  10 March 2022

Top 100 in Cell and Molecular Biology

This collection highlights our most downloaded* cell and molecular biology papers published in 2021. Featuring authors from around the world, these papers showcase valuable research from an international community.

*Data obtained from SN Inights, which is based on Digital Science's Dimensions.

Antibacterial apple cider vinegar eradicates methicillin resistant Staphylococcus aureus and resistant Escherichia coli

• Darshna Yagnik
• Malcolm Ward
• Ajit J. Shah

Inhibiting SARS-CoV-2 infection in vitro by suppressing its receptor, angiotensin-converting enzyme 2, via aryl-hydrocarbon receptor signal

• Keiji Tanimoto
• Kiichi Hirota
• Takemasa Sakaguchi

Targeted clearance of senescent cells using an antibody-drug conjugate against a specific membrane marker

• Marta Poblocka
• Akang Leonard Bassey
• Salvador Macip

Catechin and curcumin interact with S protein of SARS-CoV2 and ACE2 of human cell membrane: insights from computational studies

• Atala B. Jena
• Namrata Kanungo
• Jagneshwar Dandapat

Structure based pharmacophore modeling, virtual screening, molecular docking and ADMET approaches for identification of natural anti-cancer agents targeting XIAP protein

• Firoz A. Dain Md Opo
• Mohammed M. Rahman
• Abdullah M. Asiri

Low-dose Drosera rotundifolia induces gene expression changes in 16HBE human bronchial epithelial cells

• Fabio Arruda-Silva
• Paolo Bellavite
• Marta Marzotto

Classification and prediction of protein–protein interaction interface using machine learning algorithm

• Subhrangshu Das
• Saikat Chakrabarti

Carvacrol exhibits rapid bactericidal activity against Streptococcus pyogenes through cell membrane damage

• Niluni M. Wijesundara
• Song F. Lee
• H. P. Vasantha Rupasinghe

SHP2 blockade enhances anti-tumor immunity via tumor cell intrinsic and extrinsic mechanisms

• Morvarid Mohseni
• Silvia Goldoni

Polyunsaturated ω-3 fatty acids inhibit ACE2-controlled SARS-CoV-2 binding and cellular entry

• Aleksandra Niedzwiecki
• Matthias Rath

Arrayed CRISPR reveals genetic regulators of tau aggregation, autophagy and mitochondria in Alzheimer’s disease model

• Robert V. Talanian

Novel myostatin-specific antibody enhances muscle strength in muscle disease models

• Hiroyasu Muramatsu
• Taichi Kuramochi
• Junichi Nezu

Serine 477 plays a crucial role in the interaction of the SARS-CoV-2 spike protein with the human receptor ACE2

• Georg Steinkellner
• Christian C. Gruber

Improved methods for RNAseq-based alternative splicing analysis

• Rebecca F. Halperin
• Apurva Hegde
• Nicholas J. Schork

SIRT1 promotes lipid metabolism and mitochondrial biogenesis in adipocytes and coordinates adipogenesis by targeting key enzymatic pathways

• Yasser Majeed
• Najeeb Halabi
• Nayef A. Mazloum

A directional 3D neurite outgrowth model for studying motor axon biology and disease

• Xandor M. Spijkers
• Svetlana Pasteuning-Vuhman
• R. Jeroen Pasterkamp

Structural insights into SARS-CoV-2 spike protein and its natural mutants found in Mexican population

• Yudibeth Sixto-López
• José Correa-Basurto
• Sarita Montaño

Lipid bilayer degradation induced by SARS-CoV-2 spike protein as revealed by neutron reflectometry

• Alessandra Luchini
• Samantha Micciulla
• Giovanna Fragneto

Scale-up fermentation of Escherichia coli for the production of recombinant endoglucanase from Clostridium thermocellum

• Iram Shahzadi
• Maryam A. Al-Ghamdi
• Imran Kazmi

Drug design and repurposing with DockThor-VS web server focusing on SARS-CoV-2 therapeutic targets and their non-synonym variants

