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Microbiology topics are some of the most researched ideas. This field entails the study of different microorganisms, ranging from eukaryotic fungi and single-celled organisms to cell-cluster organisms. When pursuing a microbiology course in a university or college, your educators will ask you to write academic papers on microbiology research topics.

Choosing the right microbiology topics to write about is essential because it determines the direction of your research and writing processes. Therefore, take your time to identify a topic you will be comfortable working with from the beginning to the end.

Current Topics in Microbiology and Immunology

Maybe you want to research and write about current topics in microbiology and immunology. That means you’re looking for topics that will enable you to explore recent information in this area. In that case, consider these microbiology topics in the news.

Virus-like particle vaccines for protozoan parasites and respiratory viruses
Quorum sensing and campylobacter biofilm formation in molecular mechanisms
Campylobacter horizontal gene and natural competence transfer
Murine investigation models for innate immune response and colonization resistance in campylobacter jejuni infections
iBALT role in respiratory immunity
Antiviral immunity for pyroptosis
Damage to the sensing tissue by Myeloid c-Type Lectin receptors
How antifungal drugs modify the cell wall
Host cell’s death pathways manipulation by the Herpes Simplex virus
Type II Secretion system structures in needle filaments
RIP Kinase signaling outcomes during neuro-invasive infection by virus
Innate immune system pathological and physiological functions of CARD 9 signaling
The genetics of the Lassa virus
Genital immunity’s memory lymphocyte- Tissue-resident memory T cells’ role
Delivery and formulation technologies for the mRNA vaccines
Peptide and protein nanocluster vaccines
Reovirus’ cell killing- Consequences and mechanisms
Leptospirosis reference lab’s role
Hypoxia-inducible and hypoxia factors in stem cell maintenance among cancer patients
Development of dengue vaccine

Pick any of these new research topics in microbiology if your goal is to work on recent information. Nevertheless, take your time reading recent literature in this field to come up with an awesome paper.

Interesting Topics in Microbiology

Perhaps, you’re looking for microbiology projects topics that most people will find interesting to read about. In that case, consider these interesting microbiology topics.

Techniques and methodologies for future research about the virus
Redox-active metabolite’s roles in microbial signaling
The role and emergence of yeast as a baking industry’s preservative
Host-pathogenic interactions study with a focus on redox and cellular metals
Yeast non-conventional use in the wine-making industry
Microbiota- What is the bifidobacterila’s role in the human gut?
Virus role in vaccines development and improvement in third world countries
Heath- Microbiology role in addressing antibiotic resistance
Human microbial ecosystems study- Microbe interactions
Impact and role of viruses in large animals’ health
How bacteria in complex organisms respond to stress
Cell to cell interaction and social behavior in bacteria interactions
Norovirus cross-contamination investigation during service procedures in the food industry in fresh produce preparation
Transfer rate determination in Salmonella sp. From nut butter to food materials
Listeria monacytogenes comparative genomic analysis for survival within a food processing situation
Thermal resistance and survival of desiccated Salmonella in dry and moist food processing environments
Effective cleaning products for removing food matrix with B. Thuringiensis spores and B. Cereus
Analysis of cleaning procedures’ effects on Bacillus spores
How temperature affects viruses survival in vegetables and fruits
How temperature and time combine to stimulate C. botulinum spores to germinate or produce a toxin

This category has some of the most interesting and easy microbiology research topics. However, take your time to research the topic you choose to write a paper that will impress your educator to award you the top grade.

Medical Microbiology Research Topics

Maybe you want to explore microbiology and human health topics. In that case, consider these medical-related microbiology paper topics.

Probiotics- A study of their preparation
How to prevent sickle cell anemia
The growth of mold
How fertilizes, polythene and manure affect the hypocotyl’s elongation rate
How cinnamon and curry inhibit the growth of bacteria
How oil spills affect microorganisms in the oceans
Reproducing yeast in sugar substitutes
Why vitamin c affects the rotting rate for fruits
Effective toothbrush disinfecting methods
Describe the spread of Ebola

Consider any of these microbiology research topics research paper if interested in something to do with medicine. However, take your time to identify good and authentic information sources before you start writing your paper. That’s because your educator will be interested in unique and relevant content.

Microbiology Research Topics for Undergraduates

Are you pursuing undergraduate studies in microbiology? If yes, you will find these microbiology research topics for college students interesting.

