best topics for thesis in pharmacology

Pharmacology Research Paper Topics

In this page on pharmacology research paper topics , we explore the diverse and dynamic field of pharmacology and provide valuable resources for students who are tasked with writing research papers in this discipline. Pharmacology, as a branch of science, encompasses the study of how drugs interact with biological systems, aiming to understand their mechanisms of action, therapeutic uses, and potential side effects. With the growing importance of pharmacology in healthcare and drug development, it is crucial for students to delve into relevant pharmacology research paper topics that contribute to advancing knowledge and addressing current challenges in the field. Additionally, we highlight iResearchNet’s writing services, offering students the opportunity to order custom pharmacology research papers tailored to their specific needs. Our team of expert writers, equipped with in-depth knowledge of pharmacology and related fields, ensures high-quality, well-researched papers that adhere to the highest academic standards.

In the field of pharmacology, research plays a critical role in advancing our understanding of drugs, their mechanisms of action, and their impact on human health. As students of pharmacology, you may be tasked with writing research papers that explore various aspects of this dynamic discipline. To assist you in your research journey, we have curated a comprehensive list of pharmacology research paper topics that cover a wide range of subfields and emerging areas of interest. Whether you are interested in drug discovery, clinical pharmacology, pharmacogenomics, or drug safety, this list provides a wealth of ideas to inspire and guide your research endeavors.

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Drug Discovery and Development

• Role of Artificial Intelligence in Drug Discovery
• Personalized Medicine: Tailoring Drug Therapy to Individual Patients
• Drug Repurposing: Exploring New Indications for Existing Drugs
• Pharmacogenomics and Drug Response Prediction
• Nanomedicine: Applications in Drug Delivery and Targeting
• Innovative Approaches for Drug Formulation and Delivery
• Drug Combinations: Synergistic Effects and Therapeutic Opportunities
• Natural Products as Sources of Novel Therapeutic Agents
• Virtual Screening and Molecular Docking in Drug Design
• Pharmacokinetics and Pharmacodynamics of New Drug Entities

Clinical Pharmacology

• Precision Dosing: Optimizing Drug Therapy for Individual Patients
• Pharmacokinetic Variability in Special Populations (Pediatrics, Geriatrics, Pregnant Women)
• Drug-Drug Interactions: Mechanisms and Clinical Implications
• Adverse Drug Reactions: Identification, Prevention, and Management
• Pharmacovigilance and Drug Safety Monitoring
• Therapeutic Drug Monitoring: Rationale and Practical Considerations
• Clinical Trials in Pharmacology: Design, Implementation, and Analysis
• Drug Development and Regulatory Approval Processes
• Pharmacoeconomics: Evaluating the Cost-Effectiveness of Drug Therapy
• Ethical Considerations in Clinical Pharmacology Research

Neuropharmacology and Psychopharmacology

• Mechanisms of Action and Therapeutic Applications of Antidepressant Drugs
• Neurotransmitter Systems and Their Role in Mental Health Disorders
• Psychotropic Drugs and Their Impact on Cognitive Functioning
• Novel Approaches for Targeting Neurodegenerative Disorders
• Pharmacological Management of Substance Use Disorders
• Pharmacogenetics in Psychiatry: Implications for Individualized Treatment
• Role of Neuroinflammation in Neurological and Psychiatric Disorders
• Neuropharmacology of Sleep and Wakefulness
• Pharmacotherapy for Schizophrenia: Current Trends and Future Directions
• Novel Treatments for Anxiety and Mood Disorders

Pharmacokinetics and Drug Metabolism

• Drug Transporters and Their Role in Drug Disposition
• Pharmacogenetics and Personalized Drug Therapy
• Pharmacokinetic Variability and Its Impact on Drug Response
• Drug Metabolism Pathways and Enzyme Polymorphisms
• Drug-Drug Interactions: Mechanisms and Clinical Significance
• Predictive Modeling in Pharmacokinetics and Dose Optimization
• Pharmacokinetics in Special Populations: Pediatrics and Geriatrics
• Impact of Genetic Variation on Drug Clearance and Toxicity
• Role of Pharmacokinetics in Individualizing Drug Dosage
• Strategies for Improving Oral Bioavailability of Drugs

Pharmacology of Infectious Diseases

• Antimicrobial Resistance: Mechanisms, Epidemiology, and Strategies
• Development of Novel Antiviral Agents: Challenges and Opportunities
• Pharmacotherapy for Bacterial Infections: Current Approaches and Future Directions
• Antifungal Drugs: Mechanisms of Action and Resistance
• Host-Pathogen Interactions and Their Implications for Drug Development
• Pharmacokinetic Considerations in the Treatment of Viral Infections
• Targeting Virulence Factors in Bacterial Pathogens
• Drug Combination Therapy for Multidrug-Resistant Infections
• Pharmacogenomics of Antimicrobial Agents
• New Approaches for Antiparasitic Drug Development

Cardiovascular Pharmacology

• Novel Antiplatelet Agents: Mechanisms and Clinical Applications
• Antihypertensive Therapy: Current Strategies and Future Perspectives
• Pharmacotherapy for Heart Failure: Advancements and Challenges
• Role of Pharmacogenomics in Cardiovascular Drug Therapy
• Therapeutic Potential of Antiarrhythmic Agents
• Pharmacological Management of Dyslipidemia and Atherosclerosis
• Emerging Therapies for Pulmonary Hypertension
• Pharmacological Approaches to Preventing Thromboembolic Disorders
• Cardiotoxicity of Chemotherapeutic Agents: Mechanisms and Cardioprotective Strategies
• Targeting Inflammatory Pathways in Cardiovascular Disease

Pharmacology and Aging

• Geriatric Pharmacotherapy: Challenges and Approaches
• Age-Related Changes in Pharmacokinetics and Pharmacodynamics
• Polypharmacy and Its Impact on Older Adults
• Adverse Drug Reactions in the Elderly: Recognition and Prevention
• Pharmacological Management of Age-Related Neurodegenerative Disorders
• Geriatric Pharmacogenomics: Implications for Personalized Medicine
• Drug-Related Falls and Fractures in the Elderly: Prevention and Intervention
• Medication Adherence in Older Adults: Barriers and Strategies
• Geriatric Pain Management: Balancing Efficacy and Safety
• Optimizing Drug Therapy in Older Adults with Multiple Comorbidities

Pharmacology of Cancer

• Targeted Therapies for Solid Tumors: Recent Advances and Future Directions
• Immunotherapy in Cancer Treatment: Current Approaches and Challenges
• Pharmacogenomics of Chemotherapy: Implications for Personalized Treatment
• Drug Resistance in Cancer: Mechanisms and Strategies for Overcoming Resistance
• Pharmacokinetics and Pharmacodynamics of Anticancer Agents
• Combination Therapies in Oncology: Rationale and Clinical Outcomes
• Oncolytic Viruses: Exploiting Viral Infections for Cancer Treatment
• Cancer Stem Cells: Targeting Tumor Initiation and Progression
• Development of Novel Imaging Agents for Cancer Diagnosis and Monitoring
• Pharmacological Interventions for Cancer-Associated Pain Management

Pharmacology and Immunology

• Immune Checkpoint Inhibitors in Cancer Immunotherapy
• Autoimmune Diseases: Novel Pharmacological Approaches and Therapies
• Immunomodulatory Effects of Drugs: Implications for Therapeutic Interventions
• Role of Pharmacogenomics in Immunomodulatory Drug Therapy
• Immunopharmacology of Allergic Reactions: Mechanisms and Treatment Strategies
• Immunosuppressive Drugs in Transplantation: Balancing Efficacy and Safety
• Targeting Inflammatory Pathways in Autoimmune Disorders
• Immunopharmacological Interventions for Infectious Diseases
• Pharmacological Modulation of Cytokines in Inflammatory Disorders
• Vaccines: Advancements in Development and Delivery

Pharmacovigilance and Drug Safety

• Post-Marketing Surveillance: Detecting and Evaluating Adverse Drug Reactions
• Signal Detection in Pharmacovigilance: Methods and Applications
• Risk Management Strategies in Drug Development and Marketing
• Pharmacogenomic Biomarkers for Predicting Drug Safety
• Pharmacovigilance in Special Populations: Pregnant Women and Pediatrics
• Drug Safety Communication: Enhancing Patient Awareness and Education
• Role of Pharmacovigilance in Drug Regulatory Affairs
• Pharmacovigilance Data Mining: Leveraging Big Data for Drug Safety
• Pharmacovigilance Systems and Reporting Structures
• Pharmacogenetic Testing in Drug Safety Assessment

This comprehensive list of pharmacology research paper topics provides a broad range of ideas and areas to explore within the field of pharmacology. From drug discovery and development to clinical pharmacology, neuropharmacology, and pharmacokinetics, each category offers multiple topics for students to delve into and contribute to the advancement of pharmacological knowledge. Whether you are interested in the impact of pharmacogenomics on drug therapy, exploring novel treatment strategies, or investigating drug safety and pharmacovigilance, there is a wealth of research possibilities awaiting exploration. By selecting a topic of interest and following the expert advice on topic selection and research paper writing, students can embark on an enriching journey of discovery and make meaningful contributions to the field of pharmacology.

Pharmacology: Exploring the Range of Research Paper Topics

Pharmacology is a captivating and dynamic scientific discipline that focuses on the study of drugs and their effects on living organisms. It plays a crucial role in improving human health by advancing our understanding of how medications interact with biological systems. Within the field of pharmacology, there is a vast array of pharmacology research paper topics that offer students an opportunity to delve into various aspects of drug discovery, development, clinical application, and safety. In this article, we will explore the breadth and depth of pharmacology as a scientific field, highlighting the range of research paper topics it encompasses.

Drug Discovery and Development:  One exciting area of pharmacology research is drug discovery and development. This field involves the identification and development of new therapeutic agents to treat a wide range of diseases. Students interested in this area can explore topics such as the exploration of novel drug targets and therapeutic approaches, investigating natural products for drug development, advancements in targeted drug delivery systems, pharmacokinetics and pharmacodynamics of new drug entities, and understanding and overcoming drug resistance mechanisms.

Clinical Pharmacology:  Clinical pharmacology focuses on the application of pharmacological principles in the clinical setting. It plays a vital role in optimizing drug therapy and ensuring patient safety. Pharmacology research paper topics in this area may include pharmacogenomics, which explores the relationship between an individual’s genetic makeup and their response to medication. Other topics of interest include the identification, prevention, and management of adverse drug reactions, the design and ethical considerations in clinical trials, pharmacovigilance, and optimizing drug regimens for special populations such as pediatrics, geriatrics, and pregnant women.

Neuropharmacology and Psychopharmacology:  The field of neuropharmacology examines how drugs interact with the central nervous system and influence brain function. Pharmacology research paper topics in this area may involve investigating the mechanisms of action and therapeutic applications of psychotropic drugs, exploring neurotransmitter systems and their role in neurological disorders, pharmacological interventions for Alzheimer’s disease and other neurodegenerative disorders, the psychopharmacology of substance use disorders, and the pharmacological management of mental health disorders.

Pharmacokinetics and Drug Metabolism:  Pharmacokinetics and drug metabolism focus on understanding how drugs are absorbed, distributed, metabolized, and eliminated by the body. Pharmacology research paper topics in this area may include studying drug interactions, such as the mechanisms, predictions, and clinical implications of drug-drug interactions. Other topics of interest include pharmacogenetics and individual variations in drug response, the role of drug transporters in drug disposition, drug metabolism and its impact on drug-drug interactions, and the use of predictive modeling in pharmacokinetics and dosing optimization.

Pharmacology of Infectious Diseases:  The pharmacology of infectious diseases involves studying how drugs can effectively treat and prevent infections. Research topics in this area may include exploring antimicrobial resistance, including its mechanisms, epidemiology, and strategies to combat it. Additionally, students may investigate the development of new antiviral agents, the pharmacological management of bacterial infections, host-pathogen interactions, and the pharmacokinetic considerations in the treatment of infectious diseases.

Cardiovascular Pharmacology:  Cardiovascular pharmacology focuses on understanding the effects of drugs on the cardiovascular system. Research topics in this area may include exploring drug therapy for hypertension and current guidelines for treatment, novel anticoagulants in the prevention and treatment of thromboembolic disorders, pharmacological approaches to managing heart failure, drug-induced cardiotoxicity and strategies for prevention, and emerging pharmacotherapies for atherosclerosis and coronary artery disease.

Pharmacology and Aging:  Pharmacology and aging is a specialized field that investigates how drug therapy can be optimized in older adults. Research topics in this area may include exploring geriatric pharmacotherapy, age-related changes in pharmacokinetics and pharmacodynamics, the impact of polypharmacy on older adults, the recognition and prevention of adverse drug reactions, pharmacological management of age-related neurodegenerative disorders, and strategies for improving medication adherence in the elderly.

The field of pharmacology offers a wide range of exciting research paper topics that span from drug discovery and development to clinical pharmacology, neuropharmacology, pharmacokinetics, and beyond. By exploring these topics, students can contribute to the advancement of pharmacological knowledge and make meaningful contributions to the field. Remember to choose a research topic that aligns with your interests and career aspirations, and be sure to consult with your instructors or mentors for guidance throughout your research journey. With dedication, curiosity, and a passion for improving patient care, you have the opportunity to shape the future of pharmacology research.

How to Choose a Pharmacology Research Topic

Choosing the right research paper topic is crucial for a successful academic journey in pharmacology. It allows you to explore your interests, contribute to the field, and showcase your knowledge and skills. However, with the vast scope of pharmacology, selecting a research topic can be a daunting task. In this section, we will provide you with expert advice on how to choose pharmacology research paper topics that are engaging, relevant, and have the potential for significant contribution.

• Identify Your Interests : Start by identifying your areas of interest within pharmacology. Reflect on the topics that have captivated your attention during your coursework or sparked your curiosity. Consider whether you are more inclined towards drug discovery, clinical applications, pharmacokinetics, neuropharmacology, or any other subfield of pharmacology. This self-reflection will help you narrow down your options and select a topic that resonates with your passion.
• Stay Updated with Current Research : To choose a compelling research topic, it is essential to stay updated with the latest advancements and trends in pharmacology. Follow reputable scientific journals, attend conferences, and engage with the pharmacological community to gain insights into the ongoing research and emerging areas of interest. This will help you identify gaps in the current knowledge and select a topic that offers the potential for novel discoveries or addressing existing challenges.
• Consult with Faculty and Experts : Seek guidance from your faculty members, mentors, or experts in the field of pharmacology. They can provide valuable insights and suggest potential research areas based on their expertise and experience. Discuss your interests, goals, and research aspirations with them, and they can help you refine your research topic, provide relevant literature references, and offer valuable advice on the feasibility and scope of your chosen topic.
• Consider Practicality and Resources : When selecting a research topic, consider the practicality and availability of resources. Assess whether the necessary laboratory facilities, equipment, or access to clinical data are readily accessible to conduct your research. Additionally, consider the time and resources required to complete the research within the given timeframe. Choosing a topic that aligns with the available resources will enhance the feasibility and success of your research endeavor.
• Address Current Challenges or Gaps : Pharmacology is a field that constantly evolves, presenting new challenges and unanswered questions. Consider selecting a research topic that addresses current challenges or explores gaps in the existing knowledge. This could involve investigating the mechanisms of drug resistance, exploring novel drug targets, or optimizing drug regimens for specific patient populations. By tackling these challenges, you can contribute to the advancement of pharmacological science and make a meaningful impact.
• Collaborate with Peers : Consider collaborating with fellow students or researchers who share similar research interests. Collaborative research projects can provide a broader perspective, foster knowledge sharing, and enhance the overall quality of your research. Collaborating with peers also allows you to divide the workload, share resources, and receive feedback and support throughout the research process.
• Seek Ethical Considerations : When selecting a pharmacology research topic, it is essential to consider ethical considerations and adhere to the principles of research ethics. Ensure that your chosen topic respects patient confidentiality, follows the guidelines for the ethical use of animal subjects (if applicable), and aligns with the ethical principles outlined by regulatory bodies. Consulting with your institution’s ethics committee or research advisor can help ensure that your research project meets the required ethical standards.
• Evaluate Feasibility and Novelty : Evaluate the feasibility and novelty of your chosen research topic. Consider whether the research question is answerable within the available resources and time constraints. Additionally, assess whether your topic brings something new to the field, whether it fills a knowledge gap, or offers a fresh perspective on an existing topic. A balance between feasibility and novelty is essential for a successful research paper.
• Consult Literature Reviews : Conduct thorough literature reviews on your chosen topic to gain a comprehensive understanding of the existing research. Literature reviews help you identify gaps in the current knowledge and provide a foundation for your research question. They also enable you to build on previous findings, develop a robust research methodology, and position your research within the context of the broader field of pharmacology.
• Remain Flexible : Lastly, remain flexible throughout the process of choosing a research topic. As you delve deeper into the literature and research process, you may discover new avenues of interest or encounter unexpected challenges. It is essential to remain open to refining or adjusting your research topic based on new insights, emerging data, or feedback from your research advisors. Flexibility allows you to adapt and ensure that your research remains relevant and impactful.

Choosing a pharmacology research paper topic is an exciting and important step in your academic journey. By following expert advice, identifying your interests, staying updated with current research, seeking guidance, considering practicality and resources, addressing current challenges or gaps, collaborating with peers, adhering to ethical considerations, evaluating feasibility and novelty, consulting literature reviews, and remaining flexible, you can select a research topic that is engaging, relevant, and has the potential to contribute to the field of pharmacology. Remember, this is your opportunity to explore, innovate, and make a lasting impact in the dynamic field of pharmacology research.

How to Write a Pharmacology Research Paper

Writing a pharmacology research paper requires careful planning, organization, and attention to detail. It is an opportunity for you to showcase your understanding of the subject matter, critical thinking skills, and ability to communicate scientific information effectively. In this section, we will provide you with expert guidance on how to write a pharmacology research paper that is well-structured, informative, and compelling.

