pediatric review international journal of pediatric research

Indexing & Abstracting

Pediatrics Review: International Journal of Pediatrics Research is constantly upgrading its indexing and abstracting in various agencies. Regular efforts are made to archive published manuscripts in various archiving platforms which are authenticate.

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• Study of C-reactive protein in healthy neonates 1631
• Effect of Gayatrimantra chanting on cognitive functions in school children 1012
• Astudy of knowledge about immunization amongst mothers of children below 5 years of age 913
• Effect of L- Carnosine, DHA and vitamin D3 on children with down’s syndrome- a pilot study on Indian population 815
• Effect of dengue fever on the total leucocyte count and neutrophil count in children in early febrile period 748

Ahead of Print

• Journal History
• Free-of-Charge Publication
• Abstracting And Indexing
• Digital Archiving and Preservation Policy
• Aims and Scope
• Editorial Board
• Scientific Advisory Board
• Instructions to Authors
• Ethical Policy
• Author Index
• Ege University Faculty of Medicine Department of Pediatrics Web Page

The Journal of Pediatric Research is an official peer-reviewed publication of Ege University Faculty of Medicine, Department of Pediatrics and Ege Children’s Foundation. This publication organ is responsible for the issue of unique clinical and laboratory research papers, case reports, reviews directly or indirectly related to children’s health and diseases. The publication language of the journal is  English.

The Journal of Pediatric Research does not charge any article submission or processing charges.

The abbreviation of The Journal of Pediatric Research is JPR; however, it should be denoted as J Pediatr Res when referenced. In the international index and database, the name of the journal has been registered as The Journal of Pediatric Research and abbreviated as J Pediatr Res. A manuscript will be considered only with the understanding that it is an original contribution that has not been published elsewhere. All manuscripts submitted to the journal for publication are peer-reviewed. Authors shall be informed within a period of 8 weeks about the process. Upon review, those manuscripts, which are accepted, shall be published in the journal and issued on the http://www.jpedres.org official website.

The scientific and ethical liability of the manuscripts belongs to the authors, and the copyright of the manuscripts belongs to the JPR. Authors are responsible for the contents of the manuscript and the accuracy of the references. All manuscripts submitted for publication must be accompanied by the Copyright Transfer Form. Once this form, signed by all the authors, has been submitted, it is understood that neither the manuscript nor the data it contains have been submitted elsewhere or previously published and authors declare the statement of scientific contributions and responsibilities of all authors.

All manuscripts submitted to the Journal of Pediatric Research are screened for plagiarism using the ‘iThenticate’ software. Results indicating plagiarism may result in manuscripts being returned or rejected.

Experimental, clinical and drug studies requiring approval by an ethics committee must be submitted to The Journal of Pediatric Research with an ethics committee approval report confirming that the study was conducted in accordance with international agreements and the Declaration of Helsinki (revised 2013) . The approval of the ethics committee and the fact that informed consent was given by the patients should be indicated in the Materials and Methods section. In experimental animal studies, the authors should indicate that the procedures followed were in accordance with animal rights as per the Guide for the Care and Use of Laboratory Animals , and they should obtain animal ethics committee approval.

Authors must provide disclosure/acknowledgment of financial or material support, if any was received, for the current study.

If the article includes any direct or indirect commercial links or if any institution provided material support to the study, authors must state in the cover letter that they have no relationship with the commercial product, drug, pharmaceutical company, etc. concerned; or specify the type of relationship (consultant, other agreements), if any.

Authors must provide a statement on the absence of conflicts of interest among the authors and provide authorship contributions.

The Journal of Pediatric Research is an independent international journal based on double-blind peer-review principles. The manuscript is assigned to the Editor-in-Chief, who reviews the manuscript and makes an initial decision based on manuscript quality and editorial priorities. Manuscripts that pass initial evaluation are sent for external peer review, and the Editor-in-Chief assigns an Associate Editor. The Associate Editor sends the manuscript to reviewers (internal and/or external reviewers). The reviewers must review the manuscript within 21 days. The Associate Editor recommends a decision based on the reviewers’ recommendations and returns the manuscript to the Editor-in-Chief. The Editor-in-Chief makes a final decision based on editorial priorities, manuscript quality, and reviewer recommendations. If there are any conflicting recommendations from reviewers, the Editor-in-Chief can assign a new reviewer.

The scientific board guiding the selection of the papers to be published in the Journal consists of elected experts of the Journal and, if necessary, selected from national and international authorities. The Editor-in-Chief, Associate Editors, biostatistics expert and English language consultant may make minor corrections to accepted manuscripts that do not change the main text of the paper.