• Isabella A. Guedes
• Leon S. C. Costa
• Laurent E. Dardenne

Ultraviolet radiation protection potentials of Methylene Blue for human skin and coral reef health

• Zheng-Mei Xiong
• Xiaojing Mao

ABBV-744 as a potential inhibitor of SARS-CoV-2 main protease enzyme against COVID-19

• Zeynab Fakhar
• Aijaz Ahmad

Green synthesis of selenium nanoparticles mediated from Ceropegia bulbosa Roxb extract and its cytotoxicity, antimicrobial, mosquitocidal and photocatalytic activities

• Vetrivel Cittrarasu
• Durairaj Kaliannan
• Maruthupandian Arumugam

Random forest classification for predicting lifespan-extending chemical compounds

• Sofia Kapsiani
• Brendan J. Howlin

Development, characterization, and applications of multi-material stereolithography bioprinting

• Bagrat Grigoryan
• Daniel W. Sazer
• Jordan S. Miller

Biosynthesis and characterization of gold nanoparticles using Brazilian red propolis and evaluation of its antimicrobial and anticancer activities

• C. E. A. Botteon
• L. B. Silva
• P. D. Marcato

Reporter gene comparison demonstrates interference of complex body fluids with secreted luciferase activity

• B. A. C. Housmans
• P. M. van der Kraan

High-resolution transcriptional landscape of xeno-free human induced pluripotent stem cell-derived cerebellar organoids

• Samuel Nayler
• Devika Agarwal
• Esther B. E. Becker

Proteome-wide profiling and mapping of post translational modifications in human hearts

• Navratan Bagwan
• Henrik H. El Ali
• Alicia Lundby

Three-dimensional ultrastructure of giant mitochondria in human non-alcoholic fatty liver disease

• Gerald J. Shami
• Delfine Cheng
• Filip Braet

Zbp1-positive cells are osteogenic progenitors in periodontal ligament

• Tsugumi Ueda
• Tomoaki Iwayama
• Shinya Murakami

Neurotropic influenza A virus infection causes prion protein misfolding into infectious prions in neuroblastoma cells

• Hideyuki Hara
• Junji Chida
• Suehiro Sakaguchi

Self-organization and culture of Mesenchymal Stem Cell spheroids in acoustic levitation

• Nathan Jeger-Madiot
• Lousineh Arakelian
• Jean-Luc Aider

Blockade of SARS-CoV-2 spike protein-mediated cell–cell fusion using COVID-19 convalescent plasma

Systematic evaluation of multiple qPCR platforms, NanoString and miRNA-Seq for microRNA biomarker discovery in human biofluids

• Lewis Z. Hong
• Shian-Jiun Shih

Ionizing radiation exposure of stem cell-derived chondrocytes affects their gene and microRNA expression profiles and cytokine production

• Ewelina Stelcer
• Katarzyna Kulcenty
• Wiktoria Maria Suchorska

Improved functional properties of meat analogs by laccase catalyzed protein and pectin crosslinks

• Kiyota Sakai
• Yukihide Sato
• Shotaro Yamaguchi

Delivery of functional exogenous proteins by plant-derived vesicles to human cells in vitro

• Luiza Garaeva
• Roman Kamyshinsky
• Tatiana Shtam

Identification of germ cell-specific Mga variant mRNA that promotes meiosis via impediment of a non-canonical PRC1

• Yuka Kitamura
• Kousuke Uranishi
• Akihiko Okuda

Modified recombinant human erythropoietin with potentially reduced immunogenicity

• Thanutsorn Susantad
• Mayuree Fuangthong
• Ram Sasisekharan

Discovery of a new class of integrin antibodies for fibrosis

• Masahisa Handa

DSS-induced colitis is associated with adipose tissue dysfunction and disrupted hepatic lipid metabolism leading to hepatosteatosis and dyslipidemia in mice

• Jeonghyeon Kwon
• Chungho Lee
• Chang-Kee Hyun

Activation of NF-κB and induction of proinflammatory cytokine expressions mediated by ORF7a protein of SARS-CoV-2