• Choose a Well-Defined Research Question : Start by formulating a clear and well-defined research question. Your research question should be focused, specific, and address a gap in the existing knowledge. Consider the significance of your research question in the context of pharmacology and how it contributes to the overall understanding of the field. A well-defined research question sets the foundation for your entire research paper.
• Conduct a Thorough Literature Review : Before diving into your research, conduct a thorough literature review on the chosen topic. Familiarize yourself with the existing research, theories, and findings related to your research question. This will provide you with a solid understanding of the current state of knowledge and help you identify gaps or areas for further investigation. Additionally, the literature review will inform your research methodology and discussion of results.
• Develop a Clear Structure : A well-structured research paper is essential for effectively conveying your ideas and findings. Begin with an engaging introduction that provides background information, context, and clearly states your research question. Follow with a comprehensive literature review that supports your research question and highlights the gaps in knowledge. Next, present your research methodology, including details on sample selection, data collection, and analysis methods. In the results section, present your findings in a clear and organized manner using tables, graphs, or figures as necessary. Finally, discuss your results, interpret their significance, and relate them back to your research question in the discussion section. Conclude with a concise summary of your findings and their implications.
• Use Reliable and Credible Sources : Ensure that the sources you use for your research paper are reliable, credible, and peer-reviewed. Consult reputable scientific journals, textbooks, and conference proceedings. Avoid relying solely on internet sources or non-scholarly publications. Citations are critical to acknowledge the work of other researchers and to support your claims and arguments. Use a consistent citation style, such as APA, MLA, or Chicago, and follow the guidelines carefully.
• Analyze and Interpret Your Data : If your research involves collecting and analyzing data, ensure that your data analysis is thorough and accurate. Use appropriate statistical methods to analyze your data and present the results in a clear and meaningful way. Interpret the findings in the context of your research question and discuss any limitations or potential sources of bias. Remember to relate your findings back to the existing literature and explain how they contribute to the broader understanding of pharmacology.
• Write Clearly and Concisely : Effective scientific writing is clear, concise, and free of unnecessary jargon. Use language that is precise and straightforward, avoiding ambiguous or vague statements. Clearly articulate your ideas and ensure that your arguments are logical and well-supported by evidence. Use appropriate scientific terminology, but also consider your target audience and strive to communicate your findings in a way that is accessible to readers who may not have expertise in pharmacology.
• Pay Attention to Formatting and Style : Follow the formatting and style guidelines specified by your instructor or the target journal. Pay attention to details such as font size, line spacing, margins, and headings. Use subheadings to organize your content and make it easier for readers to navigate. Adhere to the specific citation style required for your paper and ensure that your references are complete and accurate.
• Revise and Edit : Revision and editing are essential steps in the writing process. Take the time to review your research paper for clarity, coherence, and accuracy. Check for grammatical errors, spelling mistakes, and punctuation errors. Ensure that your ideas flow logically and that your paper is well-structured. Consider seeking feedback from peers, instructors, or mentors to gain different perspectives and improve the overall quality of your paper.
• Proofread : Before submitting your research paper, thoroughly proofread it to ensure that it is error-free. Check for any typos, inconsistencies, or formatting issues. Read your paper aloud to catch any awkward phrasing or unclear sentences. It can also be helpful to have someone else read your paper to identify any errors or areas that need improvement.
• Ethical Considerations : Ensure that your research paper adheres to ethical considerations. If your research involved human subjects, ensure that you have obtained the necessary approvals and informed consent. Respect patient confidentiality and anonymity when presenting your research findings. Adhere to the ethical guidelines set by your institution or the relevant regulatory bodies.

Writing a pharmacology research paper requires careful planning, thorough research, effective communication, and attention to detail. By following the expert advice provided in this section, you can develop a well-structured and informative research paper that contributes to the field of pharmacology. Remember to choose a well-defined research question, conduct a thorough literature review, use reliable sources, analyze and interpret your data, write clearly and concisely, pay attention to formatting and style, revise and edit your paper, proofread for errors, and ensure ethical considerations are met. With diligence and commitment, your pharmacology research paper has the potential to make a meaningful impact in the field of pharmacology.

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Recent Pharmacology Theses

Here is a list of students who have recently defended their Ph.D. Thesis in Pharmacology, along with a brief description of their thesis work.

03/10/2023 Joel Sexton - Disentangling Sequence Constraints on the Coflin N-terminal Phosphorylation Site

Mar 2023 Iris van Alderwerelt van Rosenburgh - Kinase Dynamics Underlie Mechanisms of Sensitivity and Resistance of EGFR with LUAD Mutations to Tyrosine Kinase Inhibitors

Feb 2023 Zechen Wang (Anderson Lab) - Tackling FGFR Fusion-Positive Cancers with a Novel Synergistic Combination of FGFR and HDAC Inhibitors

Mar 2022 Chun Hu - Understanding distinct roles of EGFR family mutations in different cancers

Feb 2022 Michael Bond - Towards Tumor-Cell Specific Proteolysis Targeting Chimeras: Identification of first-in-class degraders of oncogenic KRASG12C, DcpS, and MAGE-A3

Jan 2022 Joshua Sheetz - The Dead Receptor Paradox: Insights into Receptor Tyrosine Kinases with Intracellular Pseudokinase Domains

Jan 2022 Joseph Fowler - Inflammatory stress disrupts endothelial cell cholesterol homeostasis and increases SREBP2-dependent gene expression to amplify the acute inflammatory response

Aug 2021 Courtney Smith - Regulation of TIM-3 by Phosphatidylserine

Jul 2021 Brian Shi - Proteome-wide screening for mitogen-activated protein kinase docking motifs and interactors

03/02/2021 Eunice Cho - PPP6C Regulation of ERK Signaling in Melanoma

02/15/2021 Ban Edani - Structural Elucidation of the cis-prenyltransferase NgBR/DHDDS Complex Reveals Novel Insights in Regulation of Protein Glycosylation

12/14/2020 Shanique Alabi - Mutant-selective Degradation by BRAF-targeting PROTACs

11/20/2020 Valerie Su - Serine Phosphorylation of ICAP1 Inhibits its Nuclear Accumulation

11/04/2020 Vincent Duong - Evaluation of NRTI-mediated toxicity through the human mitochondrial polymerase PrimPol

08/04/2020 Victor Ruiz - Computer-Aided Discovery of New Inhibitors of C. hominis Thymidylate Synthase-Dihydrofolate Reductase

01/15/2020 Keith Weise - Regulation of activity and localization of the budding yeast kinases Kin1 and Kin2

01/10/2020 Eric Rosenberg - Perturbing the activities of chemokine receptors CXCR4 and CXCR5

11/25/2019 Yasmin Kadry - Biochemical and functional characterization of kindlin interactions

09/23/2019 Ashley Sizer - O-GlcNAc transferase-dependent regulation of serum response factor and vascular smooth muscle cell phenotype

03/01/2019 Zachary Gannam - Exploring the allosteric inhibition of a MAPK phosphatase linked to Duchenne muscular dystrophy

01/24/19 William Gray - Nucleoid Size Scaling and Intracellular Organization of Translation Across Bacteria.

01/14/19 Lee Ying - Epigentic Approaches to Understanding Adipogenesis, and Translational Approaches to Treating Obesity.

10/05/18 Molly Ryan - Understanding the Consequences of Oncogenic FGFR Mutations on Drug Resistance, Signaling, and Tumorigenesis

09/27/18 Daniel Iwamoto - Structural basis of the filamin A actin-binding domain interaction with F-actin

09/12/18 Lie Ma - Elucidation of the Activated State of Fibroblast Growth Factor Receptor

09/10/18 David E. Puleo -Targeting the Mutant JAK2 V617F Tyrosine Kinase by Small Molecules that Bind to its Pseudokinase Domain

03/01/18 Tomoaki Sasaki - Characterization of APOBEC3 Family Proteins as Potent DNA Mutators in Human Cancers

02/12/18 Elizabeth Mo - Augmentors are in vivo ligands to the ALK family of receptor tyrosine kinases: function and evolution

09/26/17 Chad Miller - Comprehensive Profiling of a Kinase Family Defines Features Essential for Selective Substrate Targeting

11/30/2016 Amelia Luciano - The Role of Akt1 & Clock S845 phosphorylation in Circadian Regulated Transcriptional Rhythms

09/23/2016 Allison Goldberg - An Exosite Required for Efficient Targeting of MAP Kinase Kinases by the Metalloproteinase Antrax Lethal Factor

08/12/2016 Yagmur Muftuoglu - Mechanisms of substrate specificity and insights into activation of phosphatidylionositol phosphate kinases

06/02/2016 Andrea Mislak - Insights into the Activity, Resistance, and Toxicity of Antivirals Targeting HIV Reverse Transcriptase

02/23/16 Phillip Murray - Discovery and Characterization of Ligands for the Receptor Tyrosine Kinase ALK: AUG-alpha, AUG-beta and Heparin

12/10/15 Yifei Yang - Molecular basis for Polycystin- 2 channel regulation and assembly its C-terminal tail

12/08/15 Jacqueline Heiss - Prion Protein Regulates Amyloid- Beta Dendritic Spine Pathology in a Mouse model if Alzheimer's Disease

10/15/15 Celeste Greer - Histone Deacetylases Positively Regulate Transcriptional Elongation

2/24/15 Oriana Fisher - Structural studies of Cerebral Cavernous Malformations 2 (CCM2) reveal the basis for its interactions with protein binding

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Pharmacology Thesis Topics for MD/DNB

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• The effect of lamotrigine on working memory in rats.
• Effectiveness of drug information pamphlets in improving patient medication adherence and usage of commonly prescribed medications and antibiotics among patients in a tertiary care hospital.
• Study of prescription pattern of antihypertensive drugs in a tertiary care hospital.
• A study to evaluate the antibacterial drugs used in upper-respiratory tract infection in pediatric age group.
• Fluorouracil Degradation Rate (5-FUDR) as a predictive biomarker for adverse effects with 5- Fluorouracil / Capecitabine therapy in South Indian cancer patients – a prospective phenotype genotype association study.
• Hepatoprotective effect of 7 – methoxy coumarin in paracetamol and ethanol toxicity induced cell lines.
• Pattern of adverse drug reaction and medication use in neonatal care units in a tertiary care hospital: a longitudinal observational study.
• Antidiabetic and pleiotropic effects of Psidium guajava Linn leaf extract. as an add on treatment in patients with type 2 diabetes mellitus – A randomized double-blind placebo controlled trial
• Characterization of pncA mutation and treatment outcome among tuberculosis patients
• Characterization of cyclosporine trough (C0) and two-hour post dose concentration (C2) monitoring in children with idiopathic nephrotic syndrome
• Clinical characteristics and early outcome of bedaquiline containing regimens for the treatment of MDR
• Clinical characteristics and treatment outcome of Isoniazid mono-resistance tuberculosis patients: A mixed-method study
• ICMR Rational use of medicines “Evaluation of the prescription pattern of drugs in different OPDs of a tertiary care hospital” task force project
• The cytokine levels and miRNA expression in patients with major depressive disorder and its modulation by silymarin.
• Subclinical hypothyroidism and plasma levels of commonly prescribed antiepileptic drugs – a cross sectional study.
• Pharmacogenetics of sodium valproate – induced weight gain in South Indian patients
• Formulation and evaluation of topical preparation of Lawsonia inermis L. (Lythraceae) for the evaluation of Capecitabine induced hand – foot syndrome in cancer patients.
• Are the users of angiotensin converting enzyme inhibitors (ACE-I) and angiotensin receptor blockers (ARBs) at a higher risk of severe COVID-19? – A Case Control study.
• Association of Nucleoside Diphosphate linked moiety X Type motif 15 (NUDT15) C415T and Inosine Triphosphate Pyrophosphatase (ITPA) C94A genetic polymorphisms with azathioprine induced adverse effects in south Indian patients.
• Effect of VDR (Vitamin D Receptor) gene polymorphisms on efficacy of zoledronic acid in south Indian women with postmenopausal osteoporosis; A cross sectional study.
• Cytogenetic and molecular characterization of teenage and young adult acute lymphoblastic leukaemia with special emphasis on identification of “Philadelphia like” profile
• Influence of EPHX1 C and UGT2B7*2 genetic polymorphism on carbamazepine maintenance dose requirement in person with epilepsy .
• Estimating Incremental Cost of treating Antimicrobial Resistant infections in India.
• Study of prescription pattern of anti-epileptic agents in a tertiary care hospital.
• Evaluation of anti-inflammatory and analgesic activities of thiophene derivatives in wistar albino rats
• Evaluation of learning and memory enhancing activities of thiazolidinone arecoline derivatives in wistar albino rats.
• Evaluation of hepatoprotective effect of gallic acid in murine model of isoniazid-induced hepatotoxicity.
• Study of prescription pattern of Antimicrobial drugs in a tertiary care hospital.
• Evaluation of effect of ciprofloxacin and levofloxacin on depressive behaviour in mice.
• Evaluation of anti-ulcer activity of vanillin using stress and aspirin induced ulcer models in wistar albino rats
• A comparative study of efficacy and safety of timolol versus latanoprost in the treatment of primary open angle glaucoma at a tertiary care hospital
• A comparative prospective study to assess the efficacy and safety of iron sucrose versus iron sorbitol citric acid complex in pregnant women with iron deficiency anaemia in a tertiary care hospital
• Comparison of the effects of imipramine and fluoxetine on the diagnostic parameters of metabolic syndrome in patients with depressive episode at a tertiary care hospital.
• A comparitive study of efficacy and safety of intralesional triamcinolone with verapamilin treatment of keloid and hypertrophic scar in tertiary care hospital
• A comparative study of the clinical efficacy and safety of topical retapamulin and mupirocin in the treatment of acute bacterial skin infections.
• A prospective randomized open- labelled comparative study of the clinical efficacy and safety of the fixed dose combination of arterolane maleate and piperaquine phosphate with artesunate and sulfadoxine – pyrimethamine in uncomplicated falciparum malaria.
• Prospective comparitive study of effect of two cephalosporin sulbactam combinations in chemoprophylaxis of open reduction & internal fixation surgery in closed limb fractures.
• The efficacy and adverse drug profile of risperidone versus olanzapine in the treatment of patients with bipolar affective disorder on combination therapy – a prospective, naturalistic, hospital based clinical study.
• Comparison of the effect of selective serotonin reuptake inhibitors and selective serotonin norepinephrine reuptake inhibitors on body mass index in patients on long term treatment.
• Comparative assessment of the efficacy of morning dose versus evening dose levothyroxine in hypothyroid patients.
• Study of prescription pattern of antitubercular drugs in a tertiary care hospital.
• Comparative assessment of oral and local probiotics as an adjunct to standard therapy for vulvo vaginitis
• Antiasthmatic effect of ethanolic extract of moringa oleifera (drumstick) seed kernels in an experimental animal mode.
• Comparison of efficacy and safety of newer antifungal agent sertaconazole with clotrimazole and fluconazole in the treatment of acute vulvovaginal candidiasis.
• Preliminary evaluation of anticonvulsant activity of aqueous extract of adhatoda vasica leaves in male and female albino rats.
• Preliminary evaluation of hypoglycemic activity of methanol extract of roots of acorus calamus in alloxan induced diabetic albino rats.
• To study effectiveness and tolerability of opipramol in the treatment of generalized anxiety disorder and somatoform disorders
• A comparative study for efficacy `of combination therapy of inhaled levosalbutamol and ipratropium bromide against combination therapy of inhaled levosalbutamol and beclomethasone dipropionate in the treatment of bronchial asthma in adults
• Monitoring and evaluation of adverse drug reactions in antiretroviraltherapy centre and dermatology department in a tertiary hospital
• A prospective observational study on pattern of steroid utilization in a rural teaching hospital
• A study of prescription pattern in musculoskeletal disorders causing low back pain(lbp) at kvg medical college, hospital,sullia,Karnataka
• A study of prescription pattern in the drug therapy of rheumatoid arthrits at kvg medical college and hospital, sullia (d.k), karnataka.
• A prospective study on the use of anaesthetic agents in modern surgical practice at k.v.g. medical college & hospital, sullia (d.k.), karnataka.
• Adverse drug reaction monitoring in a teaching hospital, mandya.
• Study of analgesics usage in third trimester of pregnancy and its illeffects on pregnancy course and outcome.
• To evaluate the analgesic activity of garlic extract in rats.
• A study to assess adverse drug reactions to anti retro viral therapy: type and risk factors in art centre at k. R. Hospital, mysore.
• A randomized, prospective study of single dose epidural 0.2% levobupivacaine with 25µg fentanyl and single dose epidural 0.2% ropivacaine with 25µg fentanyl for post-operative analgesia in patients undergoing elective lower limb surgeries.
• A prospective study of oral betahistine and ondansetron in the prevention of post operative nausea and vomiting, in patients undergoing tympanomastoid surgeries under local anaesthesia
• Effect of minoxidil on blood glucose levels in normal and type 2 diabetic model of rats and its pharmacodynamic interation with glibenclamide: an experimental study
• Prescription audit of antibacterials in suspected neonatal sepsis at a tertiary care hospital
• Efficacy of supplementation of probiotics along with antimicrobial agents in vulvovaginal infections in a tertiary care hospital
• Study of anticonvulsant effect of nebivolol in maximal electro shock (mes) and pentylenetetrazole (ptz) induced seizure models in mice
• A prospective study to evaluate the effect of cilostazol on the lipid profile in patients of peripheral arterial disease as an adjunct to statins.
• Experimental evaluation of anti convulsant activity of atorvastatin in wistar rats.
• A randomised controlled study to compare the efficacy of racecadotril versus diphenoxylate in acute radiation enteritis.
• Assessment of adverse drug reactions in geriatric patients in a tertiary care hospital
• Factors affecting adherence to drugs and its influence on outcomes in select chronic disese (cardiovascular disease and diabetes mellitus at a tertiary care hospital
• Patterns and determinants of poly pharmacy in perioperative patients in general surgical war ds of a tertiary care hospital: a prospective observational study
• Pattern of use of analgesis for post-operative pain managment in adults undergoing laparotomy surgery-a prospective observational study in a tertiary care hospital
• Patterns of drug use and factors affecting adherence to medication in rheumatoid arthritis- a prospective, observational, hospital based study
• Study of prescription pattern in the management of herpes zoster at brims hospital, bidar
• A comparative study of efficacy and safety of alternate day rosuvastatin dosing versus daily rosuvastatin dosing in patients with dyslipidemia”
• Evaluation of the appropriateness of prescribing in geriatric patients admitted in various departments in government teaching hospital, bidar institute of medical sciences, bidar. Karnataka
• A prospective study of various poisoning, pattern, pharmacological management and their outcome in a tertiary care hospital
• Drug utilization study of antibiotics use in orthopaedic units of basaveshwar teaching and general hospital attached to hke society mahadevappa rampure medical college Gulbarga
• A comparative study to evaluate the efficacy, tolerability and response rates of two antidepressants escitalopram with sertraline in patients of major depressive disorder.
• Role of antimicrobial agents for the prevention of surgical site infections with pharmacoeconomics in the general surgery units.
• A prospective study to compare efficacy and tolerability of ranolazine and nicorandil in the patients of angina pectoris.
• Drug utilisation study of anticonvulsant agents in paediatric unit in a teritiary care hospital.
• Comparative study of safety and efficacy of inhalation anti-asthma drugs versus systemic anti-asthma drugs in a tertiary care hospital.
• Study of prescription pattern of antiemetic drugs in a tertiary care hospital.
• A comparative study of antinociceptive activity of paroxitine with pethidine in acute pain in albino rats.
• A comparative study of efficacy, tolerabilty and safety profile of fluoxetine with desvenlafaxine in patients with depression in a tertiary care hospital.
• A comparative study of efficacy of silodosin and tamsulosin in patients of lower ureteric culculi in a tertiary care hospital
• A prospective comparative efficacy & safety study of topical retapamulin and mupirocin.
• A comparative study of the efficacy and safety of levocetirizine and rupatadine.
• A comparative study of the efficacy and safety of amitryptyline and topiramate in the prophylaxis of migraine.
• A comparative study of intravenous paracetamol and tramadol for post operative analgesic efficacy in orthopedic surgeries at a tertiary care hospital, bangalore.
• Study of anti inflammatory activity of ficus racemosa linn stem bark extract in albino rats.
• Study of analgesic activity of murraya koenigii leaves extractin albino mice.
• A comparative study of the efficacy and safety of oral flunarizine to oral propranalol in prophylaxis of migraine .
• A comparitive study of efficacy and tolerability of oral desloratadine, ketotifen and rupatadine in seasonal allergic rhinitis.
• A study of the pattern of drug use for postoperative analgesia following lower abdominal surgeries in a tertiary care hospital.
• Study of prescription pattern of oral contraceptive pills in a tertiary care hospital.
• A study of the pattern of preanaesthetic medication for major surgeries under general anaesthesia in a tertiary care hospital
• A comparative study of efficacy and tolerability of olopatadine, ketotifen and epinastine in seasonal allergic conjunctivitis.
• A comparative study of efficacy and tolerability of methotrexate, sulfasalazine and leflunomide in rheumatoid arthritis.
• A study of the pattern of drug use for general and regional anesthesia for caesarean section and to compare the maternal and neonatal outcome.
• Adverse effects of anti tubercular treatment in cases of MDR tuberculosis.