In case of any suspicion or claim regarding scientific shortcomings or ethical infringement, the Journal reserves the right to submit the manuscript to the supporting institutions or other authorities for investigation. The Journal accepts the responsibility of initiating action but does not undertake any responsibility for an actual investigation or any power of decision.

The Editorial Policies and General Guidelines for manuscript preparation specified below are based on “ Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals (ICMJE Recommendations) ” by the International Committee of Medical Journal Editors (2016, archived at.

The presentation of the article types must be designed in accordance with trial reporting guidelines:

Human research: Helsinki Declaration as revised in 2013

Systematic reviews and meta-analyses: PRISMA guidelines

Case reports: the CARE case report guidelines

Clinical trials: CONSORT

Animal studies: ARRIVE and Guide for the Care and Use of Laboratory Animals

GENERAL GUIDELINES

Manuscripts can only be submitted electronically through the Journa lAgent online manuscript system after creating an account. This system allows online submission and review.

The manuscripts are archived according to  Web of Science-Emerging Sources Citation Index (ESCI), Directory of Open Access Journals (DOAJ), EBSCO, British Library, CINAHL Complete Database, ProQuest, Gale/Cengage Learning, Tübitak/Ulakbim TR Index, TurkMedline, J-GATE, IdealOnline, Hinari, GOALI, ARDI, OARE, AGORA  and  Türkiye Citation Index.

The  ORCID  (Open Researcher and Contributor ID) number of the correspondence author should be provided while sending the manuscript. A free registration can be created at  http://orcid.org .

Format:  Unique research papers cover clinical research, observational studies, novel techniques, and experimental and laboratory studies. Unique research papers shall consist of a heading, abstract, keywords related to the main topic of the paper, introduction, materials and methods, results, discussion, acknowledgements, bibliography, tables and figures. Manuscripts should be prepared using 12 pt “Times New Roman” and 1.5 line spacing. The text shall not exceed 2500 words. Case reports must contain rare cases or those that are unique in diagnosis and treatment, those which contribute to current knowledge and provide educational information, along with the introduction, case reporting and discussion sections. The whole text must not exceed 1500 words. Reviews are texts in which a current subject is examined independently, with reference to scientific literature. The whole text must not exceed 18 A4 paper sheets. Letters to the Editor must be manuscripts, which do not exceed 1000 words, with reference to scientific literature, and those written in response to issued literature or those which include development in the field of paediatrics. These manuscripts do not contain an abstract. The number of references is limited to 5.

Abbreviations:  Abbreviations should be defined at first mention and used consistently thereafter. Internationally accepted abbreviations should be used; refer to scientific writing guides as necessary.

Cover letter:  The cover letter should include statements about manuscript type, single-journal submission affirmation, conflict of interest statement, sources of outside funding, equipment (if applicable), approval of language for articles in English and approval of statistical analysis for original research articles.

Authors are solely responsible for the accuracy of all references.

In-text citations : References shall be listed as the below formats on a separate page according to their sequence within the text and referred to within the text in parentheses.

Presentations presented in congresses, unpublished manuscripts, theses, Internet addresses, and personal interviews or experiences should not be indicated as references. If such references are used, they should be indicated in parentheses at the end of the relevant sentence in the text, without reference number and written in full in order to clarify their nature.

References section:  All author names shall be stated within all references. References shall be listed as the below formats on a separate page according to their sequence within the text and referred to within the text in parentheses. However, in studies where author numbers exceed 6, names of the first 3 authors shall be stated;“et al.” additions shall be made to the list of authors in English references, respectively. The titles of journals should be abbreviated according to the style used in the Index Medicus.

Reference Format

Journal : Last name(s) of the author(s) and initials, article title, publication title and its original abbreviation, publication date, volume, the inclusive page numbers.

Example : Koening JQ. Airpollutionandasthma. J Allergy Clin Immunol 1999; 104:717-22.

Book : Last name(s) of the author(s) and initials, chapter title, book editors, book title, edition, place of publication, date of publication and inclusive page numbers of the extract cited.

Example : Fletcher CDM, Unni KK, Mertens F. Genetics of Tumours of Soft Tissue and Bone. Lyon, France, IARC Press, 2002. p. 225-419.

Book Chapter : Last name(s) of the author(s) and initials, chapter title, book editors, book title, edition, place of publication, date of publication and inclusive page numbers of the cited piece.