• Chia-Ming Su
• Dongwan Yoo

Development of a target identification approach using native mass spectrometry

• Miaomiao Liu
• Wesley C. Van Voorhis
• Ronald J. Quinn

Optimized design parameters for CRISPR Cas9 and Cas12a homology-directed repair

• Mollie S. Schubert
• Bernice Thommandru
• Garrett R. Rettig

Single-cell differential splicing analysis reveals high heterogeneity of liver tumor-infiltrating T cells

• Biaofeng Zhou
• Shiping Liu

Generation of proliferating human adult hepatocytes using optimized 3D culture conditions

• Sophie Rose
• Frédéric Ezan
• Georges Baffet

Evaluation of microalgae polysaccharides as biostimulants of tomato plant defense using metabolomics and biochemical approaches

• Farid Rachidi
• Redouane Benhima
• Hicham El Arroussi

Detection and quantification of γ-H2AX using a dissociation enhanced lanthanide fluorescence immunoassay

• Felicite K. Noubissi
• Amber A. McBride
• Sandra M. Davern

Unraveling the stability landscape of mutations in the SARS-CoV-2 receptor-binding domain

• Mohamed Raef Smaoui
• Hamdi Yahyaoui

A comprehensive analysis of novel disulfide bond introduction site into the constant domain of human Fab

• Hitomi Nakamura
• Moeka Yoshikawa
• Takatoshi Ohkuri

Homology between SARS CoV-2 and human proteins

• Vladimir Khavinson
• Alexander Terekhov
• Alexander Maryanovich

A genome-wide CRISPR/Cas9 screen to identify phagocytosis modulators in monocytic THP-1 cells

• Benjamin Lindner
• Michael Schuler

PTEN loss promotes oncogenic function of STMN1 via PI3K/AKT pathway in lung cancer

• Guangsu Xun

Development of a yeast cell surface display method using the SpyTag/SpyCatcher system

• Kaho Kajiwara
• Wataru Aoki
• Mitsuyoshi Ueda

The dimer-monomer equilibrium of SARS-CoV-2 main protease is affected by small molecule inhibitors

• Lucia Silvestrini
• Norhan Belhaj
• Francesco Spinozzi

In-depth transcriptomic analysis of human retina reveals molecular mechanisms underlying diabetic retinopathy

• Kolja Becker
• Holger Klein
• Remko A. Bakker

Identification of extracellular matrix proteins secreted by human dermal fibroblasts cultured in 3D electrospun scaffolds

• Atena Malakpour-Permlid
• Irina Buzzi
• Stina Oredsson

Novel methods to establish whole-body primary cell cultures for the cnidarians Nematostella vectensis and Pocillopora damicornis

• James D. Nowotny
• Michael T. Connelly
• Nikki Traylor-Knowles

Culture and differentiation of rabbit intestinal organoids and organoid-derived cell monolayers

• Michael Frese
• Robyn N. Hall

Cannabidiol induces autophagy via ERK1/2 activation in neural cells

• Talita A. M. Vrechi
• Anderson H. F. F. Leão
• Gustavo J. S. Pereira

Seaweed cellulose scaffolds derived from green macroalgae for tissue engineering

• Nurit Bar-Shai
• Orna Sharabani-Yosef
• Alexander Golberg

Outer membrane vesicles containing OmpA induce mitochondrial fragmentation to promote pathogenesis of Acinetobacter baumannii

• Varnesh Tiku
• Eric M. Kofoed
• Man-Wah Tan

A scaffold-free approach to cartilage tissue generation using human embryonic stem cells

• Lauren A. Griffith
• Katherine M. Arnold
• Franchesca D. Houghton

The Penn State Protein Ladder system for inexpensive protein molecular weight markers

• Ryan T. Santilli
• John E. Williamson III

Inhibition of succinate dehydrogenase activity impairs human T cell activation and function

• Claudia Nastasi
• Andreas Willerlev-Olsen
• Anders Woetmann

Glucose confers protection to Escherichia coli against contact killing by Vibrio cholerae

