thesis nootropics funding

Thesis, the First High Quality and Customized Nootropics Solution, Raises Total of $13.5 Million in Funding

Unilever Ventures is the Largest Investor in Seed and Series A Rounds

NEW YORK--( BUSINESS WIRE )-- Thesis , the company that offers a customized approach to cognitive performance products based on your unique brain chemistry, today announced that it has raised over $13.5 million in funding. The company recently closed on a Series A round totaling $8.4 million with investors that included Unilever Ventures, Redo Ventures, Alive VC, Break Trail, NBA superstar Kevin Love and model Kate Bock. Previously the company raised $5.1 million in an undisclosed seed round that included Unilever Ventures, MBX, Trust Ventures and Redo Ventures.

Thesis recognizes that nootropics are not a one-size-fits-all wellness category. Through the highest quality ingredients and a customized approach, the brand helps people effectively boost their cognition & productivity.

“Nootropics have helped me a great deal, as someone who originally struggled in school and who eventually went on to graduate from some of the world’s most prestigious universities. I spent a significant amount of time learning about these compounds and finding the blend that worked for me. It shouldn’t be so hard,” said Dan Freed, founder and CEO of Thesis. “I created Thesis products for people who feel that they might not be living up to their full potential and want a real solution to close the gap.”

Rachel Harris, Partner at Unilever Ventures said, “In today’s 'always on' world, consumers are increasingly looking for solutions to optimize their mental acuity and the demand for products that allow you to perform at your best has never been greater. With Thesis’s customized offering, education-focused and digital-first model rooted in a highly compelling founder story, we have been impressed by Dan’s vision and the exacting standards that he is setting for the brand. We are excited to support him on the next chapter of the business’s growth.”

“I am excited to be part of Dan’s vision of customized health and wellness solutions. Thesis is defining a new wellness category and reshaping how people approach brain care," said Michael Lynton, Thesis Board Director.

The new capital will support Thesis as it makes key executive hires, expands out its product selection and undergoes clinical trials.

Thesis products are formulated with clinically studied active ingredients with the highest possible bioavailability and adhere to the FDA Current Good Manufacturing Processes (cGMP).

For more information, visit https://www.takethesis.com

About Thesis:

Thesis offers potent nutrient compounds formulated to enhance mental performance, based on your unique brain chemistry and the cognitive states you want to achieve. Whether taking the Energy Formula to overcome fatigue, the Clarity Formula to enter a flow state, or the Motivation Formula to decrease procrastination, Thesis offers these specific blends and more to target specific outcomes.

[email protected]

CEO Corner: Thesis’ Dan Freed Is Leading the Nootropics Movement

Dan Freed founded Thesis in 2017 after nootropics helped him go from high school dropout to Yale grad. The brand recently raised $13.5 million

Few executives have a deeper personal connection to the brand they founded than Dan Freed, who went from high school dropout to Yale graduate thanks in large part to the power of nootropics, a category of supplements touted for their abilities to improve cognitive functions like attention, memory and creativity. 

Freed established Thesis in 2017 to bring the benefits of nootropics to the masses. Thesis takes a personalized approach to nootropics; users take a detailed online quiz to receive a personal product blend optimized for their unique characteristics. 

Over the last six-plus years, Thesis has come a long way from its humble beginnings operating out of Freed’s apartment; in May, the company raised $13.5 million in funding rounds that included participation from former NBA star Kevin Love. Dr. Gabrielle Lyon, a popular functional medicine practitioner, currently serves as a scientific advisor to Thesis . 

Athletech News spoke with Freed about his incredible journey from high school dropout to CEO, the power of nootropics, and his plans for Thesis following its recent funding round. 

The following conversation has been lightly edited for clarity and length.

Athletech News: Can you tell us about your background and how you were introduced to nootropics?

Dan Freed : I have severe ADHD, so for as long as I can remember I’ve struggled with functioning in structured environments. I was expelled from preschool when I was four, and I was formally diagnosed (with ADHD) when I was six. I continued to struggle in school – I was constantly in the principal’s office, getting suspended and dealing with behavioral issues. When I was 16, I dropped out of high school and went to work in fast food. It was a really difficult time in my life. 

I ended up getting a lucky break and became a chef. I loved cooking – the type of focus needed to be successful in a kitchen is completely different than a classroom. ADHD is like a superpower. I spent my 20s traveling around the world and cooking, being fortunate enough to work in a Michelin three-star restaurant in France. By my late 20s, I started to burn out. I wanted to do something different with my life but I didn’t have a high school diploma, so my options were really limited.  

I decided to go back to school. I had a crazy ambitious goal to get an MBA, so I got a GMAT study guide, and it felt like I was back in 10th grade. I would read a page five times but couldn’t understand it and couldn’t sit down long enough to take practice tests. I heard about nootropics on a study forum, and I went out and bought everything I could find. I would take different ingredients and study. Most of them did nothing, but a couple of them worked. When I figured out how to combine it into a winning formula, the results were life-changing. I ended up scoring in the 99th percentile on the GMAT, which opened up so much opportunity in my life. I did my MBA at INSEAD, and from there, I was offered a partial scholarship to do another Master’s degree at Yale, where I got to study some of the science behind nootropics and really indulge my intellectual curiosity. 

Because nootropics were so impactful for me, I became an evangelist. This was around 10 years ago. I was the crazy guy at dinner parties that wouldn’t shut up about nootropics.

ATN: How did you go from nootropics evangelist to founding Thesis?

DF : I had this realization that the ingredients that worked for me didn’t work for everyone, because I was literally giving them out to people. I started selling (nootropic blends) out of my apartment to friends and friends of friends and before I knew it, it just kind of took off.

The name we initially launched with “Placebo Proof.” It was structured like a four-way crossover clinical trial, and there were actual placebos in the box. We tested more than 100 different ingredients, tons of different dosages, and we started to see very clearly that certain formulas, for certain use cases, with certain ingredients and certain dosages, worked the best. After more than 2,500 people went through that Placebo Proof product, we adjusted it and created (something) very similar to what Thesis is today. We incorporated Thesis in 2017.  (In 2023), we did more than 50 million capsules. 

ATN: How does Thesis personalize nootropics for customers?

DF : We’re still constantly beta testing, it’s really a data-driven approach. Our core hypothesis was to structure something similar to a clinical trial, but with a lot fewer controls, so you’re not going into a doctor, you’re not giving blood tests, you’re giving subjective data on how you feel, but we increase sample sizes by orders of magnitude. At this point, we have millions of people who’ve gone through our quiz, which has been there from the beginning. Hundreds of thousands of people have left individual reviews on formulations throughout the lifetime of the company, from Placebo Proof all the way to what Thesis is today. We use this data to constantly optimize. 

Stasis is our newest product line to launch, and it came directly from our customers. We saw that there were people purchasing Thesis, but they were on stimulants like Adderall; Thesis isn’t meant to be taken alongside powerful medications like that. Those customers were talking about jitters, (energy) crashes, trouble sleeping. So we formulated a new product line specifically meant to be taken alongside stimulants, including things like caffeine, to mitigate short-term side effects and long-term damage caused by oxidative stress.

ATN: The nootropics movement is still in its infancy. How do you view nootropics within the larger supplement industry?

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DF : I look at us as a new, emerging category of supplements as classified by the FDA. If you look at new categories within the broad supplement industry, the closest thing I would compare nootropics to is probiotics. Five years ago, the concept of ingesting good bacteria to improve gut health was absurd, almost nobody had heard of it. Now you walk into Whole Foods and there’s an entire section of probiotics , prebiotics, all of that. I think nootropics as a category within the broader supplement category is at this inflection point where probiotics were five years ago.

ATN: How has Thesis grown and evolved following the recent $13.5 million funding rounds? 

DF : (Funding) has forced this level of ruthless prioritization and capital efficiency. Not too long ago, the entire company was in my apartment. We now have the capital to invest in longer-term initiatives like content and community, which are on our roadmap. We’ve also spent a lot of time hiring. The last several months have been about filling out the executive team, because we were bootstrapped for so long. We’ve done a great job of recruiting some of the best talent in the world, and I’m really proud of that. We also have product launches planned for 2024. 

ATN: Looking ahead, what are your main short and long-term goals for Thesis?

DF : Short term, it’s just continuing to build out this data-driven approach to personalization and to get more people to the right formula faster. That’s a really complex challenge, especially when you have both Thesis and Stasis. 

Long term, I keep going back to when I was diagnosed at six, and I remember what it felt like when I thought there was something wrong with me, and I couldn’t understand why other people could just sit down and do their homework and I couldn’t. I remember how much pain it caused me throughout my childhood and into adulthood. I’m just as intelligent now as I was when I dropped out of high school. The key difference is my ability to focus. And it’s not only nootropics, it’s nootropics with behavioral interventions, that made the difference. But I just keep thinking about how many people aren’t living up to their potential, about how many people could do what I’ve done if they just have the same options. That’s our core mission.

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Thesis Raises Another $8.4M to Improve your Cognitive Performance Based on Your Body’s Brain Chemistry

The use of nootropics, chemical or natural substances that have a positive impact on mental skills, is an emerging field in neuropsychology.  The most common nootropic in use today is caffeine, which has been proven to improve thinking skills as caffeine has an impact on neurotransmitters in your brain that helps with short-term memory and learning.  Nootropics are also becoming popular beyond caffeine as supplements are being developed to help with mental acuity.  Thesis is a supplement brand that’s focused on improving cognitive performance by focusing on your individual chemistry as well as your specific goals.  Most nootropics brands offer a one-size fits all approach to their offerings; Thesis instead takes a personalized approach, using the first month to understand what works best for a specific person and then formulates the ingredients based on specific factors.  This initial assessment can be done for only $79, while other offerings could take you six months and cost ten times that.  Offering formulations for energy, creativity, logic, clarity, confidence, and motivation, Thesis has helped over half a million customers since 2017. All nutrients used are vegan, offer high bioavailability (absorbed efficiently), and are rigorously tested for purity.

AlleyWatch caught up with Thesis CEO and Founder Dan Freed to learn more about the business, the company’s strategic plans, latest round of funding, which brings the company’s total funding raised to $13.5M, and much, much more…

Who were your investors and how much did you raise?

Thesis has raised $8.4M in Series A financing. Our investors include Unilever Ventures, Redo Ventures, Alive VC, Break Trail , NBA player Kevin Love , and model Kate Bock . Previously, we raised $5.1M in an unreported seed round that included Unilever Ventures, MBX, Trust Ventures, Redo Ventures, and XRC Labs.

Tell us about the product or service that Thesis offers.

Thesis offers a customized approach to cognitive performance products, or nootropics, based on the user’s unique brain chemistry. Through the highest quality ingredients, Thesis helps people boost their cognition and productivity.

What inspired the start of Thesis?

How is Thesis different?

While other nootropic brands take a one-size-fits-all approach, Thesis is customized to each person’s unique brain chemistry. We give customers the opportunity to experiment with the highest quality nootropic ingredients in a systematic way that maximizes results. We condensed a process that would otherwise cost over $800 and take six months to complete into a $79, one-month process to test different formulas and find the combinations of ingredients that work best for each person. We have the highest quality ingredients that are all tested for purity by third-party labs, the gold standard for safety. All of our products are manufactured in the United States in facilities following FDA supplement manufacturing guidelines (cCGMP regulations). Also, we have some of the strongest health and wellness advocates who use our product, including Dr. Andrew Huberman, Rich Roll, Kevin Love, and Kate Bock.

What market does Thesis target and how big is it?

Thesis is the first line of defense for people who have trouble focusing and being productive. Unfortunately, this is all too common in today’s world. Given macro trends like TikTok, smartphones, working from home, and more, people are struggling with focus more than ever, and nootropics is a category in hyper growth ($14B global market in 2023). Thesis offers a highly effective, approachable product to help people try nootropics.

What’s your business model?

Thesis is DTC and products are available on our website.

How are you preparing for a potential economic slowdown?

At the beginning of Covid, we got a little nervous because we didn’t know how our audience would respond to what was happening. A lot of people were losing their jobs. While we did lose some customers, we sent free boxes to customers who expressed that they loved our product but couldn’t afford it anymore. We also saw customers hoard our product like toilet paper, asking to buy six months or a year’s supply at a time to make sure they had enough of it. In good times and in bad times, people still need to focus. Whether people use Thesis to power through a high-pressure job or are looking for a job, Thesis provides meaningful benefits, and I couldn’t imagine my life without nootropics. I’ve taken nootropics for ten years, and it would be one of the last things I would ever cut.

What was the funding process like?

Thesis was growing profitably and investors started to notice. We received a lot of outreach and started meeting with people that we really liked. We then decided to set up a process and formally opened our Series A. We are fortunate that we received multiple term sheets.

What are the biggest challenges that you faced while raising capital?

Capital markets have shifted and are now much more risk-averse. We are profitable and have a strong growth trajectory, but the fundraising process still took us longer than expected. We took a much broader approach to fundraising and spoke with many investors, versus the narrower focus we had in our seed round.

What factors about your business led your investors to write the check?

The number one factor is that we are EBITA-positive and growing, so we didn’t need the money. The second is that the nootropics category is a historically highly fragmented market with a lot of competitors (candidly, a lot of shady competitors). Thesis stands out because we are best in class from our supply chain to our values and testing protocols to our partners. We’ve partnered with some of the most incredible voices in the health and wellness space, including Dr. Andrew Huberman, Rich Roll, Kevin Love, and Kate Bock. We are assembling a world-class scientific advisory board that sets us apart from the competition.

What are the milestones you plan to achieve in the next six months?

Our main focus for the next six months is hiring. Now that the round has closed, most of our time will be spent building our executive team to set us up for explosive growth. Our focus now is more on the long term, taking our company to $100 million in revenue per year and beyond.

What advice can you offer companies in New York that do not have a fresh injection of capital in the bank?

Now is a time where, if you have to go into survival mode, do it sooner, rather than later. Focus on your customers. We made it through our early days of bootstrapping by focusing on our loyal base of customers who genuinely loved our product. When we weren’t in hyper-growth, I was able to spend a lot more time focusing on our core customers and setting our foundation focused on our customers.

Where do you see the company going now over the near term?

In the near term, we are expanding our offerings on both a product level and on a content and community level. Nootropics have been transformational for me, and I’ve taken them daily for the last ten years, but nootropics alone can only do so much. To see incredible results, you have to combine the right nootropics with healthy habits. We’re building a content strategy that will help people develop and maintain healthy habits to get the most transformative results. Another thing we’re really excited about is our second product line, Stasis. Stasis was born from a customer need. We watched so many people take stimulants and deal with the downsides of taking them, so we created a formulation specifically designed to support the brains of people taking stimulants. We launched Stasis eight months ago and it has exceeded all of our expectations.

With a plethora of commuting options in the city, how do you typically get to work each day?

I am fortunate that I live five blocks away from our office, so I walk to work. I’m in the office every day, and I bring my dog to work.

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June 2, 2023 - Q&A

Dan Freed, Co-founder & CEO of Thesis

Personalized nootropics for cognitive performance..

In this Q&A, you’ll hear from Dan Freed, co-founder & CEO of Thesis, a personalized nootropic company. Dan talks about how his own struggles with focus led him on a path to self-experimentation and the first iteration of his company. He also details the market for cognitive performance products and future plans following Thesis’ recent Series A fundraise.

Can you tell us about what you’re working on at Thesis?

Dan Freed: Thesis offers a customized approach to cognitive performance products, known as nootropics, based on the user’s unique brain chemistry. Through the highest-quality ingredients, Thesis helps people boost their cognition and productivity.

While other nootropic brands take a one-size-fits-all approach, Thesis is customized to each person’s unique brain chemistry. We give customers the opportunity to experiment with the ingredients in a systematic way that maximizes results.

We condensed a process that would otherwise cost thousands of dollars and take six months to complete into a $79, one-month process to test different formulas and find the combinations of ingredients that work best for each person.

Our inputs are all tested for purity by third-party labs, the gold standard for safety. All of our products are manufactured in the United States in facilities following FDA supplement manufacturing guidelines (CGMP regulations).

Also, we have some of the strongest health and wellness advocates using our product, including Dr. Andrew Huberman, Rich Roll, Kevin Love, and Kate Bock.

How did you come up with the idea? What key insight led you to pursue this opportunity?

DF: For as long as I can remember, I’ve had trouble focusing. I dropped out of high school after failing all of my classes, and people always thought that I was lazy or stupid. I worked at a sandwich shop before I got my big break in the culinary industry in my 20s.

Despite having success in hospitality, I got burnt out and decided to go back to school. When I tried to study again, I faced the same difficulties in focusing that I experienced growing up. I did a ton of online research and discovered nootropics, a class of supplements that enhance cognitive performance.

Only after trying them did I find my true potential. I was never lazy or stupid; I just couldn’t focus. My brain chemistry wasn’t set up to function in the traditional structure of the American educational system. When I found the right combination of nootropics that worked for my brain, I was able to adapt and succeed in a way that I never thought would be possible.

Because nootropics were so impactful for me, I became an evangelist. Before I found nootropics, my inability to focus caused a lot of pain in my life. One of the most gratifying things to me is when I share my story and people say that it reminds them of themselves, their siblings, or their friends — and then they try nootropics and have success with them.

There is an enormous amount of people who aren’t living up to their potential, not because they aren’t intelligent but because they don’t have the tools they need to adapt to today’s modern work and educational environment.

So, I started giving away nootropics to my friends and family, and one of the first realizations I had was that the ingredients that worked for me didn’t work for everyone.

The core idea that Thesis was built on was that I could create a system that would allow people to quickly iterate and find the combinations of nootropic ingredients that worked for them.

Though, nootropics aren’t the silver bullet; there isn’t one set of pills that will fix everyone, but they are a cornerstone habit that, along with other healthy habits like exercise and meditation, can be completely transformative.

I’ve taken nootropics for ten years now, and I would not be able to function in my current responsibilities without them.

How did you turn your idea into a company?

DF: Our first 20 customers were my friends, and Thesis was still just a hobby and an experiment to see if I could create something that solved this very unique challenge of helping people find what nootropics worked for them.