Disclaimer!

There are many methods of sample size determination. It is one of the first hurdle when someone starts writing a thesis. I have tried to give simplest way of determination of sample size. You need to show the method to your PG teacher before you include this method in your thesis. First confirm from your PG teacher and then only proceed.

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 40+ pharmacology research topics: a comprehensive guide for nursing students, carla johnson.

• August 24, 2023
• Essay Topics and Ideas

Understanding pharmacology is crucial for nursing students as it forms the foundation of safe and effective patient care. This article aims to give nursing students insights into pharmacology research topics and potential research directions.

What You'll Learn

The Importance of Pharmacology in Nursing Education

Pharmacology involves studying how drugs interact with living organisms, including their effects, mechanisms, and possible side effects. Pharmacology knowledge is essential for administering medications, understanding drug interactions, and ensuring patient safety . By grasping pharmacological principles, nursing students can make informed decisions and deliver evidence-based care.

Exploring PICOT Questions in Pharmacology

• P: Adult psychiatric patients; I: Daily RS questionnaire; C: Units without daily survey; O: Reduced RS utilization; T: 6 months. Compared to units without the survey, can introducing a daily RS (Recovery Scale) questionnaire in psychiatric units lead to significantly decreased RS utilization over six months?
• P: Pediatric asthma patients; I: Peak flow monitoring; C: Standard symptom-based management; O: Decreased severe asthma exacerbations; T: 1 year. Does incorporating peak flow monitoring for pediatric asthma patients result in significantly fewer severe asthma exacerbations over a year compared to standard management?
• P: Elderly long-term care residents; I: Structured medication reconciliation; C: Informal reconciliation; O: Reduced medication discrepancies; T: 3 months. Among elderly in long-term care, does implementing structured medication reconciliation lead to significantly fewer medication discrepancies within three months compared to informal methods?
• P: Postoperative patients; I: Multimodal pain management ; C: Traditional pain management; O: Reduced opioid consumption; T: Postoperative period. Can adopting a multimodal pain management approach significantly reduce opioid consumption in postoperative patients compared to traditional methods?
• P: Diabetic patients; I: Interactive technology education; C: Conventional education; O: Improved glycemic control; T: 6 months. Among diabetic patients, does interactive technology education lead to better glycemic control over six months compared to conventional education?
• P: Oncology patients on chemotherapy ; I: Pre-chemotherapy antiemetic; C: Post-chemotherapy antiemetic; O: Reduced chemotherapy-induced nausea and vomiting; T: During chemotherapy. For oncology patients undergoing chemotherapy, does administering antiemetics before chemotherapy significantly decrease chemotherapy-induced nausea and vomiting compared to post-chemotherapy administration?
• P: Hypertensive patients; I: Home blood pressure monitoring; C: Clinic-based monitoring; O: Improved blood pressure control; T: 3 months. Does home blood pressure monitoring lead to better blood pressure control in hypertensive patients over three months compared to clinic-based monitoring?
• P: Critically ill ventilated patients; I: Early mobilization; C: Delayed mobilization; O: Shorter mechanical ventilation; T: ICU stay. Among critically ill ventilated patients, does early mobilization lead to shorter mechanical ventilation durations during ICU stays compared to delayed mobilization?
• P: Chronic pain patients; I: Mindfulness program; C: Standard pain management; O: Improved pain relief, quality of life; T: 8 weeks. Can participating in a mindfulness program lead to better pain relief and quality of life for chronic pain patients over eight weeks compared to standard pain management?
• P: Postmenopausal women; I: Calcium, vitamin D supplementation; C: No supplementation; O: Decreased bone density loss; T: 1 year. Among postmenopausal women at risk of osteoporosis, does calcium, vitamin D supplementation significantly reduce bone density loss over a year compared to no supplementation?

Evidence-Based Practice (EBP) Projects in Pharmacology

• Analyzing medication reconciliation’s impact on adverse drug events in geriatric patients.
• Comparing patient-controlled analgesia and nurse-controlled analgesia in postoperative pain management.
• Studying medication adherence’s effect on glycemic control in diabetes patients.
• Investigating antipsychotic medication use and fall risk in elderly psychiatric patients.
• Assessing pharmacogenomic testing’s role in psychiatric medication personalization.
• Comparing antiemetic agents for chemotherapy-induced nausea and vomiting prevention.
• Evaluating a structured pain assessment tool’s impact on pediatric pain management.
• Examining home blood pressure monitoring’s effect on hypertension control .
• Investigating opioid-sparing techniques in orthopedic postoperative pain management.
• Exploring herbal supplement use for managing menopausal symptoms.

Nursing Capstone Project Ideas in Pharmacology

• Designing a comprehensive medication education program for pediatric patients and caregivers.
• Developing a protocol for high-alert medication administration in critical care units.
• Creating a chronic pain interdisciplinary management plan in long-term care.
• Implementing a medication safety campaign to reduce errors in emergency departments.
• Designing a rural telehealth platform for medication counseling and adherence.
• Establishing immunosuppressive medication adverse reaction monitoring post-transplant.
• Creating a guideline for nurses in helping patients optimize polypharmacy.
• Designing a chemotherapy administration and monitoring training module.
• Developing a vasopressor medication titration protocol for septic shock.
• Creating a herbal supplement interaction resource guide.

Research Paper Topics in Pharmacology for Nursing Students

• Pharmacogenomics’ role in personalizing psychiatric medication regimens.
• Nurse contributions to preventing opioid misuse and overdose in the epidemic.
• Evaluating cultural diversity’s impact on medication beliefs and adherence.
• Strategies for optimizing medication regimens and preventing adverse effects in the elderly.
• Pharmacovigilance’s importance in monitoring and reporting adverse drug reactions.
• Herbal supplement-drug interaction evidence and practice analysis.
• Ethical considerations in pediatric medication administration.
• Antibiotic resistance’s implications and nurses’ role in prudent antibiotic use.
• Addressing medication disparities in healthcare.
• Medication errors: Causes, consequences, and prevention in nursing practice.

Understanding pharmacology is paramount for nursing students’ ability to provide safe and effective patient care. With knowledge of pharmacology, nursing students can make informed decisions and contribute to healthcare. Explore PICOT questions, research projects, and essay topics to enhance learning and engage in impactful healthcare practices. For further assistance, consider our writing services tailored to nursing students’ needs, helping you merge pharmacological knowledge with effective communication to excel in healthcare.

FAQs about Pharmacology in Nursing

Q: What is pharmacology in nursing?

A: Pharmacology in nursing studies how drugs interact with living organisms, encompassing their effects, mechanisms, and potential side effects. It’s a crucial field for nurses to ensure safe and effective patient care through proper medication administration and management.

Q: What are the 5 importance of pharmacology in nursing?

A: The importance of pharmacology in nursing includes enabling nurses to understand drug interactions, administer medications safely, manage patient responses, prevent adverse reactions, and provide evidence-based care.

Q: What are the principles of pharmacology for nurses?

A: The principles of pharmacology for nurses involve understanding drug actions, indications, contraindications, interactions, and adverse effects. It also includes proper dosage calculation, patient education , and ethical considerations.

Q: What are the types of pharmacology?

A: Pharmacology can be broadly categorized into several types, including clinical pharmacology (study of drugs in clinical settings), neuropharmacology (study of drugs affecting the nervous system), and psychopharmacology (study of drugs for mental disorders). Additionally, there’s pharmacokinetics (drug absorption, distribution, metabolism, excretion) and pharmacodynamics (drug effects on the body).

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Recent research project titles in Part II Pharmacology

The department offers a wide range of research projects, which are undertaken during the Lent Term. Below are a selection of projects offered recently. The subheadings are fairly arbitrary – many projects have clear impact in a range of areas – but hopefully convey the breadth of research topics available.

Understanding receptors

• The role of intracellular loop 1 of the adenosine A2a receptor in mediating signalling bias
• Biased agonists of the Apelin receptor
• RAMP-directed signalling bias of the calcitonin-receptor-like receptor
• Visualizing activation-induced structural changes in ionotropic glutamate receptors using AFM imaging

Intracellular signalling

• Repurposing known drugs as inhibitors of the store-operated calcium entry pathway
• How do intracellular Ca 2+ stores refill?
• Calcium responses underlying Insulin-like peptide 5 signalling in mouse colonic epithelium
• Effects of fluoride on ion transport in epithelial cell monolayers

Neuropharmacology

• Characterisation of sensory neurones using retrograde tracing
• Role of Ca 2+ signals in chemotaxis of glioma cells

Cardiovascular pharmacology

• The effect of shear stress on the prothrombotic responses of the endothelium
• Cl - -sensing properties of WNK4 modulates K + homeostasis in the distal nephron
• ‘Surfing the PHOME ’: extending and probing the druggable platelet proteome
• Elucidating the mechanisms underlying neutrophil recruitment to the vascular endothelium
• Novel vasoactive peptides and cardio-metabolic function

Cancer pharmacology

• Novel approaches for the inhibition and degradation of intracellular protein targets associated with pancreatic and colorectal cancers
• Investigating the biology of BCL11A in basal-like breast cancer
• Searching for modifiers of Aurora kinase stability using tandem fluorescent protein tags

Antibacterial pharmacology

• Evaluating the intrinsic mammalian toxicity of some molecules that inhibit lipoteichoic acid synthase of Gram-positive bacteria
• Transport mechanism of a multidrug transporter from Vibrio cholera

Recent pharmacology dissertation titles offered in Part II BBS

The department offers a wide range of dissertation titles for students taking Part II BBS. Below are a selection of titles offered recently. The subheadings are somewhat arbitrary, but hopefully convey the wide scope of themes on offer and the huge importance of pharmacology to biomedical science.

New therapeutic strategies

• Therapeutic potential of intrabodies
• Targeting protein-protein interactions as a therapeutic strategy
• The use of pluripotent stem cells in regenerative medicine
• Quantitative systems pharmacology – is this the future of drug discovery?
• Is germline CRISPR editing ready for the clinic?
• Impact of big data on drug R&D and healthcare
• Targeting virulence as a potential strategy for combating pathogenic bacteria
• Pharmacological chaperones and their application in treating diseases

Challenging the dogma

• Is aspirin a useful anti-thrombotic?
• Are SSRIs really competitive inhibitors of SERT?
• What are the mechanisms of drug entry in cells and tissues?
• The relative significance of drugs and diet in influencing plasma lipid levels?

Understanding disease to guide therapy

• The amyloid hypothesis and potential treatments for neurodegenerative diseases
• Cystic fibrosis-related diabetes
• The role of neutrophils in arterial thrombosis
• What are the links between hypoxia and neurodegenerative diseases (e.g. Alzheimer’s disease)?
• Is chronic visceral pain a manifestation of central or peripheral processes?
• Bacterial host interactions in the development of chronic visceral pain: does early life exposure to pathogen influence pain sensitivity in adulthood?
• Bacterial host interactions in cystic fibrosis

From molecular mechanism to drug target

• Targeted degradation of CFTR: prospects for therapeutic interventions in CF
• Duel glucagon and glucagon-like peptide 1 agonists as new treatments for type II diabetes
• The structure of the exocytotic fusion pore
• How do SNAREs mediate membrane fusion?
• Trapping pain with TRPs: are TRP channels good targets for alleviating pain?
• Pharmacological intervention in the cell cycle
• Lipid transporters in health and disease
• Store-operated calcium entry pathway as a potential therapeutic target
• Cellular functions of Bax inhibitor-1
• Can the naked mole-rat cure cancer?

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The advanced degree programs at the Indiana University of Medicine Department of Pharmacology and Toxicology prepare scientists for careers across the spectrum of biomedical research. The Master of Science (M.S.) degree is a thesis research degree that gives a student the intellectual background to understand and participate in ongoing research projects. The Doctor of Philosophy (Ph.D.) degree is offered for the student who wants to pursue an independent career in research. Students with the Ph.D. degree are prepared for an academic career combining research with teaching or for a career in industrial pharmaceutical research. A combined M.D./Ph.D. degree is open to qualified individuals who ultimately seek to direct biomedical research with a clinical emphasis.

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Hot topics in pharmacology

Recent publications of interest recommended by nc-iuphar.

2020: Jan | Feb 2019: Jul | Aug | Sep | Oct | Nov | Dec

February 2020

Hot Topics: A brief update on coronaviruses Prof. Michael Spedding, Spedding Reseach Solutions; Prof. Steve Alexander ( @mqzspa ), University of Nottingham; Dr. Elena Faccenda, University of Edinburgh; and Prof. Francesca Levi-Schaffer, The Hebrew University of Jerusalem.

January 2020

Preclinical Pharmacological Evaluation of the Fatty Acid Amide Hydrolase Inhibitor BIA 10-2474 (1) Bonifacio M-J et al. (2020). Preclinical Pharmacological Evaluation of the Fatty Acid Amide Hydrolase Inhibitor BIA 10-2474. Br J Pharmacol , DOI: 10.1111/bph.14973. [PMID: 31901141 ]

Super-resolution Microscopy Compatible Fluorescent Probes Reveal Endogenous Glucagon-Like peptide-1 Receptor Distribution and Dynamics (1) Ast J et al. (2020). Super-resolution Microscopy Compatible Fluorescent Probes Reveal Endogenous Glucagon-Like peptide-1 Receptor Distribution and Dynamics. Nat Commun , DOI: 10.1038/s41467-020-14309-w. [PMID: 31980626 ]

Quantitative Proteomics of the Cancer Cell Line Encyclopedia (1) Nusinow DP et al. (2020). Quantitative Proteomics of the Cancer Cell Line Encyclopedia. Cell , DOI: 10.1016/j.cell.2019.12.023. [PMID: 31978347 ]

Structural Insight Into Small Molecule Action on Frizzleds (1) Kozielewicz et al. (2020). Structural Insight Into Small Molecule Action on Frizzleds. Nat Commun , DOI: 10.1038/s41467-019-14149-3. [PMID: 31964872 ]

Rigor and Transparency Index, a new metric of quality for assessing biological and medical science methods (1) Menke J et al. (2020). Rigor and Transparency Index, a new metric of quality for assessing biological and medical science methods. bioRxiv , doi: https://doi.org/10.1101/2020.01.15.908111. [bioRxiv: Abstract ]

Identifying Drug Targets in Tissues and Whole Blood With Thermal-Shift Profiling (1) Perrin J et al. (2020). Identifying Drug Targets in Tissues and Whole Blood With Thermal-Shift Profiling. Nat Biotechnol , DOI: 10.1038/s41587-019-0388-4. [PMID: 31959954 ]

A Combined Computational and Structural Approach Into Understanding the Role of Peptide Binding and Activation of the Melanocortin Receptor 4 (1) Zachmann J et al. (2020). A Combined Computational and Structural Approach Into Understanding the Role of Peptide Binding and Activation of the Melanocortin Receptor 4. J Chem Inf Model , DOI: 10.1021/acs.jcim.9b01196. [PMID: 31944109 ]

From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9 (1) Petrilli WL et al. (2020). From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9. Cell Chem Biol , DOI: 10.1016/j.chembiol.2019.10.002. [PMID: 31653597 ]

Structure of the M2 Muscarinic Receptor-β-Arrestin Complex in a Lipid Nanodisc (1) Staus DP et al. (2020). Structure of the M2 Muscarinic Receptor-β-Arrestin Complex in a Lipid Nanodisc. Nature , DOI: 10.1038/s41586-020-1954-0. [PMID: 31945772 ]

Resting State Structure of the Hyperdepolarization Activated Two-Pore Channel 3 (1) Dickinson MS et al. (2020). Resting State Structure of the Hyperdepolarization Activated Two-Pore Channel 3. Proc Natl Acad Sci USA , DOI: 10.1073/pnas.1915144117. [PMID: 31924746 ]

Impact of commonly used drugs on the composition and metabolic function of the gut microbiota (1) Vila AV et al. (2020). Impact of commonly used drugs on the composition and metabolic function of the gut microbiota. Br J Pharmacol , DOI: 10.1038/s41467-019-14177-z. [PMID: 31953381 ]

New Chemical Modalities and Strategic Thinking in Early Drug Discovery (1) Blanco M-J & Gardinier KM et al. (2020). New Chemical Modalities and Strategic Thinking in Early Drug Discovery. ACS Med Chem Lett , doi.org/10.1021/acsmedchemlett.9b00582. [ACS: Article ]

Therapies for Rare Diseases: Therapeutic Modalities, Progress and Challenges Ahead (1) Tambuyzer E et al. (2020). Therapies for Rare Diseases: Therapeutic Modalities, Progress and Challenges Ahead. Nat Rev Drug Discov , DOI: 10.1038/s41573-019-0059-7. [PMID: 31913355 ]

2019 FDA drug approvals (1) Mullard A. (2020). 2019 FDA drug approvals. Nat Rev Drug Discov , doi: 10.1038/d41573-020-00001-7. [Nature: News Article ]

Hot Topics: Cryo-EM structure of a selective T-type calcium channel blocker bound to the Cav3.1 voltage-gated calcium channel Jörg Striessnig, University of Innsbruck

(1) Zhao Y et al. (2019). Cryo-EM Structures of Apo and Antagonist-Bound Human Ca v 3.1. Nature , DOI: 10.1038/s41586-019-1801-3. [PMID: 31766050 ]

(2) Zhao, Y., Huang, G., Wu, J., Wu, Q., Gao, S., Yan, Z., Lei, J., and Yan, N. (2019). Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca 2+ Cell 177, 1495-1506 [PMID: 31150622 ].

(3) Tang, L., El-Din, T.M.G., Swanson, T.M., Pryde, D.C., Scheuer, T., Zheng, N., and Catterall, W.A. (2016). Structural basis for inhibition of a voltage-gated Ca 2+ channel by Ca 2+ antagonist drugs. Nature 537, 117–121 [PMID: 27556947 ].

(4) Tang, L., Gamal El-Din, T.M., Lenaeus, M.J., Zheng, N., and Catterall, W.A. (2019). Structural Basis for Diltiazem Block of a Voltage-Gated Ca 2+ Mol. Pharmacol. 96, 485–492 [PMID: 31391290 ].