Using polymerase chain reaction to diagnose infectious diseases
Preliminary antimicrobial and phytochemical screening of coat and seed of citrus sinensis
Microbiology effect on mining
Human skin colonization by bacteria
Sweet orange’s antibacterial activity on Escherichia coli and staphylococcus aureus isolated from wound infection
The susceptibility pattern of bacteria to antibiotics
Bush pear analysis and the oil project
Spoilt avocado microbial examination- What it reveals
Characterization and isolation of microorganisms from a stored pap
CryoEM use in understanding pathogen resistance and transport
Additive manufacture of skin-facing antimicrobial devices for surgery
Oral bacteria’s role in cardiovascular disease
Nutrient-mediated ‘Dual warhead’ antimicrobials’ delivery
Induction mechanisms of the protective lung tissue memory cells in influenza
The activity of eukaryotic, elucidating topoisomerase in homologous recombination
Oral bacteria involvement in chronic periodontitis- Metabolomics investigation
Effect of metal nanoparticles on the multi-species biofilm consortia- A metabolomics investigation
How vaping or smoking affects the risk of CoV-2, SARS, and COVID-19 outcomes
Soil contaminants risks on below and above ground eco-systems in urban areas
Protective microbes- How to rebuild microbiota when treating AMR infection

This category also has some of the best microbiology topics for presentation. However, get ready to research any of these topics to write an impressive paper.

Hot Topics in Microbiology

Perhaps, you’re looking for the most interesting microbiology essay topics to research and write about. In that case, consider some of the ideas in this category.

Shea butter’s microbiological analysis
Research of tapeworms and their dangers
Influenza spread in the world and its impact on the war
Restriction-modification cellular microbiology
Applied microbiology- Biofuels generation using microorganisms
Microscope invention and its effect on microbiology knowledge
Microbiology role in food industries and pharmaceutical
How microbiology has helped in preventing life-threatening illnesses
Bacterial polymer- A study of cyanophycin
A study of the functionalities and properties of wetland bacteria
Microbiological study of a commercial preparation of yogurts
A study of bacteria that withstand antibiotics
Human immunodeficiency virus diagnosis- How it’s done
A study of plasmodium species correlation
A study of onions’ microorganisms
An investigation of starch fermentation, specificities, and activities of its enzymes
Listeria growth and survival in freshly cut vegetables
Low moisture food inoculation protocols
Survival and growth of Salmonella during partially sprouted products processing and chia powders
Environmental organisms’ risk assessment and the importance of better control and knowledge

This category also has some of the best food microbiology topics. Nevertheless, students should be ready to spend time and effort researching any of these ideas before writing. That’s because educators expect them to present fresh and relevant information in their papers.

Learners have many topics or ideas to consider when researching and writing academic papers. However, every student should look for an interesting topic they are comfortable researching and writing about. That’s because writing a research paper or essay takes time. Choosing a boring topic means a learner will spend their time working on something they’re not interested in. And this can reflect on the quality of their paper. Thus, their grade will suffer.

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Home > Life Sciences > Microbiology and Molecular Biology > Theses and Dissertations

Microbiology and Molecular Biology Theses and Dissertations

Theses/dissertations from 2024 2024.

Characterization of Cellular Metabolism Regulation by the Transcription Factor Centromere Binding Factor 1 (Cbf1) , Spencer Ellsworth

Theses/Dissertations from 2023 2023

Elucidating the Architecture of the TclIJN Complex that Converts Cysteine to Thiazoles in the Biosynthesis of Micrococcin , Diana G. Calvopina Chavez

Manipulating and Assaying Chromatin Architecture Around Enhancer Elements in vivo , John Lawrence Carter

Halophilic Genes that Impact Plant Growth in Saline Soils , Mckay A. Meinzer

Characterizing Stress Granule Regulation by PAS Kinase, Ataxin-2 and Ptc6 and Investigating the Lifespan of Covid-19 Virus on Currency , Colleen R. Newey

Changes in RNA Expression of HuT78 Cells Resulting From the HIV-1 Viral Protein R R77Q Mutation , Joshua S. Ramsey

Theses/Dissertations from 2022 2022

Biofilm Characterization and the Potential Role of eDNA in Horizontal Gene Transfer in Hospital and Meat Isolates of Staphylococcus aureus and Their Biofilms , Ashley Lynne Ball

Novel Patterns for Nucleosome Positioning: From in vitro to in vivo , David Andrew Bates

The Effects of Polymorphisms of Viral Protein R of HIV-1 on the Induction of Apoptosis in Primary Cells and the Characterization of Twelve Novel Bacillus anthracis Bacteriophage , Jacob D. Fairholm

Analysis of the Cytopathogenic Effect of Different HIV-1 Vpr Isoforms on Primary Human CD4+ T Cells and a Model Cell Line , Jonatan Josue Fierro Nieves

The Role of Chitinase A in Mastitis-Associated Escherichia coli Pathogenesis , Weston D. Hutchison

Big Data Meta-Analyses of Transcriptional Responses of Human Samples to Orthohantavirus Infection and Shotgun Metagenomics From Crohn's Disease Patients. , John L. Krapohl