I received overwhelmingly positive feedback from my first customers about the idea of creating a system for personalized nootropics to achieve better results. From there, I refined the product, made it easier to use, and it started spreading through word of mouth. Before I knew it, I was running around New York delivering boxes of nootropics, and that’s when I decided to turn it into a business.

I was building the company out of my apartment, and my first hire was my old roommate, who was an engineer. He worked with me part-time and helped to build the website as we started serving more customers.

About six months in, I was working around the clock and was stretched incredibly thin. I couldn’t keep up with orders and regular maintenance of the website. He quit his job without me even asking and said what I was building was really special, but I needed help to turn it into what it could be.

We started the company when no one knew what nootropics were. I pitched investors over and over again, but they were skeptical about the product and market, and I kept getting rejected. Because of that, all of our early angel investors were friends and customers. I maxed out all my credit cards and moved into the tiniest apartment I could find. I put everything I had into keeping the business running.

Once we got our first hundred customers, we started doing light advertising, and it took a couple of years to get to the first few thousand customers. We were constantly iterating on the product and the brand through that time, and we hit an inflection point at 2.5K customers.

That’s when the flywheel effect of growth took off.

We didn’t raise our first venture round until we were earning a million dollars per month in revenue. At this point, nootropics were starting to become more mainstream. Given our strong metrics, we raised a $5M seed round, but it took years and hundreds of rejections prior. Now, riding the momentum, we’re excited to have just raised over $8M in a Series A round.

How big can this get? What’s the addressable market and how do you go about capturing it?

DF: Thesis is the first line of defense for people who have trouble focusing and being productive — which, unfortunately, is all too common in today’s world.

Given macro trends like TikTok, smartphones, working from home, and more, people are struggling to focus more than ever, and nootropics is a category in hyper-growth ($14B global market in 2023).

A strength of ours, Thesis offers a highly effective, approachable product to introduce people to nootropics.

Who is the core customer? How are you acquiring customers? And how will you grow the customer base?

DF: Our customers are all people who have goals they want to achieve but who are fighting mental barriers that are holding them back from making the most of their potential.

Before completely profiling our customer, it may be helpful to share who shouldn’t take nootropics, too.

I remember growing up, my sister (who is now a doctor) would come home from school, sit down, and diligently work on her homework. She didn’t struggle with the same barriers to focus with which I struggled. She had evolved and adapted to working in a structured environment, and she excelled at it. If this applies to you, and if you’re able to get stuff done and feel like you’re meeting your potential, then you don’t need nootropics.

However, if my story resonates with you, and if you feel like you aren’t living up to what you could accomplish because your personal limitations are getting in the way, then you should try nootropics. Your limitations don’t need to be as severe as mine were; if you struggle to achieve your goals and establish healthy habits, nootropics could unblock you and help you gain momentum.

Nootropics is a new category, and as some influencers in the space start evangelizing them, they’re starting to show up in functional foods and beverages and on the shelves of grocery stores. Whereas before, when our acquisition strategy focused on educating people about what nootropics are, we are now able to educate people on why Thesis is the best solution in the category, becoming a thought leader as nootropics experience explosive growth.

To continue to grow our customer base, we will invest heavily in content and community for two key reasons: First, we already have a strong and active community and want to provide tools to help our community to support each other. Second, nootropics alone are not magic pills; to have a transformative impact, nootropics must be combined with healthy habits.

We strongly believe in educating our customers about the habits that, together with nootropics, help people achieve their goals.

Looking at your road map, what are some of the milestones you’re targeting over the next 3-6 months?

DF: Our main focus for the next six months is hiring. We just closed our Series A round, and most of our time will be spent now on building our executive team to set us up for explosive growth. Our focus now is on the long term, taking our company to $100M in revenue per year and beyond.

In the near term, we are expanding our offerings on both a product level and a content and community level. Nootropics have been transformative for me, and I’ve taken them daily for the last 10 years, but nootropics alone can only do so much.

To see incredible results, you have to combine the right nootropics with healthy habits. We’re building a content strategy that will help people develop and maintain healthy habits to get the most transformative results.

Another thing we’re really excited about is our second product line, Stasis. Stasis was born from a different customer need. We watched so many people take stimulants and deal with the downsides of taking them, so we created a formulation specifically designed to support the brains of people taking stimulants. We launched Stasis eight months ago, and it has exceeded all of our expectations.

Anything else you’d like to share with readers?

DF: Because nootropics are a new category, it’s hard enough to get people to try them, and when they finally do, people will often choose a brand that isn’t good and will only try them once.

They’ll buy a mushroom coffee or nootropic drink and then will give up on the category after they didn’t experience a great result. It took me months of experimenting and combing through many ineffective products to experience transformational results. If you’re looking to try nootropics, you need to evaluate the product’s ingredients and dosages.

All products that contain the same ingredients are not created equal. A lot of companies under-dose active ingredients and also use inferior ingredients.

For example, just because a product says it includes Lion’s Mane doesn’t mean you will actually receive the benefits of Lion’s Mane; you need 500 milligrams of Lion’s Mane to receive an effective dose. In addition, not all Lion’s Mane is created equal, and most brands include the cheapest available on the market.

At Thesis, one of our core differentiators is that we use the strongest, most effective ingredients available, at the highest possible dosage. All of Thesis’ ingredients and formulas are third-party lab tested to ensure they are effective dosages of the most potent ingredients, and we have enough variety in our product mix that a majority of people will find at least one formula that works well for them.

Related reading from Fitt Insider: Issue No. 171: The State of Supplements

If you’re interested in having your company featured in our Startup Q&A series, send an email to [email protected].

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Nootropics Start-Up Thesis Raises $8.4 Million Series A

Thesis, the wellness start-up with a customized approach to cognitive performance products based on brain chemistry, closed on a Series A round totaling $8.4 million.

WHO: New York-based DTC brand Thesis offers potent nutrient compounds formulated to enhance mental performance based on your unique brain chemistry and the cognitive states you want to achieve. Dan Freed founded Thesis in 2017, recognizing that nootropics are not a one-size-fits-all wellness category. Thesis is customized to each person’s unique brain chemistry by allowing customers to experiment with the highest-quality nootropic ingredients systematically to maximize results. For $79, the initial assessment takes one month to test different formulas and find the combinations of ingredients that work best for each person. All products are manufactured in the United States in facilities following FDA supplement manufacturing guidelines. 

WHY: The new capital will support Thesis as it makes key executive hires, expands its product selection, and undergoes clinical trials. The company has 30 employees, which will double over the next year as roles in customer experience, product development, and marketing are added. 

IN THEIR OWN WORDS: “Nootropics have helped me a great deal, as someone who originally struggled in school and who eventually went on to graduate from some of the world’s most prestigious universities. I spent a significant amount of time learning about these compounds and finding the blend that worked for me. It shouldn’t be so hard,” said Dan Freed, founder and CEO of Thesis. “I created Thesis products for people who feel that they might not be living up to their full potential and want a real solution to close the gap.”

Rachel Harris, Partner at Unilever Ventures, said, “In today’s 'always on' world, consumers are increasingly looking for solutions to optimize their mental acuity and the demand for products that allow you to perform at your best has never been greater. With Thesis’s customized offering, education-focused and digital-first model rooted in a highly compelling founder story, we have been impressed by Dan’s vision and the exacting standards that he is setting for the brand. We are excited to support him on the next chapter of the business’s growth.”

“I am excited to be part of Dan’s vision of customized health and wellness solutions. Thesis is defining a new wellness category and reshaping how people approach brain care," said Michael Lynton, Thesis Board Director.

• The company recently closed on a Series A round totaling $8.4 million with investors that included Unilever Ventures, Redo Ventures, Alive VC, Break Trail, NBA superstar Kevin Love, and model Kate Bock. 
• Previously the company raised $5.1 million in an undisclosed seed round that included Unilever Ventures, MBX, Trust Ventures, and Redo Ventures.
• The business has raised over $13.5 million in funding and is reportedly profitable with a strong growth trajectory. 
• Thesis will remain DTC to build out the category. Omnichannel expansion is at least a year away.

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Thesis stands out in the wellness industry with its personalized nootropic supplements, designed to cater to the individual’s specific cognitive needs. It has been pushed by health and wellness celebrities, causing a wave of popularity.

Do Thesis nootropics live up to the hype?

• Variety Of Blends: Various nootropic blends based on individual brain chemistry, maximizing effectiveness for each user.
• Strong Advocacy and Support: Gained endorsements from notable wellness advocates and public figures, like Andrew Huberman, enhancing credibility.
• Limited Clinical Research: While the company plans clinical trials, the current scientific backing may be limited.
• Price: The ongoing cost of customized nootropics may be higher than standard off-the-shelf supplements or medications.
• Dependence on Self-Reporting: The effectiveness of blends relies partly on user feedback, which may not always be accurate or consistent.
• Many Underdosed Ingredients: As you’ll read below, many ingredients are dosed below what was used in human clinical trials.

Quick Verdict

Thesis has a range of suitable nootropic blends to cater to many needs.

However, our #1 nootropic of choice is Nooceptin. It’s designed for long-term brain changes, not short-term boosts in mental performance.

What Is Thesis Nootropics?

Thesis Nootropics is a company specializing in customized cognitive performance products. It was founded by Dan Freed in 2017.

Freed’s personal challenges with focusing, which he faced from a young age, led him to discover nootropics.

This personal journey of transformation through nootropics inspired him to create Thesis, aiming to help others find the right combination of nootropic ingredients that work for them.

The company’s unique approach involves allowing customers to experiment with high-quality nootropic ingredients to maximize results systematically.

Thesis has gained popularity primarily through word-of-mouth and a strong focus on personalization.

The company has raised over $13.5 million in funding and is reportedly profitable with a robust growth trajectory.

Thesis has garnered support from health and wellness advocates like Dr. Andrew Huberman, Rich Roll, Kevin Love, and Kate Bock.

Thesis Nootropics

Customized Blends For Cognitive Enhancement

Take the quiz and see which blends are right for you.

Thesis Nootropic Ingredients

Thesis have six unique blends designed to target various aspects of cognitive function. What’s similar between them is the option to include or exclude caffeine and L-theanine. The caffeine and l-theanine combination is the most potent instant nootropic, making each blend effective.

The caffeine L-theanine stack benefits physical and cognitive function. Some advantages include faster reaction time, faster visual processing speed, better working memory, increased awareness, and less tiredness and mental fatigue [1] [2] .

The research employs a 2:1 L-theanine to caffeine ratio, which Thesis has followed. Since this stack is available in every blend, I won’t include it in the ingredients breakdown below.

Thesis Clarity Blend

Alpha gpc (speculative).

Alpha GPC, a choline-containing phospholipid, improves cognitive function in neurological conditions like dementia [3] .

Research indicates it enhances memory and attention and may support brain health. Clinical trials show it can improve cognitive performance, especially when combined with other treatments like donepezil [4] .

It’s generally well-tolerated and safe. Alpha GPC increases acetylcholine levels in the brain, which is essential for memory and learning [5] .

It’s used both as a medicine and a nutritional supplement. Studies suggest Alpha GPC effectively boosts cognitive functions, particularly in adult-onset dementia disorders [6] .

Thesis Clarity Blend contains 500 mg, which is more than any other nootropic available.

Lions Mane Mushroom (Speculative)

The Lion’s Mane mushroom (Hericium erinaceus) includes chemicals that stimulate nerve growth factor (NGF) synthesis, which is necessary for nerve cell proliferation and differentiation [7] .

According to research, Lion’s Mane improves cognitive abilities, particularly memory and brain cell regeneration [8] .

It is renowned for its neuroprotective qualities, which may be effective in treating illnesses such as Alzheimer’s disease and cognitive impairment [9] .

Brain functioning, memory, and mood improvements have been linked to regular ingestion [10] .

While the mushroom does not directly improve cognitive skills, it does increase NGF, which improves brain health [11] . The dosage varies but is generally well-tolerated and has few negative effects.

Thesis Clarity contains 500 mg of Lions Mane, which may give a long-term nootropic effect.

Mycelium is typically avoided since the active chemicals are found in the primary mushroom. Jeff Chilton, a long-time mushroom researcher, discusses this in the podcast below:

Camellia Sinensis Tea Leaf (Speculative)

Camellia Sinensis, commonly known as tea, exhibits varying neuropharmacological effects based on the part of the plant used.

Seed extracts tend to be more stimulating, enhancing motor functions and showing potential as an antidepressant without causing drowsiness.

Leaf extracts, on the other hand, tend to produce a calming effect on the mind and mood. Both seeds and leaves have shown positive results in various tests assessing motor function and behavior in animal models [12] .

The study suggests these parts of the Camellia Sinensis plant have potential as cognitive enhancers, warranting further research, especially on seed extracts for their mode of action and possible new beneficial compounds.

I couldn’t find any human studies for this ingredient, so I can’t give you an efficacious dose range. But Thesis Clarity contains 278 mg of Camellia Sinensis Tea Leaf.

Dihydroxyflavone

Dihydroxyflavone research is all performed in rodents, so extrapolating to humans is rather challenging. 7,8-Dihydroxyflavone (7,8-DHF) is a compound that acts as an agonist for the TrkB receptor, which is associated with brain-derived neurotrophic factor (BDNF).

BDNF is crucial for neuronal survival and brain plasticity. Studies have shown that 7,8-DHF can improve memory and cognitive functions [13] .

It enhanced memory formation in healthy rats, and in Alzheimer’s disease mouse models, it improved spatial memory [14] .

Further, 7,8-DHF has been shown to counteract aging-related cognitive impairments in rats, improving spatial memory and synaptic plasticity in the hippocampus [15] .

This suggests that 7,8-DHF is a potential therapeutic agent for memory impairment and dementia, at least in rodents.

Thesis Energy Blend Ingredients

Citicoline is commonly mentioned in relation to memory enhancement. According to studies, 500 mg daily may improve episodic memory or the ability to recall personal experiences and specific events [16] .

According to other research, taking at least 500 mg of this supplement daily may provide cognitive benefits to healthy persons [17] .

The formulation of Thesis Energy Blend contains 300 mg of Citicoline. This dose may not achieve the full potential seen in studies proposing a higher dose.

Mango leaf extract, rich in the polyphenolic compound mangiferin, shows promise in neuropharmacology due to its anti-inflammatory, antioxidant, and antidiabetic properties.

Studies indicate its potential in treating central complications associated with metabolic disorders like type 2 diabetes, which are risk factors for Alzheimer’s disease and vascular dementia [18] .

In animal models, mango leaf extract has demonstrated effects on reducing brain inflammation and spontaneous bleeding and improving cognitive functions [19] .

These findings suggest its utility in addressing symptoms of neurodegenerative diseases and cognitive impairments [20] .

Thesis Energy contains 300 mg of mango leaf.

Theacrine is a purine alkaloid similar to caffeine, found in the Camellia Kucha plant, and often included in dietary supplements.

Studies show that it can increase energy, focus, and cognitive performance, similar to caffeine, but without habituation [21] .

Theacrine’s impact on cognitive performance and physical endurance has been researched in athletes, indicating possible benefits in reaction time and endurance [22] .

It may work well alone or in combination with caffeine to enhance cognitive function and physical performance [23] .

Theacrine appears to be a promising supplement for improving mental alertness and physical capacity. Bear in mind the manufacturers of Theacrine fund some of these studies.

Thesis Energy contains 100 mg of Theacrine, which tends to be less than the dose used in these studies, suggesting it may have a weaker effect.

N-Acetyl Cysteine

N-acetyl cysteine (NAC) is explored for its potential to improve cognitive functions in psychosis and bipolar disorder due to its antioxidant, neurogenesis, and anti-inflammatory properties.

Studies show N-acetyl cysteine can improve working memory in psychosis [24] . However, results in bipolar disorder didn’t show significant cognitive improvements [25] .

Research indicates potential benefits for Alzheimer’s disease by promoting cognitive health and countering oxidative stress [26] .

The effectiveness of N-acetyl cysteine in various cognitive disorders still requires more targeted, larger studies to confirm its benefits [27] .

N-acetyl cysteine’s role is promising but not yet firmly established in cognitive enhancement.

In human trials, it seems a 600 – 2000 mg dose is needed for cognitive benefits. Thesis Energy contains 500 mg, being potentially underdosed.

Indian Trumpet Tree

Indian Trumpet Tree is known as Oroxylum indicum. In a 12-week study, older adults with memory complaints took 500 mg of Oroxylum indicum extract twice daily [28] .

Compared to a placebo, this supplementation led to improvements in episodic memory and numeric working memory. It also accelerated learning in location tasks.

However, there were no significant changes in other cognitive tests or overall cognitive and memory skills.

The study suggests that Oroxylum indicum, while well-tolerated, may primarily enhance specific memory functions.

Its potential effects could be linked to its antioxidant and anti-inflammatory properties and interactions with neurotransmitters like dopamine and GABA.

This is the only human study on the Indian Trumpet Tree, so more research is needed to fully understand its impact on cognitive health. Thesis Energy only contains 100 mg of this, making it potentially underdosed.

L-tyrosine, an amino acid, has been shown to increase dopamine levels in the brain. L-tyrosine supplementation has improved cognitive regulation, particularly in mentally demanding settings [29] .

It is especially helpful in improving cognitive flexibility, which is impacted by dopamine.

While L-Tyrosine’s promise for treating clinical problems and improving physical activity is limited, it is useful in stressful or cognitively taxing situations.

It has the greatest cognitive benefits when neurotransmitter activity is intact, but dopamine and norepinephrine levels are momentarily decreased [30] .

According to research, optimal doses for cognitive improvement begin at a minimum of 2 grams. That is more than six times the dose in Thesis Energy.

Thesis Creativity Blend Ingredients

Thesis Creativity contains 150 mg of Alpha GPC, yet their Clarity Blend contains 500 mg. I’m not sure why there is a large discrepancy, especially when 500 mg is likely a more efficacious dose.

Agmatine Sulfate

Currently, agmatine sulfate has only been tested in rodents. It is a central nervous system (CNS) neurotransmitter/neuromodulator that has been studied for its potential effects on stress-related conditions like depression, anxiety, and cognitive performance.

Research suggests that agmatine can have antidepressant and anxiolytic (anxiety-reducing) effects, possibly related to its influence on the nitric oxide pathway [31] .