• Cristian V. Crisan
• Holly L. Nichols
• Brian K. Hammer

Novel standardized method for extracellular flux analysis of oxidative and glycolytic metabolism in peripheral blood mononuclear cells

• Joëlle J. E. Janssen
• Bart Lagerwaard
• Vincent C. J. de Boer

3D bioprinting of hepatocytes: core–shell structured co-cultures with fibroblasts for enhanced functionality

• Rania Taymour
• David Kilian

Role of miRNAs shuttled by mesenchymal stem cell-derived small extracellular vesicles in modulating neuroinflammation

• Debora Giunti
• Chiara Marini
• Antonio Uccelli

Isolation of viable Babesia bovis merozoites to study parasite invasion

• Hassan Hakimi
• Masahito Asada
• Shinichiro Kawazu

Nutritional, phytochemical, and in vitro anticancer potential of sugar apple ( Annona squamosa ) fruits

• Mohamed Gamal Shehata
• Marwa Muhammad Abu-Serie
• Sobhy Ahmed El-Sohaimy

AptaNet as a deep learning approach for aptamer–protein interaction prediction

• Reza Ferdousi

Comprehensive virtual screening of 4.8 k flavonoids reveals novel insights into allosteric inhibition of SARS-CoV-2 M PRO

• Gabriel Jiménez-Avalos
• A. Paula Vargas-Ruiz
• COVID-19 Working Group in Perú

Comparison of the sensitivity of Western blotting between PVDF and NC membranes

• Yufang Xiang
• Yuanyuan Zheng
• Weijie Dong

Elovanoids downregulate SARS-CoV-2 cell-entry, canonical mediators and enhance protective signaling in human alveolar cells

• Jorgelina M. Calandria
• Surjyadipta Bhattacharjee
• Nicolas G. Bazan

The post-translational modification landscape of commercial beers

• Edward D. Kerr
• Christopher H. Caboche
• Benjamin L. Schulz

Anticancer potential of rhizome extract and a labdane diterpenoid from Curcuma mutabilis plant endemic to Western Ghats of India

• T. Lakshmipriya
• P. R. Manish Kumar

Chemotaxis and swarming in differentiated HL-60 neutrophil-like cells

• Kehinde Adebayo Babatunde
• Daniel Irimia

Integrated, automated maintenance, expansion and differentiation of 2D and 3D patient-derived cellular models for high throughput drug screening

• Ibrahim Boussaad
• Gérald Cruciani
• Rejko Krüger

In vitro synthesis of 32 translation-factor proteins from a single template reveals impaired ribosomal processivity

• David Foschepoth
• Christophe Danelon

Comparative transcriptome analysis reveals resistant and susceptible genes in tobacco cultivars in response to infection by Phytophthora nicotianae

• Mingming Sun
• Yuanying Wang

Protocol for preparation of heterogeneous biological samples for 3D electron microscopy: a case study for insects

• Alexey A. Polilov
• Anastasia A. Makarova
• Harald Hess

Downregulation of E-cadherin in pluripotent stem cells triggers partial EMT

• A. Lombardi

Identification of the first highly selective inhibitor of human lactate dehydrogenase B

• Sachio Shibata
• Satoshi Sogabe
• Tomoyoshi Soga

Estrogen-related receptor alpha (ERRα) is a key regulator of intestinal homeostasis and protects against colitis

• Charlotte Scholtes

Precision modification of the human gut microbiota targeting surface-associated proteins

• Raquel Marcos-Fernández
• Lorena Ruiz
• Borja Sánchez

Test conditions can significantly affect the results of in vitro cytotoxicity testing of degradable metallic biomaterials

• Eva Jablonská
• Jiří Kubásek

A systems pharmacology approach to identify the autophagy-inducing effects of Traditional Persian medicinal plants

• Pouria Mosaddeghi
• Mahboobeh Eslami
• Younes Ghasemi

Molecular dynamics and in silico mutagenesis on the reversible inhibitor-bound SARS-CoV-2 main protease complexes reveal the role of lateral pocket in enhancing the ligand affinity