An Exploration of Factors that Impact Uptake of Human Papillomavirus Vaccines , David Samuel Redd

Genomic Analysis and Therapeutic Development of Bacteriophages to Treat Bacterial Infections and Parasitic Infestations , Daniel W. Thompson

The Use of Nucleotide Salvage Pathway Enzymes as Suitable Tumor Targets for Antibody-Based and Adoptive Cell Therapies , Edwin J. Velazquez

Comparative Sequence Analysis Elucidates the Evolutionary Patterns of Yersinia pestis in New Mexico over Thirty-Two Years , M. Elizabeth Warren

Regulation of T Cell Activation by the CD5 Co-Receptor and Altered Peptides, Characterization of Thymidine Kinase-Specific Antibodies, and Integrating Genomics Education in Society , Kiara Vaden Whitley

Theses/Dissertations from 2021 2021

Evolution and Selection: From Suppression of Metabolic Deficiencies to Bacteriophage Host Range and Resistance , Daniel Kurt Arens

Identifying Sinorhizobium meliloti Genes that Determine Fitness Outcomes , Alexander B. Benedict

Pushing the Limits of SARS-CoV-2 Survival: How SARS-CoV-2 Responds to Quaternary Ammonium Compounds and Wastewater , Benjamin Hawthorne Ogilvie

Mutations in HIV-1 Vpr Affect Pathogenesis in T-Lymphocytes and Novel Strategies to Contain the Current COVID-19 Pandemic , Antonio Solis Leal

Theses/Dissertations from 2020 2020

Staphylococcus aureus Metal Acquisition in Milk and Mammary Gland Tissue , Shalee Killpack Carlson

Antimicrobial Peptide Development: From Massively Parallel Peptide Sequencing to Bioinformatic Motif Identification , Alexander K. Erikson

A Comparison of Chikungunya Virus Infection, Dissemination, and Cytokine Induction in Human and Murine Macrophages and Characterization of RAG2-/-γc-/- Mice as an Animal Model to Study Neurotropic Chikungunya Disease , Israel Guerrero

The Effects of Immune Regulation and Dysregulation: Helper T Cell Receptor Affinity, Systemic Lupus Erythematosus and Cancer Risk, and Vaccine Hesitancy , Deborah K. Johnson

Identification of Genes that Determine Fitness, Virulence, and Disease Outcomes in Mastitis Associated Eschericia coli , Michael Andrew Olson

Theses/Dissertations from 2019 2019

Investigation of Thymidine Kinase 1 in Cancer Progression , Eliza Esther King Bitter

Ribosomally Synthesized and Post-Translationally Modified Peptides as Potential Scaffolds for Peptide Engineering , Devan Bursey

Bioaerosols Associated with Evaporative Cooler Use in Low-Income Homes in Semi-Arid Climates , Ashlin Elaine Cowger

PAS Kinase and TOR, Controllers of Cell Growth and Proliferation , Brooke Jasmyn Cozzens

Regulation of Immune Cell Activation and Functionby the nBMPp2 Protein andthe CD5 Co-Receptor , Claudia Mercedes Freitas

Characterizing Novel Pathways for Regulation and Function of Ataxin-2 , Elise Spencer Melhado

Interactions Between the Organellar Pol1A, Pol1B, and Twinkle DNA Replication Proteins and Their Role in Plant Organelle DNA Replication , Stewart Anthony Morley

SNFing Glucose to PASs Mitochondrial Dysfunction: The Role of Two Sensory Protein Kinases in Metabolic Diseases , Kai Li Ong

Characterizing the Function of PAS kinase in Cellular Metabolism and Neurodegenerative Disease , Jenny Adele Pape

Isolation, Characterization, and Genomic Comparison of Bacteriophages of Enterobacteriales Order , Ruchira Sharma

Isolation, Genetic Characterization and Clinical Application of Bacteriophages of Pathogenic Bacterial Species , Trever Leon Thurgood

Investigation of Therapeutic Immune Cell Metabolism , Josephine Anna Tueller

Theses/Dissertations from 2018 2018

Innate Immune Cell Phenotypes Are Dictated by Distinct Epigenetic Reprogramming , Kevin Douglas Adams

Bacteriophages for Treating American Foulbrood and the Neutralization of Paenibacillus larvae Spores , Thomas Scott Brady

Methods for Detection of and Therapy for Carbapenem-Resistant Enterobacteriaceae , Olivia Tateoka Brown

The Diversity Found Among Carbapenem-Resistant Bacteria , Galen Edward Card

Exploration of Antimicrobial Activity in Natural Peptides and High-Throughput Discovery of Synthetic Peptides , Emma Kay Dallon

Gut Microbiota Regulates the Interplay Between Diet and Genetics to Influence Insulin Resistance , Jeralyn Jones Franson