It may reduce oxidative stress and corticosterone levels while increasing brain-derived neurotrophic factor (BDNF), which is beneficial for brain health.

Agmatine sulfate has been shown to be safe and well-tolerated in animal studies, with oral administration effectively increasing its levels in the brain [32] .

This indicates potential for therapeutic use in neurological disorders, though more research is needed to fully understand its effects and mechanisms.

Thesis Creativity contains 250 mg. In these studies, patients were administered 15-600 mg per kg, which is a much higher dose.

Panax Ginseng

Panax ginseng is available in two varieties: white ginseng and red ginseng. It has vasorelaxant and moderately hypotensive effects on nitric oxide generation in the body [33] .

It increases antioxidant enzyme activity and may prevent oxidative damage associated with aging in rats [34] .

Ginseng has shown promise in boosting memory, particularly in age-related cognitive decline, as well as in improving mental and physical resilience, reducing fatigue, and assisting the body in adapting to stress [35] .

Daily doses of 200 mg extract or 0.5 to 2 g dry root are recommended. It is not suggested for persons with acute asthma or hypertension because it may cause overstimulation and elevate blood pressure in excessive dosages.

Thesis Creativity has an effective dose of 200 mg, which may provide you with these mental performance benefits.

Ashwagandha Root

Ashwagandha is a traditional herbal remedy used to improve various health conditions. Animal studies have shown that it can increase blood cell counts, which might enhance aerobic capacity [36] .

It also demonstrates the potential to reduce oxidative stress and lipid peroxidation, which could be beneficial in treating disorders like tardive dyskinesia [37] .

Additionally, Ashwagandha has shown nootropic effects and might be useful in treating Alzheimer’s disease [38] . Recommended dosages range from 6 to 10 grams of ground roots or 100 to 1250 mg of extract daily [39] [40] .

It’s generally safe but should be used cautiously, especially in cases of hyperthyroidism or pregnancy. High doses can have sedative effects and may cause gastrointestinal issues.

Thesis Creativity contains 300 mg of Ashwagandha, which is within the recommended range for cognitive benefits.

Sceletium Tortuosum

Sceletium tortuosum, also known as Kanna, is traditionally used for its mood-enhancing properties. It’s been studied for its potential in treating cognitive and neurodegenerative disorders like Alzheimer’s and Parkinson’s [41] .

Research suggests its constituents could target enzymes and receptors relevant to these diseases, offering neuroprotective benefits like antioxidant activity [42] .

Additionally, Sceletium Tortuosum is known for its antidepressant and anxiolytic effects, promoting relaxation and well-being, which could be beneficial in managing stress, anxiety, and depression [43] .

The plant’s bioactive alkaloids are also being explored for commercial medicinal use.

The 25 mg dose in Thesis Creativity is the same as used within the human trials.

Thesis Motivation Blend Ingredients

L-phenylalanine.

L-phenylalanine is a vital amino acid and has been explored for its potential benefits in managing conditions like attention deficit disorder and depression.

In studies, doses of up to 1200 mg showed initial improvements in mood and attention in individuals with attention deficit disorder, but tolerance developed over 2-4 months [44] .

In another study involving depressed patients, a dosage range of 75–200 mg/day for 20 days led to significant improvements in 12 out of 20 patients [45] .

However, the effectiveness and safety of L-phenylalanine can vary, and it is used in the treatment of various conditions, including depression and arthritis, and even as part of addiction recovery [46] .

Thesis Motivation has a 500 mg dose, which may provide some of these benefits. Will it improve motivation? I’m not sure.

Methylliberine

Methylliberine is a purine alkaloid explored for its cognitive and mood-enhancing effects. Studies have shown it can improve concentration, motivation, and mood, especially when combined with caffeine.

Methylliberine also appears to positively affect energy levels and well-being without significantly impacting vital signs like heart rate and blood pressure [47] .

These findings suggest its potential as a nootropic supplement, particularly for enhancing cognitive function and mood in various contexts, such as gaming or in tactical scenarios [48] [49] .

However, it’s essential to consider the dosage and combination with other compounds like caffeine for optimal effects.

The 100 mg dose in Thesis Motivation aligns with the current research.

Vitamin B12 (Speculative)

Vitamin B12 is essential for cognitive health and may be linked to neurodegenerative diseases like Alzheimer’s and Parkinson’s.

Low levels of B12 are associated with cognitive impairment, but supplementation is only shown to be effective in improving cognition in cases of existing B12 deficiency [50] .

There is limited evidence that increasing B12 levels benefits people without B12 deficiency [51] .

B12’s impact on cognitive health may involve multiple mechanisms, including brain volume and function [52] . However, more extensive research is needed to fully understand its effects and potential as a cognitive enhancer.

Thesis Motivation contains 1000mcg. The research states that it may have no effect if you’re not Vitamin B12 deficient.

Forskolin (Speculative)

Forskolin has only been studied in rodents regarding cognitive function. Forskolin is an herbal extract that shows the potential to improve memory and reduce Alzheimer’s disease symptoms.

In studies, it restored nest-building and social behaviors in mice with Alzheimer-like symptoms, reduced amyloid plaque deposition, and regulated brain inflammation [53] .

Forskolin also influences memory and tau protein phosphorylation in the brain, which is relevant in Alzheimer’s [54] .

Additionally, forskolin has shown protective effects against Huntington’s disease-like neurodegeneration in rats by improving learning and memory and reducing oxidative stress [55] .

These findings indicate forskolin’s potential as a neuroprotective agent for certain neurological conditions, at least in rodents.

I’m skeptical whether 250 mg of Forskolin in Thesis Motivation will help you “feel” more motivated.

Artichoke (Speculative)

Artichoke extract is known for its prebiotic properties and promotes probiotic bacteria growth in the gut, potentially benefiting cognitive functions in mice [56] .

In elderly individuals with mild cognitive impairment, combining artichoke extract and aerobic training improved cognitive status and reduced blood glucose and insulin resistance [57] .

Artichoke varieties Spinoso Sardo and Romanesco Siciliano demonstrated antioxidant properties and potential protective effects against cardiovascular and neurodegenerative disorders, with Romanesco Siciliano showing higher antioxidant power [58] .

The 450 mg dose is well under the dose used in these studies.

Thesis Confidence Blend Ingredients

Saffron (speculative).

Saffron is traditionally used in herbal medicine and shows promise in improving cognitive function in individuals with Alzheimer’s Disease (AD) and Mild Cognitive Impairment (MCI) [59] .

Research indicates that saffron’s effectiveness is comparable to common drugs used for these conditions without increasing side effects. It’s also well-tolerated in cognitively normal individuals [60] .

However, most current studies have a high risk of bias. More comprehensive, low-bias clinical trials are needed to confirm saffron’s potential as a treatment for cognitive impairments like AD and MCI.

All of the research used 30 mg of saffron daily. Thesis Confidence has 28 mg, and I’m unsure why they formulated it without the extra 2 mg.

Magnesium Bisglycinate

Magnesium is essential for brain functions and has been researched for its potential cognitive benefits. Magnesium is particularly effective in increasing brain magnesium levels and has shown promise in improving memory and cognition in healthy adults [61] .

However, its role in anxiety and mood disorders is less clear [62] .

Studies indicate magnesium may help reduce symptoms of depression, but results are not consistent across all mental health conditions [63] .

Further research is needed to conclusively establish magnesium’s effectiveness and appropriate use as a therapeutic supplement in various psychiatric and cognitive disorders [64] .

500 mg of magnesium may help if you’re deficient, but there’s no clear benefit to making you more confident.

Sage (Speculative)

Sage is known as Salvia and has been traditionally known to enhance memory. A recent study supports this, showing that acute ingestion of sage oil can significantly improve immediate word recall in healthy young adults [65] .

This suggests that sage may positively influence cognitive functions like memory, potentially due to its acetylcholinesterase inhibition activity in the brain.

However, this has not been replicated.

While historically used for various mental disorders, such as depression and age-related memory loss, contemporary research is needed to fully understand its benefits and potential as a cognitive enhancer.

Regardless of the 333 mg dose, this is one of the more speculative ingredients in all Thesis blends.

Sceletium Tortuosum (Speculative)

As mentioned in the Creativity Blend, Sceletium Tortuosum is known for its mood-enhancing properties. It is the same dose of 25 mg, which is used in human trials.

Magnolia Bark (Speculative)

Magnolia officinalis is commonly used in traditional medicine for mental disorders like anxiety and depression and shows potential as a nootropic supplement.

Studies have demonstrated that its ethanol extract can improve cognitive function and memory in stress-induced situations. It also exhibits anxiolytic properties, reducing anxiety-related behaviors in rats [66] .

The extract’s effectiveness is also evident in lowering stress-induced increases in corticosterone and tyrosine hydroxylase levels.

Moreover, Magnolia officinalis, especially its component honokiol, has neuroprotective effects and can regulate mood disorders by modulating GABA and CB1 receptors in rats [67] .

These are rodent studies, so it’s impossible to extrapolate to humans. Regardless, it’s included based on the mechanistic data with the theory of doing the same thing in humans with the 10 mg dose.

Ashwagandha Leaf & Root

The 120 mg of root and leaf ashwagandha may be enough to have a nootropic effect as the extract dose is between 100-1200 mg, as stated in the Creativity Blend section. However, this is root and leaf, and the main benefits are derived from the root.

Thesis Logic Blend Ingredients

Ginko biloba.

Ginkgo biloba is extracted from the leaves and fruit to improve cognitive function. Its compounds include antioxidants, enhance blood flow, and have anti-inflammatory properties.

Ginkgo biloba extract has been shown in animal studies to help with chronic brain difficulties by modifying inflammatory mediators and the cholinergic system [68] .

It has been shown in clinical trials to improve working memory and processing speed [69] . However, its usefulness in healthy people under the age of 60 is debatable [70] .

Typical daily doses vary from 120 to 300 mg. Although side effects are uncommon, they can include stomach irritation and headaches, which may cause blood to thin, affecting people on certain drugs.

Thesis Logic contains 160 mg of Ginkgo Biloba, which is within the recommended dosage range.

Theobromine

Theobromine is a compound found in chocolate and has been studied for its potential cognitive effects.

Research indicates that theobromine might have a lesser immediate nootropic effect compared to caffeine but could have neuroprotective benefits with long-term consumption, possibly reducing Alzheimer’s disease-related pathology [71] .

Further studies are needed to fully understand its impact on cognition.

Additionally, theobromine’s effects on mood and vigilance appear to be different from caffeine, with some studies suggesting it might not significantly influence these aspects in nutritionally relevant doses [72] .

However, combining theobromine with caffeine could modify its effects, potentially offering cognitive and mood benefits without significant blood pressure increases [73] .

More research is required to confirm theobromine’s cognitive and mood-related effects.

Thesis Logic contains 100 mg of theobromine, but it seems doses greater than 400 mg are needed to enhance cognition.

Phosphatidylserine

Phosphatidylserine is essential for proper brain function. Phosphatidylserine has been proven to be critical for maintaining nerve cell membranes and myelin, which is required for successful neurotransmission [74] .

Phosphatidylserine can help reverse cognitive loss as the brain ages by boosting cognitive activities such as memory formation, learning, concentration, and problem-solving [75] .

It is well absorbed in humans and crosses the blood-brain barrier.

Supplements containing phosphatidylserine have been shown to increase cognitive functions and are generally well-tolerated, with dosages ranging from 100 to 800 mg per day advised for cognitive support [76] [77] .

Thesis Logic contains 400 mg of phosphatidylserine, which may provide you with these cognitive-enhancing effects.

High DHA Algae

DHA is a vital component of neuronal membranes and plays an important role in brain health and cognitive function.

Adult cognitive abilities are improved by DHA consumption, especially when paired with eicosapentaenoic acid (EPA) [78] .

This impact is most noticeable in older people who have mild memory problems. Higher DHA and EPA doses (above 1 g per day) have been associated with better episodic memory.

Observational studies also show a link between DHA/EPA intake and memory performance in the elderly. DHA, both alone and in combination with EPA, improves memory in the elderly.

Thesis Logic contains 200 mg of DHA, suggesting insufficient DHA to provide a benefit.

Triacetyluridine (Speculative)

Triacetyluridine is being explored as a potential treatment for bipolar depression. In a study involving eleven patients with bipolar depression, high doses of triacetyluridine (up to 18 g per day) were administered over 6 weeks [79] .

The study measured the effects on depression symptoms using the Montgomery-Asberg Depression Rating Scale (MADRS) and evaluated cellular bioenergetics using phosphorus magnetic resonance spectroscopic imaging (P-MRSI).

Results indicated significant early improvement in depression symptoms.

Additionally, triacetyluridine responders showed notable differences in pH changes from baseline, suggesting triacetyluridine may improve mitochondrial function and reduce symptoms of depression.

Thesis Logic has 30 mg of triacetyluridine, which is well below the dose used in this study.

Bacopa Monnieri

Bacopa monnieri is a traditional plant that has been shown to improve cognitive performance, particularly memory.

Bacopa extract, namely bacosides A and B, has been demonstrated in studies to increase memory formation, recall, and cognitive function [80] .

It has neuroprotective properties and is used to treat cognitive dysfunctions such as Alzheimer’s disease.

Adults should take between 200 and 400 mg each day. Bacopa is generally well accepted, with only rare reports of mild drowsiness or stomach difficulties.

Clinical trials show that older people have better memory, attention, mood, and overall cognitive ability [81] [82] [83] . More research is needed, however, to thoroughly grasp its usefulness across many cognitive domains.

Thesis Logic contains 320 mg of Bacopa, giving you the efficacious dose to feel these benefits.

Thesis Nootropics Price

Thesis has two options: one time purchase or a subscription. Here’s how the prices break down:

• Subscription = $79
• One Time Purchase = $119

This is regardless of whether you purchase a personalized starter kit or build your own box.

You can’t buy them individually either. You must purchase 4 boxes. When building your own, you can choose if you want 4 of the same blend or mix and match.

They want you to try each blend for a week as part of the starter kit (there’s only a week’s worth of each blend in each container) to see which you like best.

Thesis has positioned itself as the most expensive nootropic available by adding the personalized element.

Is Thesis Nootropics Really Personalized?

I went through the initial quiz to see how they “personalize” their nootropic stack.

Here is what they recommended me:

Look, I get the marketing angle. In no way is this a truly personalized nootropic product. It’d be nearly impossible to create custom formulations for every unique individual.

However, the fact they have multiple blends means people can experiment to find which works best for them.

I will say, though, if you choose the caffeine options, every blend will work. Many of the ingredients used in these blends are speculative and only based on animal research, with many being underdosed.

Benefits Of Thesis Nootropics

Multiple blends for different purposes.

To be honest, this benefit is more of a marketing tactic. However, some people may find certain blends jive well with them over others, giving you options within the same brand.

Further, Thesis claims the ingredients in each formulation work synergistically. There’s no research to back that claim, but at least know there are no negative side effects from their interaction.

Options For Stimulants Or Not

You can choose whether or not you want stimulants within your Thesis Blends. Every blend will provide similar benefits if you add the caffeine and L-theanine nootropic stack, which is the most potent synergistic brain booster.

However, if you’re already a coffee addict or plan to take Thesis in the evening, having no stimulants is the better option.

My Experience With Thesis

Based on my quiz, I was recommended Thesis Clarity, Logic, Motivation, and Confidence Blends. I tried each for a week to see if one stood out. I took them without caffeine as they all work if you have the caffeine L-theanine stack.

I have to say the Confidence and Motivation Blends did absolutely nothing for me. I didn’t “feel” any brain-boosting effects or feel more confident or motivated.

I felt the Logic and Clarity Blends had small positive effects when concentrating on mentally demanding tasks like writing, coaching, or podcasting.

If I were to continue taking Thesis, I’d opt for either of these two blends.

Who Is Thesis For?

Busy working professionals.

Thesis Nootropics are ideal for busy professionals facing demanding schedules and high-stress environments. These blends can help enhance focus, improve decision-making, and increase productivity.

They are designed to support sustained mental energy throughout the day, enabling professionals to manage their workload more effectively without the usual mental fatigue.

Creative Artists

For creative artists, Thesis offers blends that stimulate creativity and enhance divergent thinking. These nootropics can aid in breaking through creative blocks, fostering innovative thinking, and maintaining a heightened state of inspiration.

They are particularly beneficial for artists seeking longer periods of creative flow and those seeking fresh perspectives.

Students can significantly benefit from Thesis Nootropics, especially during intense studying or when facing challenging academic projects.

The blends are formulated to enhance memory retention, improve concentration, and boost learning capabilities. This makes them a valuable tool for students who need to absorb and retain large amounts of information and perform well in academic assessments.

Gamers find Thesis Nootropics beneficial for improving their gaming performance. The blends can enhance reaction times, increase focus, and improve strategic thinking skills.

They are particularly useful during long gaming sessions, helping gamers stay alert and responsive, which is crucial in competitive gaming scenarios.

Coffee Haters

Thesis Nootropics provides an excellent alternative for those who dislike coffee or want to avoid caffeine jitters.

These blends offer a way to boost mental energy and alertness without relying on caffeine. This makes them ideal for individuals sensitive to caffeine or those seeking to reduce caffeine intake while maintaining high cognitive function.

User Testimonials And Reviews

You can’t access the review database on the Thesis website, so I did some digging to find user reviews. Here’s a couple of positive reviews:

“I must admit that during the weeks that I consistently take them, I perform better & I generally feel better just knowing I’ve ingested something intended to positively alter my natural brain state. Minor tasks/chores no longer seem as daunting and I get this underlying kick to complete my work well.” – ParsnipExtreme2502 (Reddit)

“I didn’t find Weeks 1 and 4 to do anything for me, but Weeks 2 and 3 really helped avoid the post-lunch, post-work slumps I tend to get now that I’ve been working from home; Energy is especially useful for days when I haven’t gotten enough sleep the night before.” – leftylucy88 (Reddit)

I can’t find many negative reviews other than potential side effects like migraines, which can be caused by many different factors.

Thesis Side Effects

Side effects are rare from the ingredients in these blends. I personally didn’t have any adverse reactions to the four blends I tried. However, like any supplement, they may have potential side effects.

Consult with a healthcare provider before starting any nootropic regimen, especially if they have pre-existing health conditions, are pregnant or breastfeeding, or are taking other medications.