• Ying Li Weng
• Shiv Rakesh Naik
• Aravindhan Ganesan

Cysteine: an overlooked energy and carbon source

• Luise Göbbels
• Anja Poehlein
• Marie Charlotte Schoelmerich

Generation of somatic mitochondrial DNA-replaced cells for mitochondrial dysfunction treatment

• Hideki Maeda
• Daisuke Kami
• Satoshi Gojo

In silico investigation of critical binding pattern in SARS-CoV-2 spike protein with angiotensin-converting enzyme 2

• Farzaneh Jafary
• Sepideh Jafari
• Mohamad Reza Ganjalikhany

Flexibility and mobility of SARS-CoV-2-related protein structures

• Rudolf A. Römer
• Navodya S. Römer
• A. Katrine Wallis

The effect of acute moderate-intensity exercise on the serum and fecal metabolomes and the gut microbiota of cross-country endurance athletes

• Mariangela Tabone
• Carlo Bressa
• Mar Larrosa

Bloom syndrome DNA helicase deficiency is associated with oxidative stress and mitochondrial network changes

• Veena Subramanian
• Brian Rodemoyer
• Kristina H. Schmidt

Robust and accurate prediction of protein–protein interactions by exploiting evolutionary information

• Yan-Bin Wang

Iron supplementation regulates the progression of high fat diet induced obesity and hepatic steatosis via mitochondrial signaling pathways

• Naho Kitamura
• Yoko Yokoyama
• Mitsuhiro Watanabe

Kokumi taste perception is functional in a model carnivore, the domestic cat ( Felis catus )

• A. Laffitte
• S. J. McGrane

Decoding empagliflozin’s molecular mechanism of action in heart failure with preserved ejection fraction using artificial intelligence

• Antoni Bayes-Genis
• Oriol Iborra-Egea
• Josep Lupón

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• v.34(1); 2022 Jan

Back to the roots: A focus on plant cell biology

Dolf weijers.

Senior Editor, The Plant Cell and Laboratory of Biochemistry, Wageningen University, Wageningen, The Netherlands

Magdalena Bezanilla

Reviewing Editor, The Plant Cell and Department of Biological Sciences, Dartmouth College, Hanover, NH, USA

Liwen Jiang

Guest Editor, The Plant Cell and School of Life Sciences, Centre for Cell and Developmental Biology, State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Hong Kong, China

Adrienne H K Roeder

Guest Editor, The Plant Cell and Weil Institute for Cell and Molecular Biology and School of Integrative Plant Sciences, Section of Plant Biology, Cornell University, Ithaca, NY, USA

Mary Williams

Features Editor, The Plant Cell, American Society of Plant Biologists, USA

Defining plant cell biology—especially in multicellular organisms—is not an easy task as it encompasses diverse tissues, organs, and ultimately the whole organism and its interaction with the environment. Events taking place at cellular scale are a consequence of molecular mechanisms that drive myriad processes occurring within and between single cells and their compartments. Perhaps, for this reason, it is fitting that The Plant Cell publishes in a broad range of topics. In this Focus Issue, we go back to the “roots” of the journal, that gave it its name, and turn our attention to the many fascinating facets of plant cell biology. The 11 review papers and 11 original research articles in this issue exemplify the breadth of the field and highlight both established concepts and recent achievements.

Much has changed in the 33 years since The Plant Cell was founded in 1989. Although molecular techniques were well established, researchers still largely studied one gene at a time, using relatively crude assays such as RNA blots to quantify gene expression. Arabidopsis research was gaining traction, but researchers still lacked a complete genome sequence or knock-out libraries. Imaging tools and probes were, by today’s standards, relatively limited; a further 5 years would pass before GFP was developed as a fluorescent protein reporter. Today’s research tools provide extraordinary insights into cell structure and function that were unimaginable in 1989, but also have opened new research avenues such as the ability to view cellular dynamics in real time in living cells and address questions about the roles of stochasticity and emergent properties in cell biology. Thus, we felt it was time to provide readers with an up-to-date view of plant cell biology.