The Antimicrobial Properties of Honey and Their Effect on Pathogenic Bacteria , Shreena Himanshu Mody

The Ability of Novel Phage to Infect Virulent Bacillus anthracis Isolates , Hyrum Smith Shumway

Galleria Mellonella as an Alternate Infection Model for Burkholderia Species and a Comparison of Suspension and Surface Test Methods for Evaluating Sporicidal Efficacy , Joseph D. Thiriot

The Clinical Significance of HPRT as a Diagnostic and Therapeutic Biomarker for Hematological and Solid Malignancies , Michelle Hannah Townsend

Biomarker Analysis and Clinical Relevance of Thymidine Kinase 1 in Solid and Hematological Malignancies , Evita Giraldez Weagel

Hospital and meat associated Staphylococcus aureus and Their Biofilm Characteristics , Trevor Michael Wienclaw

Theses/Dissertations from 2017 2017

Comparison of Cytokine Expression and Bacterial Growth During Periparturient and Mid Lactation Mastitis in a Mouse Model , Rhonda Nicole Chronis

Influence of Epstein-Barr Virus on Systemic Lupus Erythematosus Disease Development and the Role of Depression on Disease Progression , Caleb Cornaby

The Effects of Nucleosome Positioning and Chromatin Architecture on Transgene Expression , Colton E. Kempton

Phosphate Signaling Through Alternate Conformations of the PstSCAB Phosphate Transporter , Ramesh Krishna Vuppada

Acetobacter fabarum Genes Influencing Drosophila melanogaster Phenotypes , Kylie MaKay White

Theses/Dissertations from 2016 2016

The Path to Understanding Salt Tolerance: Global Profiling of Genes Using Transcriptomics of the Halophyte Suaeda fruticosa , Joann Diray Arce

Genetic and Biochemical Analysis of the Micrococcin Biosynthetic Pathway , Philip Ross Bennallack

Characterizing Interaction Between PASK and PBP1/ ATXN2 to Regulate Cell Growth and Proliferation , Nidhi Rajan Choksi

The Activity of Alkaline Glutaraldehyde Against Bacterial Endospores and Select Non-Enveloped Viruses , Justen Thalmus Despain

The Role of Viral Interleukin-6 in Tumor Development of Kaposi's Sarcoma-Associated Herpesvirus Lymphomas , Rebecca A. Fullwood

The Role of the Transcriptional Antiterminator RfaH in Lipopolysaccharide Synthesis, Resistance to Antimicrobial Peptides, and Virulence of Yersinia pseudotuberculosis and Yersinia pestis , Jared Michael Hoffman

A CryAB Interactome Reveals Clientele Specificity and Dysfunction of Mutants Associated with Human Disease , Whitney Katherine Hoopes

The pmrHFIJKLM Operon in Yersinia pseudotuberculosis Enhances Resistance to CCL28 and Promotes Phagocytic Engulfment by Neutrophils , Lauren Elizabeth Johnson

Characterization of Five Brevibacillus Bacteriophages and Their Genomes , Michael Allen Sheflo

Analysis of Nucleosome Isolation and Recovery: From In Silico Invitrosomes to In Vivo Nucleosomes , Collin Brendan Skousen

Human Herpesvirus 6A Infection and Immunopathogenesis in Humanized Rag2 -/-γc-/- Mice and Relevance to HIV/AIDS and Autoimmunity , Anne Tanner

Theses/Dissertations from 2015 2015

Identifying and Characterizing Yeast PAS Kinase 1 Substrates Reveals Regulation of Mitochondrial and Cell Growth Pathways , Desiree DeMille

The Detection and Molecular Evolution of Francisella tularensis Subspecies , Mark K. Gunnell

Isolation and Host Range of Staphylococcus aureus Bacteriophages and Use for Decontamination of Fomites , Kyle C. Jensen

The Antioxidant and DNA Repair Capacities of Resveratrol, Piceatannol, and Pterostilbene , Justin Ryan Livingston

High Salinity Stabilizes Bacterial Community Composition and Activity Through Time , Tylan Wayne Magnusson

Advancing Phage Genomics and Honeybee Health Through Discovery and Characterization of Paenibacillaceae Bacteriophages , Bryan Douglas Merrill

Specialized Replication Operons Control Rhizobial Plasmid Copy Number in Developing Symbiotic Cells , Clarice Lorraine Perry

Gene Networks Involved in Competitive Root Colonization and Nodulation in the Sinorhizobium meliloti-Medicago truncatula Symbiosis , Ryan D. VanYperen

Theses/Dissertations from 2014 2014

Snf1 Mediated Phosphorylation and Activation of PAS Kinase , Bryan D. Badal

Studies of PhoU in Escherichia coli: Metal Binding, Dimerization,Protein/Protein Interactions, and a Signaling Complex Model , Stewart G. Gardner