Thesis Alternatives

If Thesis Nootropics isn’t quite the right match for you or you’re just curious about other products, here are some alternatives I’ve tried and can provide an insider’s look into.

SAP Nutra nootropic Nooceptin improves memory, concentration, and cognitive performance without stimulants. It offers gradual brain health gains.

It improves memory and focus and provides a prolonged boost without a caffeine crash. Students, gamers, professionals, and seniors should use Nooceptin to boost cognition.

This brain supplement contains Lion’s Mane Extract, Citicoline, Rhodiola Rosea Extract, L-Theanine, Bacopa Monnieri, Ginkgo Biloba, and Panax Ginseng.

Some of these compounds have been shown to be useful, but others are experimental. Nooceptin, a non-stimulant method for long-term cognitive enhancement, usually works after 7-14 days.

Despite the risk of underdosed components and increased cost, Nooceptin may provide a stimulant-free cognitive boost.

Read more in our Nooceptin review .

Mind Lab Pro

Mind Lab Pro is a popular nootropic that has gained appeal as a result of its alleged cognitive benefits.

Pure substances are used in its formulation, which is intended to improve mental clarity and attention. It is stimulant-free, making it an excellent choice for anyone seeking a well-rounded routine.

Its unique combination of 11 research-backed components distinguishes it from competitors in the brain health supplement sector.

These compounds were carefully chosen to help cognitive processes like memory, focus, mental clarity, mood, and cognitive processing speed.

Despite some criticism about the quantity of specific substances and the need for more scientific data, Mind Lab Pro has earned worldwide recognition for its ability to improve cognitive performance in professionals, students, the elderly, and athletes.

Our Mind Lab Pro review goes into great detail.

Braini distinguishes itself by being stimulant-free, providing long-term results, and having a short ingredient list focusing on long-term cognitive gains. It does not, however, deliver the immediate euphoric boost that some users may expect from a brain supplement.

Peptylin, a silk protein peptide with neuroprotective effects and potential benefits for executive function; NeurXcel, which is rich in omega fatty acids; and Wild Canadian Blueberry extract, which is known for its antioxidant characteristics and cognitive support, are all key ingredients in Braini.

Braini is backed by clinical trials, a 60-day money-back guarantee, and a 30-day challenge to scientifically quantify changes in brain function.

Our Braini review contains an in-depth breakdown.

Vyvamind is a nootropic supplement containing caffeine and L-theanine to help focus and improve cognitive performance. Users claim increased focus, vitality, and cognitive abilities without big crashes.

Vyvamind’s formulation, which contains less L-tyrosine and citicoline than some studies suggest, is intended to supplement the major nootropic duo of caffeine and L-theanine.

This combination is well-known for boosting concentration and cognitive function. The supplement is touted as a non-stimulant alternative, appealing to clients seeking a more natural and less intensive approach to cognitive growth.

Vyvamind is suitable for coffee-averse people, busy professionals who require a focus boost, and students during study sessions.

Our Vyvamind review goes into great detail.

Because of its purported fast cognitive effects, NooCube is a popular brain-boosting product. NooCube contains ingredients such as Bacopa Monnieri, L-Tyrosine, and L-Theanine.

These are well-known for their mental health advantages. Several compounds, such as Huperzine-A and Alpha GPC, remain speculative without additional investigation.

NooCube is intended to improve cognition and alertness without using stimulants, and the amounts of each ingredient are clearly labeled.

Because it gives different cognitive benefits without the jittery side effects associated with caffeine, NooCube is especially good for working professionals, students, elders, gamers, and combat athletes.

Our detailed analysis can be found in our NooCube review .

Frequently Asked Questions

What is thesis nootropic and what does it do.

Thesis Nootropic is a personalized supplement formulated to enhance cognitive functions. Users can expect improvements in focus, reduction in procrastination, stress management, and memory recall, depending on which blend you choose.

Does Thesis Work Like Adderall?

Thesis Nootropics and Adderall are used to enhance cognitive functions, but they are fundamentally different. Adderall is primarily prescribed for treating Attention Deficit Hyperactivity Disorder (ADHD) and narcolepsy.

Adderall is an amphetamine, classified as a controlled substance due to its strong stimulating effects and potential for abuse and dependency.

Thesis Nootropics are dietary supplements designed to enhance healthy individuals’ cognitive functions, such as memory, focus, and mental clarity. They are not intended to treat medical conditions like ADHD.

How Long Does It Take Thesis Nootropics To Work?

If you have the caffeine version, within 30 minutes. You may feel the non-stimulant blends kicking in just as quickly, but they won’t be as pronounced. Sometimes, they can take multiple weeks to feel them working.

I’ve taken a deep dive into the world of nootropics and shared my firsthand experience with Thesis Nootropic’s various blends. While the personalization is nothing more than a marketing tactic, the different blends are a nice touch for those who want to experiment with different ingredients.

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'It Turned Everything Around': How This CEO Conquered His ADHD Using Brain Boosters Dan Freed, founder and CEO of Thesis, found mental clarity with nootropics. Now, he is sharing his formulas with the world.

By Jon Bier • Apr 2, 2024

Key Takeaways

• Dan Freed is Founder and CEO of Thesis, a nootropics brand
• ADHD caused him to drop out of school and become a world-class chef
• After he discovered nootropics, he was no longer dependent on pharmaceutical stimulants

Opinions expressed by Entrepreneur contributors are their own.

When he was eight years old, Dan Freed could not sit still in school.

"I remember coming home and bouncing off the walls. I was getting suspended. I'm in the principal's office. They're sending me to a psychiatrist," Freed says. "People thought I was stupid, lazy, or unmotivated. I started to believe it."

Doctors later diagnosed Freed with ADHD and prescribed the stimulant Adderall. This helped him focus, but also left him depressed and irritable.

It wasn't until he was an adult that Freed discovered nootropics , nutrient compounds shown to support motivation, creativity, mood, memory, and cognitive processing.

"Nootropics turned everything around for me and helped me form the positive habits that I built my success on," he says.

Freed is now the founder and CEO of Thesis , a leading nootropics company that makes specially formulated blends to enhance an individual's personal neurochemistry. I spoke with him recently on my podcast One Day with Jon Bier about his personal and professional journey.

From chef to CEO

Early in Freed's career, he became a saucier at Michelin-starred restaurants and an esteemed chef worldwide. He credits part of his success to his ADHD.

"It was my superpower," he says. "As a chef, you're constantly in the weeds doing five things at once, but I was able to concentrate on so many different things."

But the work was also burning him out. He dreamed of taking the GMAT and going back to school. While working as an executive sous chef on a cruise ship, he learned how to run a successful operation from his boss, a former investment banker.

"One day, he said to me, 'If you're able to do all of this without an education, imagine what you could do with one," Freed recalls.

Around this time, he discovered nootropics, which were a total game changer.

"I scored in the 99th percentile on the GMAT and earned a master's degree from Yale and INSEAD," he says. "For years, I was always on and off Adderall, Vyvanse, Concerta, every couple of months," he says. "But nootropics were the first thing where I'm like, hey, this is sustainable. It doesn't have these side effects. I was able to make meaningful progress and be more productive and creative."

Related: How to Upgrade Your Brain to Boost Focus and Productivity

Solving a problem

Freed's newfound appreciation for nootropics changed the trajectory of his life, but it wasn't without its challenges.

For one, he realized early on that nootropics weren't a one-size-fits-all solution. He couldn't find a product in the market that was the perfect formulation for him.

"I was constantly experimenting with different ingredients, dosages, combinations to find what worked," Freed says. "When I found something that worked, it was much better than anything I could find on the market. And that was when it clicked: How can we get this tailored experience?"

A business idea was born.

Freed and his team tried out various combinations of different dosages and ingredients on a test group of 2,500 people until they got the desired results. The result was Thesis--nootropic blends formulated for different outcomes, including logic, creativity, motivation, energy, clarity, and confidence.

Freed says, "Nootropics is a data science problem. The solution is to get a massive amount of customer data on how they respond to different ingredients and formulations."

New product line

On the podcast, Freed also talks about a new product line they have developed called Stasis, which he describes as "supplements that are synergistic with stimulants."

Unlike Thesis, which is tailored to replace the effects of pharmaceutical stimulants such as Adderall, Stasis is designed to complement these drugs.

"We're able to find the right ingredients for the right person based on their genetics and their goals and knowing this person's taking a stimulant that very predictably altered their brain chemistry," he explains.

So far, customers have given the product exceptional reviews.

"I've been formulating for almost a decade now, and I've never seen such a positive response from any product," Freed says.

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Thesis Nootropics Review

Thesis has a range of targeted nootropics you can combine to optimize your results. our team will help you decide which ones are right for you..

Daniel is a senior editor and writer at Innerbody Research. After receiving his bachelor’s degree in writing, he attended post-graduate studies at George Mason University and pursued a career in nutritional science.

Dr. Segar is a cardiology fellow at the Texas Heart Institute and a member of Innerbody Research's Medical Review Board.

In this Review

Nootropics in general offer the potential to improve cognitive abilities and regulate mood without the need for a prescription. And while more research is necessary, current data suggests that they consist of ingredients that are generally safe and effective for healthy adults. 35 However, Thesis isn’t the only provider of high-quality nootropics, nor do they offer especially low prices. In this review, we'll compare and contrast Thesis’ six formulas and see how they stack up against a growing field of competitors.

Our Findings

Despite the somewhat high price, we recommend Thesis to anyone looking for a nootropic subscription that can be tailored to their specific needs. The formulas from Thesis provide tangible benefits with minimal ingredients, and each formula is available with or without caffeine. Thesis also offers stellar customer service and delivers their product in individually packed doses you can take just about anywhere.

• You can feel most results within an hour
• Products are third-party-tested for purity
• All options available without stimulants
• Outstanding phone support
• Subscriptions include complimentary wellness coaching
• Free shipping on all orders
• Use code INNERBODY for 10% off your first order
• Somewhat more expensive than competitors
• Up to four large pills per dose

GREAT PICKS FROM THESIS

Special Offer: Take 10% OFF with code INNERBODY

Why you should trust us

Over the past two decades, Innerbody Research has helped tens of millions of readers make more informed decisions about staying healthy and living healthier lifestyles. As nootropics have become more important players in the supplements landscape, we’ve taken a serious look at the key players to see which ones are worthwhile.

Thesis exists in a class of nootropics that combines multiple nootropic ingredients to achieve specific goals. We’ve spent hundreds of hours researching and testing various nootropics, including both individual ingredients and combinations like Thesis offers. In researching Thesis and their competitors, our team has read more than 100 clinical studies examining the efficacy and safety of nootropic ingredients, and we’ve combined all of that knowledge with our experiences to create this review.

If you're curious about our team's experience using Thesis nootropics and wondering how the products will arrive at your door, we made this handy, 5-minute video summarizing those details:

Additionally, like all health-related content on this website, this review was thoroughly vetted by one or more members of our Medical Review Board for accuracy.

How we evaluated Thesis

To evaluate Thesis, we examined the extensive research available on each ingredient the company uses and compared them to a growing marketplace of nootropics, many of which our testing team has tried over the past few years. Specifically, we assessed how effectively Thesis' formulas work, as well as their safety, cost, and the convenience of acquiring and taking them.

Ultimately, we found Thesis to be one of the more reliable companies in terms of product quality and customer care, even if they are among the more expensive nootropic brands. For any nootropic, you’re looking to create a noticeable effect in brain performance, and altering anything to do with that sensitive chemistry likely warrants a fair investment. The bargain bin is not typically where you want to shop for mind-enhancing substances.

We’ll get into a more direct comparison between Thesis and their competitors a little later, and you’ll see that the balance between their price and overall value is quite reasonable. For now, let’s look at each criterion in more detail.

Effectiveness

Nootropic companies have a plethora of ingredients at their fingertips when they formulate their products. Some companies take a modern approach, focusing on the latest research into established Western medicines. Others look to the past, where ancient Chinese and Ayurvedic practices employed various botanicals to achieve cognitive effects. The best companies combine these approaches, using potentially beneficial ingredients that science supports.

Thesis takes this combined approach, employing just under three dozen ingredients from amino acids to ancient herbs across their six products. The company scores highly in effectiveness thanks to the ingredients they choose and the doses they offer for each, making it likely that you can notice their combined effects.

Individual results will vary due to everything from sleep patterns to diet, but most people should find benefits in at least one of Thesis' six formulas. Caffeinated formulas generally have more pronounced effects than stimulant-free versions, but the value of Thesis offering every formula with or without stimulants cannot be overstated.

One minor knock against Thesis is that, unlike some of their competitors, Thesis does not have a nootropic blend designed for improved sleep. Better sleep supports cognition and mood, so some companies offer formulas designed specifically for sleep promotion with ingredients like melatonin. That said, some of Thesis’ formulas contain lion’s mane or Zembrin (a branded form of Sceletium tortuosum that’s been shown to reduce anxiety and promote sleep). 2 3 And the amount of Zembrin used in Thesis’ Creativity and Confidence blends is the exact same amount used in these successful studies — 25mg.

Good nootropics are, unfortunately, a bit expensive. You can find less expensive options than Thesis, but their $79 monthly rate is right in the middle of what the market demands. You could also argue that the ingredient quality, customization options, and overall efficacy Thesis offers make it a superior value to many less expensive alternatives. Still, the price remains a sticking point for some.

Let's compare the monthly and per-dose costs with some of Thesis' closest competition. The prices below reflect subscription savings where available.

Three of the seven competitors included in the chart above are more expensive than Thesis, and another three are no more than $15 less expensive, revealing their generally average cost. Focus Factor — consistently our top budget pick among nootropics — costs much less than others in the field and includes many ingredients with associated clinical research. The downside is that increasing the number of ingredients (even when they seem to work) increases the odds of an adverse reaction.

TruBrain is the only company that truly compares to Thesis from a quality and variety standpoint. Other companies offer only one or two formulas, whereas Thesis and TruBrain each offer several more targeted products. TruBrain allows you to spend just $69 on your first jar when you subscribe — $10 less than Thesis — but that price shoots up to $119 every month after that, making Thesis the superior value.

When we consider the safety of any supplement, we look at available research into individual ingredients and compare those dosages with what the supplement offers. Whenever possible, we also test the product ourselves to observe its effects on us. Additionally, we look for safety standards in manufacturing that can provide added peace of mind, like third-party testing and compliance with the FDA’s Good Manufacturing Practices (GMP).

Thesis manufactures their products in GMP-compliant facilities and has third-party testing performed to assess the purity of each ingredient and formula. And the clinical research involving the lion's share of their ingredients reveals minimal risk profiles with few to no adverse effects reported. That said, ashwagandha isn’t safe for pregnant or breastfeeding individuals, and it can stimulate thyroid activity, so anyone with thyroid concerns (hyper- or hypothyroidism) or on medication to regulate thyroid function should be careful. 36 37

Thesis also limits their formulas to a handful of ingredients, which reduces the likelihood that any one of them would cause an adverse reaction. This is pretty typical of nootropics in Thesis’ class, but less expensive nootropics might try to convince you of their value by stuffing a single blend with several dozen components. That might increase the chances you feel some positive effect, but the side effect risk goes up by the same token.

Convenience

Our convenience rating considers various aspects of a user's experience. It usually starts with the quality of a product's website design and whether or not its pages are easy to navigate. We also consider the presence of subscription systems that make reordering easier and money-back guarantees that protect your investment. A company's customer service is another vital aspect of convenience, especially if you need questions answered. The quality of an FAQ section, the availability of representatives via chat or phone call, and the responsiveness to email inquiries all play a part here.

Our convenience rating is also informed by the steps required to actually take the product. Nootropics often consist of large capsules, and doses can contain anywhere from 1-7 capsules, which is awful for anyone with difficulty taking pills. Smaller capsules, fewer capsules per dose, and simple dosing schedules are ideal. Thesis’ capsule count varies per formula, ranging from 2-4 mid-size capsules you can take 30 minutes before you might want or need their effects.

To summarize some important aspects of nootropic company convenience, let's look at which companies have large capsule counts, good money-back guarantees, and subscription systems.

Thesis also provides a service that few other companies offer: free consultations with in-house nootropic coaches. These experts can help you figure out the best time to take specific Thesis formulas and guide your experience so you can tell whether or not they're working for you. Follow-up consultations are also free as long as you subscribe to the product.

What are nootropics?

Nootropic is a term most people use to refer to any non-prescription supplement that can boost brainpower. 4 The technical definition is a little more nuanced — encompassing prescription medications like Ritalin and Adderall — but the supplement industry has largely co-opted it to categorize the new class of non-prescription products. The word loosely translates from its Greek origins to mean mind-changing, and the majority of ingredients in a given nootropic seek to alter the brain’s cognitive abilities, as well as its governance of mood and energy.

Most nootropic supplements contain botanical ingredients, vitamins, minerals, and amino acids that boast at least some clinical research connecting them with improvements in any of the following:

Compared to their prescription cousins, nootropic supplements aren't particularly strong. Still, limited clinical research indicates a tangible benefit to taking them.

What is Thesis?

Thesis is a supplement company with a focus on nootropics. Their founders each had experiences growing up with what would today be considered learning disabilities, and they credit nootropics for changing their lives. They make six distinct nootropic formulas, each with a specific ingredient profile.

Thesis differentiates themselves from their competitors in several critical ways:

• They offer a starter kit containing a personalized combination of four blends.
• You have the option to remove caffeine by request from any formula.
• They provide some of the best phone support we've ever experienced.
• Their targeted formulas conform to changing needs.

By providing you with a mix of formulas, Thesis gives you the ability to enhance the aspects of your cognitive and emotional life that need it the most on any given day. Maybe you know you have low energy levels on Mondays and Wednesdays, so you can take the Energy formula on those days. Maybe you want to devote your weekends to artistic pursuits. You can use the Creativity blend for that. Or you might find that one of their six blends works well for you in any situation. In that case, you can adjust your order to receive only that formula.

Thesis' customer service — particularly over the phone — is outstanding. While many customers might find chat support more convenient, our testers rarely waited more than a minute to speak to someone, and Thesis employs phone operators who are extraordinarily knowledgeable about the product and nootropics in general. Their email support is fine, and their chat support often redirects to an email inquiry. But that phone support is some of the best our testing team has experienced.