Relative Selectivity of Covalent Inhibitors Requires Assessment of Inactivation Kinetics and Cellular Occupancy: A Case Study of Ibrutinib and Acalabrutinib (1) Hopper M et al. (2019). Relative Selectivity of Covalent Inhibitors Requires Assessment of Inactivation Kinetics and Cellular Occupancy: A Case Study of Ibrutinib and Acalabrutinib. J Pharmacol Exp Ther , DOI: 10.1124/jpet.119.262063. [PMID: 31871305 ]

Fluorescent Ligands: Bringing Light to Emerging G Protein-Coupled Receptor Paradigms (1) Soave M et al. (2019). Fluorescent Ligands: Bringing Light to Emerging G Protein-Coupled Receptor Paradigms. Br J Pharmacol , DOI: 10.1111/bph.14953. [PMID: 31877233 ]

Methods to Identify and Optimize Small Molecules Interacting With RNA (SMIRNAs) (1) Ursu A et al. (2019). Methods to Identify and Optimize Small Molecules Interacting With RNA (SMIRNAs). Drug Discov Today , DOI: 10.1016/j.drudis.2019.06.019. [PMID: 31356880 ]

The Pharmacology and Therapeutic Applications of Monoclonal Antibodies (1) Castelli MS et al. (2019). The Pharmacology and Therapeutic Applications of Monoclonal Antibodies. Pharmacol Res Perspect , DOI: 10.1002/prp2.535. [PMID: 31859459 ]

PROTACs: Great Opportunities for Academia and Industry (1) Sun X et al. (2019). PROTACs: Great Opportunities for Academia and Industry. Signal Transduct Target Ther , DOI: 10.1038/s41392-019-0101-6. [PMID: 31885879 ]

December 2019

Structure of the Cardiac Sodium Channel (1) Jiang D et al. (2019). Structure of the Cardiac Sodium Channel. Cell , DOI: 10.1016/j.cell.2019.11.041. [Cell: Article ]

Hot Topics: Deciphering the crystal structure of the leukotriene receptor CysLT2 opens up for improved therapeutics Magnus Bäck, MD PhD, ( @TransCardio ), Karolinska Institutet and University Hospital, Stockholm, Sweden; Chairman NC-IUPHAR subcommittee on Leukotriene Receptors)

(1) Gusach A et al. (2019). Structural Basis of Ligand Selectivity and Disease Mutations in Cysteinyl Leukotriene Receptors. Nat Commun , DOI: 10.1038/s41467-019-13348-2. [PMID: 31811124 ]

GPR101 Mediates the Pro-Resolving Actions of RvD5n-3 DPA in Arthritis and Infections (1) Flak MB et al. (2019). GPR101 Mediates the Pro-Resolving Actions of RvD5n-3 DPA in Arthritis and Infections. J Clin Invest , DOI: 10.1172/JCI131609. [PMID: 31793912 ]

Elucidating the Active δ-Opioid Receptor Crystal Structure With Peptide and Small-Molecule Agonists (1) Claff T et al. (2019). Elucidating the Active δ-Opioid Receptor Crystal Structure With Peptide and Small-Molecule Agonists. Sci Adv , DOI: 10.1126/sciadv.aax9115. [PMID: 31807708 ]

A Complex Structure of arrestin-2 Bound to a G Protein-Coupled Receptor (1) Yin W et al. (2019). A Complex Structure of arrestin-2 Bound to a G Protein-Coupled Receptor. Cell Res , DOI: 10.1038/s41422-019-0256-2. [PMID: 31776446 ]

November 2019

Chemokine Receptor Crystal Structures: What Can Be Learned From Them? (1) Arimont M et al. (2019). Chemokine Receptor Crystal Structures: What Can Be Learned From Them?. Mol Pharmacol , DOI: 10.1124/mol.119.117168. [PMID: 31266800 ]

The Druggability of Solute Carriers (1) Wang W et al. (2019). The Druggability of Solute Carriers. J Med Chem , DOI: 10.1021/acs.jmedchem.9b01237. [PMID: 31774679 ]

Hot Topics: New crystal structure of the muscarinic M5 receptor completes the set Comments by Dr. Fiona H. Marshall, Discovery Research UK, MSD ( @aston_fm )

(1) Vuckovic Z et al. (2019). Crystal Structure of the M 5 Muscarinic Acetylcholine Receptor. Proc Natl Acad Sci USA , DOI: 10.1073/pnas.1914446116. [PMID: 31772027 ]

GPR75 Receptor Mediates 20-HETE-signaling and Metastatic Features of Androgen-Insensitive Prostate Cancer Cells (1) Cardenas S et al. (2019). GPR75 Receptor Mediates 20-HETE-signaling and Metastatic Features of Androgen-Insensitive Prostate Cancer Cells. Biochim Biophys Acta Mol Cell Biol Lipids , DOI: 10.1016/j.bbalip.2019.158573. [PMID: 31760076 ]

Crystal Structure of Dopamine Receptor D4 Bound to the Subtype Selective Ligand, L745870 (1) Zhou Y et al. (2019). Crystal Structure of Dopamine Receptor D4 Bound to the Subtype Selective Ligand, L745870. Elife , DOI: 10.7554/eLife.48822. [PMID: 31750832 ]

The human secretome (1) Uhlen M et al. (2019). The human secretome. Science Signaling , 12 (609) DOI: 10.1126/scisignal.aaz0274. [SciSignalling: Article ]

Resistance to Autosomal Dominant Alzheimer's Disease in an APOE3 Christchurch Homozygote: A Case Report (1) Arboleda-Velasquez JF et al. (2019). 25 (11), 1680-1683 DOI: 10.1038/s41591-019-0611-3. [PMID: 31686034 ]

In Vivo Validation of a Small Molecule Inhibitor of Tau Self-Association in Htau Mice (1) Davidowitz EJ et al. (2019). In Vivo Validation of a Small Molecule Inhibitor of Tau Self-Association in Htau Mice . J Alzheimers Dis , DOI: 10.3233/JAD-190465. [PMID: 31771053 ]

A New Alzheimer’s Approval in China (1) Lowe D. (2019). In The Pipeline: A New Alzheimer’s Approval in China. Sci Trans Med , 10 May 2019. [In The Pipeline: Article ] (2) Wang X et al. (2019). Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression. Cell Res. , 29(10):787-803. doi: 10.1038/s41422-019-0216-x. [PMID: 31488882 ]

Free-Wilson Analysis of Comprehensive Data on Phosphoinositide-3-kinase (PI3K) Inhibitors Reveals Importance of N-Methylation for PI3Kδ Activity (1) Barnes L et al. (2019). Free-Wilson Analysis of Comprehensive Data on Phosphoinositide-3-kinase (PI3K) Inhibitors Reveals Importance of N-Methylation for PI3Kδ Activity. J Med Chem , doi: 10.1021/acs.jmedchem.9b01499. [PMID: 31647659 ]

An Alzheimer's-disease-protective APOE mutation (1) Zalocusky KA et al. (2019). An Alzheimer's-disease-protective APOE mutation. Nat Med , doi: 10.1038/s41591-019-0634-9. [PMID: 31686033 ]

Discovery of ABBV/GLPG-3221, a Potent Corrector of CFTR for the Treatment of Cystic Fibrosis (1) Scanio MJC et al. (2019). Discovery of ABBV/GLPG-3221, a Potent Corrector of CFTR for the Treatment of Cystic Fibrosis. ACS Med Chem Lett , doi: 10.1038/s41589-019-0387-2. [ACS: Letter ]

Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptorsr (1) Foster S et al. (2019). Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors. Cell , doi: 10.1016/j.cell.2019.10.010. [Cell: Full text ]

October 2019

Structure of an allosteric modulator bound to the CB1 cannabinoid receptor (1) Shao Z et al. (2019). Structure of an allosteric modulator bound to the CB1 cannabinoid receptor. Nat Chem Biol , doi: 10.1038/s41589-019-0387-2. [PMID: 31659318 ]

Structural basis of species-selective antagonist binding to the succinate receptor (1) Haffke M et al. (2019). Structural basis of species-selective antagonist binding to the succinate receptor. Nature , 574(7779):581-585. doi: 10.1038/s41586-019-1663-8. [PMID: 31645725 ]

A Point of Inflection and Reflection on Systems Chemical Biology (1) Johnson EO & Hung DT. (2019). A Point of Inflection and Reflection on Systems Chemical Biology. ACS Chem Biol , doi: 10.1021/acschembio.9b00714. [PMID: 31613592 ]

A tetrapeptide class of biased analgesics from an Australian fungus targets the µ-opioid receptor (1) Dekan Z et al. (2019). A tetrapeptide class of biased analgesics from an Australian fungus targets the µ-opioid receptor. Proc Natl Acad Sci USA , 116(44):22353-22358. doi: 10.1073/pnas.1908662116. [PMID: 31611414 ]

Hot Topics: 3D structure of the full-length P2X7 receptor provides insight into factors controlling agonist potency and receptor desensitisation Comments by Charles Kennedy , Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde

(1) McCarthy et al. (2019). Full-length P2X7 structures reveal how palmitoylation prevents channel desensitization. Cell . https://doi.org/10.1016/j.cell.2019.09.017. [ScienceDirect: View Article ]

September 2019

A Comparative Assessment Study of Known Small-Molecule Keap1−Nrf2 Protein–Protein Interaction Inhibitors: Chemical Synthesis, Binding Properties, and Cellular Activity (1) Tran KT et al. (2019). A Comparative Assessment Study of Known Small-Molecule Keap1−Nrf2 Protein–Protein Interaction Inhibitors: Chemical Synthesis, Binding Properties, and Cellular Activity. J Med Chem , 62(17):8028-8052. doi: 10.1021/acs.jmedchem.9b00723. [PMID: 31411465 ]

Advances and Challenges in Rational Drug Design for SLCs (1) Garibsingh RA & Schlessinger A et al. (2019). Advances and Challenges in Rational Drug Design for SLCs. Trends Pharmacol Sci , doi.org/10.1016/j.immuni.2019.08.008. [PMID: 31519459 ]

Estimating cumulative point prevalence of rare diseases: analysis of the Orphanet database (1) Nguengang Wakap S et al. (2019). Estimating cumulative point prevalence of rare diseases: analysis of the Orphanet database. Eur J Hum Genet , doi: 10.1038/s41431-019-0508-0. [PMID: 31527858 ]

August 2019

Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells (1) Dutertre C-A et al. (2019). Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells. Immunity , doi.org/10.1016/j.immuni.2019.08.008. [Immunity: View Article ]

SEP-363856, A NOVEL PSYCHOTROPIC AGENT WITH A UNIQUE, NON-D2 RECEPTOR MECHANISM OF ACTION (1) Dedic N et al. (2019). SEP-363856, A NOVEL PSYCHOTROPIC AGENT WITH A UNIQUE, NON-D2 RECEPTOR MECHANISM OF ACTION. J Pharmacol Exp Ther , pii: jpet.119.260281. doi: 10.1124/jpet.119.260281. [PMID: 31371483 ]

Hot Topics: GPR139 as a potential target for increasing opioid safety Comments by Simon R. Foster , Monash University and Professor David E. Gloriam , University of Copenhagen and Head of GPCRdb ( @David_Gloriam )

(1) Selbie, L. A. & Hill, S. J. G protein-coupled-receptor cross-talk: the fine-tuning of multiple receptor-signalling pathways. Trends in pharmacological sciences 19, 87-93, (1998). [PMID: 9584624 ]

(2) Wang, D. et al. Genetic behavioral screen identifies an orphan anti-opioid system. Science (New York, N.Y.), eaau2078, (2019). [PMID: 31416932 ]

(3) Vedel, L., Nohr, A. C., Gloriam, D. E. & Brauner-Osborne, H. Pharmacology and function of the orphan GPR139 G protein-coupled receptor. Basic & clinical pharmacology & toxicology , (2019). [PMID: 31132229 ]

Over 1,000 genetic loci influencing blood pressure with multiple systems and tissues implicated (1) Cabrera CP et al. (2019). Over 1,000 genetic loci influencing blood pressure with multiple systems and tissues implicated. Hum Mol Genet , pii: ddz197. doi: 10.1093/hmg/ddz197. [PMID: 31411675 ]

Large-Scale Analyses of Human Microbiomes Reveal Thousands of Small, Novel Genes (1) Sberro H et al. (2019). Large-Scale Analyses of Human Microbiomes Reveal Thousands of Small, Novel Genes. Cell , pii: S0092-8674(19)30781-0. doi: 10.1016/j.cell.2019.07.016. [PMID: 31402174 ]

Resting-State Structure and Gating Mechanism of a Voltage-Gated Sodium Channel Comments by Jörg Striessnig, University of Innsbruck

(1) Wisedchaisri G et al. (2019). Resting-State Structure and Gating Mechanism of a Voltage-Gated Sodium Channel. Cell , 178(4):993-1003.e12. doi: 10.1016/j.cell.2019.06.031. [PMID: 31353218 ]

Identification of a novel allosteric GLP–1R antagonist HTL26119 using structure- based drug design (1) O'Brien A et al. (2019). Identification of a novel allosteric GLP–1R antagonist HTL26119 using structure- based drug design. Biol Med Chem Lett , doi: 10.1016/j.bmcl.2019.08.015. [ScienceDirect: Abstract ]

Visualization of drug target interactions in the contexts of pathways and networks with ReactomeFIViz (1) Blucher AS et al. (2019). Visualization of drug target interactions in the contexts of pathways and networks with ReactomeFIViz. F1000 Res , doi: 10.12688/f1000research.19592.1. [PMID: 31372215 ]

Structure and mechanism of the cation-chloride cotransporter NKCC1 (1) Chew TA et al. (2019). Structure and mechanism of the cation-chloride cotransporter NKCC1. Nature , doi: 10.1038/s41586-019-1438-2. [PMID: 31367042 ]

Building a Hybrid Physical-Statistical Classifier for Predicting the Effect of Variants Related to Protein-Drug Interactions (1) Wang B et al. (2019). Building a Hybrid Physical-Statistical Classifier for Predicting the Effect of Variants Related to Protein-Drug Interactions. Structure , pii: S0969-2126(19)30200-X. doi: 10.1016/j.str.2019.06.001. [PMID: 31279629 ]

Revisiting the classification of adhesion GPCRs (1) Scholz N et al. (2019). Revisiting the classification of adhesion GPCRs. Ann N Y Acad Sci , doi: 10.1111/nyas.14192. [PMID: 31365134 ]

The atlas of aminergic GPCR mutagenesis Comments by Chris De Graaf ( @Chris_de_Graaf )

(1) Santos et al. (2017). A comprehensive map of molecular drug targets. Nat Rev Drug Discov. doi: 10.1038/nrd.2016.230. [PMIDs: 27910877 ]

(2) Munk et al. (2019). An online resource for GPCR structure determination and analysis. Nat Methods . doi: 10.1038/s41592-018-0302-x. [PMIDs: 30664776 ]

(3) Vass et al. (2018). Chemical Diversity in the G Protein-Coupled Receptor Superfamily. Trends Pharmacol Sci. doi: 10.1016/j.tips.2018.02.004. [PMIDs: 29576399 ]

(4) a) Munk et al. (2016). Integrating structural and mutagenesis data to elucidate GPCR ligand binding. Curr Opin Pharmacol . doi: 10.1016/j.coph.2016.07.003. [PMIDs: 27475047 ] b) Arimont et al. (2017) Structural Analysis of Chemokine Receptor–Ligand Interactions. J Med Chem doi: 10.1021/acs.jmedchem.6b0130. [PMIDs: 28165741 ]. c) Jespers et al. (2018). Structural Mapping of Adenosine Receptor Mutations: Ligand Binding and Signaling Mechanisms. Trends Pharmacol Sci. doi: 10.1016/j.tips.2017.11.001. [PMIDs: 29203139 ]

(5) a) Kufareva et al. (2011) Status of GPCR modeling and docking as reflected by community-wide GPCR Dock 2010 assessment. Structure . doi: 10.1016/j.str.2011.05.012. [PMIDs: 21827947 ]; b) Kufareva et al. (2014). Advances in GPCR modeling evaluated by the GPCR Dock 2013 assessment: meeting new challenges. Structure. doi: 10.1016/j.str.2014.06.012. [PMIDs: 25066135 ]

(6) Vass et al. (2019). Aminergic GPCR-Ligand Interactions: A Chemical and Structural Map of Receptor Mutation Data. J Med Chem.  doi: 10.1021/acs.jmedchem.8b00836. [PMIDs: 30351004 ]

EPA’s DSSTox Database: History of development of a curated chemistry resource supporting computational toxicology research (1) Grulke CM et al. (2019). EPA’s DSSTox Database: History of development of a curated chemistry resource supporting computational toxicology research. computational Toxicology , https://doi.org/10.1016/j.comtox.2019.100096. [ScienceDirect: Abstract ]

Sharing of clinical trial data and results reporting practices among large pharmaceutical companies: cross sectional descriptive study and pilot of a tool to improve company practices (1) Miller J et al. (2019). Sharing of clinical trial data and results reporting practices among large pharmaceutical companies: cross sectional descriptive study and pilot of a tool to improve company practices. BMJ , 366:l4217. doi: 10.1136/bmj.l4217. [PMID: 31292127 ]

New drugs: where did we go wrong and what can we do better? (1) Wieseler B et al. (2019). New drugs: where did we go wrong and what can we do better?. BMJ , 366:l4340. doi: 10.1136/bmj.l4340. [PMID: 31292109 ]

A genetics-led approach defines the drug target landscape of 30 immune-related traits (1) Fang H et al. (2019). A genetics-led approach defines the drug target landscape of 30 immune-related traits. Nat Genet , 51(7):1082-1091. doi: 10.1038/s41588-019-0456-1. [PMID: 31253980 ]

The human endogenous metabolome as a pharmacology baseline for drug discovery (1) Bofill et al. (2019). The human endogenous metabolome as a pharmacology baseline for drug discovery. Drug Discov Today , pii: S1359-6446(19)30104-7. doi: 10.1016/j.drudis.2019.06.007. [PMID: 31226432 ]

Chemokine receptor crystal structures: what can be learnt from them? (1) Arimont M et al. (2019). Chemokine receptor crystal structures: what can be learnt from them?. Mol Pharmacol , pii: mol.119.117168. doi: 10.1124/mol.119.117168. [PMID: 31266800 ]

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Clinical Pharmacology: Current Topics and Case Studies

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• Markus Müller (Professor and Head of Department) 0

Department of Clinical Pharmacology, Medical University Vienna, Vienna General Hospital (AKH), Vienna, Austria

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Comprehensive overview of current topics in clinical pharmacology

Case studies for every issue

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Table of contents (26 chapters)

Front matter, introduction, the discipline of clinical pharmacology.

Markus Müller

Current issues in drug development

Current issues in drug regulation.

• Marcus Müllner, Hans-Georg Eichler

Current issues in drug reimbursement

• Anna Bucsics

Clinical Trials

Ethics in clinical research.

• Ernst Singer, Christiane Druml

Good Clinical Practice (GCP) and scientific misconduct

• Brigitte Bloechl-Daum, Christiane Druml

Phase-I studies and first-in-human trials

• Ulla Derhaschnig, Bernd Jilma

Clinical trials - interventional studies

• Michael Wolzt, Stefan Aschauer

Observational studies

• Harald Herkner, Christoph Male

Pharmacokinetics I: PK-PD approaches - antibiotic drug development

• Sreedharan N. Sabarinath, Rajendra Pratap Singh, Hartmut Derendorf

Pharmacokinetics II: 14C-labelled microdosing in assessing drug pharmacokinetics at Phase-0

• Graham Lappin

Epidemiology and bio statistics

• Gerhard Garhöfer, Leopold Schmetterer

Placebo effects and placebo control in clinical trials

• Magdalena Pilz, Johannes Pleiner

Tools in Clinical Pharmacology

Tools in clinical pharmacology - imaging techniques.

• Martin Bauer, Oliver Langer

Current concepts of pharmacogenetics, pharmacogenomics, and the “druggable” genome

• Wolfgang M. Schmidt
• Volker Wacheck
• clinical research
• clinical trial
• drug development
• drug research
• gene therapy
• pharmacodynamics
• pharmacokinetics
• pharmacology

About this book

Editors and affiliations, about the editor, bibliographic information.