Example : Whitsett JA, Pryhuber GS, Rice WR. Acuteres piratory disorders. In: Avery GB, Mac- Donald MG (eds). Neonatology: Pathophysiology and Management of the Newborn, 5th ed. Philadelphia, Lippincott Williams & Wilkins, 1999;505-15.

TABLES, GRAPHICS, FIGURES, AND IMAGES

All visual materials, together with their legends, should be located on separate pages that follow the main text. Original documents such as films, ECG records must not be delivered. All cost related to colored printouts shall be covered by the authors’ own expenses.

Images:  Images (pictures) should be numbered and include a brief title. Permission to reproduce pictures that were published elsewhere must be included. All pictures should be of the highest quality possible, in JPEG format, and at a minimum resolution of 300 dpi.

Tables, Graphics, Figures:  All tables, graphics, or figures should be enumerated according to their sequence within the text, and a brief descriptive caption should be written. Tables shall be numbered by Roman numerals (I, II) according to their sequence and shall include a heading. Figures shall be numbered by Arabic numerals (1,2) according to their sequence.  Any abbreviations used should be defined in the accompanying legend. Tables, in particular, should be explanatory and facilitate readers’ understanding of the manuscript and should not repeat data presented in the main text. A maximum of 2 figures or photographs shall be added to case reports.

BIOSTATISTICS

To ensure controllability of the research findings, the study design, study sample, and the methodological approaches and applications should be explained, and their sources should be presented.

The “p” value defined as the limit of significance along with appropriate indicators of measurement error and uncertainty (confidence interval, etc.) should be specified. Statistical terms, abbreviations and symbols used in the article should be described, and the software used should be defined.

Statistical terminology (random, significant, correlation, etc.) should not be used in non-statistical contexts.

All results of data and analysis should be presented in the Results section as tables, figures and graphics; biostatistical methods used and application details should be presented in the Materials and Methods section or under a separate title.

MANUSCRIPT TYPES

Original articles.

Unique research papers cover clinical research, observational studies, novel techniques, and experimental and laboratory studies. Unique research papers shall consist of a heading, abstract, keywords related to the main topic of the paper, introduction, materials and methods, results, discussion, acknowledgements, bibliography, tables and figures. The text shall not exceed 2500 words. Case reports must contain rare cases or those that are unique in diagnosis and treatment, those which contribute to current knowledge and provide educational information, along with the introduction, case reporting and discussion sections. The whole text must not exceed 1500 words. Reviews are texts in which a current subject is examined independently, with reference to scientific literature. The whole text must not exceed 18 A4 paper sheets. Letters to the Editor must be manuscripts, which do not exceed 1000 words, with reference to scientific literature, and those written in response to issued literature or those which include development in the field of paediatrics. These manuscripts do not contain an abstract. The number of references is limited to 5.

Title Page:  This page should include the title of the manuscript, short title, name(s) of the authors and author information. The following descriptions should be stated in the given order:

1. Title of the manuscript as concise and explanatory as possible, including no abbreviations, up to 135 characters

2. Short title up to 60 characters

3. Name(s) and surname(s) of the author(s) (without abbreviations and academic titles) and affiliations

4. Name, address, e-mail, phone and fax number of the corresponding author

5. The place and date of the scientific meeting in which the manuscript was presented and its abstract published in the abstract book, if applicable

Abstract: A summary of the manuscript should be written in English. References should not be cited in the abstract. The use of abbreviations should be avoided as much as possible; if any abbreviations are used, they must be taken into consideration independently of the abbreviations used in the text.

For original articles, the structured abstract should include the following sub-headings:

Aim:  The aim of the study should be clearly stated.

Materials and Methods:  The study and standard criteria used should be defined; it should also be indicated whether the study is randomized or not, whether it is retrospective or prospective, and the statistical methods applied should be indicated, if applicable.

Results:  The detailed results of the study should be given, and the statistical significance level should be indicated.

Conclusion : Should summarize the results of the study, the clinical applicability of the results should be defined, and the favorable and unfavorable aspects should be declared.

Keywords:  A list of minimum 3, but no more than 5 keywords must follow the abstract. Keywords in English should be consistent with “ Medical Subject Headings (MESH) ”.

Original research articles should have the following sections:

Introduction:  Should consist of a brief explanation of the topic and indicate the objective of the study, supported by information from the literature.

Materials and Methods:  The study plan should be clearly described, indicating whether the study is randomized or not, whether it is retrospective or prospective, the number of trials, the characteristics, and the statistical methods used.