Is Thesis safe?

Most of the ingredients that Thesis uses in their nootropics exhibit minimal side effects in clinical research, so there’s a good chance that Thesis' various formulas will be safe for most people. But Thesis has nearly three dozen ingredients in their catalog, and not all of them will be safe for all users, including those who are pregnant or breastfeeding. Of course, the most important thing you can do is talk to your doctor before taking Thesis.

The most common side effects to watch out for when you start taking Thesis nootropics include:

• Loss of appetite
• Digestive issues

Thesis advises discontinuing their nootropics if you experience persistent headaches or an upset stomach.

Some Thesis products may present contraindications with certain prescription medicines. For example, ashwagandha has been shown to normalize thyroid hormone levels in people with hypothyroidism. 5 This has led some to believe that it could conversely cause thyrotoxicity in people with hyperthyroidism, though it’s worth noting that the study in question employed double the highest ashwagandha dose you’ll find in Thesis nootropics — the study used 600mg, and the ashwagandha dose in Thesis’ Creativity is 300mg.

Still, this should make abundantly clear the case for speaking with your doctor prior to taking Thesis. This is especially true considering the lack of research into the specific ingredient combinations you’ll find in Thesis products. There is also very little research looking into the risks of combining nootropic supplements with prescription stimulants such as Ritalin, Adderall, or Vyvanse.

Some side effects, such as jitteriness, can be attributed to the caffeine in Thesis formulas. The fact that you can elect to remove caffeine from any formula expands the company’s reach to anyone with caffeine sensitivities and those who really don’t want to give up their morning cup of coffee. If you want caffeine in your Thesis formula, we recommend trying it without having had any coffee first, so you can see how it affects you.

Insider Tip: If you’re not sure whether to get your formula with or without caffeine, we recommend getting it with caffeine. Thesis isolates the included caffeine in a single capsule separate from other ingredients. Caffeinated formulas cost the same as uncaffeinated ones, and you can always elect not to take the caffeine capsule (the smallest capsule in any formula, containing a white powder).

What are the ingredients in Thesis?

Thesis uses an impressive set of ingredients, many of which have been part of respectable clinical research. Not all of the effects they hope these ingredients provide have been proven with sufficient statistical significance or over multiple studies in different populations, but what we do know strongly suggests efficacy.

Here's a look at several Thesis ingredients that have encouraging research behind them:

Several studies on mice show that dihydrohonokiol-B (DHH-B) has potent anxiolytic effects. 6 That means it may be able to help combat anxiety. However, we can’t say this for sure since there haven’t been any studies conducted on humans yet, so any potential benefits are speculative at this time. 25 Converting the successful dose used in mice (1mg) to the equivalent human amount (4.86 mg) is about half the amount used in Thesis’ Confidence (10mg). 6

In numerous studies, ashwagandha has been shown to reduce stress and anxiety. 32 Thesis uses a branded KSM-66 ashwagandha, which has a high standardized count of withanolides — the component of ashwagandha responsible for its positive effects. 33 This ensures both efficacy and consistency from doses that align with those used in successful studies.

While every formula is different, you'll notice that each contains caffeine and L-theanine. The nootropic properties of caffeine are well established. 19 L-theanine — a non-stimulant derived from green tea — has been shown to smooth out the jittery effects of caffeine. You can easily have caffeine removed from any Thesis formula for no extra cost, which is unique in the nootropic market. The L-theanine will remain, as it has its own set of cognitive benefits in addition to its ability to tame caffeine. 20

Saffron offers multiple benefits, including increased levels of dopamine and glutamate, that are dose-dependent. Human studies have also shown positive effects on depression symptoms. Thesis’ Confidence uses 28mg, which is 2mg less than what was used in many of the studies on saffron’s antidepressant effects. However, one study did find success with as little as 15mg. 7

A review of more than 120 scientific articles looking into the cognitive effects of phosphatidylserine concluded that it “safely slows, halts, or reverses biochemical alterations and structural deterioration in nerve cells.” The study goes on to say that it “supports human cognitive functions, including the formation of short-term memory, the consolidation of long-term memory, the ability to create new memories, the ability to retrieve memories, the ability to learn and recall information, the ability to focus attention and concentrate, the ability to reason and solve problems, language skills, and the ability to communicate.” 34

Derived from a South African plant, Zembrin appears to provide cognitive and anti-anxiety effects as demonstrated in clinical studies on human participants that used the same 25mg dose found in Thesis Creativity and Confidence. 8

Synapsa is a patented form of Bacopa extract, a traditional Ayurvedic memory enhancer. Studies on humans resulted in statistically significant improvements in cognitive tests. The study used 150mg twice daily (300mg total), which is only 20mg less than the 320mg used in Thesis’ Logic. 9

7,8 DHF is a small molecular TrkB agonist that can easily cross the blood-brain barrier. It can increase brain-derived neurotrophic factor (BDNF), a protein that improves neuroplasticity, learning, and memory. BDNF deficiencies are connected to numerous cognitive ailments as well. However, no human studies have been conducted. 26 In mice, 7,8 DHF appears to enhance spatial memory. When converting the effective dose for mice to humans, Thesis’ Clarity offers roughly 6mg more (about 24mg compared to Thesis’ 30mg). 27

Choline is a precursor to acetylcholine, a powerful neurotransmitter in the peripheral, autonomic, and enteric nervous systems. 10 One study on older adult human participants found that taking 187-399mg per day of choline reduced the risk of low cognitive functioning by nearly 50% compared to an intake under 187mg per day. 28 The CDP choline content in Thesis’ Energy is 300mg.

A 2010 clinical study on 485 older adult (over 55 years old) subjects found that 900mg per day of DHA improved memory and learning in those with age-related cognitive decline. 11 And another study in healthy adults 18-90 years old found that 580mg per day helped improve memory. 29 Unfortunately, the amounts used in many studies to improve cognitive function are quite a bit more than the 200mg (which is DHA and L-lysine combined) found in Thesis’ Logic.

Like choline, Alpha-GPC acts as an effective acetylcholine precursor. Studies also show that supplementation with Alpha-GPC can stave off exercise-induced reductions in choline levels. The effective amount used in the mentioned study is 200mg, which is less than half of what you’ll find in Thesis’ Clarity (500mg). 12

In addition to being an effective treatment for neuropathic pain, agmatine appears to have potent effects as an antidepressant. A five-year safety case report study concluded that there are no long-term side effect risks. Thesis’ Creativity only contains 250mg, which is well below the amount tolerated by study participants (2.67g per day). 13

Research into epicatechin indicates that it can enhance cerebral blood flow, delivering more oxygen to the brain to ensure it operates at its highest efficiency. The most effective dose for cognitive benefits appears to be over 50mg per day, and Thesis’ Clarity contains 278mg. 14

Lion's mane has been shown to increase nerve growth factor and promote neurite outgrowth of specific neural cells. It's a safe and reliable neurotrophic, but studies have debunked claims of neuroprotective properties. 15 A very small study of only 41 participants found that 1.8g of Lion’s mane may reduce stress and improve cognitive performance. 30 Thesis’ Clarity contains 500mg of Lion’s mane.

Hyperphenylalaninemia, a severe deficiency in phenylalanine, results in reduced dopamine, serotonin, and noradrenaline levels in the brain. 16 It can also alter cerebral myelin and protein synthesis. Supplementing with phenylalanine may provide neuroprotective benefits.

In a 2020 study, phenylalanine was a large component in a mix of seven amino acids that appeared to improve cognitive, psychological, and social functioning in middle-aged and older adults. Effective doses ranged from 0.85g to 1.7g of phenylalanine. A serving of Thesis’ Motivation contains 500mg, a bit under half of the average amount. 31

Examining the six formulas

Thesis has six nootropic formulas in their lineup (even though you can only choose up to four of them per box). Several other nootropic companies like TruBrain and BrainMD boast targeted lineups, as well, but Thesis is the Goldilocks of the bunch. Where BrainMD’s hyper-specific formulas rely on perhaps too few ingredients to make them worthwhile, many of TruBrain’s complex blends lack real specificity. With Thesis, you get targeted effects from numerous ingredients in moderately complex and reasonably priced combinations.

Each Thesis formula has a blend of ingredients that addresses specific needs. Their names give you a pretty big clue as to what the company intends each to do, but a closer look at their ingredients will help you understand how they achieve this.

Their formulas are:

Interestingly, the company thinks of its formulas as working well in pairs. You don't have to utilize them as such, but it's helpful to know how they view their most effective combinations. The following list details their purported combined benefits.

Enhances focus, eliminates brain fog, and lets thoughts flow naturally

Gets you going, keeps you going, and never crashes

Sparks new ideas, inspires extroversion, and revels in openness

You'll usually only take one formula at a time, but these pairs may act synergistically for specific personality types or cognitive needs.

Note that your first shipment of Thesis will contain six individually packed doses for four of these six formulas. Thesis chooses these formulas for you based on the results of an intake questionnaire, but you can make adjustments to that shipment on the customer dashboard before the shipment leaves their warehouse.

Let's take a closer look at each formula as they would appear with caffeine included.

Thesis Clarity

Thesis Clarity relies on 7,8 DHF (dihydroxyflavone), Alpha GPC (glycerylphosphorylcholine), epicatechin, and lion's mane to increase blood flow to the brain and stimulate the production of acetylcholine, a powerful neurotransmitter associated with learning, memory, and attention. It's particularly adept at cutting through brain fog.

Here's a look at Clarity's full ingredients list:

• Alpha GPC: 500mg
• Lion's Mane Mushroom: 500mg
• Camellia sinensis tea leaf: 278mg
• Dihydroxyflavone: 30mg
• Caffeine: 100mg
• L-Theanine: 200mg

One dose of Clarity consists of four capsules for the caffeinated formula and three capsules for the stimulant-free formula.

Thesis Logic

Thesis Logic contains triacetyluridine (TAU), which caters to the health of the entire central nervous system. It also uses phosphatidylserine to help facilitate communication between and protection of brain cells. 17

This is Logic’s complete ingredients list:

• Ginkgo Biloba: 160mg
• Theobromine: 100mg
• Phosphatidylserine: 400mg
• High DHA Algae: 200mg
• Triacetyluridine: 30mg
• Bacopa Monnieri: 320mg

One dose of Logic consists of four capsules for the caffeinated formula and three capsules for the stimulant-free formula.

Thesis Energy

Thesis Energy uses cysteine and tyrosine alongside caffeine to deliver a steady energy supply. It also includes TeaCrine, a branded form of theacrine, which partners with caffeine to affect adenosine signaling and prevent fatigue.

Here’s a full list of Energy’s ingredients:

• Citicoline: 300mg
• Mango leaf: 300mg
• Theacrine: 100mg
• N-Acetyl cysteine: 500mg
• Indian trumpet tree: 100mg
• N-Acetyl L-tyrosine: 300mg

One dose of Energy consists of three capsules for the caffeinated formula and two capsules for the stimulant-free formula.

Thesis Motivation

Blood flow and cellular function are at the core of Thesis Motivation . It employs artichoke extract, forskolin, and B12 to achieve these goals, with a healthy dose of phenylalanine for added focus and motivation.

Here's Motivation's full ingredients list:

• L-Phenylalanine: 500mg
• Methylliberine: 100mg
• Vitamin B12: 1000mcg
• Forskolin: 250mg
• Artichoke: 450mg

One dose of Motivation consists of three capsules for the caffeinated formula and two capsules for the stimulant-free formula.

Thesis Creativity

Thesis Creativity aims to realign you with your inspiration by removing barriers caused by stress, anxiety, and depression. It contains ingredients with powerful anxiolytic properties and 5-HT reuptake inhibition.

Here's a look at Creativity’s ingredients list:

• Alpha GPC: 150mg
• Agmatine sulfate: 250mg
• Panax ginseng: 200mg
• Ashwagandha root: 300mg
• Sceletium tortuosum : 25mg

One dose of Creativity consists of three capsules for the caffeinated formula and two capsules for the stimulant-free formula.

Thesis Confidence

Confidence is designed to work hand-in-hand with Creativity, using saffron and DHH-B from magnolia bark to increase dopamine levels and decrease anxiety. One fascinating ingredient in this formula is sage extract, which one 2021 study showed can help with various memory tasks, including name and face recognition. 18 It’s worth noting, though, that this study employed a 600mg dose compared to Thesis’ 333mg dose.

Here is Confidence's complete ingredients list:

• Saffron: 28mg
• Magnesium bisglycinate: 500mg
• Sage: 333mg
• Magnolia Bark: 10mg
• Ashwagandha leaf & root: 120mg

One dose of Confidence consists of three capsules for the caffeinated formula and two capsules for the stimulant-free formula.

Our Thesis testing results

Our testing team has tried every Thesis formula (with and without caffeine) to determine their short- and long-term efficacy, at least at an anecdotal level. Here’s a quick summary of our experiences:

Clarity provided our testers with a combined sense of focus and mental ease, though we mostly found that it worked best from its second day forward. The very first dose is mildly effective, but it served us better as a loading dose. We had no crash from either caffeinated or uncaffeinated formulas.

Our testers found that Logic provided a similar experience as Clarity, increasing focus and mental acuity, but the caffeinated formula caused a crash in two of our testers. By excluding the caffeine, that crash can be avoided, though that comes at the expense of some efficacy.

We were very curious about how this formula would perform without the caffeine. Our testers had a noticeable increase in energy without jitteriness about one hour after taking Energy. The caffeinated version caused the worst crash of all the formulas, but we were pleased to find that the formula without caffeine still provided noticeable energy increases without a crash.

Our testers are generally a pretty motivated bunch, so we might not have been the best group to evaluate this particular formula. The testers who felt an uptick in a sense of motivation described it more like a feeling of being able to follow through on tasks with less distraction and completion anxiety.

Creativity, like Clarity, seemed to work better for our testers on its second and third days than on its first. Testers generally described a sensation similar to Motivation but without the feeling of being “on rails,” as one tester put it. It seems to allow for more curiosity and exploration, though not necessarily as much follow-through.

This is Thesis’ newest formula, so fewer of our testers have tried it. Among those who have, one tester with a mild case of social anxiety described feeling a bit more relaxed among groups of people. Testers preferred this formula without caffeine.

Thesis pricing, shipping, and returns

Thesis keeps their price structure decidedly simple. This is refreshing, considering the range of nootropics they offer. You don't have to worry about one formula costing you more than another. However, Thesis doesn't make a non-subscription approach economically feasible.

Every Thesis shipment — including the starter pack — consists of four small boxes, each containing six doses of a single formula. That’s 24 doses/month.

Here's how it works:

• Any one-time purchase of a one-month supply, including the starter kit, costs $119.
• When you subscribe, that monthly cost is only $79.
• You can take an extra 10% off your first order with the coupon code INNERBODY

Subscriptions require an account with Thesis, which gives you access to a well-designed customer dashboard. This is where you can easily make formula adjustments, alter your shipping schedule, or cancel your subscription entirely.

Shipping from Thesis is free in the U.S., and the company offers a 30-day money-back guarantee. In our testing experience, we attempted a return on a second shipment into the subscription. While it isn’t the company’s policy to do so, they refunded our money and let us keep the product. This is similar to some other “Keep it” guarantees we’ve seen from competitors, and we appreciated it.

Getting started with Thesis Nootropics

Thesis' website is easy to navigate, but it is inconvenient that you must complete the signup questionnaire before accessing formula-specific pages. There are ways around this — like direct searching or just knowing the formula URLs — but we think reviewing formulas should be a little easier when you first get to the site. And you won’t be able to place an order for anything until you complete the questionnaire.

The user interface for managing your subscription is exceptionally intuitive. You can quickly adjust your formula combinations, specifying whether or not you want specific formulas to contain caffeine.

Setting up a subscription with Thesis is a straightforward process. Here are the basic steps:

• Take the Thesis quiz . This will create a starter kit specific to your results. (You can also build a box from scratch if you know which formulas you want to try.)
• Order your starter kit. We recommend going with the kit Thesis creates after your quiz, but if you change your mind, you can use the customer portal after placing your order to make any changes to the formula combination before it ships.
• Set up a coaching consultation. This is an optional step, but we recommend it and encourage you to have your first consultation before your kit arrives.
• Take your nootropics as needed. Most people can experience some of Thesis nootropics' benefits within a few hours of ingestion. Some ingredients and formulas may take a few days to produce results.
• Refine your order. As you near the end of your first month, you can head over to the Thesis website and customize your next order to include the formula or formulas you like most.
• Set up follow-up consultations as needed. These will help you refine your future orders and maximize your results.

When you subscribe to the starter kit, you will continue receiving that kit every month until you customize your order. Thesis divides their boxes into four six-dose supplies, and you can mix and match those supplies to suit your needs. For example, you could boost energy on the weekdays and creativity on the weekends by getting a one-month supply with 18 servings of Energy in three packages and six servings of Creativity in a single package.

Personalized insights and coaching

When you take the quiz on the Thesis website, you'll get personalized insights comparing your results to other quiz-takers and a data set developed from nearly 500 scientific studies. The parameters in your results cover don’t completely line up with their formulas, but they include:

These results inform the system to make recommendations for your starter kit. After you order, you can set up a consultation with a Thesis coach. These consultations are free, and you can have as many follow-up sessions as you like. Other companies have apps or online resources like blogs or courses to help you on your nootropic journey, but Thesis’ personalized coaching offers a unique approach and execution.

Consultation calls last around 15 minutes, though some of our testers had their sessions go longer as their coaches' schedules allowed. We received best practices information about taking nootropics that covered dose timing, formula application, and more. Some of our testers also received diet and exercise advice that coincided with their formulas.

Alternatives to Thesis

There are generally two tiers of products in the nootropics landscape. The lower tier consists of products that cost between $20 and $40. Many of these nootropics contain proprietary blends that obscure the exact quantities of ingredients, presumably so companies can use more of the least expensive components. Some companies in this tier disclose their ingredient quantities but may not source them from the highest quality suppliers or perform third-party testing of any kind.