Book Title : Clinical Pharmacology: Current Topics and Case Studies

Editors : Markus Müller

DOI : https://doi.org/10.1007/978-3-7091-0144-5

Publisher : Springer Vienna

eBook Packages : Biomedical and Life Sciences , Biomedical and Life Sciences (R0)

Copyright Information : Springer-Verlag Vienna 2010

eBook ISBN : 978-3-7091-0144-5 Published: 04 February 2011

Edition Number : 1

Number of Pages : XXIV, 430

Topics : Pharmacology/Toxicology , Pharmacy

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Home > FACULTIES > Physiology and Pharmacology > PHARMTOX-ETD

Pharmacology and Toxicology Theses and Dissertations

This collection contains theses and dissertations from the Department of Pharmacology and Toxicology, collected from the Scholarship@Western Electronic Thesis and Dissertation Repository

Theses/Dissertations from 2017 2017

The Effects of Acetylenic Tricyclic Bis-(Cyano Enone) on Cell Migration , Eddie Chan

Regulation of Cardiac Hypertrophy and Metabolism by Regulator of G Protein Signalling 2 (RGS2) , Katherine N. Lee

Theses/Dissertations from 2016 2016

Effects of Prenatal Exposure to Bisphenol A on Fetal Lung Development , Ayten Hijazi

Regulation of E2F1 in Keratinocytes During UV-Damage and Differentiation , Randeep K. Singh

Theses/Dissertations from 2015 2015

Quantitative Estimation of P-glycorptein-Mediated Drug Transport by Mechanistically Modeled Intrinsic Clearance , Alex D. Morgan

Epidermal Growth Factor Receptor in Joint Health and Osteoarthritis , Michael A. Pest

Regulation of Hepatic Drug Metabolizing Enzymes in Chronic Kidney Disease , Thomas J. Velenosi

Theses/Dissertations from 2014 2014

American Ginseng Modulation of Immune Function and Phytochemical Analysis , Chike G. Azike

Analysis of the Vascular Phenotype of the ENT1-null mouse , Keisha A. Best

Cortisol and Testosterone in Hair as Biological Markers of Systolic Heart Failure , Justin Chan

Regulation of the High-Affinity Choline Transporter Activity and Trafficking in Alzheimer’s Disease-Related Pathological Conditions , Leah K. Cuddy

Erythropoietin and Chronic Kidney Disease Alter Hepatic Expression of Cytochrome P450 Enzymes and Drug Transport Proteins , David A. Feere

The Role of c-Kit Receptor Tyrosine Kinase in Beta-Cell Proliferation, Function and Survival , Zhi Chao Feng

The Effects of Atypical Protein Kinase C on TGFβ Signalling , Adrian D. Gunaratne

Investigating Risk Factors for Pediatric Opioid Morbidity and Mortality , Lauren E. Kelly

Role Of Nitric Oxide In Embryonic Heart Development And Adult Aortic Valve Disease , Yin Liu

The ATP2C2 Gene as Transcribed from a Novel Transcriptional Start Site in Pancreatic Acinar Cells , Caitlin M. Sullivan

Effect of Ascorbate on Coagulation and Fibrinolytic Factors in the Septic Microvasculature , Scott Swarbreck

In Vitro Functional Analysis Of Novel Single Nucleotide Polymorphisms In OATP1B1 And Potential Clinical Relevance , Zhiyuan P. Yin

Theses/Dissertations from 2013 2013

Role of iNOS in septic pulmonary microvascular endothelial cell activation , Zahra Asad

ER stress coupled pannexin channel activation via STIM proteins , Ankur Bodalia

Pharmacogenetics of Oral Anticoagulants and Antiplatelets , Inna Gong

N-acetylcysteine as a chemoprotectant against ifosfamide nephrotoxicity; from mechanism to prevention , Lauren Hanly

Fetal and Neonatal Exposure to Nicotine Augments Hepatic Fatty Acid Synthesis in Rat Offspring Long-Term , Noelle L. Ma

Reorganization of inhibitory synapses in experimental epilepsy , Emily J. Pollock

Mechanism of Ascorbate Protection Against Sepsis-Induced Capillary Blood Flow Impairment , Dan Secor

Theses/Dissertations from 2012 2012

Statin Transport by Hepatic Organic Anion-Transporting Polypeptides (OATPs) , Marianne K. DeGorter

The Role of Drug Transporters in Statin-Induced Myopathy , Michael J. Knauer

The role of GRK2 in hypertension and regulation of GPR30 , Bonan Liu

Human Equilibrative Nucleoside Transporter Subtype 1: Structure-Function Analysis Using Cysteine Mutagenesis and Thiol Modifying Techniques , Jamie Park

Methodological Challenges and Clinical Applications of Hair Cortisol Analysis , Evan W. Russell

Intestinal and hepatic drug transporters and their role in the disposition of lipid-lowering drugs , Ute I. Schwarz

Molecular Mechanisms of Cell Migration Inhibition by Synthetic Triterpenoids , Ciric Chi Wing To

Characterization of EIF2Be and Its Interaction with RGS2 , William H. Xue

Theses/Dissertations from 2011 2011

Purine Transport and Metabolism in Microvascular Endothelial Cells , Derek B J Bone

Predicting Drug Hypersensitivity Reactions: Mechanistic and Clinical Implications , Abdelbaset A. Elzagallaai

Regulation of G Protein Signaling by GoLoco Motif Containing Proteins , Peishen Zhao

Theses/Dissertations from 2010 2010

Pharmacokinetics and Therapeutic Uses of Mesna , Murray J. Cutler

Regulation of DNA Damage Processing by Covalent Modification of Thymine DNA Glycosylase , Ryan D. Mohan

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©1878 - 2016 Western University

MSc Thesis-Based Program

Students in the Thesis-Based MSc are expected to think critically about scientific issues and develop a knowledge base in pharmacology while formulating hypotheses in a specific area of pharmacological research. You will test your hypotheses through active research and present your investigations in a thesis.

Program Requirements

Students in the Thesis-Based MSc must fulfill the following requirements:

• Complete PCL1002Y: Graduate Pharmacology. The academic program may require additional coursework.
• Present a departmental seminar after one year in the program.
• Participate in a research program and present the results of the investigation as a written thesis. The thesis will be evaluated and defended to the satisfaction of a thesis examination committee.
• Spend a minimum of one full year of residence, during which time the student is required to be on campus full-time and in such geographic proximity as to be able to participate fully in the department's activities associated with the program.

The MSc program can be completed in 6 sessions (2 years) full-time.

Monitoring and Progress

In addition to the immediate supervisor, MSc students in the thesis-based program select an advisor -- an additional Graduate Faculty member that monitors your progress and provides guidance.

The Advisor is selected by you in consultation with your Supervisor and is subject to the approval of the Graduate Coordinator. Selection of the advisor should be made within the first 3 months of program registration by submitting an  Advisor Selection Form  to the Graduate Office.   

Both the Supervisor and the Advisor are required to submit formal annual reports on your progress at the beginning of each academic session, prior to re-registration. See  MSc Advisor Report  and  MSc Supervisor Report . 

The Supervisor, the Advisor, or the student, may report problems directly to the Graduate Coordinator or the Department Chair.

First-Year Seminar

All M.Sc. students are required to give a seminar after one year in the program. The seminars are normally held in the fall and are an opportunity for you to become familiar with the expectations for the defense.

You should aim to present the results/progress made thus far and include any problems you are encountering. If you are still awaiting results from your thesis research, you can still give a seminar focusing on scientific thought and rationale. The length of your presentation should be 15 minutes. A 10-minute question period will follow your presentation.

Since supervisors are required to attend all of their students’ seminars, it is not possible for the Graduate Office to give students a choice of dates. We will do our best to distribute a tentative schedule early enough so that if there are any conflicts you and your supervisor(s) can inform the Graduate Office before the final schedule is complete.

Program Completion

Begin by familiarizing yourself with the Program Completion procedures.

Thesis write-up and defence should be completed within 3 months after active research has been completed. Once your thesis is complete and approved by your Supervisor, finalize the date and time of the defence with your committee members and submit the  MSc Oral Examination Committee form  along with a copy of your thesis to the Graduate Office at least  FOUR WEEKS PRIOR  to the date you are scheduled to defend.   IMPORTANT : In preparing for the oral examination, you should be aware that the Examination Committee is not required to restrict their questions to the specific subject area of the defence since it is expected that students would have gained a broad knowledge base in pharmacology during the course of their studies. It is your responsibility to ensure that the thesis is delivered to the Examination Committee in a reasonable period of time (i.e., minimum four weeks) so the committee members can read the thesis and the appraiser can write the appraisal. All members of the examination committee (including the Chair) must receive a copy of the thesis.  The  MSc Examination Committee  is composed of:

• Supervisor(s) 
• Voting Member 
• Chair (obtained by the Graduate Office) 

The Appraiser:  For the purposes of the M.Sc. defence, the Appraiser of the thesis should be an expert on the subject of the thesis and, normally, will be an Assistant, Associate or Full Professor at the University of Toronto. In nominating someone as Appraiser for a thesis, the Supervisor must certify to the Graduate Coordinator that the nominee has an arm’s-length relationship both with the candidate and with the Supervisor. The Appraiser provides a 1-2 page report with brief, constructively critical and analytical comments, in addition to an explicit recommendation that the thesis be or not be accepted in partial fulfillment of the requirements for the degree. 

Voting Members:  One of the 2 voting members should have a graduate appointment in Pharmacology. The student's Advisor can be a voting member. 

Potential Examination Outcomes

• Successful Defence:  After successful examination, the corrected thesis must be submitted to the School of Graduate Studies. Please visit their website for information on  program completion  procedures.
• Postponement:  An examination may be postponed   if more than one negative vote concerning the suitability of the written thesis for defence is received in advance. Only one postponement of an oral examination is permitted.
• Adjournment:  During the examination, more than one negative vote (or abstention) in either the thesis or oral examination category causes the oral examination to be adjourned. In situations where an examination was adjourned, a reconvened examination is to be held within one year of the adjournment. If the candidate is not successful at the reconvened exam, they will be ineligible for further M.Sc./Ph.D. candidacy at the University.

A Thesis Approval Form is given to your Supervisor after the Defense. If your supervisor did not receive it, you may obtain another copy from the Graduate Office. This form must be submitted to the Graduate Office in enough time for the Graduate Office to prepare and submit your Degree Recommendation to the School of Graduate Studies.

Transfer to the Ph.D. Program

Outstanding MSc students may apply for transfer to the Ph.D. program in Pharmacology after one year.  Transfer after the end of April of the second year is not permitted.  Students enrolled in the course-based Applied Clinical Pharmacology program are not eligible to transfer to the Ph.D. program; however, they are eligible to apply for the Ph.D. program upon completion of the MSc program.

Eligibility Criteria

• B+ or higher in all graduate courses taken
• The current MSc research project must be expandable in scope to meet Ph.D. thesis research requirements and must have resulted in sufficient progress to support the likelihood of a successful outcome at the Ph.D. level
• The full support of the current MSc Supervisor (and Co-Supervisor where applicable)
• The proposed Ph.D. supervisor MUST be the same as the current MSc supervisor

How to Apply

• Notify the Graduate Office you wish to be considered for Ph.D. transfer
• a review of background literature;
• a statement of hypotheses and/or goals;
• a progress report on work accomplished to date;
• a research plan for experiments to be completed in the Ph.D. program;
• a statement of the overall significance of the research project.
• A one-page summary  of the Research Proposal
• Curriculum Vitae  (be sure to include any publications and presentations)
• One letter from the proposed Ph.D. supervisor (current MSc supervisor)
• Two letters from Graduate Faculty members (Assessors) who are well acquainted with your work, are subject matter experts on the research field of the proposed project, and might possibly serve on your Ph.D. supervisory committee
• If you have a co-supervisor, an additional letter from the co-supervisor is also required.

Assessors should indicate:

• The proposed project is suitable for a Ph.D. project (comment on the scientific quality of the proposal and potential impact of anticipated results)
• The student has the qualities and potential for the Ph.D. program

The letter from the proposed Ph.D. supervisor should comment on the above and also confirm that adequate financial and infrastructure resources are in place to support both the student and the project.

Upon receipt of the above, the Graduate Education Committee will recommend whether the student should be allowed to proceed with the transfer.

Ph.D. Transfer Checklist

The following are some statements to guide your thinking about the feasibility of your proposed Ph.D. research:

• The scope of my current M.Sc. project is expandable to a Ph.D. project.
• My project has generated sufficient preliminary data to support the feasibility of the research goals.
• The progress of my project is being monitored at reasonable time intervals.
• Clinical Projects: I have made sufficient progress in patient recruitment to demonstrate the feasibility of my proposed study
• There are no experimental/methodological issues that could hamper the progress of the project being addressed.
• My study scope and timeline for achieving my research objectives align with the program completion time guidelines.

Continuing from the MSc to the Ph.D. Program

As per SGS regulations, all students applying for admission are required to submit and pay the posted application fee; this includes those currently registered who wish to continue on to a second program of study. Full application must be made by all applicants by the posted application dates.

Eligibility for the Ph.D. Program

To be eligible, the student must have achieved an average grade of at least B+ or higher in their Master's degree courses.

Continuing from the M.Sc. to Ph.D. program in Pharmacology may be carried out in one of two ways:

• For those Pharmacology M.Sc. students in the thesis-based program who have already obtained a Ph.D. supervisor and proposed Ph.D. project, there is the opportunity to screen at their Master's defense. This option is usually for students who are continuing on in the same laboratory with the same supervisor. An  online application  must still be completed but the process is expedited.
• M.Sc. Pharmacology graduates who do not screen at their outgoing M.Sc. defense must apply via the  online application system . As with all other applicants to the Ph.D. program, students will be admitted based on their academic qualifications, references and a detailed examination of the full application package. An admission interview may or may not be required.

Ph.D. Screening (Option #1)

Application to screen at the M.Sc. defense must be made to the Graduate Education Committee at least SIX WEEKS ahead of the proposed date of the defense (i.e., in time for the committee to evaluate the application and Ph.D. proposal prior to the proposed Defense+Screening).

Continuing students may enter the Ph.D. program either in September or January.

Application is made via the  online application system  and applicants must pay the processing fee and comply with the posted deadlines and required documentation rules.

The application must include:

• Three references . One from the current M.Sc. supervisor, which states that the current project is suitable for a Ph.D. project and that the student has the qualities and potential for the Ph.D. program; the second should be from a faculty member (e.g., the M.Sc. Advisor) who is well acquainted with the student's work. [For students proposing to change supervisors for the Ph.D. program, an additional letter from the proposed Ph.D. supervisor discussing the suitability of the proposed project should be included.]  
• A one-page summary of the research proposal
• A statement of hypotheses and/or goals;
• A progress report on work accomplished to date (if applicable);
• A research plan for experiments to be completed in the Ph.D. program;
• A statement of the overall significance of the research project.
• Curriculum Vitae  (be sure to include publications if any). 

Once the application to screen has been approved, a standard M.Sc. examination committee must be assembled. Two additional Graduate Education Committee members will be added to the examination committee to evaluate the Ph.D. screening. These two additional Screening Committee Members are not required to have a copy of the thesis unless specifically requested.

The student undergoing simultaneous M.Sc. Defense/Ph.D. Screening should be prepared to give an oral presentation (20 mins) that outlines the M.Sc. thesis research and a very brief description of the proposed Ph.D. project. Questions at the M.Sc. Defense/Ph.D. Screening can involve the M.Sc. thesis research, the proposed Ph.D. work, and general principles of pharmacology.

1.     The effect of lamotrigine on working memory in rats.

2.     Effectiveness of drug information pamphlets in improving patient medication adherence and usage of commonly prescribed medications and antibiotics among patients in a tertiary care hospital.

3.     Study of prescription pattern of antihypertensive drugs in a tertiary care hospital.

4.     A study to evaluate the antibacterial drugs used in upper-respiratory tract infection in pediatric age group.

5.     5- Fluorouracil Degradation Rate (5-FUDR) as a predictive biomarker for adverse effects with 5- Fluorouracil / Capecitabine therapy in South Indian cancer patients – a prospective phenotype genotype association study.

6.     Hepatoprotective effect of 7 – methoxy coumarin in paracetamol and ethanol toxicity induced cell lines.

7.     Pattern of adverse drug reaction and medication use in neonatal care units in a tertiary care hospital: a longitudinal observational study.

8.     Antidiabetic and pleiotropic effects of Psidium guajava Linn leaf extract. as an add on treatment in patients with type 2 diabetes mellitus – A randomized double-blind placebo controlled trial

9.     Characterization of pncA mutation and treatment outcome among tuberculosis patients

10. Characterization of cyclosporine trough (C0) and two-hour post dose concentration (C2) monitoring in children with idiopathic nephrotic syndrome

11. Clinical characteristics and early outcome of bedaquiline containing regimens for the treatment of MDR

12. Clinical characteristics and treatment outcome of Isoniazid mono-resistance tuberculosis patients: A mixed-method study

13. ICMR Rational use of medicines “Evaluation of the prescription pattern of drugs in different OPDs of a tertiary care hospital” task force project

14. The cytokine levels and miRNA expression in patients with major depressive disorder and its modulation by silymarin.

15. Subclinical hypothyroidism and plasma levels of commonly prescribed antiepileptic drugs – a cross sectional study.

16. Pharmacogenetics of sodium valproate – induced weight gain in South Indian patients

17. Formulation and evaluation of topical preparation of Lawsonia inermis L. (Lythraceae) for the evaluation of Capecitabine induced hand – foot syndrome in cancer patients

18. Are the users of angiotensin converting enzyme inhibitors (ACE-I) and angiotensin receptor blockers (ARBs) at a higher risk of severe COVID-19? – A Case Control study

19. Association of Nucleoside Diphosphate linked moiety X Type motif 15 (NUDT15) C415T and Inosine Triphosphate Pyrophosphatase (ITPA) C94A genetic polymorphisms with azathioprine induced adverse effects in south Indian patients.

20. Effect of VDR (Vitamin D Receptor) gene polymorphisms on efficacy of zoledronic acid in south Indian women with postmenopausal osteoporosis; A cross sectional study

21. Cytogenetic and molecular characterization of teenage and young adult acute lymphoblastic leukaemia with special emphasis on identification of “Philadelphia like” profile

22. Influence of EPHX1 c.337T>C and UGT2B7*2 genetic polymorphism on carbamazepine maintenance dose requirement in person with epilepsy from South Indi

23. Estimating Incremental Cost of treating Antimicrobial Resistant infections in India.

21. Study of prescription pattern of anti-epileptic agents in a tertiary care hospital

22. Evaluation of anti-inflammatory and analgesic activities of thiophene derivatives in wistar albino rats

23. Evaluation of learning and memory enhancing activities of thiazolidinone arecoline derivatives in wistar albino rats

24. Evaluation of hepatoprotective effect of gallic acid in murine model of isoniazid-induced hepatotoxicity.

25. Study of prescription pattern of Antimicrobial drugs in a tertiary care hospital.

26. Evaluation of effect of ciprofloxacin and levofloxacin on depressive behaviour in mice

27. Evaluation of anti-ulcer activity of vanillin using stress and aspirin induced ulcer models in wistar albino rats

28. A comparative study of efficacy and safety of timolol versus latanoprost in the treatment of primary open angle glaucoma at a tertiary care hospital

29. A comparative prospective study to assess the efficacy and safety of iron sucrose versus iron sorbitol citric acid complex in pregnant women with iron deficiency anaemia in a tertiary care hospital

30. Comparison of the effects of imipramine and fluoxetine on the diagnostic parameters of metabolic syndrome in patients with depressive episode at a tertiary care hospital

31. A comparitive study of efficacy and safety of intralesional triamcinolone with verapamilin treatment of keloid and hypertrophic scar in tertiary care hospital

32. A comparative study of the clinical efficacy and safety of topical retapamulin and mupirocin in the treatment of acute bacterial skin infections

33. A prospective randomized open- labelled comparative study of the clinical efficacy and safety of the fixed dose combination of arterolane maleate and piperaquine phosphate with artesunate and sulfadoxine – pyrimethamine in uncomplicated falcip

34. Prospective comparitive study of effect of two cephalosporin sulbactam combinations in chemoprophylaxis of open reduction & internal fixation surgery in closed limb fractures

35. The efficacy and adverse drug profile of risperidone versus olanzapine in the treatment of patients with bipolar affective disorder on combination therapy – a prospective, naturalistic, hospital based clinical study.