Results : The results of the study should be stated, with tables/figures given in numerical order; the results should be evaluated according to the statistical analysis methods applied. See General Guidelines for details about the preparation of visual material.

Discussion : The study results should be discussed in terms of their favorable and unfavorable aspects and they should be compared with the literature. The conclusion of the study should be highlighted.

Study Limitations : Limitations of the study should be discussed. In addition, an evaluation of the implications of the obtained findings/results for future research should be outlined.

Conclusion : The conclusion of the study should be highlighted.

Acknowledgements : Any technical or financial support or editorial contributions (statistical analysis, English evaluation) towards the study should appear at the end of the article.

References : Authors are responsible for the accuracy of the references. See General Guidelines for details about the usage and formatting required.

Case Reports

Case reports should present cases that are rarely seen, feature novelty in diagnosis and treatment, and contribute to our current knowledge. The first page should include the title in English, an unstructured summary not exceeding 50 words, and keywords. The main text should consist of an introduction, case report, discussion and references. The entire text should not exceed 1500 words (A4, formatted as specified above). A maximum of 10 references shall be used in case reports.

Review Articles

Review articles can address any aspect of clinical or laboratory pediatry. Review articles must provide critical analyses of contemporary evidence and provide directions for future research. The journal only accepts and publishes invited reviews. Before sending a review, a discussion with the editor is recommended.

Reviews articles analyze topics in depth, independently and objectively. The first chapter should include the title in English, an unstructured summary and keywords. Source of all citations should be indicated. The entire text should not exceed 18 pages (A4, formatted as specified above).

Letters to the Editor

Letters to the Editor should be short commentaries related to current developments in pediatrics and their scientific and social aspects or may be submitted to ask questions or offer further contributions in response to work that has been published in the Journal. Letters do not include a title or an abstract; they should not exceed 1.000 words and can have up to 5 references.

COMMERCIALIZATION

Commercialization issues shall be discussed with the editor. It is possible to include an advertisement on the outer and inner pages of the journal.

All copyright of the journal belongs to the related institutions.

The Journal of Pediatric Research is the publication organ of Ege University Faculty of Medicine Department of Pediatrics, supported by Ege Children’s Foundation (EÇV).

Correspondence

Prof. Dr. Özgür Çoğulu

Ege University Faculty of Medicine, Department of Pediatrics, Bornova, 35100 İzmir/Turkey Phone:  +90 232 390 10 05 - 390 10 31 Fax:  +90 232 390 13 57 E-mail:   [email protected]

Galenos Publishing House

Address: Molla Gürani Mahallesi Kaçamak Sokak No: 21 34093 Fındıkzade - İstanbul/Turkey Phone: +90 (212) 621 99 25 E-mail: [email protected]

About The Journal

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Welcome to Pediatric Research

The official publication of the American Pediatric Society, the European Society for Paediatric Research, and the Society for Pediatric Research

• Olaf Dammann
• Cynthia F. Bearer

Assessment of hemodynamic dysfunction in septic newborns by functional echocardiography: a systematic review

• Flaminia Pugnaloni
• Domenico Umberto De Rose
• Cinzia Auriti

Maximizing the impact of reach out and read literacy promotion:anticipatory guidance and modeling

• Manuel E. Jimenez
• Nila Uthirasamy
• Alan L. Mendelsohn

Hydrogen gas can ameliorate seizure burden during therapeutic hypothermia in asphyxiated newborn piglets

• Toui Tsuchiya
• Shinji Nakamura
• Takashi Kusaka

Current issue

Editor’s focus, why pediatric research needs “insights”.

• Cynthia Bearer

How many times must a man look up before he can see the sky?

• Roser Porta
• Sergio Verd
• Gemma Ginovart

Pediatric produce prescription initiatives in the U.S.: a scoping review

• Hemen Muleta
• Laura K. Fischer

Neonatal sepsis and cardiovascular dysfunction I: mechanisms and pathophysiology

• Sophie M. Duignan
• Satyan Lakshminrusimha
• Agnes van den Hoogen

Effect of psychostimulant medications on physical function in children with cerebral palsy: scoping review

• Anwar B. Almutairi
• Naif Z. Alrashdi
• Mansour M. Alotaibi

Announcements

New manuscript submission process.

The Editors-in-Chief of Pediatric Research are excited to announce that starting February 1st, 2024 we will update our new manuscript submission workflow in favor of a streamlined process.

PAS 2024 Schedule

The Editors-in–Chief of Pediatric Research are excited to announce the following events at PAS 2024 in Toronto, Canada. We hope to see you there!