Top brands in this tier include:

• Onnit Alpha BRAIN
• Moon Juice Brain Dust
• Focus Factor

The second tier — where you'll find Thesis — consists of more expensive nootropics that spell their contents out clearly, use high-quality ingredients, and often perform third-party testing to ensure safety and potency. Top brands in this tier include:

• Qualia Mind

Hunter Focus

We have a comprehensive breakdown of our top nootropics , but here's a concise breakdown of Thesis' most comparable competition.

TruBrain offers one of the widest varieties of nootropics of any company — one of the few catalogs that rivals the variety Thesis offers. They also have some novel and beneficial delivery methods for their nootropic ingredients. Those include energy bars and liquid shots that are outstanding for anyone with difficulty swallowing pills.

TruBrain offers their nootropics in a targeted fashion, not unlike what you get from Thesis. They formerly offered their targeted blends in shot form only, but now you can get any of these targeted blends in capsule or liquid shot form. The shots come in small 1oz pouches that make them easy to take anywhere.

TruBrain's targeted blends include:

This is TruBrain's original blend. It contains seven nootropics, including Noopept, a branded form of N-phenylacetyl-L-prolylglycine ethyl ester. This blend is caffeine-free.

The Strong blend is identical to the Medium formulation in contents and doses, but it also contains 100mg of caffeine.

The Extra Strong formula builds on the Strong blend by adding 150mg of adrafinil (2-(diphenylmethyl)sulfinyl-N-hydroxyacetamide). 21 This wakefulness-promoting substance may also help with weight loss and athletic performance.

TruBrain's Sleep formula contains just four nootropic ingredients: GABA, melatonin, 5-HTP, and a blend that TruBrain calls "functional oils."

Mellow is identical to the medium strength formula, but it adds the functional oil combination used in Sleep.

This formula contains Lion's mane, a mushroom that may promote neural growth , though human studies are necessary to determine if this is true. 22 Its other nootropic ingredients are rhodiola, guayusa, and rosehips.

A 30-day supply of TruBrain nootropic shots costs $89. That's $10 more than the subscription cost for a one-month supply of Thesis. Some of their shots contain caffeine, and others don't. If it already contains caffeine, there's no way to alter a TruBrain formula to be stimulant-free.

The first month of TruBrain capsules costs a bit less, coming in at $69. After your first month, however, the price goes up to $119. That makes Thesis the better value, but if you want the best possible nootropics for sleep support, it might be worth the extra money to check out TruBrain.

Qualia Mind is a brand under the Neurohacker Collective, a company that offers several products to address things like sleep quality, skin health, and vision. They have three nootropics available:

• Qualia Mind Caffeine-Free
• Qualia Mind Focus

Their original blend is comprehensive, consisting of nearly 30 ingredients in high doses. That means it's liable to provide you with noticeable effects. It also means you might not know which of those effects are coming from which ingredients, and some of the less beneficial components in your body may also have side effects you'd rather avoid.

The caffeine-free version is identical to the original formula but leaves the caffeine out. Qualia Focus is a more streamlined offering with only seven nootropic ingredients, including caffeine, L-theanine, and L-ornithine. 23

Initial shipments from Qualia Mind are significantly discounted, but after the first month, the price makes theirs one of the most expensive nootropics we've tested. For example, the first month of a subscription to Qualia Mind costs just $39. After that, it costs $139/month. And a one-time purchase is $159.

One inconvenient aspect of Qualia Mind is that a single dose consists of seven capsules, which can get tiresome even for people who don't have trouble swallowing pills. On the bright side, Qualia's 100-day money-back guarantee allows you to try it for a little over three months to determine if you can handle that kind of daily dosing.

Hunter Focus is one of three supplements in the Hunter stack alongside the company's Test and Burn supplements. The stack is intended for male use — Test is a testosterone supplement — but Focus and Burn are suitable for men and women.

Like Qualia Mind, Focus has a long list of ingredients in generous doses. In fact, one serving of Hunter Focus is like taking all six of Thesis' formulas at once. That said, the serving itself is difficult to swallow, as it consists of six large pills.

Another knock on Hunter is that they don't offer a subscription system. That means you can't get an extra discount, and you must remember to reorder when you're running low (theoretically, a nootropic like this should boost your memory). There's also no money-back guarantee to speak of, only a return policy with a relatively short window that only applies to unopened products.

One bottle of Hunter Focus costs $90, and shipping is $8.95 unless you buy more than one bottle at a time. The company will throw a fourth in for free if you buy three bottles at once. That's the only way to get any savings through Hunter.

Individual nootropic components

Many companies offer combinations of nootropic ingredients to perform specific brain-related tasks or even provide globally positive cognitive benefits. However, the scientific research behind most of these ingredients almost always includes just one rather than a combination. Some people prefer to try one at a time to minimize the potential for side effects and determine if one particular ingredient works for them. A few companies offer single-ingredient nootropic supplements for this specific purpose.

Our favorite company dealing in individual nootropic components is Nootropics Depot. They offer a wide variety of single-ingredient supplements and a few targeted blends. The prices are generally fair, with an average range running from $16-$70. A 30-day money-back guarantee covers every purchase, and you get free shipping on orders over $50.

Nootropics FAQ

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Specific nootropics affect different parts of the brain in their own ways. Some — like caffeine — reduce fatigue by blocking adenosine receptors, while others act to protect neural connections that are already present while possibly contributing to new neural growth. 24 Some also mitigate depression and anxiety, which frees up the brain to perform at its best.

Are nootropics safe?

The safety of a nootropic depends on the specific ingredients involved. Many are perfectly safe in the doses commonly employed by nootropic companies, but some can cause reactions like increased heart rate, gastrointestinal discomfort, headache, and even tremors. The smartest thing to do is to talk to your doctor before introducing any new supplement to your regimen.

Do nootropics really work?

Many nootropic supplements are noticeably effective — caffeine is a great example. Efficacy varies depending on the specific component or combination. Fortunately, a lot of companies offer money-back guarantees, so you can try their products to see if they work for you without much financial risk.

Will nootropics make me smarter?

Nootropics won't necessarily make you smarter, but many can increase your alertness, improve short-term recall, and promote neural growth and protection. That creates a great environment for learning if you apply yourself while using nootropics, and many ingredients can help you with the motivation it takes to do so.

How do you pronounce nootropics?

The 'noo' in nootropics comes from the Greek nous , which philosophers use to mean mind or intelligence. The 'tropic' in nootropic comes from the Greek tropikos , which relates to turning or changing. So, nootropic roughly translates to mind-changing. You pronounce the 'noo' like 'new' and the 'tropic' with a long O sound, like 'toe pick.'

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Thesis, the First High Quality and Customized Nootropics Solution, Raises Total of $13.5 Million in Funding

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Unilever Ventures is the Largest Investor in Seed and Series A Rounds

NEW YORK, May 2, 2023-- Thesis, the company that offers a customized approach to cognitive performance products based on your unique brain chemistry, today announced that it has raised over $13.5 million in funding. The company recently closed on a Series A round totaling $8.4 million with investors that included Unilever Ventures, Redo Ventures, Alive VC, Break Trail, NBA superstar Kevin Love and model Kate Bock. Previously the company raised $5.1 million in an undisclosed seed round that included Unilever Ventures, MBX, Trust Ventures and Redo Ventures. Thesis recognizes that nootropics are not a one-size-fits-all wellness category. Through the highest quality ingredients and a customized approach, the brand helps people effectively boost their cognition & productivity. “Nootropics have helped me a great deal, as someone who originally struggled in school and who eventually went on to graduate from some of the world’s most prestigious universities. I spent a significant amount of time learning about these compounds and finding the blend that worked for me. It shouldn’t be so hard,” said Dan Freed, founder and CEO of Thesis. “I created Thesis products for people who feel that they might not be living up to their full potential and want a real solution to close the gap.” Rachel Harris, Partner at Unilever Ventures said, “In today’s 'always on' world, consumers are increasingly looking for solutions to optimize their mental acuity and the demand for products that allow you to perform at your best has never been greater. With Thesis’s customized offering, education-focused and digital-first model rooted in a highly compelling founder story, we have been impressed by Dan’s vision and the exacting standards that he is setting for the brand. We are excited to support him on the next chapter of the business’s growth.” “I am excited to be part of Dan’s vision of customized health and wellness solutions. Thesis is defining a new wellness category and reshaping how people approach brain care," said Michael Lynton, Thesis Board Director. The new capital will support Thesis as it makes key executive hires, expands out its product selection and undergoes clinical trials. Thesis products are formulated with clinically studied active ingredients with the highest possible bioavailability and adhere to the FDA Current Good Manufacturing Processes (cGMP). For more information, visit https://www.takethesis.com About Thesis: Thesis offers potent nutrient compounds formulated to enhance mental performance, based on your unique brain chemistry and the cognitive states you want to achieve. Whether taking the Energy Formula to overcome fatigue, the Clarity Formula to enter a flow state, or the Motivation Formula to decrease procrastination, Thesis offers these specific blends and more to target specific outcomes.

Contact: [email protected]

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Table of Contents

About Thesis Nootropics

Hands up if you guzzle five coffees a day to stay awake, have tried all the supplements in the book desperate to improve your headspace, and aren’t interested in prescribed medications. Designed to increase focus , Thesis nootropics might be for you. 

Thesis offers a customized blend of ingredients designed to optimize your cognitive function , with personalized details that tackle your specific needs. Nootropics boost brain performance in the same way a stimulant would, without the common negative effects. 

A study published in the Journal of Alzheimer’s Disease found that nootropics may help improve cognitive function in people with Alzheimer’s disease.

Interested in finding out more about the brand and how it works? Leaf through our Thesis Nootropics review. We’ll be your guide through the company and the process, as well as details on the treatments, highlights from customer reviews, answers to important FAQs, and more, to help you decide if it’s worth the try.

Pros and Cons

• Multiple cognitive benefits: Thesis Nootropics offers a variety of blends that cater to multiple aspects of cognitive function.
• Long-term effects: On top of short term benefits for daily life, Thesis nootropics ingredients are designed to impact the brain in the long-term.
• Personalized recommendations: Thesis Nootropics makes personalized recommendations based on your goals and unique brain chemistry.
• Potential side effects: The most common side effects to watch out for when you start taking Thesis Nootropics include heartburn, headaches, confusion, dizziness, loss of appetite, and digestive issues.
• Need to stop taking if issues arise: If you experience a headache or an upset stomach that won’t go away while taking their nootropics, Thesis recommends that you stop taking them.

What is Thesis Nootropics?

Nootropics are nutrient compounds and substances that are known to improve brain performance , such as caffeine and creatine. They help with issues that affect motivation, creativity, mood, memory, focus, and cognitive processing.

Nootropics are the ideal addition to an already healthy lifestyle that consists of exercise, proper nutrition, and enjoyable activities.  Thesis nootropics are carefully formulated to target specific needs, ranging from energy to creativity. The brand focuses on safety, ensuring that all supplements adhere to FDA guidelines and go through multiple clinical trials. 

How Thesis Nootropics Works

With all that being said, you may be wondering how Thesis provides users with an option that is specific to their needs. Fortunately, the process is simple and hassle free. Here’s how it works:

• Take the Thesis nootropics quiz
• Answer questions about your basic information
• Receive personalized recommendations 
• Get your starter kit for $120 , or $79 monthly when you subscribe 

After that, you’ll select one formula to take each week, taking one day off in between each different option. You’ll also track your results in the daily journal over the month to see how they affect your daily life. 

From there, it operates as a subscription service. Users will be able to optimize their next shipment by telling the brand which formulas worked best.

If you don’t like any of the blends in your box, let the company know and they’ll switch it for something that’s a better fit for your lifestyle, genetics, and goals.

Thesis Nootropics Ingredients

Thesis Nootropics is a brand that offers personalized nootropics designed to enhance cognitive function and overall brain health. Their blends contain a variety of ingredients that are carefully chosen for their cognitive-boosting properties. Here are some of the key ingredients in Thesis Nootropics:

• Cognizin (Citicoline) : Cognizin is a type of choline that is known for its ability to enhance cognitive function, including memory and focus.
• L-Theanine : L-Theanine is an amino acid that is found in green tea, and is known for its ability to promote relaxation and reduce stress and anxiety.
• Lion’s Mane Mushroom : Lion’s Mane Mushroom is a type of medicinal mushroom that is believed to have cognitive-boosting properties, including improved memory and focus.
• Rhodiola Rosea : Rhodiola Rosea is an adaptogenic herb that is known for its ability to reduce stress and fatigue, and improve mental clarity and cognitive function.
• Ashwagandha : Ashwagandha is an adaptogenic herb that is known for its ability to reduce stress and anxiety, and improve memory and cognitive function.
• Phosphatidylserine : Phosphatidylserine is a type of phospholipid that is found in high concentrations in the brain, and is believed to support cognitive function, including memory and focus³
• Alpha-GPC : Alpha-GPC is a type of choline that is known for its ability to enhance cognitive function, including memory and focus.
• TAU (uridine): TAU is a blend of uridine, choline, and DHA, which is believed to support brain health and cognitive function.
• Artichoke extract : Artichoke extract is believed to enhance cognitive function by increasing levels of acetylcholine, a neurotransmitter that is important for memory and learning.
• Dynamine : Dynamine is a type of alkaloid that is believed to enhance cognitive function by increasing levels of dopamine, a neurotransmitter that is important for mood and motivation.

Overall, the ingredients in Thesis Nootropics are carefully chosen for their cognitive-boosting properties, and are designed to work together to enhance overall brain health and cognitive function.

Thesis Nootropics Health Benefits

Thesis Nootropics is a brand that offers personalized nootropics designed to enhance cognitive function and overall brain health. Their blends contain a variety of ingredients that are carefully chosen for their cognitive-boosting properties, and offer numerous health benefits. Here are some of the health benefits of Thesis Nootropics:

• Increased cognitive energy : One of the key benefits of Thesis Nootropics is increased cognitive energy, which can help improve productivity, mental alertness, and motivation, as it contains cognizin .
• Enhanced mental clarity : Another benefit of Thesis Nootropics is enhanced mental clarity,given from Lion’s Mane Mushroom which can help reduce brain fog and improve focus.
• Improved memory and learning abilities : Thesis Nootropics contains ingredients that are believed to improve memory and learning abilities, like Phosphatidylserine , which can help users retain information more effectively.
• Elevated mood : Thesis Nootropics may help elevate mood and reduce symptoms of anxiety and depression, thanks to ingredients like L-Theanine and Ashwagandha .
• Lowered stress levels : The adaptogenic herbs in Thesis Nootropics, such as Rhodiola Rosea and Ashwagandha , are known for their ability to lower stress levels and promote relaxation.
• Boosted focus : Thesis Nootropics contains ingredients like Alpha-GPC and Artichoke extract , which are believed to boost focus and concentration.

While Thesis Nootropics offers numerous health benefits, it’s important to note that the long-term effects of nootropics are not yet fully understood and more research is needed.

3 Thesis Nootropics Bestsellers

Thesis energy review.

If you’re constantly struggling to keep up with the demands of your busy life, it might be time to try a natural energy booster like Thesis Energy. This powerful nootropic blend is specifically designed to increase energy, overcome fatigue, and build mental stamina.

Thesis Energy is caffeine-free, making it a great option for those who are sensitive to caffeine or looking for a natural alternative to traditional energy drinks. The Energy formulation is designed to help improve focus and mental clarity, increase cognitive energy, and reduce fatigue. Whether you’re facing a busy day at work, recovering after a night of poor sleep, or gearing up for an intense workout, Thesis Energy can help you power through.

Each ingredient in Thesis Energy is carefully chosen for its energy-boosting properties. The specific ingredients can vary depending on your needs, but they work together to help increase energy, improve mental clarity, and reduce fatigue.

To get the most out of Thesis Energy, take it every morning on an empty stomach. You can also take it again after lunch if you need an extra boost. It’s designed to help you tackle busy, hectic days, recover from poor sleep, and power through intense workouts.

If you’re tired of relying on coffee and energy drinks to get through the day, it might be time to give Thesis Energy a try. Check availability and start boosting your energy naturally today!

Thesis Creativity

If you’re someone who struggles with creativity or finds yourself feeling stuck in your creative endeavors, Thesis Creativity may be worth considering. This nootropic supplement is designed to help spark inspiration, enhance verbal fluency, and boost confidence in your own great ideas.

So what’s in Thesis Creativity? The ingredients may vary depending on your specific needs, but these ingredients work together to support stress management, memory function, mood regulation, and energy production.

By supporting stress management, memory function, and mood regulation, Thesis Creativity can help free up mental space for more creative thinking. Additionally, the caffeine and L-theanine combo can provide a boost of energy and focus without the jitters and crash that can come with caffeine alone.

To get the most out of Thesis Creativity, it is recommended to take it every morning on an empty stomach and again after lunch if you need an extra boost. This nootropic blend is particularly helpful for brainstorming and creative thinking, writing and creative projects, and public speaking and social situations.

As with any nootropic supplement, it’s important to note that the long-term effects of Thesis Creativity are not yet fully understood and more research is needed. It’s always a good idea to speak with a healthcare professional before adding any new supplements to your routine.

In summary, if you’re looking for a little extra help in the creativity department, Thesis Creativity may be a valuable addition to your nootropic lineup. Its unique blend of ingredients can help support mental clarity, mood regulation, and energy production, making it a valuable tool for any creative individual.

Thesis Logic

If you’ve been having trouble with your memory lately, such as forgetting what you had for lunch yesterday or struggling to recall common words, then Thesis Logic may be just what you need. This formula is designed to help enhance your processing speed, boost your memory, and deepen your thinking.

Thesis Logic is caffeine-free, making it a great option for those who are sensitive to caffeine. The formula is ideal for use during deep, focused work, complex problem-solving, research projects, and completing tedious tasks.

Taking Thesis Logic is easy – simply take it every morning on an empty stomach, and take it again after lunch if you need an extra boost. By incorporating Thesis Logic into your daily routine, you may notice improvements in your cognitive function and overall mental performance.

Who Is Thesis Nootropics For? 

Thesis nootropics are designed for a number of different specific needs, including anyone who wants to focus better, have more energy, and maintain mental clarity. All in all, the products are specifically formulated to improve day to day life and target your specific needs .

Thesis Nootropics Side Effects

While Thesis nootropics are designed to enhance cognitive performance and provide a range of benefits, it’s important to be aware of the potential side effects that can occur. As with any supplement, individual reactions can vary, and some people may experience side effects while others may not.