36. Comparison of the effect of selective serotonin reuptake inhibitors and selective serotonin norepinephrine reuptake inhibitors on body mass index in patients on long term treatment

37. Comparative assessment of the efficacy of morning dose versus evening dose levothyroxine in hypothyroid patients.

38. Study of prescription pattern of antitubercular drugs in a tertiary care hospital.

39. Comparative assessment of oral and local probiotics as an adjunct to standard therapy for vulvo vaginitis

40. “antiasthmatic effect of ethanolic extract of moringa oleifera (drumstick) seed kernels in an experimental animal model”.

41. Comparison of efficacy and safety of newer antifungal agent sertaconazole with clotrimazole and fluconazole in the treatment of acute vulvovaginal candidiasis.

42. Preliminary evaluation of anticonvulsant activity of aqueous extract of adhatoda vasica leaves in male and female albino rats

43. Preliminary evaluation of hypoglycemic activity of methanol extract of roots of acorus calamus in alloxan induced diabetic albino rats

44. To study effectiveness and tolerability of opipramol in the treatment of generalized anxiety disorder and somatoform disorders

45. A comparative study for efficacy `of combination therapy of inhaled levosalbutamol and ipratropium bromide against combination therapy of inhaled levosalbutamol and beclomethasone dipropionate in the treatment of bronchial asthma in adults

46. Monitoring and evaluation of adverse drug reactions in antiretroviraltherapy centre and dermatology department in a tertiary hospital

47. A prospective observational study on pattern of steroid utilization in a rural teaching hospital

48. A study of prescription pattern in musculoskeletal disorders causing low back pain(lbp) at kvg medical college, hospital,sullia,karnataka

49. A study of prescription pattern in the drug therapy of rheumatoid arthrits at kvg medical college and hospital, sullia (d.k), karnataka.

50. A prospective study on the use of anaesthetic agents in modern surgical practice at k.v.g. medical college & hospital, sullia (d.k.), karnataka.

51. Adverse drug reaction monitoring in a teaching hospital, mandya.

52. Study of analgesics usage in third trimester of pregnancy and its illeffects on pregnancy course and outcome.

53. To evaluate the analgesic activity of garlic extract in rats

54. A study to assess adverse drug reactions to anti retro viral therapy: type and risk factors in art centre at k. R. Hospital, mysore.

55. A randomized, prospective study of single dose epidural 0.2% levobupivacaine with 25µg fentanyl and single dose epidural 0.2% ropivacaine with 25µg fentanyl for post-operative analgesia in patients undergoing elective lower limb surgeries.

56. A prospective study of oral betahistine and ondansetron in the prevention of post operative nausea and vomiting, in patients undergoing tympanomastoid surgeries under local anaesthesia

57. Effect of minoxidil on blood glucose levels in normal and type 2 diabetic model of rats and its pharmacodynamic interation with glibenclamide: an experimental study

58. Prescription audit of antibacterials in suspected neonatal sepsis at a tertiary care hospital

59. Efficacy of supplementation of probiotics along with antimicrobial agents in vulvovaginal infections in a tertiary care hospital

60. Study of anticonvulsant effect of nebivolol in maximal electro shock (mes) and pentylenetetrazole (ptz) induced seizure models in mice

61. A prospective study to evaluate the effect of cilostazol on the lipid profile in patients of peripheral arterial disease as an adjunct to statins

62. Experimental evaluation of anti convulsant activity of atorvastatin in wistar rats

63. A randomised controlled study to compare the efficacy of racecadotril versus diphenoxylate in acute radiation enteritis.

64. Assessment of adverse drug reactions in geriatric patients in a tertiary care hospital

65. Factors affecting adherence to drugs and its influence on outcomes in select chronic disese (cardiovascular disease and diabetes mellitus at a tertiary care hospital

66. Patterns and determinants of poly pharmacy in perioperative patients in general surgical war ds of a tertiary care hospital: a prospective observational study

67. Pattern of use of analgesis for post-operative pain managment in adults undergoing laparotomy surgery-a prospective observational study in a tertiary care hospital

68. Patterns of drug use and factors affecting adherence to medication in rheumatoid arthritis- a prospective, observational, hospital based study

69. Study of prescription pattern in the management of herpes zoster at brims hospital, bidar

70. “a comparative study of efficacy and safety of alternate day rosuvastatin dosing versus daily rosuvastatin dosing in patients with dyslipidemia”

71. Evaluation of the appropriateness of prescribing in geriatric patients admitted in various departments in government teaching hospital, bidar institute of medical sciences, bidar. Karnataka

72. A prospective study of various poisoning, pattern, pharmacological management and their outcome in a tertiary care hospital

73. Drug utilization study of antibiotics use in orthopaedic units of basaveshwar teaching and general hospital attached to hke society mahadevappa rampure medical college gulbarga

74. A comparative study to evaluate the efficacy, tolerability and response rates of two antidepressants escitalopram with sertraline in patients of major depressive disorder.

75. Role of antimicrobial agents for the prevention of surgical site infections with pharmacoeconomics in the general surgery units.

76. A prospective study to compare efficacy and tolerability of ranolazine and nicorandil in the patients of angina pectoris at basaveshwara teaching and general hospital, gulbarga

77. Drug utilisation study of anticonvulsant agents in paediatric unit in a teritiary care hospital

78. Comparative study of safety and efficacy of inhalation anti-asthma drugs versus systemic anti-asthma drugs in a tertiary care hospital.

79. Study of prescription pattern of antiemetic drugs in a tertiary care hospital.

80. A comparative study of antinociceptive activity of paroxitine with pethidine in acute pain in albino rats

81. A comparative study of efficacy, tolerabilty and safety profile of fluoxetine with desvenlafaxine in patients with depression in a tertiary care hospital.

82. A comparative study of efficacy of silodosin and tamsulosin in patients of lower ureteric culculi in a tertiary care hospital

83. A prospective comparative efficacy & safety study of topical retapamulin and mupirocin

84. A comparative study of the efficacy and safety of levocetirizine and rupatadine

85. A comparative study of the efficacy and safety of amitryptyline and topiramate in the prophylaxis of migraine

86. A comparative study of intravenous paracetamol and tramadol for post operative analgesic efficacy in orthopedic surgeries at a tertiary care hospital, bangalore

87. Study of anti inflammatory activity of ficus racemosa linn stem bark extract in albino rats

88. Study of analgesic activity of murraya koenigii leaves extractin albino mice

89. A comparative study of the efficacy and safety of oral flunarizine to oral propranalol in prophylaxis of migraine in rajarajeswari medical college and hospital bangalore

90. A comparitive study of efficacy and tolerability of oral desloratadine, ketotifen and rupatadine in seasonal allergic rhinitis

91. A study of the pattern of drug use for postoperative analgesia following lower abdominal surgeries in a tertiary care hospital.

92. Study of prescription pattern of oral contraceptive pills in a tertiary care hospital.

93. A study of the pattern of preanaesthetic medication for major surgeries under general anaesthesia in a tertiary care hospital

94. A comparative study of efficacy and tolerability of olopatadine, ketotifen and epinastine in seasonal allergic conjunctivitis

95. A comparative study of efficacy and tolerability of methotrexate, sulfasalazine and leflunomide in rheumatoid arthritis

96. A study of the pattern of drug use for general and regional anesthesia for caesarean section and to compare the maternal and neonatal outcome

97. Evaluation of nephroprotective action of ethanolic extract of leaves of alocasia macrorrhizos in rats

98. Study of prescription patterns and pharmacoeconomic evaluation of anti-epileptic drugs

99. A prospective study on pattern of poisoning among adult in-patients in a tertiary care hospital.

100. Evaluation of Glycemic Index and Insulin Index of a marketed sugar product.

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M. Pharm Thesis Topics (2024): Pharmaceutics, Pharmacology & Pharmacognosy

M. Pharm Thesis Topics (2024)- Select your M. Pharm Thesis Topics (2024) from the below list for your M. Pharm Thesis in Pharmaceutics, Pharmacology, and pharmacognosy.

Contact for Unique Written Thesis (Completely Human Written)

Introduction-m. pharm thesis topics (2024).

M. Pharm thesis is a research project that is completed as part of the requirements for an M. Pharm degree in pharmacy. The M. Pharm degree is a postgraduate degree program that is typically completed after completing a Bachelor’s degree in pharmacy.

The M. Pharm thesis is usually completed over the course of two years and involves conducting original research in a specific area of pharmacy or pharmaceutical sciences.

The research project is typically supervised by a faculty member who is an expert in the field and who provides guidance and support throughout the research process.

The M. Pharm Thesis Topics is typically based on a review of the literature and may involve conducting experiments, analyzing data, and interpreting results. The findings of the M. Pharm thesis are typically presented in a written dissertation, which is defended in front of a panel of experts in the field.

Best Lab for M. pharm and PhD. Projects

M. Pharm Thesis Topics (2024) of Pharmaceutics

M. Pharm Thesis Topics (2023) of Pharmaceutics offers a wide variety of topics for students to choose from. Students can select a topic from any area of pharmacy, including pharmaceutics , pharmacology, Pharmacognosy, and more.

Theses topics are usually based on the latest research in the field of pharmacy, so students can be sure they are working on cutting-edge topics. Additionally, because thesis projects are typically completed over the course of two years, students have ample time to explore their chosen topic in depth.

USE: M. Pharmacy Project Topic Generator

Some popular M. Pharm Thesis Topics (2024) of Pharmaceutics include:

• Development and evaluation of a novel sustained-release drug delivery system
• Formulation and optimization of a targeted nanomedicine for cancer therapy
• Investigating the effect of excipients on the stability and bioavailability of a drug
• Evaluation of the impact of processing conditions on the physical properties of a solid dosage form
• Development of a predictive model for predicting the in vivo performance of a drug delivery system
• Development of a novel transdermal drug delivery system for the sustained release of a poorly water-soluble drug
• Evaluation of the effect of pH and ionic strength on the stability and release of a drug from a polymeric delivery system
• Formulation and optimization of a self-emulsifying drug delivery system for improved bioavailability of a poorly soluble drug
• Development of a mucoadhesive drug delivery system for the targeted release of a therapeutic agent to the oral mucosa
• Investigation of the effect of process variables on the physical and chemical stability of a protein-based drug delivery system
• Development of a novel lipid-based drug delivery system for the targeted release of a therapeutic agent to the small intestine
• Formulation and optimization of a microsphere-based drug delivery system for the sustained release of a protein drug
• Investigation of the effect of excipients on the physical stability and in vitro release of a drug from a matrix-based drug delivery system
• Evaluation of the impact of processing conditions on the in vitro and in vivo performance of a novel drug delivery system
• Development and validation of a predictive model for predicting the release of a drug from a polymer-based drug delivery system
• Development of a novel injectable drug delivery system for the sustained release of a hydrophobic drug
• Formulation and optimization of a nanoparticle-based drug delivery system for the targeted release of a therapeutic agent to the liver
• Investigation of the effect of pH and temperature on the stability and release of a drug from a polymeric drug delivery system
• Evaluation of the impact of process variables on the physical and chemical stability of a protein-based drug delivery system
• Development and validation of a predictive model for predicting the in vivo performance of a drug delivery system

M. Pharm Thesis Topics (2024) for Pharmacology

M. Pharm Thesis topics in pharmacology that are popular in 2023. The field of pharmacology is constantly evolving, and new research is constantly uncovering new and fascinating information about the way drugs work in the body. As a result, there are always new M. Pharm thesis topics to choose from.

Some of the most popular M. Pharm thesis topics in recent years have included studies on the efficacy of various drugs, the mechanisms by which they work, and their potential side effects. Other topics have explored the role of pharmacists in patient care, the impact of new technologies on drug development and delivery, and the ethical implications of prescribing drugs.

Whatever your interests may be, there is sure to be an M. Pharm thesis topic that will suit you. So don’t hesitate to explore all the options before making your final choice! However, some potential ideas for M. Pharm thesis topics in pharmacology that may be of interest in the future could include:

• Investigating the mechanisms of action and potential therapeutic uses of new drugs or drug candidates.
• Examining the impact of genetic variations on drug response and the potential for personalized medicine.
• Developing new drug delivery systems or formulations to improve the effectiveness and safety of medications.
• Evaluating the long-term safety and effectiveness of drugs in clinical practice.
• Exploring the role of pharmacology in the treatment of specific diseases or conditions, such as cancer, cardiovascular disease, or neurological disorders.
• Analyzing the impact of environmental factors, such as diet or stress, on drug response.
• Investigating the potential for using natural products or traditional medicine in pharmacology.
• Studying the effects of drug-drug interactions on the efficacy and safety of medications.
• Examining the role of pharmacology in pain management, including the use of opioids and non-opioid alternatives.
• Investigating the use of pharmacogenomics to optimize drug therapy and prevent adverse reactions.
• Developing new methods for predicting and preventing drug toxicity.
• Evaluating the impact of drug regulations and policies on patient access and outcomes.
• Examining the use of pharmacology in the treatment of mental health disorders, such as depression, anxiety, or psychosis.
• Investigating the potential for using pharmacology to prevent or treat infectious diseases, including emerging diseases.
• Studying the impact of cultural and social factors on drug use and outcomes.
• Evaluating the effectiveness and safety of over-the-counter (OTC) medications.
• Investigating the use of pharmacology in the management of chronic conditions, such as diabetes or hypertension.
• Examining the role of pharmacology in the treatment of addiction and substance abuse disorders.
• Developing new methods for synthesizing and purifying drugs.
• Studying the impact of aging on drug metabolism and response.
• Investigating the use of pharmacology in the treatment of cancer, including the development of targeted therapies.
• Examining the use of pharmacology in the management of allergies and immune disorders.
• Evaluating the impact of environmental exposures, such as pollution or radiation, on drug response.
• Investigating the potential for using pharmacology to enhance physical performance or treat sports-related injuries.

Again, these are just a few examples, and there are many other potential topics that could be explored in an M. Pharm thesis in pharmacology.

M. Pharm Thesis Topics (2024) for Pharmacognosy

There are many potential topics that could be explored for a Master of Pharmacy (M. Pharm) thesis in the field of pharmacognosy, which is the study of natural products with pharmaceutical properties. Here are a few examples:

• Isolation and characterization of bioactive compounds from medicinal plants
• Development of natural product-based drugs for the treatment of specific diseases
• Evaluation of the antioxidant and anti-inflammatory properties of natural products
• Comparison of the efficacy and safety of natural products with synthetic drugs
• Molecular mechanisms of action of natural products in the body
• Traditional uses of medicinal plants and their scientific validation through pharmacological studies
• Natural products as sources of new cosmetic ingredients
• Development of herbal formulations for specific health indications
• Exploration of natural products as potential alternatives to antibiotics for the treatment of infections
• Evaluation of the quality, safety, and effectiveness of herbal products available on the market.
• Identification of new natural products with anti-cancer properties
• Exploration of the use of natural products in the management of diabetes
• Development of natural product-based therapies for the treatment of neurological disorders
• Evaluation of the potential of natural products to treat cardiovascular diseases
• Study of the effects of natural products on the immune system
• Exploration of natural products as potential treatments for viral infections
• Evaluation of the anti-microbial activity of natural products
• Development of natural product-based insecticides
• Exploration of natural products as sources of food preservatives
• Identification of natural products with anti-aging properties
• Study of the effects of natural products on skin health
• Evaluation of the use of natural products in the treatment of respiratory disorders
• Investigation of natural products as potential treatments for gastrointestinal diseases
• Exploration of the use of natural products in the management of kidney disorders
• Study of the effects of natural products on bone health
• Evaluation of the potential of natural products to treat eye disorders
• Investigation of natural products as potential treatments for reproductive health issues
• Exploration of natural products as sources of natural sweeteners
• Study of the effects of natural products on mental health
• Evaluation of the use of natural products in the treatment of sleep disorders.

In the conclusion of an M. Pharm thesis in Pharmaceutics, Pharmacology & Pharmacognosy, the main findings and conclusions of the research should be summarized and discussed in relation to the research objectives and questions.

This may include a summary of the methods used, the results obtained, and the implications of the findings. The conclusion should also highlight any limitations of the study and suggest directions for future research.

It is important to remember that the conclusion should not introduce any new information, but should rather provide a synthesis of the main points made in the thesis. It should provide a clear and concise summary of the research and its contributions to the field of Pharmaceutics, Pharmacology & Pharmacognosy.

The conclusion should also provide a final reflection on the significance and relevance of the research, and may include recommendations for further study or future research in the field.

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Know the Best Pharmacology Dissertation Topics from Experts

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How to Choose a Pharmacology Dissertation Idea?

Excellent list of 40+ pharmacology dissertation topics, tips to write a pharmacology dissertation from experts, how can we help you with your pharmacology dissertation.

Are you asked to write a pharmacology dissertation? Well completing such a lengthy document requires accurate research, in-depth drafting, and thorough proofreading. But all this is only possible if you have a good idea to work on. So, if you are looking for pharmacology dissertation topics, then this is it! In this blog, the researchers of the Assignment Desk will offer 40+ options to choose from. But first, let us understand how to pick one topic from a long list of ideas.

Documents like dissertations are very complex and involve extensive research and analysis. Students seek dissertation help online because they cannot find a good topic for their project. So, let us learn from our experts how to choose the best idea and score decent grades on this academic task.

1. Understanding Requirements

To choose ideas for pharmacology dissertation, you should have an in-depth understanding of all the instructions and requirements provided by the professor. It is because even if you defy even the slightest rule, the dissertation can be rejected.

2. Developing Niche

The next thing to do to pick out the finest pharmacology dissertation ideas is to develop a niche. It is the main focus of your entire document, and it can be a trending issue, an unsolved problem, or a research gap.

3. Formulating Hypothesis

Every dissertation has objectives that the student wishes to accomplish using pre-defined research methods. So, before finalising the topic and dissertation titles on pharmacology, you need to formulate all your objectives and other goals.

4. Reading Literature Review

Dissertation topics on pharmacology are only useful if an ample literature review is available for reference. So, after formulating the hypothesis, browse the internet and find articles, journals, and other information relevant to the topic.

5. Considering Ethical Factors

Following ethical guidelines is very essential while writing dissertations on pharmacology. Your research should not hamper anyone's emotions, personal property, or anything else. Therefore, take into consideration rules like information consent, voluntary participation, etc.

6. Seeking Professor's Approval

Before beginning a dissertation, students need to seek the professor's approval. So, finalise your idea, and if you have any doubts, then seek assistance from experts. After this, discuss with the professor and get their approval.

Well, now that you know how to select an idea, we can move ahead. So, let us jump to the next section and unravel the list of pharmacology dissertation topics. Read each idea and pick the one that matches your requirements.

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Our researchers can provide you with a list of ideas on any subject you like. So, if you are looking for medical, psychology, or  chemistry dissertation topics , then this is it! Just contact our experts, and you will get your perfect idea. Until then, dive into the list of ideas for pharmacology dissertation. So, dive ahead and pick out an amazing topic.