This Focus Issue has two types of review papers: a set of eight traditional review papers, as well as three reviews that each are a collection of vignettes contributed by several authors. In the first of the vignette-style reviews, Kang et al. (2022) offer visual insight into the structures that compose plant cells, and present open questions related to plant cell structure. In the Cheung et al. (2022 ) review, seven eminent plant cell biologists offer first-hand narratives of several seminal discoveries that helped shape the field. Lastly, in Roeder et al. (2022) , experts in a range of areas within the field of plant cell biology formulate important outstanding questions to inspire future investigation.

The remaining reviews cover a broad range of topics at both subcellular and supracellular scales. Gu and Rasmussen (2022) provide an extensive overview of the cell biology underlying primary cell wall biosynthesis. Codjoe et al. (2022) focus on how plant cells sense and respond to physical forces through the mechanobiology of the walls, plasma membrane, and protoplast. Plant cells consist of many internal membrane structures, and Aniento et al. (2022) discuss the endomembrane trafficking processes that organize, maintain, and remodel these internal membrane structures. A notable aspect of the organization of plant cells and their membranes is the ability to define polar membrane domains. Ramalho et al. (2022 ) present an overview of the processes underlying plant cell polarity and its evolution. For any multicellular plant, cell division must be connected to growth and cell identity. Sablowski and Gutierrez (2022) describe the mechanisms that control cell cycle progression, cell growth, and cell fate. Zuch et al. (2022 ) integrate many of the elements in each of these reviews in a developmental context: the leaf epidermis. They discuss how cell division plane, cell cycle, cell polarity, and growth are coordinated to arrive at an organized multicellular structure. Since the development of molecular biology, genomics, and transgenesis, many cell biology studies have used flowering plant models such as tobacco and Arabidopsis. However, many of the developmental processes in flowering plants are derived from ancestral processes in early land plants. Naramoto et al. (2022) discuss the insights gained and open questions in using the bryophytes Physcomitrium patens and Marchantia polymorpha as models. The plant cell biology field has developed with the advent of methodologies that allow visualizing molecules and structures, and their dynamics. Colin et al. (2022 ) discuss the development of methodologies that enable present and future plant cell biologists to obtain a quantitative and dynamic view of plant cells.

Besides insightful and inspiring review papers, the Focus Issue contains 11 original research articles, of which two are Breakthrough Reports. These two Breakthrough Reports present crisp, shorter studies that are of exceptional novelty, or that open new avenues of investigation. Duncombe et al. (2022) describe the use of structured illumination microscopy (SIM) to track Arabidopsis Cellulose Synthase A (CESA) particle movement in the plasma membrane. This super-resolution approach provides new insight into the particle density and velocity, as well as their variation. Hacker et al. (2022) used a strategy revolving around CRISPR/Cas mutant analysis to identify the proteins in Arabidopsis that mediate the repair of DNA breaks and DNA-protein crosslinks induced by stalled topoisomerase 2 cleavage complexes. While this mechanism was suspected to exist in plants, its components had not yet been discovered.