Some of the potential side effects of Thesis nootropics include:

• Insomnia : Some nootropics contain caffeine or other stimulants that can disrupt sleep patterns and lead to difficulty falling asleep or staying asleep.
• Blurry vision : Certain nootropics, such as those containing alpha GPC, have been linked to temporary blurry vision.
• High blood pressure : Stimulant-based nootropics can increase blood pressure, which can be dangerous for people with hypertension or other heart conditions.
• Fast heart rate : Similarly, stimulants can also increase heart rate, leading to palpitations or a rapid pulse.
• Circulation problem s: Certain nootropics, such as vinpocetine, can affect blood flow and circulation, leading to issues like dizziness, nausea, or headaches.
• Addiction : Some nootropics, such as those containing racetams, have been associated with the potential for addiction or dependence if used long-term.

It’s important to remember that not all nootropics will produce these side effects, and the severity of any reactions will depend on individual factors such as dosage, duration of use, and underlying health conditions. However, it’s always wise to discuss any potential risks with a healthcare professional before starting any new supplement regimen.

Additionally, it’s important to follow dosage instructions carefully and not to exceed recommended amounts, as this can increase the risk of side effects. By being mindful of potential risks and using nootropics responsibly, users can reap the benefits of these supplements without experiencing adverse effects.

Thesis Nootropics Reviews: What Do Customers Think?

At this point in our Thesis nootropics review, it’s time to turn to what customers are saying. So, we sourced testimonials from the brand’s website, Reddit, and ZenMasterWellness. And spoiler alert, the Thesis nootropics reviews we came across have nothing but good things to say.

On takethesis.com , the brand earns 4.4/5 stars out of 7,956 reviews. One patron describes their particular blend as the perfect alternative to prescription meds :

“ I have been off stimulants for months now and these formulas are far superior. My husband and daughter both noticed the change and said I have been more productive, focused, less anxious, and more “thinking outside the box”. I have tried for years to get off stims and nothing would work .”

On Reddit, many reviewers share similar sentiments about how effective the products are. One buyer shares that they tried tons of different nootropics on the market, and Thesis stands out amongst the crowd . 

On ZenMasterWellness, one reviewer states that their blend provided the exact results they were looking for :

“ They offer notable improvements to how well I’m able to focus, stay on task, and grind when it’s time to grind. In practice, this usually looks like a clearer mind and an improved ability to just… chill. With the Clarity and Creativity blends, in particular, I just feel leveled out .”

Backed by clinical trials and real customer experiences, Thesis stands out in the world of nootropics and supplements. The personalized selections prove effective, while the quality ingredients live up to expectations. 

Is Thesis Nootropics Legit?

If you’re wondering if this brand offers products that are too good to be true, this Thesis nootropics review is here to say that it is the real deal .

The brand is backed by numerous clinical trials, which highlight how 86% of customers reported improvements in a wide range of cognitive challenges, while 89% noticed an improvement in their ability to reduce stress and maintain energy.

Is Thesis Nootropics Worth It?

Thesis is an appealing choice in the world of nootropics because it provides a completely customized selection based on your needs and goals. Plus, the ingredients are potent and ensure the best effects—and you only end up paying for the benefits you actually need.

With that in mind, this Thesis nootropics review deems the brand worth the try.

Alternatives

Here are some alternatives to Thesis Nootropics that you might find interesting:

• Mind Lab Pro – This nootropic supplement is designed to improve cognitive function and mental performance. It contains 11 ingredients that work together to enhance memory, focus, and overall brain health.
• Thorne Supplements : If you’re looking for high-quality, science-based supplements, Thorne is a great choice. Their products are designed with the latest research in mind and are rigorously tested for quality and purity. Some of their popular offerings include multivitamins, protein powders, and omega-3 supplements.
• WeAreFeel Supplements : WeAreFeel is a supplement brand that offers a variety of products designed to support different aspects of your health. Their supplements are vegan-friendly and free from artificial colors, flavors, and preservatives. Some of their popular offerings include multivitamins, probiotics, and omega-3 supplements.
• Neuro Gum : If you’re looking for a quick and easy way to boost your focus and energy levels, Neuro Gum is a great option. This gum is infused with caffeine and other natural ingredients that can help improve mental clarity and alertness. Plus, it’s sugar-free and comes in a variety of delicious flavors.
• Neuriva Plus : Neuriva Plus is a brain supplement that’s designed to improve memory, focus, and cognitive performance. It contains a blend of natural ingredients, including coffee fruit extract and phosphatidylserine, that have been shown to support brain health. If you’re looking for a natural way to boost your cognitive function, Neuriva Plus is worth considering.

Thesis Nootropics Promotions & Discounts 

There aren’t currently any Thesis promos or discounts available. That being said, if you subscribe for recurring shipments of your recommended products, you’ll save $40 monthly .

Where to Buy Thesis Nootropics

At the time of this Thesis nootropics review, the products are exclusively available on the brand’s website, takethesis.com .

Is Thesis Nootropics vegan?  

Thesis nootropics are made with only vegan ingredients . That being said, while the brand has taken precautions to protect against cross contamination, the products are not certified vegan.

Is Thesis Nootropics gluten-free? 

On top of being vegan, Thesis products are made without gluten, eggs, or nuts . Again, while the brand strives to protect users against cross contamination, the products are not certified gluten free. 

What is Thesis Nootropics’ Shipping Policy?

If you’re anxiously awaiting your order from this Thesis nootropics review, you’ll be happy to hear that the company offers speedy shipping, sending orders out within 1 business day. After that, packages should arrive within only 1-3 business days . Costs are calculated at checkout.

At this time, Thesis is not able to offer international shipping. This Thesis nootropics review recommends following the brand on social media and signing up for the newsletter to stay up to date with shipping policies. 

What is Thesis Nootropics’ Return Policy?

If you find that your Thesis formula isn’t working out, the company requests that you contact them to make changes and adjustments to ensure you are able to receive the proper help.

If you would still like to make a return, follow these simple steps for a refund:

• Submit your refund request
• Ship the items back within 30 days of the original delivery
• Send an email with your tracking number to the brand
• Return any remaining product in their original packaging to: 

Thesis Returns 902 Broadway

6th Floor New York, NY 

Once your return has been received, a refund will be processed and email confirmation will be sent. It’s also important to note that the brand can only refund one month’s supply per customer and return shipping is the customer’s responsibility. 

How to Contact Thesis Nootropics

We hope you enjoyed this Thesis nootropics review! If you have any further questions about the brand or its products, you can contact them using the following methods:

• Call 1 (646) 647-3599
• Email [email protected]

902 Broadway Floor 6 New York, NY 10010

If you’re looking for other ways to boost your productivity via supplements, check out these other brands we’ve reviewed:

Thorne Supplements Review

WeAreFeel Supplements Review

Neuro Gum Review

Neuriva Plus Review

Our team is dedicated to finding and telling you more about the web’s best products. If you purchase through our links, we may receive a commission. Our editorial team is independent.

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What Is Thesis?

How does it work, thesis nootropics benefits, thesis blend breakdown, thesis energy benefits, clarity benefits, motivation benefits, logic benefits, creativity benefits, side effects, who should take it, who shouldn't take it, where can you buy it, other user reviews, how does thesis compare to other supplements, our verdict on thesis nootropics.

• Supplements >
• Nootropics >
• ThesIs Nootropics Review

Thesis Nootropics Review (2024) Is It Worth The Hype?

As a fitness coach, I've seen the impact of high-quality nootropic supplements on motivation and concentration during workouts.

Teaming up with my dietitian and 12 clients, we documented the significant cognitive benefits and general effects of Thesis over a period of four weeks.

Does it genuinely fulfill its promise of enhancing your mental performance and focus?

Before trying out the supplement, keep reading and find out if it's right for your mental wellness needs.

Thesis is a stack of supplements that aims to improve cognitive function, mental stamina, mood, and overall mental energy levels.

Thesis nootropics' energy formula claims to boost energy levels while catering to individuals following a certified gluten-free diet, promoting positive habits and supporting nerve health.

What's particularly interesting about purchasing this stack is the Thesis algorithm.

It’s a set of questions that assess your personal needs to create a bespoke starter kit.

More on this shortly.

As a result, you get a recommendation from a couple of their products to provide personalized blends for nootropics.

Let’s learn more about how Thesis supplements work with your brain health.

Thesis Nootropics

Rated With Total Shape's Scoring System

The Thesis experience begins with a questionnaire to assess your needs and goals, like improved physical and mental energy.

Based on your responses, the algorithm will recommend different Thesis blends to help you achieve your goals.

After going through the quiz, you get a recommended Thesis starter kit.

The five different products Thesis then recommends claim to work similarly to smart drugs by boosting your cognitive function and mood.

But unlike prescription medications, Thesis uses natural ingredients like vitamins, amino acids, minerals, and herbs.

“Nootropics, a greek word meaning 'Towards the Mind', are compounds that are both (1) neurologically active and (2) directly or indirectly enhance cognitive potential via increased capabilities (ie. reflexes), state of well-being, or learning potential.” - Kamal Patel, MPH, MBA at Examine.com

Once you are a Thesis customer, you can also set up a meeting with a Thesis coach to review your stack and the effects you are looking for and experiencing.

But does that make Thesis legit?

Let’s see what our detailed clinical research reveals.

The first thing that we got our testing team to do is to go through a full week of keeping an hourly journal to self-evaluate their mood, concentration, and cognitive function.

Then we put them through three weeks of taking their Thesis recommended stack and got them all to keep their hourly journaling going.

The first thing we noted was that the energy blend and creativity formula seemed to give our clients a good boost in brain performance.

And the folks that took the motivation blend a few hours before heading to the gym also found they were more focused on their workouts.

However, the majority of our test group highlighted that the effects seemed to wear off after about 4–5 hours.

We also noted that the logic formula didn’t provide a huge benefit, which could be down to a lack of a proven formula.

We also found that the Thesis nootropics cost can mount up if you want to stack a few of them.

• Allows you to combine different product formulas for personal goals
• Provides support from coaches to help you refine your stack
• Positive impacts on mood and concentration levels
• Some of the ingredients are not supported by reliable clinical trials
• You may need to swallow quite a few capsules, depending on your particular blend

Thesis Nootropics offers a unique blend of ingredients that target thesis energy, thesis creativity, cellular function, and even skin health, making it a notable contender in the supplement industry.

For this part of the Thesis supplements review, I got my dietitian to help out and analyze the Thesis formula for each of the products.

We also tested the effects with 12 clients to see whether the marketing hype lives up to expectations.

Let's have a more detailed look at the features and benefits of each blend.

The idea behind Thesis Energy is to help people clear brain fog and feel more mentally energized.

To verify this, we paid close attention to the journal entries our testing team made in the afternoons. This is typically when people feel a slump.

What we found was that folks who took this supplement after lunch gained some mental clarity.

But it seems like the effect wears off after about four hours, so you don’t gain an all-day effect like with other nootropics.

Key Ingredients:

• Choline: According to PubMed, this mineral may boost memory function and verbal fluency [ 1 ].
• L-Theanine: A controlled trial posted in Nutritional Neurosciences suggests that this amino acid can work well with caffeine to increase alertness without causing jitters [ 2 ].
• Caffeine: This stimulant can boost alertness, but you can get this from a morning coffee, so I’m not overly impressed that it’s added here [ 3 ].

Thesis Clarity is another product that aims to improve neural communication and allow you to think more clearly and effectively.

Thesis Nootropics' clarity formula provides an extra boost of cognitive performance, targeting stress response reduction and improving sleep quality, all while delivering a healthy dose for enhanced mental clarity and improved ability.

We did note in our testing review that there seems to be an improvement in mental function for several hours after taking it.

But this also seemed to happen more with those testers who took the clarity and energy formula.

• 7,8-DHF: Studies have shown that Dihydroxyflavone can cross the blood-brain barrier and act as a neuroprotective ingredient [ 4 ].
• Alpha GPC: This is an ingredient that has been shown to protect against neurological decline [ 5 ].
• Lion’s Mane: This mushroom is common in nootropics and has been shown to improve mental performance and creativity [ 6 ].

A large part of improving mental health comes down to how focused and motivated you are with daily tasks. Our clients who tested the Thesis Motivation noted that it seemed to help them remain more motivated during workouts.

But this doesn’t seem to happen if you take it in the morning and go to the gym later in the day. So you’d need to get your timing right.

• L-Phenylalanine: Research has shown that this ingredient can help with signs of depression and improve overall mood [ 7 ].
• Dynamine: Also known as Methylliberine, studies have highlighted that it can impact your mental well-being when combined with caffeine [ 8 ].
• Forskolin: The interesting thing about this herbal ingredient is that it can improve blood flow to the brain for better focus and motivation [ 9 ].

For this product, we looked at what our clients noted in their journals when they were at work or studying. While they did find a boost in focus, none of them noted that it helped improve verbal fluency or problem-solving skills.

• Ginkgo Biloba: This is a common ingredient in traditional medicine, but modern clinical trials have shown that it can help brain health through improved blood flow and anti-inflammatory properties [ 10 ].
• Ashwagandha: This herb can have a direct impact on stress and memory, allowing you to think clearly and effectively [ 11 ].
• Saffron: It’s the most expensive herb in the world, and studies have linked it to improved stress, mood, and cognitive capacity [ 12 ].

A few of our clients tried the creativity blends, but this is one of the products where most of them didn’t report any significant improvements.

Combinations with other products above did positively impact mood and stress, but we couldn’t find any comments where our clients highlighted that they felt more creative in their work or any other creatively demanding context.

• Agmatine: This amino acid doesn’t just boost cognitive performance but may also help to protect brain cells against oxidative stress [ 13 ].
• Zembrin: Research has shown that this herb can impact both stress and anxiety, but there’s no specific evidence that it can help with creativity [ 14 ].
• Ginseng: This is a common ingredient in diet supplements as it can improve blood sugar levels, but that wouldn’t directly influence creativity [ 15 ].

We also asked all of our clients to provide any feedback they had on side effects related to the nootropic blends.

Overall, the majority of people found that it didn't cause any major issues.

We only noted that one person had a bit of a rash, which could have been a result of an allergic reaction to one of the ingredients.

We also found that it’s best not to take these capsules on an empty stomach. Ideally, take them within 20 minutes of eating a meal to avoid stomach upset.

Based on my personal experience, people who want to achieve a moderate boost in brain function may want to take nootropic supplements.

You would need to experiment with the timing as these capsules don’t provide effects for the entire day. But after about a week, you should be in a position to spread out the capsules for maximum effect.

You can also contact a coach directly for advice on timing. It's especially important when you have no prior experience in taking these supplements. However, a good starting point is to take the minimum and adjust from there.

Based on our own experience, people with high blood pressure or neurological diseases shouldn’t take Thesis natural nootropics to enhance cognitive function.

In such cases, it’s best to have a doctor review your detailed medical history and the nootropic ingredients for any potential side effects.

Our testing team didn’t note any improvements whatsoever, and when we specifically asked them after the trial, none of them said they saw a noticeable difference.

You can buy Thesis Nootropics directly from the company website.

We generally recommend avoiding third-party retailers to ensure that you always get the real product, so this is a positive highlight.

We placed two orders, and the package arrived within four days, which is about average for nootropic supplement companies.

One thing to point out on the Thesis supplements shipping policy is that currently, the company doesn’t offer international shipping.

We also had a look for other nootropic reviews online to see what users were saying.

“It gave me more energy. I have struggled with low energy and I felt like my old self again. I could get up & get things done.” - Laurie C., taketheseis.com

“After 1 month of using Energy, Creativity, Clarity and Logic pack, I do not note any difference in mindset. I opted for the non-caffeinated blends as I am not a big caffeine person to begin with so a caffeinated blend might show some improvement.” - Beefnug, Reddit

“I have been continuously nauseated every day using thesis packets. I have given it a week and a half and cannot handle the negative side effects. Disappointed.” - AdGroundbreaking5162, Reddit

Our Thesis scientific research suggests that it doesn’t compare well to our testing of three other products for improving cognitive function.

First of all, we looked at the results we have for Mind Lab Pro .

The one thing that stands out the most is that it seems to be effective for many more hours than Thesis, so the timing doesn’t become an issue.

The second one we compared is Onnit Alpha Brain . This nootropic supplement seems to provide a lot more focus and motivation, especially while you’re at the gym.

Compared to Gorilla Mind Smooth , Thesis doesn’t have the same effect on boosting energy and reducing stress.

Related Articles:

• Avantera Elevate Review
• Best Nootropics For Men
• Best Nootropics For Women

Is It Safe To Take Thesis Nootropics Every Day?

Yes, it is safe to take Thesis Nootropics every day. We found Thesis to be generally easy to process, but you need to look out for allergies to any of the ingredients. A good way to do this is to ask your physician for advice since they will know whether these ingredients are good for your health.

Does Thesis Nootropics Contain Banned Ingredients?

No, Thesis Nootropics doesn’t contain any banned ingredients. All of the ingredients are based on minerals, amino acids, and herbs that won’t cause a positive drug test result.

Based on our feedback from a nutritionist and the test results with 12 clients, we don't recommend Thesis.

Not only do its effects wear off after a few hours, which makes timing your intake a problem, but it also burns a hole in your pocket for just a stack of three or four products.

Instead, I highly recommend one of the best nootropic brands we have tested so far: Mind Lab Pro .

Our results show that its effects last for most of the day and provide great clarity, energy, focus, and concentration, making it a favorite among clients of all age groups.

We Recommend This Instead

Mind Lab Pro

• Great combination of herbs and amino acids that work as a cognitive enhancer
• Added B vitamins to support red blood cell production and boosted energy levels
• Great feedback from users that it can help with relieving anxiety
• Get the BEST PRICE until the end of April
• The capsules are not the smallest ones to swallow

About The Author

James Cunningham is an author and dietary supplement connoisseur with a solid academic foundation, holding a BSc in Sport & Exercise Science from the University of Hertfordshire. Specializing in Performance Psychology, his expertise is backed by both rigorous study and practical experience.

As an author, James is committed to guiding his readers towards optimal health and performance, providing actionable insights and strategies through his writings.