1. What are the current practice guidelines in pharmacology?

2. How can we make safer drugs for the treatment and care of children?

3. Discuss the future scope of clinical pharmacology in the UK.

4. What are the problems associated with integrative pharmacology? Explain in detail.

5. What are your opinions on the prevailing status of behavioural pharmacology in the UK?

6. What changes is the BPS, or British Pharmacological Society, going through?

7. Explain in detail the clinical pharmacology of anti-HIV drugs.

8. What challenges do scientists face during the development of cancer drugs?

9. Does hemodynamics have any adverse effects of oxytocin in the C-section under spinal anaesthesia?

10. What is vaccinology? State the current advancements in this area.

11. Explain the neurobiology of rapid-acting anti-depressants.

12. System pharmacology concerning metabolic bone disease.

13. What is the pharmacology of inhaled anaesthetics? Also, discuss your opinions.

14. Discuss the molecular pharmacology of rapid-acting anti-depressants.

15. What is the pharmacology of cancer, and are there any recent developments?

16. What is the apelin receptor? What are its biased agonists?

17. How can we control signalling bias, and how does the intracellular loop of the adenosine A receptor assist?

18. Explain the process of intracellular store refill.

19. Does fluoride have any effects on ion transport? Explain in detail.

20. Discuss sensory neurons and their characteristics.

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21. What is the significance of Ca signals in the chemotaxis of glioma cells?

22. Explain the novel vasoactive cardiometabolism and its uses.

23. Does anxiety affect the prothrombotic responses of the endothelium? If yes, then how?

24. Analyse the BCA as basal-like breast cancer and explain in detail.

25. What is therapeutic potential? What is the potential of intrabodies?

26. How can nig data impact healthcare and drugs?

27. What are the practice guidelines for anti-depressants in pharmacology?

28. How is the working memory of rodents affected by lamotrigine?

29. What is the prescription pattern in tertiary hospitals for antihypertensive drugs?

30. What is the treatment approach used for tuberculosis patients?

31. What processes are used in the treatment of MDR? Explain in detail.

32. What is the incremental cost of treatment for patients suffering from antimicrobial-resistant infections in the UK?

33. What intervention approach and methods are used for the treatment of generalised anxiety disorder?

34. What are somatoform disorders, and how are their patients treated? Explain the process in detail.

35. Evaluate negative drug reactions in a dermatology department.

36. What is anti-retroviral therapy, its type, and its adverse effects? Discuss in detail.

37. What are the effects and uses of cilostazol on patients suffering from peripheral arterial disease?

38. How is herpes zoster treated, and what is the common prescription pattern?

39. What is the efficacy of levocetirizine? Does it have any adverse effects?

40. Conduct an efficacy study on topical retapamulin. Also, explain its negative impacts.

41. How is a patient suffering from MDR tuberculosis treated? What methods and drugs are used?

We hope that we have provided you with a list of the best ideas for pharmacology dissertation. Now, you can continue to write your document, and if you need any assistance, then have a look at the tips given by our  dissertation writers in UK .

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Students need  PhD dissertation help  as this document is extremely lengthy and brings several challenges in steps like data collection and analysis. To make things easier, follow the tips given by our experts.

1. Create an Intact Outline

The dissertation comprises 250+ pages. It includes several chapters, sections, and sub-sections. To make things easier for the readers and to make the pharmacology dissertation topics understandable, you must create an intricate outline for each section.

2. Thorough Literature Review

A literature review is a compilation of all the existing theories and findings. It enhances the relevancy and credibility of the speaker. It also showcases that you have an in-depth understanding of the pharmacology dissertation ideas. So, include a thorough literature review, and to tackle any issues, seek aid from  cheap dissertation writing services .

3. Citing All Sources

Referencing is one of the most crucial elements of dissertations on pharmacology. You should cite all your sources as per the university guidelines. To make sure that you cite all the information, start noting down all your references from the beginning. Also, follow the university citation format.

4. Stating the Implications

In the discussion chapter of the dissertation, you not only interpret the results but also discuss their implications. So, put the outcomes and findings of your dissertation topics on pharmacology into context and describe their uses for the readers.

5. Highlighting the Achievements

To score decent grades in a dissertation, you must highlight all your achievements and accomplishments. State them in detail in the discussion section. Moreover, you should highlight them in the conclusion section. If you want, you can also state how you overcame the challenges during steps like data collection and analysis.

6. Including Credible Information

A dissertation is a PhD-level document. Therefore, students must show their subject knowledge, expertise, skills, and abilities. Not only this, but you should also make sure that you include only credible information. So, exclude all the traces of false data in every step, from research to the final proofreading.

Well, with the above tips, you can write an excellent document on good dissertation titles on pharmacology. Still, if you face any issues, you can always reach out to experts at the Assignment Desk.

Students often contact our experts and ask, "Can we  buy dissertation  from your team?". It is because they have faith in the research, drafting, and proofreading abilities of our professionals. These experts are the best in the UK because of their doctorate degrees and several years of experience. So, if you are a student who is looking for top-notch assistance at budget-friendly rates, then this is it! Our team will assist you in every step and will resolve all your doubts and queries with descriptive answers. So, if you are struggling with your pharmacology dissertation topics, contact our experts now!

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MINI REVIEW article

Past and future of an imi-pharmatrain (imi-pht)-initiated multinational pharmaceutical medicine course at the semmelweis university in hungary.

• 1 Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary
• 2 Independent Consultant, Berlin, Germany
• 3 Ethics Committee for Clinical Pharmacology, Medical Research Council, Budapest, Hungary
• 4 Retired, Budapest, Hungary
• 5 Pharmahungary Group, Szeged, Hungary

The pharmaceutical medicine course at the Semmelweis University of Budapest, Hungary, was initiated as part of the Innovative Medicines Initiative ( IMI is the main program, IMI-PharmaTrain is one of the IMI projects) Pharmaceutical Medicine Training Programs (16 IMI Call 2008/1/16). The aim was to extend training in the development of pharmaceutical medicine to those EU member states where no such education was present. The final program envisaged the development of a cooperative education supported by universities located in Central and Eastern Europe. It was considered to be the economically and scientifically most viable approach to combine the expertise from these countries to form a united teaching staff and provide education jointly for young professionals of the region. Semmelweis University was selected to manage this coordinated program. In this report, we describe the organization and functioning of this international university-based pharmaceutical medicine education project called the Cooperative European Medicines Development Course (CEMDC) and evaluate its successes and shortcomings. During the pandemic, the educational course was interrupted. The follow-on program is reorganized as a postgraduate MSc course named “Semmelweis Pharma MBA” and will be started in 2025. It will continue the established PharmaTrain educational tradition. However, it will deal in more detail with the transition from basic pharmacological to industrial research, as well as biopharmaceutical formulation and manufacturing and marketing aspects of medicines development.

Introduction

The very rapid increase of the scientific knowledge underpinning modern medicines development presents a great challenge for both pharmaceutical and medical device industries as well as for the healthcare system. Intensive cooperation between industry experts, treating physicians, and recently, non-medically trained scientists has become a well-accepted approach to develop highly complex advanced therapies. Already, in the second half of the 20th century, the need to provide complex training for experts working in both pharmaceutical and healthcare industries has become apparent. This has led to the emergence of pharmaceutical medicine as a new medical specialty since earlier only medically trained personnel were engaged in clinical development, both in the pharmaceutical industry and in hospitals. The professional organization of medical advisers working in the pharmaceutical industry was started in the 1970s ( Stonier et al., 2007 ). In 1975, 12 national pharmaceutical medicine societies formed the International Federation of Associations of Pharmaceutical Physicians and Pharmaceutical Medicine (IFAPP) ( Stonier et al., 2007 ; IFAPP ). According to the generally accepted definition, “Pharmaceutical Medicine is the medical scientific discipline concerned with the discovery, development, evaluation, registration, monitoring and medical aspects of marketing of medicines for the benefit of patients and public health.” (IFAPP).

Pharmaceutical medicine courses were offered first in countries having large, worldwide-acting pharmaceutical industries. In regions having smaller pharmaceutical companies predominantly producing generic drugs with a low profit margin, such training was mostly absent due to the lack of money available for funding the education of employees. However, with the increasing local production of medicines for supporting national healthcare, it has become necessary to train experts in pharmaceutical medicine in many countries with moderate and/or developing pharmaceutical industries. Such expertise became also necessary for physicians organizing international and local clinical trials. Parallel with the rapidly increasing number of non-medically trained specialists involved in complex therapies, the course material also had to be adapted to cover the needs of this new group.

The vision to improve the teaching of medicine development in the EU led to the Innovative Medicines Initiative PharmaTrain (IMI-PhT) project. Its aim was to promote the cooperation between academic centers and pharmaceutical companies for modernizing and harmonizing the education of medicine development courses offered by various universities and to extend professional education to new EU member states in Central and Eastern Europe (CEE).

The organization of the IMI-PhT program and the foundation of the CEMDC

The IMI was a project of the European Union implemented in 2008. It is a public–private partnership between the European Union (represented by the European Commission) and the European pharmaceutical industry (represented by the European Federation of Pharmaceutical Industries and Associations, EFPIA). The aim of this partnership was to modernize and speed up medicine development and to improve patient access to innovative medicines in general and in particular in areas of unmet medical needs. To achieve this goal, the IMI facilitated intense collaboration between universities, research centers, patient organizations, regulatory bodies, and the pharmaceutical industry (IMI). The 5-year-long IMI-PhT cooperation was started in 2009 in the first round of accepted IMI projects ( PharmaTrain a ). First, the project was called the European Federation of Course Providers in Pharmaceutical Medicine (EFCPM). It was renamed to PharmaTrain in 2012. Altogether, 15 pharmaceutical companies representing the EFPIA and 33 universities, research organizations, public bodies, and non-profit groups, including the Semmelweis University of Hungary, participated in the IMI-PhT project. The main achievement of the PhT cooperation was to provide shared standards and guidelines for postgraduate pharmaceutical medicine courses. This was realized by updating the teaching topics listed in the IFAPP syllabus ( The PharmaTrain Syllabus, 2018 ) and defining the expected learning outcomes of the education. It also suggested precise criteria for the evaluation of medicine development courses ( IFAPP World, 2015 ). The PhT organized a network of 13 courses recognized as Centers of Excellence because of fulfilling all the agreed educational standards. One of them was the CEMDC (Cooperative European Medicines Development Course), which was established during the lifetime of the IMI-PhT program. After the termination of the IMI-PhT project in 2014, the cooperation of centers teaching the PhT program continued in an independent follow-up organization called PharmaTrain Federation ( PharmaTrain b ).

One of the aims of the PhT program was to establish a pharmaceutical medicine course in CEE, where education on medicine development was not yet well-developed. It was known that local courses were already organized earlier in the Czech Republic and the Republic of Serbia; however, these countries did not participate in the PhT project. On the other hand, Hungary joined the IMI-PharmaTrain program because a pharmaceutical medicine course was already initiated at Semmelweis University in Budapest using the available IFAPP educational guidelines. In addition, Hungary has a relatively well-developed pharmaceutical industry firmly established in the region. Considering these circumstances, the participants selected the Hungarian course for further support in the PhT project. Semmelweis University accepted this challenge and volunteered to modify its already running course according to the new ideas emerging during the PhT discussions ( Kerpel-Fronius, 2015 ). Two persons were selected to manage this program: Matthias Gottwald of Bayer, representing the EFPIA, and Sandor Kerpel-Fronius, serving as the study director of the running Hungarian course.

The geographical extension plan envisaged supporting one course in CEE to work according to the PhT standards. However, this approach would not solve the issue of education of experts working in the other countries of CEE. Therefore, following the suggestion provided by Hungary, we began to think of a course jointly run by several universities located in CEE. After a thorough discussion and with the energetic support of Professor Fritz Bühler, head of the IMI-PhT project, a draft plan was produced. It envisaged organizing a cooperative course having its administrative center at Semmelweis University in Budapest. The idea was to involve the teaching staff from the universities located in CEE countries for offering pharmaceutical medicine development education jointly to an entire region. We realized that none of these countries have enough experts and students for running individual courses efficiently. The draft plan was accepted both by the IMI program and by Semmelweis University, which also agreed to manage the administrative work associated with international education.

Following the principal agreement on the organization of the CEMDC, many universities were contacted. Originally, 16 universities signaled interest, some of them located outside CEE. The PhT generously sponsored five joint meetings at which the interested universities discussed many administrative and practical aspects of joint education. It was decided that all administrative issues of all enrolled students will be handled, according to the Hungarian Law, by Semmelweis University. A governing board representing all participating universities will define the actual course program based on the PhT principles and syllabus. They will also elect a study director responsible for managing all educational and administrative issues during the course. Finally, Semmelweis University was appointed to provide quality control over the overall management of education, while the quality control over the pharmaceutical medicine-teaching program remained the responsibility of PhT, similar to all other courses. Based on these discussions, relevant standard operating procedures were prepared. The rectors of 10 participating universities finally signed the Memorandum of Understanding at the inauguration ceremony of the CEMDC, which took place in Budapest at Semmelweis University on 30 October 2012 ( Figure 1 ).

Figure 1 . Participating countries and universities in the CEMDC.

As mentioned above, the first Hungarian pharmaceutical medicine course was already running at Semmelweis University in 2009 when the PhT project was initiated. We used the six basic modules of the IFAPP pharmaceutical medicine course program together with the IFAPP syllabus. These were further developed during the IMI program and renamed to the PhT course and PhT syllabus. Therefore, it was relatively easy to adapt the new modifications to our running program given in English. Many participants of the PhT cooperation accepted kindly to lecture at the Hungarian course and also supported us by providing guidance regarding the best practices for course management, examination practices, and quality control applied in IFAPP courses.

One of the most important goals of the PhT cooperation was to develop a master level program by adding six freely selectable elective modules to the basic course. Since we also planned to develop the CEMDC to become later a master course, we decided to add several topics of the newly developed elective modules to the running program. These were primarily dealing with health economics, biological and advanced therapies, pharmacovigilance, and follow-on generic and biosimilar medicinal agents. Semmelweis University together with experts from the Hungarian pharmaceutical industry prepared this last module. Finally, the continuously adapted first course contained 319 teaching hours, of which 179 and 140 belonged to the base and elective modules, respectively. Twenty-six students started the first course, of whom 22 finished the basic course and 20 also completed the master-level modules and defended a thesis. Of those who followed the entire course, 10 were physicians, 5 were pharmacists, and 5 had MSc degrees in natural sciences. Essentially, during this IMI-PhT training phase, almost a full program for a master course was developed. This first course was quality-controlled by PhT in 2013. They concluded that the Hungarian course reached the PhT quality standards and recommended to award the title “PharmaTrain Center of Excellence.” They also reviewed the organization plan for the new international cooperative course and found it satisfactory for initiating the joint CEMDC education program ( Report of the PharmaTrain Assessment Report, 2013 ; Kerpel-Fronius, 2015 ).

The learning environment and the educational program of the CEMDC between 2013 and 2019

In this section, the experience obtained in three consecutive CEMDC courses provided between 2013 and 2019 is presented jointly. Unfortunately, the great expectations of the PhT geographical extension program could be fulfilled only partially because the international and local pharmaceutic companies operating in CEE failed to support their coworkers to participate in the course. Frequent traveling because of face-to-face teaching also limited international enrollment. Indeed, in addition to the Hungarian participants, only two students registered from Lithuania followed and finished the CEMDC course. This was not only a local problem. Just when finishing the IMI-PhT project, the pharmaceutical industry began to withdraw from the joint program claiming that the combined basic-master course is far too expensive and time-consuming for the pharmaceutical industry. Instead, the companies reverted to their internal training model providing limited practice-oriented education for their employees and short external training courses on specific topics. In addition, budgets for training were primarily linked to central units, while the subsidiaries in CEE countries mostly lacked sufficient budgets for such programs. As the headquarters are almost all located in Western Europe, they usually sent their employees to training centers in their regional vicinity.

The original organizational plan of the CEMDC had to be modified because of the low number of students registering for the course. Nevertheless, we considered continuing the CEMDC joint program supported so generously by the IMI-PhT cooperation as an ethical obligation. In addition, several Hungarian and a few foreign students already registered for the course, covering privately their tuition fees. In the following three courses, we had 8, 6, and 7 students finishing the entire course. Of the students, 29% were physicians, 26% pharmacists, and 39% natural scientists. We accepted also one lawyer and one economist because of their extensive working experience in medicine development. In addition, several students from different European courses participated in selected modules since according to the PhT agreement, the modules finished in courses following the PhT program were mutually recognized. We managed the program exclusively with the participation fee of the students. It was a great support that Semmelweis University offered its facilities and administrative background free of charge. In addition, many colleagues did not ask for honoraria, and we had to support only their travel and local expenses.

Our main goal was to maintain the international university network concept at least in a modified form primarily based on email communication with university representatives. In practice, the study director working at Semmelweis University planned, executed, and supervised the courses. He prepared and distributed the advertisement material and the draft program to the participating countries. The national representatives were asked to advertise the program locally, provide their comments, and nominate possible local lecturers for the planned modules. In addition, for supporting the international cooperative concept of the CEMDC, professors Mlinaric-Rascan and Klimas offered to organize modules 2 and 5 in Slovenia and Slovakia, respectively. This provided the opportunity to involve many local experts as lecturers. In Slovenia, additional students joined the core pharmaceutical medicine audience since the module dealing with non-clinical and early clinical development was included in their local PhD program. These students received the standard modular certificate issued by Semmelweis University after passing the examination at the end of the module. However, they were not accounted as pharmaceutical medicine course participants. Following the Slovenian example, the PhT modules were later accepted by the Semmelweis University PhD program as freely selectable topics. This linking between different programs was a unique and very fruitful cooperation facilitated by teaching pharmaceutical medicine in the university environment.

Altogether, 103 lecturers participated in the three consecutive courses. The largest proportion (36%) of the lecturers came from academic institutions. The industry, the contract research organizations, and the regulatory agencies contributed 29%, 16%, and 19% of the teachers, respectively. Of the lecturers, 45% were Hungarian. Several foreign lecturers were former participants of the IMI-PhT cooperation, who kindly offered their continuous support, while other experts were recommended by the participating universities of the CEMDC project. If needed, we invited also lecturers with special expertise without any formal ties with the PhT program.

The plan to provide a complete MSc course also was modified primarily due to the limited financial resources of the students to cover the entire program. The second course only contained the six base modules. Later, the program was extended since we considered it important to present new developments in pharmaceutical medicine. Pharmacoeconomy was included in the revised basic Module 6 dealing with healthcare economics. In addition, two new elective modules, one covering biologicals and advanced medicinal products and another on follow-on generic and biosimilar agents, were added. This extension also satisfied the criteria for retaining the PhT Center of Excellence qualification. Topics dealing with ethics were presented in Module 1 and were additionally discussed in more detail in a case discussion dealing with trial organization. In all modules, much time was devoted to carefully explain the relevant scientific background of the topics ( Table 1 ).

Table 1 . Titles and teaching hours of modules (M) presented in courses (C) 2, 3, and 4.

Pedagogical principles and quality standards underlying the CEMDC educational activity

Learning outcomes (los).

The PhT program provides a competency-oriented education. For supporting this pedagogical goal, the experts writing the modules have to define specific learning outcomes (LO), which have to be achieved by the education program. Usually, 8 to 10 LOs are defined per module. In the programs prepared for a given module, the relations of the lectures both with the respective topics listed in the PhT syllabus and with the predefined LOs are indicated. In our course, the study director was responsible to guide the lecturers in preparing their material in harmony with these requirements. The firm link of LOs with the program was further emphasized by asking the students to rate how far the specified learning outcomes (LOs) were supported by the lectures. In addition, the quality of the lectures was rated according to expectation, content, and presentation.