Annual Review Issue 2025– Call for Proposals

Deadline for proposals: April 15, 2024! The Editors-in-Chief of Pediatric Research announce the topic of the 2025 Annual Review Issue, entitled “Genomics in Child Health”.

April : What's hot in Endocrinology? Listen by clicking the link above.

Guide to Authors

International Pediatric Research Foundation

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A complex inflammatory mix: chorioamnionitis, antenatal steroids and early postnatal budesonide

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Habits that might seriously damage preterm infants’ kidneys

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Risk of traumatic brain injury among patients with ADHD and their unaffected siblings

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Social factors and health: pathways and promise

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Endoplasmic reticulum stress is attenuated by glycolysis in lymphatic malformations

• Wenqun Zhong

Meeting the need for effective and standardized neonatology training: a pan-European Master’s Curriculum

• Deanna Santoro
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Nutritional interventions to prevent retinopathy of prematurity

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Pediatric Review: International Journal of Pediatric Research

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Introduction: Hypoxic Ischaemic Encephalopathy (HIE) following perinatal asphyxia, due to cerebral hypoxia is an important cause of neonatal morbidly and mortality. Hypoxia causes cell death in various tissues like liver, kidney and muscles also. The leakage of enzymes from the dying cells causes elevation of Lactate Dehydrogenase (LDH), Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST) etc. Aim: To investigate whether serum LDH, ALT and AST levels in the first 12 hours of birth can be used as a predictor of severe HIE and/or the neurodevelopmental outcome at one year of age. Materials and Methods: A prospective longitudinal diagnostic test evaluation was done on in neonates with perinatal asphyxia admitted in a tertiary level neonatal intensive care unit in South India from March 2014 to September 2015 (18 months). Blood was collected for assay of LDH, AST and ALT within the first 12 hours of life. They were staged using the Levene's modification of Sarnat and...

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Hypoxic-ischemic encephalopathy (HIE) due to perinatal asphyxia remains an important cause of neonatal morbidity and mortality. The aim of this study was to investigate the predictive values of biochemical parameters, including serum creatine kinase (CK), lactate dehydrogenase (LDH), uric acid (UA), and lactate, in newborns with HIE. A total of 94 patients who were diagnosed with HIE were prospectively enrolled into the study. According to the Sarnat and Sarnat classification, 29 (30.9%) patients had Stage I, 36 (38.3%) Stage II, and 29 (30.9%) Stage III HIE. When CK, LDH, UA, and lactate were used together in order to determine the stage of HIE, specificity and sensitivity were calculated to be 87% and 94%, respectively. Measurement of serum CK, LDH, lactate, and UA levels together is a promising method in determining the stage of hypoxia in the laboratory before clinical manifestations occur so that hypothermia treatment can be initiated earlier.

Experimental and Therapeutic Medicine

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Abstract PURPOSE: To study temporal pattern of serum liver enzymes levels in newborns with hepatic injury associated with birth asphyxia (BA). METHODS: Singleton term newborns with BA and ≤72 hours of age admitted to neonatal intensive care unit were prospectively enrolled. Term newborns with physiological jaundice and without BA were studied as controls. Serum liver enzymes were measured at <24 hours, 24-72 hours, and at 6-12 days of age for cases and at 1-6 days of age for controls. BA was defined by 1 minute Apgar score <7 or delayed or absent cry with hypoxic ischemic encephalopathy. BA-associated liver injury was defined as serum alanine aminotransferase (ALT) elevation beyond +2 standard deviation (ALT > +2 SD) above the mean of control subjects at any of the three time points. RESULTS: Sixty controls and 62 cases were enrolled. Thirty-five cases (56%) developed BA-associated liver injury (ALT>81 IU/L). They had higher serum levels of ALT, aspartate aminotransferase, lactate dehydrogenase than the control infants, with peak at 24-72 hours. In controls, serum liver enzyme levels were significantly higher in appropriate-for-date (AFD) babies than small-for-date (SFD) babies. Serum enzyme pattern and extent of elevation were comparable between SFD and AFD babies. Degree of serum liver enzyme elevation had no relationship with severity of hypoxic encephalopathy. CONCLUSION: Serum liver enzyme elevation is common in BA; it peaks at 24-72 hours followed by a sharp decline by 6-12 days of age. Pattern and extent of enzyme elevation are comparable between SFD and AFD babies. KEYWORDS: Asphyxia neonatorum; Hepatitis; Ischemia; Transaminases

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