The nine regular original research articles in this Focus Issue span a range of topics at different levels of cellular organization. Noack et al. (2022) describe the identification and characterization of a protein complex that acts as a scaffold to target the Arabidopsis PI4 kinase alpha1 to membrane nanodomains. Genetic analysis demonstrates a central role of this complex, which thus controls local membrane composition, in gametophyte and sporophyte development. Chang et al. (2022) present an extensive cell biological and genetic analysis of the Physcomitrium family of COPII coat proteins belonging to the Sec23 and Sec24 families. Within the Sec23 family, different isoforms have unique localization and functions related to endomembrane trafficking, secretion, and growth and development. The same COPII coat protein complex is linked to PI3P and autophagy in Arabidopsis by Kim et al. (2022) . In this study, the FYVE2 PI3P-binding protein is found to interact both with the COPII regulator SAR1, and with the ATG18A autophagy protein. Ma et al. (2022) report the formation of membrane nanodomains compartments containing Remorin proteins upon pathogen perception in Arabidopsis. Remorin in these clusters appears to undergo condensation, an example of liquid–liquid phase separation. Through interaction, Remorin concentrates the Formin protein, which causes local Actin nucleation. In a second paper from the same team, Minh Tran et al. (2022) report that outer membrane vesicles from the pathogenic bacterium Xanthomonas campestris can fuse with the plasma membrane in Arabidopsis , thus modifying host cell membrane properties. To complete a set of papers on organelles and endomembrane compartments, Liu et al. (2022) report an analysis of the FtsZ protein which is involved in chloroplast division. The authors show that weak membrane association through a newly identified protein motif, coupled to protein polymerization, is sufficient for membrane tethering and function. De Jaeger-Braet et al (2022) used live imaging of male meiocytes in Arabidopsis under normal and heat stress conditions to follow progression of meiosis. Their study revealed the existence of a previously unknown checkpoint that is sensitive to heat stress. Finally, two papers report on aspects of stomatal development and function. Yang et al. (2022a ) reveal an interesting link between cuticle formation and stomatal patterning in Arabidopsis . Analysis of the transcription factor MYB16 revealed that its downregulation by the SPCH transcription factor is necessary to prevent excess cuticle formation and clustering of stomata. Yang et al. (2022b ) describe the analysis of the Arabidopsis stomatal closure-related Actin-binding protein1 (SCAB1). This protein binds the membrane phospholipid PI3P and thereby controls its ability to oligomerize. As such, membrane PI3P influences Actin bundling during ABA-induced stomatal closure.

Beyond this set of papers in the Focus Issue, a larger collection of papers in the area of cell biology, published ∼1 year before or after this issue, will be bundled into a Focus Collection. This Focus Issue, together with the Focus Collection, showcases past and present insights, victories, and successes in this research field. The field has progressed immensely in the past decades, and we wonder what the next 33 years have in store. If one thing has become clear, it is that scientific progress, and thereby the development of a research field, is difficult to predict. Who would have predicted the concepts and findings reported in this Focus Issue 33 years ago? A key element of surprise is the development of new technologies that bring new boundaries into view, and challenges of which previously we were unaware. It seems biology has gotten much more complex, and yet we are also increasingly able to manage this complexity through computational approaches, including artificial intelligence. This latter development is also removing the shackles inherent to the limitations of the human mind in grasping complexity and thinking non-linearly. Perhaps the field of cell biology will be revolutionized by the computer sciences? We leave it to future Focus Issues to tell that story.

Contributor Information

Dolf Weijers, Senior Editor, The Plant Cell and Laboratory of Biochemistry, Wageningen University, Wageningen, The Netherlands.

Magdalena Bezanilla, Reviewing Editor, The Plant Cell and Department of Biological Sciences, Dartmouth College, Hanover, NH, USA.

Liwen Jiang, Guest Editor, The Plant Cell and School of Life Sciences, Centre for Cell and Developmental Biology, State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Hong Kong, China.

Adrienne H K Roeder, Guest Editor, The Plant Cell and Weil Institute for Cell and Molecular Biology and School of Integrative Plant Sciences, Section of Plant Biology, Cornell University, Ithaca, NY, USA.

Mary Williams, Features Editor, The Plant Cell, American Society of Plant Biologists, USA .

• Aniento F, Sánchez de Medina Hernández V, Dagdas Y, Rojas-Pierce M, Russinova E (2022) Molecular mechanisms of endomembrane trafficking in plants . Plant Cell   34 : 146–173 [ PMC free article ] [ PubMed ] [ Google Scholar ]
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Cell Biology News

Cell Biology is the study of cells, the fundamental unit of life, and their various functions within living organisms. It encompasses a wide range of topics, including cell structure, function, communication, and division, as well as the role of cells in disease and the development of new therapies. Cell biologists use a variety of techniques, from microscopy to genetic engineering, to investigate the complex mechanisms that govern cellular behavior. On this page, you will find a collection of articles related to cell biology research and discoveries, including updates on current projects, new findings, and insights into the interesting world of cells. Stay informed about the latest developments in cell biology research by with the articles here at SciTechDaily.