Pharmacologic Immunomodulation of Macrophage Activation by Caffeine , Ryan Perry Steck

Analysis of Nucleosome Mobility, Fragility, and Recovery: From Embryonic Stem Cells to Invitrosomes , Ashley Nicolle Wright

Enhancing Protein and Enzyme Stability Through Rationally Engineered Site-Specific Immobilization Utilizing Non-Canonical Amino Acids , Jeffrey Chun Wu

Theses/Dissertations from 2013 2013

Thymidine Kinase 1: Diagnostic and Prognostic Significance in Malignancy , Melissa Marie Alegre

Promoter Polymorphisms in Interferon Regulatory Factor 5 , Daniel N. Clark

Modulators of Symbiotic Outcome in Sinorhizobium meliloti , Matthew B. Crook

Evidences for Protein-Protein Interactions Between PstB and PhoU in the Phosphate Signaling Complex of Escherichia coli , Kristine Dawn Johns

Identification of the Binding Partners for HspB2 and CryAB Reveals Myofibril and Mitochondrial Protein Interactions and Non-Redundant Roles for Small Heat Shock Proteins , Kelsey Murphey Langston

A Quadruplex Real-Time PCR Assay for the Rapid Detection and Differentiation of the Burkholderia pseudomallei Complex: B. mallei , B. pseudomallei , and B. thailandensis , Chinn-woan Lowe

The Role of Nuclear BMP2 in the Cell Cycle and Tumorigenesis , Brandt Alan Nichols

Nuclear BMP2 and the Immune Response , Daniel S. Olsen

Hypersaline Lake Environments Exhibit Reduced Microbial Dormancy , Joshua Christopher Vert

Theses/Dissertations from 2012 2012

Characterization of the Cellular and Organellar Dynamics that Occur with a Partial Depletion of Mitochondrial DNA when Arabidopsis Organellar DNA Polymerase IB is Mutated , John D. Cupp

Effect of Antioxidants and Oxidative Stress on Different Cancer Cell Types , Gaytri Devi Gupta Elera

Effects of Chemical Stimulation and Tumor Co-Incubation on Macrophage Activation and Aggressiveness, Measured Through Phagocytosis and Respiratory Burst , Bo Marcus Gustafsson

Loss of the Lipopolysaccharide Core Biosynthesis rfaD Gene Increases Antimicrobial Chemokine Binding and Bacterial Susceptibility to CCL28 and Polymyxin: A Model for Understanding the Interface of Antimicrobial Chemokines and Bacterial Host Defense Avoidance Mechanisms , Cynthia S. Lew

Partial Characterization of the Antimicrobial Activity of CCL28 , Bin Liu

Characterizing the Role of HspB2 in Cardiac Metabolism and Muscle Structure Using Yeast and Mammalian Systems , Jonathan Paul Neubert

Humanized Mice as a Model to Study Human Viral Pathogenesis and Novel Antiviral Drugs , Freddy Mauricio Sanchez Tumbaco

Transgene Delivery via Microelectromechanical Systems , Aubrey Marie Mueller Wilson

Theses/Dissertations from 2011 2011

Antioxidants in Cancer Research and Prevention: Assay Comparison, Structure-Function Analysis, and Food Product Analysis , Andrew Robert Garrett

Characterization of the Role Nuclear Bmp2 (nBmp2) Plays in Regulating Gene Expression , Fialka Grigorova

Theses/Dissertations from 2010 2010

Effects of Diabetic State and Gender on Pro-Inflammatory Cytokine Secretion by Human Macrophages Infected with Burkholderia pseudomallei , Annette J. Blam

Organellar DNA Polymerases Gamma I and II in Arabidopsis thaliana , Jeffrey M. Brammer

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Microbiology

The microbiology sector has seen huge development over the years to what it is now. You might be well aware that our earth’s surface consists of a huge microbial diversity and these wide microbial communities are present in all nooks of the earth. They offer several services to our environment. Without microbial communities, the whole earth will be a different place to live in. This is the reason microbiological research is so vital.

Microbiology is one of the very actively researched grounds, that deal with the study of microorganisms starting from the eukaryotic fungi to single celled and various cell cluster organisms. Various courses like B.Sc., M. Sc., M. Phil and Ph.D in subjects like Microbiology , Biotechnology and Molecular Biology, students are doing projects for their thesis. Excluding these, students from other courses including B. Tech, M. Tech courses in Biotechnology , paramedical courses like Pharmacy (B. Pharm. and M. Pharm.) and even Medical are searching projects or thesis topics for microbiology. If you are thinking of starting a research or project work in microbiology, then you must be searching for a good topic. So we planned to make it somewhat simple and easy for you.