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• Ingredients

blends tailored to your unique needs.

Ingredients with purpose.

For all of our formulations, we source top-quality, vegan ingredients from around the world.

• GMP Certified
• Gluten Free

GINKGO BILOBA

Theobromine, l-phenylalanine, methylliberine, lion's mane mushroom, camellia sinensis tea leaf, vitamin b12, agmatine sulfate, n-acetyl cysteine, indian trumpet tree, phosphatidylserine, n-acetyl l-tyrosine, panax ginseng, high dha algae, ashwagandha root, dihydroxyflavone, uridine monophosphate, bacopa monnieri, magnesium bisglycinate, sceletium tortuosum, magnolia bark, ashwagandha leaf & root.

Key Focus Areas

• Visual Memory

Extracted from the leaves of the Ginkgo Biloba tree, which is native to China.

why we use it

Ginkgo Biloba has been studied for it's impact on dopamine in the prefrontal cortex. Increasing dopamine supports cognitive flexibility.

Highlighted Studies

Study 1 - Effects of Ginkgo biloba extract on cognitive control functions, mental activity of the prefrontal cortex and stress reactivity

Study 2 - Neuroregulatory role of ginkgolides

Study 3 - A double-blind, placebo-controlled, randomized trial of Ginkgo biloba extract

• Neurogenesis
• Neuroprotection

AlphaGrain™Alpha GPC 50% is a standardized form of Alpha GPC. It can be produced synthetically or naturally derived from some food sources, like eggs, dairy, meat, and fish.

Alpha GPC is a useable source of choline, which is used in the brain to make acetylcholine. Acetylcholine is the neurotransmitter primarily associated with learning and memory.

Study 1 - The effects of alpha-glycerylphosphorylcholine, caffeine or placebo on markers of mood, cognitive function, power, speed, and agility

Study 2 - Choline alphoscerate in cognitive decline and in acute cerebrovascular disease: an analysis of published clinical data

Study 3 - Quantitative electroencephalography changes in patients with mild cognitive impairment after choline alphoscerate administration

Citicoline is found in high concentrations in soybeans, animal products, eggs and fish.

Citicoline supports healthy cognitive function and is the building block of Acetylcholine a key neurotransmitter associated with learning and memory.

Study 1 - Citicoline and Memory Function

Study 2 - Citicoline and verbal memory in aging

Study 3 - Citicoline and the treatment of cognitive impairment

Theobromine is the primary alkaloid found in Cocoa.

Theobromine stimulates the release of dopamine and norepinephrine, which help maintain alertness and healthy energy levels. Theobromine is a molecule similar to caffeine, but has a slower onset and longer lasting effect.

Study 1 - Methylxanthines: the psycho-pharmacologically active constituents of chocolate

Study 2 - A study on Theobromine, and the up-regulation of cerebral brain-derived neurotrophic factor

Study 3 - A study on Theobromine and working memory (CaMKII/CREB/BDNF Pathway)

L-Phenylalanine is an essential amino acid found in high concentrations in meat, fish, eggs, soybeans, and cheese.

L-Phenylalanine is an amino acid that is a precursor of the excitatory neurotransmitters dopamine and norepinephrine.

Study 1 - Effects of tyrosine/phenylalanine depletion on electrophysiological correlates of memory

Study 2 - A study on DL-phenylalanine as an antidepressant

Study 3 - Behavioral and cognitive effects of tyrosine intake

Zynamite® is a standardized extract from Mangifera indica, commonly known as mango leaves.

Mangifera indica has been shown to support performance accuracy, information processing and memory in select clinical trials. Mango leaf extracts have been used for centuries to support healthy energy levels.

Study 1 - Acute Effects of a Polyphenol-Rich Leaf Extract of Mangifera indica L. (Zynamite) on Cognitive Function

Study 2 - Analysis of phenolic compounds in mango leaves varieties

Study 3 - Central nervous system activities of extract Mangifera indica L

Dynamine™ is a standardized molecule naturally found in coffee beans, tea, guarana, cocoa, and yerba mate.

Studies show that Dynamine™ has been found to support alertness, and maintain energy levels. Dynamine™ is an alkaloid compound that is structurally similar to caffeine.

Study 1 - Effects of caffeine, methylliberine, and theacrine on vigilance, marksmanship, and hemodynamic responses in tactical personnel: a double-blind, randomized, placebo-controlled trial

Study 2 - Supplementation with Methylliberine (Dynamine®) Alone and in Combination with TeaCrine®

Study 3 - A Combination of Caffeine, TeaCrine (Theacrine), and Dynamine (Methylliberine) Increases Cognitive Performance and Reaction Time Without Interfering With Mood in Adult Male Egamers

Lion’s Mane Mushrooms are native to Northern United States and Canada.

Studies have shown Lion's Mane may increase levels of Brain Derived Neutropic Factor. It has been studied for its ability to maintain cognitive performance and support memory.

Study 1 - Study on the effects of the mushroom Yamabushitake (Hericium erinaceus)

Study 2 - A study on Hericium erinaceus impact on Mood and Sleep

Study 3 - Study on cognitive functions by oral intake of Hericium erinaceus

Epicatechin is a molecule found in high concentration in green tea and dark chocolate.

Studies have shown Epicatechin to be a potent antioxidant that can pass the blood brain barrier. Antioxidants help neutralize oxidative stress which supports healthy cellular function.

Study 1 - The Impact of Epicatechin on Human Cognition: The Role of Cerebral Blood Flow

Study 2 - Green tea effects on cognition, mood and human brain function: A systematic review

Study 3 - Beneficial Effects of Green Tea Catechins on Neurodegenerative Diseases

• Nerve Health
• Cellular Function

Methylcobalamin is a bioavailable form of Vitamin B12 that can be man-made or found in high concentrations of animal protein.

Vitamin B12 is known to support energy levels and is essential for nerve health. Studies have shown deficiencies in B12 can lead to decreased cognitive function.

Study 1 - Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue

Study 2 - Neurological symptoms of vitamin B12 deficiency

Study 3 - Vitamin B12 deficiency: case report and review of literature

Agmatine Sulfate is naturally produced by bacteria, plants, and human cells.

Agmatine Sulfate is an amino acid derived from L-arginine that has been studied for its ability to block acetylcholine receptors in the adrenal glands.

Study 1 - Neuroprotective offerings by agmatine

Study 2 - Agmatine, a potential novel therapeutic strategy for depression

Study 3 - Neuroprotective Role of Agmatine in Neurological Diseases

TeaCrine® is a standardized alkaloid naturally found in the plant Cupuaçu, related to the cacao tree.

Research indicates TeaCrine® increases activity in the nucleus accumbens (NAc) region of the brain, which is believed to support motivation and and maintain healthy cognitive function.

Study 1 - Safety of TeaCrine®, a non-habituating, naturally-occurring purine alkaloid over eight weeks of continuous use

Study 2 - Cognitive Performance and Mood Following Ingestion of a Theacrine

Study 3 - The effects of TeaCrine® and caffeine on endurance and cognitive performance during a simulated match in high-level soccer players

• Cellular function

Cysteine is found in most high-protein foods, like turkey, yogurt, eggs, sunflower seeds and legumes.

Studies have shown NAC may increase levels of glutathione, which help regulate the neurotransmitter glutamate, as well as support detoxification.

Study 1 - A study on N-Acetyl Cysteine and it's function as a Fast-Acting Antioxidant

Study 2 - Therapeutic potential of N-acetylcysteine

Study 3 - A study on N-acetylcysteine and selective protection of cerebellar granule cells

Sabroxy®is a standardized extract from the bark of Oroxylum Indicum, the Indian trumpet tree.

Oroxylum Indicum acts as a dopamine reuptake inhibitor, which maintains healthy dopamine levels and supports memory consolidation.

Study 1 - Effects of an Oroxylum indicum Extract (Sabroxy®) on Cognitive Function in Adults With Self-reported Mild Cognitive Impairment

Study 2 - Oroxylum indicum (L.) extract and human neuroblastoma

Study 3 - Systematic Elucidation of the Mechanism of Oroxylum indicum via Network Pharmacology

Made from the root of a plant in the mint family, Forskolin grows in Nepal, India, and Thailand.

Studies have shown that Forskolin increases cellular levels of a molecule called cyclic adenosine monophosphate, or cAMP. Forskolin maintains healthy blood flow to the brain.

Study 1 - Cerebral blood flow regulation and cognitive function: a role of arterial baroreflex function

Study 2 - Body composition and hormonal adaptations associated with forskolin consumption

Study 3 - Effects of forskolin on cerebral blood flow

A naturally occurring phospholipid, our Phosphatidylserine is from sunflowers.

Studies have shown this supplement to maintain memory formation and support the body's cortisol response.

Study 1 - The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder

Study 2 - Effects of phosphatidylserine in age-associated memory impairment

Study 3 - Positive effects of soy lecithin-derived phosphatidylserine plus phosphatidic acid on memory, cognition, daily functioning, and mood in elderly patients

Artichoke leaves and roots.

Studies have shown Artichoke extract blocks an enzyme called phosphodiesterase IV which supports healthy blood flow. Flavonoids like those found in Artichoke extract are antioxidants.

Study 1 - The role of luteolin against cognitive dysfunction

Study 2 - Phosphodiesterase Inhibitors as a Therapeutic Approach to Neuroprotection and Repair

Study 3 - A study on Luteolin, long-term potentiation and cognitive function

High concentrations in animal protein, dairy products, and whole grains.

Tyrosine is an amino acid precursor to the excitatory neurotransmitters, dopamine and norepinephrine.

Study 1 - Influence of nutritional tyrosine on cognition and functional connectivity

Study 2 - Effect of tyrosine supplementation

Study 3 - A study on Tyrosine benefits cognitive and psychomotor performance during body cooling

GS15-4® is a standardized extract from Panax Ginseng, a root native to Eastern Russian, Northeast China, and the Korean Peninsula.

Studies have shown the active components of Panax Ginseng, Ginsenosides, to support the expression of acetylcholine in the brain, which maintains learning and memory.

Study 1 - Benefits of American Ginseng on mood and cognition in healthy young adults

Study 2 - Efficacy of Omega-3 and Korean Red Ginseng in Children with Subthreshold ADHD

Study 3 - Panax ginseng enhances cognitive performance in Alzheimer disease

AvailOm® is a standardized form of DHA, an omega-3 fatty acid derived from algae.

DHA is a complex fatty acid molecule crucial for it's role in supporting neurological development and maintaining brain health.

Study 1 - Omega-3 supplementation improves cognition and modifies brain activation in young adults

Study 2 - Dietary DHA and health: cognitive function ageing

Study 3 - Supplementation with DHA and the psychological functioning of young adults

KSM-66® is a standardized extract found in high concentrations of the Ashwagandha root.

Ashwagandha modulates our body’s stress response to cortisol. This non-sedating modulation supports calm in stressful situations. Ashwagandha roughly translates to the “smell and strength of a horse!”

Study 1 - Clinical evaluation of the pharmacological impact of ashwagandha root extract

Study 2 - Efficacy and Safety of Ashwagandha

Study 3 - Ashwagandha Root Extract: A Double-Blind, Randomized, Placebo-Controlled Trial

7,8 Dihydroxyflavone is a flavone molecule found in the plants Godmania aesculifolia, Tridax procumbens, and in Primula tree leaves.

Studies have shown 7,8 Dihydroxyflavone can cross the blood brain barrier and bind to TrkB receptors. TrkB is a receptor for brain-derived neurotrophic factor.

Study 1 - 7,8-dihydroxyflavone as a promising nutraceutical against CNS disorders

Study 2 - 7,8-Dihydroxyflavone and Neuropsychiatric Disorders

Study 3 - 7,8-Dihydroxyflavone as a pro-neurotrophic treatment for neurodevelopmental disorders

Uridine is found in foods such as fish, walnuts, broccoli, and tomatoes.

Uridine is needed to build the cell membrane of our nerve cells and produce choline. It also supports neurotrophic factors BDNF and NGF, which maintains healthy cognitive function.

Study 1 - Triacetyluridine (TAU) study on depressive symptoms, brain pH

Study 2 - Oral uridine and neuroprotection

Study 3 - Study on Oral uridine pro-drug PN401, neurodegeneration, behavioral impairment

Synapsa® is a standardized extract of the Bacopa Monnieri plant. It has a wide range of active constituents that contribute to its therapeutic properties.

Bacopa is one of the most studied nootropics. Traditionally, Bacopa Monnieri Extract is used to support cognitive function as well as overall brain health.

Study 1 - Effects of a standardized Bacopa monnieri extract on cognitive performance

Study 2 - The cognitive-enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials

Study 3 - Bacopa monnieri on memory performance

Affron® is a standardized extract from saffron, originating from the flower Crocus Sativus.

Saffron has been studied for it's ability to modulate the amount of serotonin available in the brain. Serotonin is a primary neurotransmitter involved in mood regulation. Saffron is the world's most expensive spice. The flowers must be hand picked, and it takes approximately 70,000 flowers to harvest a single pound of saffron stigmas.

Study 1 - Effects of Saffron Extract Supplementation on Mood, Well-Being, and Response to a Psychosocial Stressor in Healthy Adults: A Randomized, Double-Blind, Parallel Group, Clinical Trial

Study 2 - A meta-analysis of randomized clinical trials

Study 3 - Saffron: A Natural Potent Antioxidant

• Neuroplasticity

A highly absorbable form of magnesium that has been shown to activate the glycine receptor, an inhibitory neurotransmitter that promotes calming effects on the brain and body.

Studies have shown magnesium may support mood, sleep, and fight oxidative stress.

Study 1 - Magnesium in drug dependences

Study 2 - The effect of vitamin D and magnesium supplementation

Study 3 - Study on Magnesium supplementation

Salvia Officinalis, more commonly known as Sage, is an herb native to the Middle East and Mediterranean areas. This herb has a long history of use in traditional medicine.

Sage has studied as an antioxidant and for its ability to modulate GABA neurotransmission. GABA is the neurotransmitter known for calm and feelings of relaxation.

Study 1 - An extract of Salvia (sage) with anticholinesterase properties improves memory and attention in healthy older volunteers

Study 2 - Effects of cholinesterase inhibiting sage (Salvia officinalis) on mood, anxiety and performance on a psychological stressor battery

Study 3 - Differential effects of the aromas of Salvia species on memory and mood

Zembrin® is a standardized extract of the South African plant Sceletium Tortuosum.

Studies have shown Zembrin® supports serotonin which regulates mood.

Study 1 - Sceletium tortuosum (Zembrin® ) ameliorates experimentally induced anxiety in healthy volunteers

Study 2 - Acute effects of Sceletium tortuosum (Zembrin), a dual 5-HT reuptake and PDE4 inhibitor, in the human amygdala and its connection to the hypothalamus

Study 3 - Ergogenic Effects of 8 Days of Sceletium Tortuosum Supplementation on Mood, Visual Tracking, and Reaction

DHH-B is a natural derivative of Magnolia Tree Bark and has been used traditionally in medicinal practices throughout much of Southeast Asia.

Magnolia Bark has been studied for it's ability to support the body’s stress response to cortisol. Cortisol is known as the body's stress hormone.

Study 1 - Honokiol: A review of its pharmacological potential and therapeutic insights

Study 2 - The Neuropharmacological Effects of Magnolol and Honokiol: A Review of Signal Pathways and Molecular Mechanisms

Study 3 - Anxiolytic-like effect of dihydrohonokiol following behavioural and biochemical assessments

Shoden® is the standardized, high potency extract from the leaves and roots of the Ashwagandha plant.

Shoden® is a highly bioavailable adaptogen. Adaptogens mimic the body’s own stress-reducing hormones, increasing the body’s ability to recover from stress and feeling of balance.

Study 1 - Efficacy and Safety of Ashwagandha Root Extract in Improving Memory and Cognitive Functions

Study 2 - An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study

Study 3 - Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: A double-blind, randomized, parallel-group, placebo-controlled study

Coffee, tea, cacao, yerba mate, and guarana berries.

Caffeine blocks adenosine molecules from their receptor. When this occurs more dopamine and norepinephrine are released from our neurons. Caffeine is commonly associated with maintaining healthy energy levels.

Study 1 - Effects of Caffeine on reaction time, vigilance and logical reasoning during extended periods with restricted opportunities for sleep

Study 2 - Study on the combination of L-theanine and caffeine across cognitive performance and subjective alertness

Study 3 - Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects

• Reaction time

L-Theanine is found in fairly high concentrations in green tea, and can also be found in several mushroom species.

L-Theanine has been taken alongside caffeine for centuries to minimize jitters, so we include it in our caffeinated formulations.

Study 1 - L-Theanine and the psychological and physiological stress responses

Study 2 - Impact of the combination of L-theanine and caffeine on cognitive performance and subjective alertness

Study 3 - The effects of L-theanine, caffeine and their combination on cognition and mood

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REAL TIME VC & PRIVATE EQUITY DEALS AND NEWS

Mezo Raises $21M in Funding

Mezo, a permissionless Bitcoin Economic Layer launched by Thesis , a NYC-based venture studio funding and building brands on Bitcoin, with $21M in funding.

The round was led by Pantera Capital with participation from Multicoin, Hack VC, ParaFi Capital, Nascent, Draper Associates, Primitive Ventures, Asymmetric Ventures and Dan Held, DCF God – among others.

The company intends to use the funds to expand operations and development efforts.

Founded by Matt Luongo, CEO, Mezo is a permissionless Bitcoin Economic Layer leveraging a neutral smart contract infrastructure to offer a more diverse range of user-centric applications. It is Bitcoin native, facilitating cheap and fast transactions for a variety of relevant use cases. This enhances the network’s resilience and ensures it serves the broader economic ambitions of Bitcoin holders.

By leveraging Proof of HODL, Mezo puts HODLers to work. The longer their bitcoin deposits are locked up, the greater their HODL Score multipliers. For the participant’s role in securing the network, Mezo provides yield. When users join Mezo, they will receive 5 one-time invitations to share with friends so they can begin earning in tandem. Reciprocal earnings gained from inviting friends to HODL will be based on the duration and size of their bitcoindeposits.

Mezo will go live with ecosystem support from Thesis-built tBTC, which allows for trust-minimized bitcoin bridging to numerous ecosystems.