Physics April 21, 2024

Mystery Solved: Scientists Uncover Origins of Enigmatic Swirling Movements in Some of Nature’s Largest Cells

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Biology April 18, 2024

“One Ring To Rule Them All” – Molecular Biologists Have Cracked the Formin Code

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Biology April 16, 2024

Unlocking the Mysteries of Cell Structure With Cutting-Edge Imaging

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Organ Architects: The Remarkable Cells Shaping Our Development

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Researchers at Nagoya University in Japan have discovered that aldehydes are metabolic byproducts associated with premature aging. Published in Nature Cell Biology, their findings reveal…

Health April 8, 2024

How Do We Age? Breakthrough New Probe Sheds Light

New research helps to understand the aging process better and develop new strategies to reverse the degenerative processes associated with aging. A collaborative effort involving…

Biology March 27, 2024

Long-Standing Mystery Solved – Researchers Uncover Protein Responsible for Cold Sensation

Researchers at the University of Michigan have discovered the protein that enables mammals to sense cold, filling a long-standing knowledge gap in the field of…

Biology March 23, 2024

Molecular Majesty: This Is How the Body’s Building Blocks Are Made

Human cells contain ribosomes, a complex machine that produces proteins for the rest of the body. Now the researchers have come closer to understanding how…

Vast Implications – Scientists Develop Novel Technique To Form Human Artificial Chromosomes

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Biology March 21, 2024

Unveiling the Molecular Conspiracy: COVID-19’s Exploitation of Fragile X

Researchers have found an unexpected connection between coronavirus and Fragile X Syndrome, which is the most common hereditary cause of intellectual disability. How does coronavirus…

Health March 20, 2024

Genetic Relics: How Ancient Viral DNA Could Accelerate Neurodegeneration

Researchers See Ancient Genes As Potential Targets for Dementia Treatment Genetic remnants of viruses that are naturally present in the human genome could affect the…

Biology March 14, 2024

Scientists Solve Century-Old Cell Division Mystery

Movies such as ‘X-Men,’ ‘Fantastic Four,’ and ‘The Guardians,’ which showcase vibrant mutant heroes, have captivated global audiences. Recently, a high-throughput genetic screening of meiotic…

Biology March 13, 2024

Nature-Inspired Breakthrough: Artificial “Worm Gut” Devours Plastic Waste

A group of researchers at Nanyang Technological University, Singapore (NTU Singapore), has created a artificial ‘worm gut’ capable of decomposing plastics. This innovation presents a…

Biology March 12, 2024

Scientists Unravel the Unusual Cell Biology Behind Toxic Algal Blooms

A distinctive photosynthetic machinery characterizes a unicellular organism present in algal blooms. What are the cellular mechanisms within a single-celled marine algae species responsible for…

Biology March 9, 2024

New Discovery Reveals How Cells Defend Themselves During Stressful Situations

Stress granules play a crucial role in the stress response, arising from the aggregation of non-translating mRNAs and proteins. Although significant knowledge exists about stress…

Biology March 7, 2024

Beyond Telomerase: The Quest for Chromosome Immortality

Recent research challenges the long-standing understanding of the end-replication problem in DNA, revealing two distinct issues rather than one. Half a century ago, scientists Jim…

Biology February 29, 2024

Health, Aging, and Zombie Cells – Mayo Clinic Sheds New Light on Senescence

As individuals age, their cells may undergo senescence, a condition in which cell growth halts, yet these cells persist in emitting molecules that promote inflammation…

Biology February 25, 2024

The Hidden Trigger of Aging: New Discovery Could Change Longevity Research

Recent research has discovered that physical harm to the cell’s outer layer can trigger aging at the cellular level in human cells. The delicate membrane…

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