MCQ examination

Each module was followed by an MCQ (multiple-choice questionnaire) examination with around 30 MCQs. Many MCQs were received from the central IMI-PhT pool, while others were prepared by the study director in cooperation with the lecturers as required. The “multiple true–false questions” (MFT) format of MCQs was used. The MCQs consisted of a question or a statement followed by five suggested answers. Any number of the suggested answers could be correct or false since the answers were not related. The students had to mark each proposed answer separately to be true (T) or false (F). One credit was given if all five of the proposed answers were correctly evaluated to be T or F; 0.75 and 0.5 credits were gained by providing four or three correct answers. No credit was obtained if only two or less answers were correct since in such cases, it was obvious that the student could not evaluate the scientific content of the question. The summary marking of the MCQ test according to the requirements of Semmelweis University from 5 to 1 was based on the % of the points obtained. We calculated the maximum number of points achievable by answering all MCQs correctly. The highest note of 5 was given if the student obtained 100%–90% of the maximum credits. The other notes were related to the following percentage of good answers: 4 (89%–75%), 3 (74%–60%), and 2 (59%–50%). Students failed if they achieved <50% of the points. Students who did not pass could repeat the examination by answering the same MCQs.

This MCQ format using five true or false answers was unknown to the students. During the first few modules, several students failed; however, the results improved significantly by gaining experience with this MCQ examination. The quality check of the MCQs was performed together with the students. After each examination, we projected the MCQs and explained the correct answers. If the joint discussion proved that one or two answers to an MCQ were not correctly formulated, we rewrote the answers for future use of the MCQ. Our experience indicated that this type of MCQ correctly represented the knowledge of the students and made the scoring system more reliable than the conventional “single best answer question.” This impression is in line with observations of Brassil and Couch, who found in a comparative study that the MTF type of MCQ better characterizes the understanding of the addressed complex problems by the students than the more frequently applied single-best answer multiple-choice (MC) format ( Brassil and Couch, 2019 ). The confidentiality of the MCQs was guarded very carefully.

Short assignments

After each module, the students had to submit a formative essay on the same subject selected by the teachers. Open-access papers related to the subject were provided. The goal was to educate students in writing short, concise reports and correctly citing the literature. The length of the assignment was defined between 800 and 1,200 words; shorter or longer assignments were considered a mistake. The short essays were evaluated using an assignment evaluation form using the format introduced during the PhT program by King’s College. The scoring was performed according to three to five predefined criteria per section. The three main sections of the form covered the selection and coverage of the material, the understanding of the issues, and finally, the structure of the presentation. The sum of maximal points was 60. The final grade was based on the % of points reached (excellent, grade 5 [60–54 points; 100%–90%]; failed, grade 1 [<30 points; <49%]). Comments given by the evaluators helped the students improve in writing short reports. For providing pedagogical consistency, the assignments were evaluated and commented on by the same two evaluators throughout the entire course.

Final examination and writing a thesis

The final examination was based on answering around 100 MCQs, and the students had to prepare a thesis based on topics selected by them. The only restrictions were that it should be connected to the non-clinical or clinical development of medicinal products and that the study director had to agree to the recommended subject. The aim was to train the students in searching and critically interpreting data of the scientific literature. The length had to be between 50,000 and 100,000 characters. The thesis was evaluated by the same method used for the essays, however, in this case by three examiners. The summary of the thesis had to be presented at the final oral examination in a 20-min-long free lecture, followed by questions related to the thesis and the entire course material. The examination board consisted of three members. One had a professional background in industrial drug research, while another in clinical drug evaluation. The third member was the study director. Of the three evaluators, two asked questions and one functioned as a notary of the examination. The mean score of the MCQs, the thesis, and the oral examination was calculated to provide the final grade.

Quality control

Semmelweis University registered the CEMDC course at the Hungarian Educational Board as a continuous professional development program. All the data related to the course and the academic records of the students were entered into the NEPTUN electronic database, which is an online educational administration system for students enrolled in Hungarian universities. On this basis, Semmelweis University issued the degree certificate in English. We also provided a description of the modules given according to the terminology used by PhT.

Reorganization and modernization of the future course

In 2019, after finishing the fourth CEMDC course, a pre-planned generation change in the leadership of the course was made due to the retirement of several key participants, including the study director. Unfortunately, due to the COVID-19 pandemic, the reorganization was delayed. The new course in the form of a postgraduate MSc course is planned to start at Semmelweis University in 2025. The rapid progress in medicine and medical device development together with the broad introduction of Internet-based distance teaching necessitates rethinking both the program and the organization of the education course. Considering the very low number of students who registered from the participating countries, the continuation of the joint CEMDC educational system is not considered practicable. Accordingly, Semmelweis University will manage the course alone in the future. Nevertheless, leading experts from other international universities and the pharma industry will be involved. The course will be open to foreign students, and the language of education will remain English.

The new postgraduate MSc course ‘Master in Pharmaceutical Innovations and Business Administration,’ or shortly ‘Semmelweis Pharma MBA,’ will continue the PhT educational traditions and will remain firmly anchored in the university teaching environment, but industrial experts will play a more dominant role in shaping the program. The primary aim of the new educational concept will be to more closely integrate basic pharmacological research with innovations in medicine development. It will incorporate the topics listed in the PhT syllabus but will deal in more detail with the transition from basic research to pharmaceutical development, patent protection of new molecules emerging from university research, and management of spin-off companies. Pharmaceutical formulation, manufacturing of medicines, management of supply chains, business administration, marketing, pricing, and reimbursement will play a prominent part as well. The development of medical devices and the use of AI in medicinal research will also receive more attention. The scientific topics will be presented and associated more closely with related production and marketing issues. Distant and face-to-face education will be combined to make participation easier.

The IMI-PhT project was a significant milestone in developing pharmaceutical medicine as an independent medical–scientific specialty. For non-medically trained students, the program planned to provide a master’s degree in science. The recommended educational program reflected many accepted principles of training medical specialists as well as other scientists working in academic research. Retrospectively, this academic focus might have been one of the causes that the pharmaceutical industry did not enthusiastically support the outcome, and many companies returned to their internal training programs, mostly limiting the teaching to the specialized tasks the attendants should be able to perform in the industry. As a result, the expected increased influx of students from the industry to academic pharmaceutic medicine training courses did not happen. The lacking enthusiasm in the industry also led to the limited success of the geographical extension program of the PhT cooperation. Only very few students were registered by the international and local companies for the long, complex, and expensive training. Several students covered the education cost, at least partly, from their own pocket.

The envisaged multinational, cooperative academic educational concept was a revolutionary new idea. It was a very courageous decision both by the leaders of the PhT cooperation and by the IMI program coordinators to enthusiastically accept and support this bold plan. No such experience was known in the European educational environment. In the existing international university cooperations, usually, two partners educate different parts of a combined curriculum separately. The participating universities issue separate national qualifications after finishing their section of the program, which together certify the completion of the education course. The aim of the Lisbon Convention was “to facilitate the recognition of qualifications granted in one Party in another Party,” which provided the legal background of this type of university cooperation ( Lisbon Recognition Convention (Council of Europe) ). The problem with the recognition of a joint PhT degree of the CEMDC was that it did not formally belong to any national education system and consequently was not covered by the Lisbon Recognition Convention. According to the final agreement reached after prolonged negotiations with the support of PhT and the International Department of Semmelweis University, the participating universities entitled Semmelweis University to enroll all the students and issue their qualifications. This solved the problem and demonstrated the real cooperative spirit of the participants. Although only few foreign students participated, in the case of two students from Lithuania who finished the entire course, we demonstrated that this new organizational system worked. A modular certificate issued by Semmelweis University also effectively supported the mobility of the students since these modular qualifications were mutually acknowledged by the courses following the PhT curriculum. This made possible that some students from other courses came to follow modules in Hungary, and Hungarian students could continue their studies for a master’s degree at another PhT course. Finally, the University of Ljubljana accepted the certificate of Module 2 for their PhD students.

An important achievement of the CEMDC was the introduction of the improved PhT educational standards in CEE, which were well-accepted by both the teachers and the students. The submission of short essays after each module was very useful for teaching to write short and informative comments on a given subject. The acquired teaching experience will be helpful to continue pharmaceutical medicine education in the PhT tradition at Semmelweis University. The close cooperation of the university and the pharma industry in planning the new program and the extension of the PhT program to include more industry-relevant topics is expected to improve academic–industrial cooperation. We hope that these changes will encourage the pharmaceutical industry to enroll more students. This would be necessary since many industry experts consider broad continuous professional education in pharmaceutical medicine to be crucial for the future of medicine development ( Imamura et al., 2019 ).

Although the geographical extension of the PhT program did not fully reach its goal to educate many regional students, mostly because of the few students enrolled by the pharmaceutical industry, its educational success should not be underestimated. It developed a unique international university cooperation to jointly educate students from the region. Although the number of non-Hungarian students finishing the course was low, it demonstrated that this bold, new type of international university cooperation is functional. The system might be operated more easily in the future using the technology of distant teaching. For Hungary, the CEMDC educated a new generation of medicine development experts, and some of them reached leading positions. They were also the same people who later organized the Pharmaceutical Medicine Section of the Hungarian Society of Experimental and Clinical Pharmacology ( huphar.org ). They will also contribute to pharmaceutical medicine education in the “Semmelweis Pharma MBA” starting in 2025.

Author contributions

SK-F: conceptualization, writing–original draft and writing–review and editing. MG: conceptualization and writing–original draft. PA: writing–original draft. GR: writing–original draft. AG: writing–original draft. RP: writing–original draft. PF: writing–original draft.

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. Semmelweis University will cover the publication of this paper. The organization phase of the Cooperative European Medicines Development Course was financed from IMI-Call 1 Pharmaceutical Medicine Training Program 2009-2014 Grant agreement number 115013.

Acknowledgments

This paper is written in memoriam of Professor Fritz Bühler, Head of the IMI-PharmaTrain project, whose enthusiastic support made possible the organization of the Cooperative European Medicines Development Course. We express our special appreciation to Professors Irena Mlinaric-Rascan from the University of Ljubljana, Slovenia, and Jan Klimas from the Comenius University, Bratislava, Slovakia, for organizing two modules of the CEMDC in their countries.

Conflict of interest

Author MG is an Independent Consultant. Author PF was employed by the Pharmahungary Group.

The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors, and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Brassil, C. E., and Couch, B. A. (2019). Multiple-true-false questions reveal more thoroughly the complexity of student thinking than multiple-choice questions: a Bayesian item response model comparison. Int. J. STEM Educ. 6, 16. doi:10.1186/s40594-019-0169-0

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Imamura, K., Criscuolo, D., Jurczynska, A., Kesselring, G., Stonier, P., Tsuda, T., et al. (2019). International perception of competence, education, and training needs among biomedical professionals involved in medicines development. Drugs Outcomes Res. Policies 10, 188. doi:10.3389/fphar.2019.00188

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Stonier, P. D., Silva, H., and Lahon, H. (2007). Pharmaceutical medicine. History, global status, evolution and development. Int. J. Pharm. Med. 21, 253–262. doi:10.2165/00124363-200721040-00001

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Keywords: pharmaceutical medicine, medicines development course, PharmaTrain, Innovative Medicines Initiative, Cooperative European Medicines Development Course, university education, Central and Eastern Europe

Citation: Kerpel-Fronius S, Gottwald M, Arányi P, Renczes G, Görbe A, Papp R and Ferdinandy P (2024) Past and future of an IMI-PharmaTrain (IMI-PhT)-initiated multinational pharmaceutical medicine course at the Semmelweis University in Hungary. Front. Pharmacol. 15:1394987. doi: 10.3389/fphar.2024.1394987

Received: 02 March 2024; Accepted: 27 March 2024; Published: 30 April 2024.

Reviewed by:

Copyright © 2024 Kerpel-Fronius, Gottwald, Arányi, Renczes, Görbe, Papp and Ferdinandy. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: S. Kerpel-Fronius, [email protected]

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

[100+] Pharmacy Research Topics For College Students With Free [Thesis Pdf] 2023

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New M. pharm Thesis Topics for Pharmaceutics and Pharmacology

• by Dr. Rudra Sharma
• August 2, 2022 August 14, 2022

ACME Research Solutions can help you with all of your M. pharm Thesis topics for Pharmaceutics, Pharmacognosy, Medicinal Chemistry and pharmacology needs!

What is M. pharm?

M. pharm is a Master of Pharmacy degree, which is a professional degree in pharmacy. The degree is typically earned after completing a four-year pharmacy program at an accredited college or university. After completing the M. pharm degree, pharmacists are eligible to take the licensure exam to become a licensed pharmacist in their state of residence.

M. pharm programs typically cover topics such as pharmacology, medicinal chemistry, pharmacy practice, and pharmacotherapy. Students learn about the properties of drugs and how they interact with the human body. They also study how drugs are manufactured, distributed, and used. In addition, M. pharm students acquire skills in communication, problem-solving, and critical thinking that can be applied to any number of career paths.

M. pharm Topics for Pharmacology, Pharmaceutics, Pharmacognosy and Medicinal Chemistry

M. pharm students have a lot of options when it comes to choosing a topic for their project. Here are some ideas to get you started:

1) Investigating the efficacy of new pharmaceutical entity.

2) Developing new methods and evaluation strategy for manufacturing drugs.

3) Studying the side and adverse effects of existing medications.

4) Researching the history of medication development.

5) Conducting market research on pharmaceutical drugs.

6) Developing new marketing strategies for pharmaceuticals.

7) Evaluating the effectiveness of current drug delivery systems.

8) Investigating ways to improve patient compliance with medication regimens.

9) Developing the Herbal medicine.

10) Combination of the plants or synthetic drug incorporation in the new drug delivery systems.

Benefits of M. pharm Course

The benefits of M. pharm are many. The most important benefit is that it gives students the opportunity to work on real-world projects. These projects can be related to research, development, or any other area of the pharmaceutical industry. Students can also get hands-on experience in the laboratory and learn about the process of drug development. In addition, M. pharm students have the chance to network with professionals in the field and learn about job opportunities.

There are many benefits to pursuing an M. pharm degree, including:

• Increased job security – With a professional degree in pharmacy, pharmacists are able to find work in a variety of settings, including hospitals, clinics, and pharmacies. They may also work as pharmaceutical sales representatives or research scientists.
• Higher earnings potential – Pharmacists with an M. pharm degree can earn a higher salary than those without the degree. In addition, they may be eligible for bonuses and other forms of compensation, such as stock options and profit sharing.
• Greater job satisfaction – Pharmacists who have an M. pharm degree report higher levels of job satisfaction than those without the degree. This is likely due to the increased responsibility and autonomy that comes with the job.
• Improved patient care – M. pharm graduates are better prepared to provide high-quality patient care. This is because the program provides hands-on experience with a variety of patients and conditions, along with clinical training.
• More effective pharmacist-physician collaboration – Pharmacists who have a master’s degree are more likely to interact with physicians and other healthcare providers to work together on important patient cases.
• Increased mobility/flexibility – Pharmacists with an M. pharm degree tend to be more mobile than those without it. They may move between jobs, states or countries in pursuit of greater professional opportunities or higher salaries, or they may become self-employed entrepreneurs after receiving their degree.

M. Pharm Topics and Experimental part

The experimental part of your M. pharm project is where you will put all of your research to the test. This is where you will take your ideas and turn them into reality, making sure that everything works as it should. This can be a daunting task, but with careful planning and execution it can be a success.

Here are some tips on how to perform the experimental part of your M. pharm Thesis Topics and Experiment:

1. Make a plan: Before you start any experiments, it is important to have a clear plan in place. This will help you to stay focused and on track, and ensure that you don’t forget any important steps. Write down what you need to do and when you need to do it, and make sure you stick to your schedule.

2. Do your research: Make sure you know exactly what you are doing before you start any experiments. Read up on the topic, and if possible talk to other people who have experience in the area. This will help you to avoid making any mistakes, and will give you a better understanding of the process.

3. Be prepared: Have everything ready before you start your experiments. This includes all of the materials and equipment you will need, as well as any data.

4. Take your time: Don’t rush your experiments. If something goes wrong, it could invalidate your entire project. Make sure you take the time to do everything properly, and don’t cut any corners.

5. Keep good records: It is important to keep accurate records of all of your experiments. This will help you to track your progress, and will make it easier to write up your results.

6. Seek help: If you are struggling, don’t be afraid to ask for help. There are many people who can offer advice and support, including your supervisor, other researchers, and experienced laboratory technicians.

7. Be flexible: Things rarely go exactly to plan, and you may need to make changes as you go along. Be prepared to adapt your methods if necessary, in order to get the best results.

8. Persevere: Doing experiments can be frustrating, and it is easy to get disheartened when things don’t work out. However, it is important to persevere and not give up. Remember that even unsuccessful experiments can provide valuable data, and every step you take brings you closer to your goal.

We hope that this article has given you some ideas for M. pharm project topics and shown you the benefits of pursuing an M. pharm degree. With so many benefits, it’s no wonder that more and more students are choosing to study pharmacy . If you’re considering a career in pharmacy, be sure to research all of your options carefully to decide if it’s the right fit for you.

Contact for M. pharm Experimental Work in Pharmaceutics/Pharmacology/Pharmacognosy/Medicinal Chemistry

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GMS PhD Spotlight: Emily Lewkowicz

Emily defended her dissertation, “Structural Basis for the Interactions of Amyloids with their Cofactors,” in March 2024 and will graduate in May 2024. Read more about Emily below!

What did you complete your dissertation research on and how did you settle on that topic?

My dissertation research focused on the structural basis for the interactions of amyloids with their cofactors. The Gursky Lab is generally interested in how various molecules influence amyloid nucleation, growth and morphology. My project used both experimental techniques and computational methods to explore these topics. Experimentally, I explored the effect of heparin and phospholipids on amyloid formation by the protein serum amyloid A. Computationally, I modeled the interactions of apolipoproteins with Alzheimer’s amyloid-β fibrils.

Why did you choose to do a PhD?

I decided to do a PhD to deepen my scientific knowledge, learn new skills and ultimately, expand my career opportunities.

How would you describe a typical day as a PhD student?

As a junior student, I spent a large part of my time in class or studying, with the afternoons reserved for doing experiments in lab. As a senior student, I split my time doing experiments or computational work, meeting with my PI to talk about current projects or manuscripts and working as a TA and tutor for the first-year courses.

What is one of your best memories from the time in your PhD?

My favorite memory from my time as a PhD student is when I travelled to the island of Spetses, Greece to attend a weeklong conference on amyloid research. The location was beautiful, and it was a great opportunity to meet amyloid experts and students from around the world.

Did you face any unexpected challenges during your time in your program? How did you overcome them?

I joined GMS in Fall 2019, and everything shut down in Spring 2020 just as I was supposed to do my last rotation and start my research project. My first few months in the Gursky Lab were entirely remote, which is why we decided to add computational elements to my project. I ended up learning many new skills, and the project resulted in multiple publications.

What are your next steps and your plans for your future?

After BU, I plan on staying in Boston and working in the biotech industry.

Do you have any advice for future PhD students or anything else you would like to share?

My advice is to make friends with the other PhD students in your cohort. It will make grad school a lot more fun, and it is really helpful to have a support system that knows exactly what you’re going through.

What do you like to do for fun in Boston?

In Boston, I enjoy going to comedy shows and concerts, and trying out new cafes and restaurants.

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