This article discusses about some of the top and current research topics on microbiology. Before coming to the lists of topics let’s have a brief discussion on some of the important and key tips that we should consider before finalizing a topic.

We should remain more focused on our investigation which will help us in planning a very clear experiment and in getting very useful and pertinent data.
We should choose a topic which will get easily manageable within the given time frame.
One of the best tips is to initiate by formulating a hypothesis and then confirming it.
The rate of success or failure depends on how well you are versed with the methodology.

We also provide Labmonk notes on some subjects on our platform. Click here to check out . If you are interested to share your notes on this platform please contact us.

Click the page numbers below to read more on this topic.

12 thoughts on “Top 50 Research Topics of Microbiology”

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Can anyone suggest a topic for research in Microbiology!

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Hello sir Research topic for microbiology and study of microbiology

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Graduate Research Topics

Discovery, biosynthesis, and chemical ecology of microbial natural products; bioactivity and mode of action of antibiotics; biocatalyst development

Joseph A. Krzycki Biochemistry and molecular biology of methanogenic Archaea emphasizing methane formation and their genetic encoding of the novel amino acid pyrrolysine.

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Six Key Topics in Microbiology: 2020

Read an essential collection of papers showcasing high-quality content from across the five FEMS Journals, which together provide an overview of current research trends in microbiology. Follow the topic area links below for access to articles:

Antimicrobial Resistance

Environmental microbiology, pathogenicity and virulence, biotechnology and synthetic biology, microbiomes, food microbiology.

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177 Captivating Microbiology Research Topics For Your Paper

Selecting microbiology research topics is the first step in the process of completing academic studies. Microbiology is among the fields that experts are constantly actively researching. It deals with microorganisms’ study, from single-cell organisms to eukaryotic fungi. When pursuing a course in microbiology, educators ask learners to write academic papers on varied topics. It is not easy to write a research paper for a high grade. However, choosing the best microbiology topics is not that simple due to the vast scope of this study field. But the issue that a college or university student selects dictates the direction of their project. If struggling to choose the best microbiology topics for research paper, this list should inspire you.

Medical Microbiology Research Paper Topics

Perhaps, you’re interested in medical microbiology. In that case, consider these interesting topics in medical microbiology.

Probiotics study and preparation
How to prevent sickle cell anemia
Analyzing the growth of mold
The ability of cinnamon and curry to hinder bacterial growth
How manure, polythene, and fertilizers affect the rate of hypocotyl elongation
How oil spills affect ocean organisms
Toxicity testing in marine pollutants with daphnia
Reproduction of yeast in sugar substitutes
Tendrils thigmotropism
The effect of light on yeast
Mold growth in cheese
Dog drool and germs
In which ground beef is bacteria level low?
Isolating staphylococcus aurous from pasteurized and raw milk
How garlic affects bacteria
Effective ways to disinfect a toothbrush
Investigating the spread of infectious diseases like Ebola
Effects of vitamin C on fruits rotting rate

These are exciting topics in microbiology and human health. Nevertheless, take your time to research any of these ideas to develop a winning paper.

Microbiology Research Topics for Undergraduates

Maybe you’re pursuing an undergraduate course in microbiology. That means your educator will ask you to write a research paper at some point. Here are brilliant microbiology ideas to consider for your essays.

Rebuilding microbiota during AMR infection treatment
Risks of soil contaminants on above and below-ground ecosystems
Effects of smoking or vaping on COVID-19, SARS, and Cov-2 results
How metal nanoparticles affect multi-species biofilm consortia
The involvement of oral bacteria in chronic periodontitis
The eukaryotic activity elucidating topoisomerase in the recombination of homologous
Protective lung tissue memory’s induction mechanisms in influenza
The role of oral bacteria in cardiovascular disease
Dual warhead antimicrobials in nutrient-mediated delivery
Skin-facing antimicrobial devices in surgery during additive manufacture
The use of CryoEM in pathogen transport and resistance study
Isolation and characterization of microorganisms
Microbial examination in spoilt avocado- What does it reveal?
Polymerase chain reaction used in the diagnosis of infectious diseases
Phytochemical and antimicrobial screening of seed and coat of Citrus Sinensis
Effects of microbiology on mining
How bacteria colonize the human skin
Antibacterial activity of sweet orange on staphylococcus aureus and Escherichia coli from wound infection
Bacteria’s susceptibility to antibiotics
The oil project and bush pear analysis

Pick any of these ideas for your research paper if pursuing an undergraduate degree. Nevertheless, prepare to research the title you choose to develop a winning piece.

PhD Research Topics in Microbiology

A microbiology PhD should prepare the learner to select medical, dental, or health studies to venture into biotechnology or pharmaceutical fields. Here are exciting thesis topics for microbiology students.

Microbial biofilms- Fungal and bacteria pathogens in environmental substrates and biomaterials
Bacterial cell fate manipulation- Signal transduction and surface sensing role
Salmonella typhi susceptibilities to hot aqueous extract from Hibiscus sabdariffa and antibiotics
Toxins characterization and isolation using Cronobacter species
Bacillus Thuringiensis and Rhizobium etli biocontrol potential
Engineered Saccharomyces cerevisiae strain construction to improve the production of whole-cell biocatalytic of melibiose
Cyclic utilization in biotransformation
Electro-activated solutions’ antibacterial activity
Understanding the Swine flu pandemic from a microbiology perspective
Investigating typhoid fever and risk factors in kids

Please choose a topic in this category and use it as the basis of your PhD. Nevertheless, prepare to invest time and resources in your research to develop a winning paper.

Microbiology Research Topics for College Students

Are you a college student looking for a microbiology paper topic? If yes, here are sample topics to consider for your paper.

Evaluating changes in Ebola
Understanding Pfiesteria piscicida subtle health effects on the worldwide population
Has the world lost the battle with malaria?
Horizontal genetic exchange role in the bacterial mutation
Understanding genetic engineering applications in the food supply chain
Analyzing genetic engineering applications in antibodies to work as enzymes
Investigating generic allegiances- Peanut allergies case study
Alternative targets development for vaccines
Prevalence and history of HIV in Africa
Biotechnology potential in smart tech
Endolithic bacteria study in low-temperature places- Making life existence case on mars
Understanding nitric oxide role in the immune system
Understanding the development of superantigens and their applications
Evaluating autoimmune disease patterns in the last decade
How different carbon sources affect antimicrobial-producing Bacillus Species
Antimicrobial susceptibility and prevalence of Gram-Negative Bacterial in urine
Possible control and prevention of intestinal Schistosomiasis
Damage and safety of water
The antibacterial activity of medicated soaps
Yogurt’s microbial contamination

Please select any of the ideas in this list and then develop it via extensive research to write a fantastic paper.

New Research Topics in Microbiology

Maybe you’re interested in the newest idea for research. If so, consider these latest research topics in microbiology.

Dengue fever vaccine development
Hypoxia and hypoxia-inducible factors in cancer patients’ stem cell maintenance
The laboratory role of Leptospirosis reference
The mechanisms and consequences of Reovorus cell killing
Protein and peptide nanocluster vaccines
Formulation and delivery techniques for mRNA vaccines
Memory lymphocyte in genital immunity- T cells’ role in tissue-resident memory
Investigating the Lassa virus genetics
Physiological and pathological functions in innate immune systems of CARD 9 signaling
Signaling outcomes in RIP Kinase during neuro-invasive virus infection
Structures of type II secretion system in needle filaments
The manipulation of death pathways in hot cells by the Herpes Simplex virus
The modification of the cell wall by antifungal drugs
Sensing tissue damage by Myeloid c-type lectin receptors
Virus-like particle immunization for respiratory viruses and protozoan parasites
Campylobacter biofilm and quorum sensing in molecular mechanisms
Natural competence transfer and campylobacter horizontal gene
Investigating marine models for innate immune response and resistance colonization in campylobacter jejuni infections
The role of iBALT in respiratory immunity
Pyroptosis antiviral immunity

These are some of the latest topics to consider for microbiology research papers. However, each of these ideas requires extensive research to write an essay that will earn you the top grade.

Hot Research Paper Topics in Microbiology

Do you want to write a research paper on one of the hottest topics? If yes, consider these ideas for your project.

Risk assessment for environmental organisms and the essence of knowledge and control
Growth and survival of Salmonella during the processing of partially sprouted products and chia powders
Innoculation protocols for low moisture foods
Listeria survival and growth in newly cut vegetables
Investigating starch specificities, fermentation, and enzyme activities
Onions’ microorganisms study
Studying the correlation of Plasmodium species
How to diagnose human immunodeficiency virus
Investigating bacteria that can withstand antibiotics
Yogurts’ microbiological study during commercial preparation
Wetland bacterial properties and functionalities
Cyanophycin study- A bacterial polymer
Microbiology and its role in the prevention of life-threatening illnesses
Microbial analysis of Shea butter
Tapeworms’ research- What are their dangers?
The spread of influenza in the world- How it affected wars?
Restriction-modification in cellular microbiology
Microscope invention- How it improved microbiology knowledge
Applied microbiology- Generation of biofuels using microorganisms
Role of microbiology in pharmaceutical and food industries

Select and work with any of these great topics to impress the educator to award you the top grade in your class.

Environmental and Marine Microbiology Research Topics

Maybe you love researching and writing about ecological and marine microbiology. If so, consider these topic ideas for your research papers.

Wastewater and water treatment- What are the target microorganisms?
Marginal water reclamation and treatment
Greenhouse gases mitigation and biofiltration
Greenhouse gases sources
Biowaste nutrient recovery
Bio-remediation of water bodies and soils in arid environments
Bio-methane production using dry climates animal wastes
Desert rocks microbial inhabitants
The role of bacterial diversity in the maintenance of functional ecosystems in arid areas
How rain events affect microbial activity, abundance, and diversity
Cycling nitrogen in dry soils
Desert soil crust role in nutrient cycling
Interrelationships between soil bacteria and plants and their effects on biochemical cycling
Microorganisms in phyllosphere and rhizosphere in desert plants
Characterization of marine viruses
Marine biofouling microbial aspects

Students can work on these topics by researching them carefully before writing academic papers.

Food Microbiology Research Topics

If interested in food microbiology, this category has some of the best ideas for you to explore.

How temperature affects viruses’ survival in vegetables and food to help in virus contamination comprehension
Evaluating process water usage as the marker for determining freshly-cut greens’ contamination status
Investigating the initial contamination, time, temperature, sanitizing rinses, indigenous microflora, and package atmosphere on E.coli’s behavior in leafy greens
How temperature and time combine to stimulate the germination of spores in c. botulinum
How cleaning procedures and physical augmentation remove bacillus spores in food matrices
Norovirus and cross-contamination in the foodservice procures for preparing fresh produce
Examining virus and abiotic surfaces in the food processing and service sectors
How to improve sprout food safety
Growth and survival of Listeria in freshly-cut vegetables
Nonthermal and thermal resistance of Shiga-Toxin producing Coli and Salmonella Enterica in low-moisture foods
How water and temperature activity affect Salmonella during storage and drying of Botanical products
Norovirus surrogates mitigation in berries using minimal high hydrostatic pressure and freeze-drying treatment
Bacterial pathogen mechanisms of internalization into freshly-cut fruits
Low moisture foods inoculation protocols

Work on any of these topics if interested in a project that involves exploring food and microbiology ideas.

Immunology Microbiology Research Topics

Perhaps, you want to write a research paper on an immunology and microbiology topic. If so, consider these brilliant ideas for your essay.

Human diseases and bacteria
Cell biology and bacterial physiology
Human health and microbiology
Investigating parasite effects on human healthy
Human diseases and viruses
Genetics of microorganisms
Studying eukaryotic pathogens and diseases
Molecular microbiology and experimental approaches
Investigating different parasitism mechanisms
What is advanced immunology?

Select any topic in this category and perform extensive research to provide valid and relevant information that will impress the educator to award you the best grade.

Easy Microbiology Research Topics

Maybe you want a topic you’ll have an easy time working on and writing a quality paper. If so, consider these ideas for your research paper.

How time and temperature stimulate toxin production by C. botulinum spores
Effects of temperature on virus survival in fruits and vegetables
Methodology and techniques for future virus studies
The role of Redox-active metabolites in microbial signaling
The emergence and essence of yeast in preservatives within the baking industry
Non-conventional uses of yeast in the wine-manufacturing sector
Microbiota- The role of bifidobacteria’s role in the human body
Microbes interactions- The study of human microbial ecosystems
The impact of viruses on the health of large animals
How bacterial interactions affect cell social behavior and interaction
How cleaning procedures impact Bacillus spores
Desiccated Salmonella’s survival in moist and dry food processing places
A comparative analysis of Listeria monacytogenes survival in the food manufacturing environments
What determines the transfer rate for Salmonella sp. From butter to foods?
Cross-contamination investigation of norovirus during service procedures within the food industry
How human fungal pathogen’s genetic variation cause phenotypic diversity that affects diseases
How microbiology research has helped humans in preventing life-threatening diseases

Any of these ideas can be a brilliant topic for a research paper. However, careful research and dedication are necessary to write a top-notch essay.

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Microbiology Thesis Topics For MD/DNB

Remember Subscribing to the premium thesis topics not only will enable you to browse through premium thesis topics but also you will get access to online guidance about synopsis writing, sample size calculation, inclusion and exclusion criteria and guidance throughout thesis writing. In case you dont subscribe still do not hesitate to contact me for guidance.

Below is the list of 100 free thesis topics for MD/DNB Microbiology. You can select any good Microbiology thesis topics for MD/DNB from here. For more thesis topics you can avail the service of premium thesis topics. The premium thesis topics include list of 2000+ Microbiology thesis topics as well as recent topics which has been published in various national and international Microbiology journals.
Bacteriological study in suspected neonatal septicaemia
Role of fine needle aspiration cytology in the diagnosis of tuberculous lymphadenitis and the utility of ziehl neelsen staining
Prevalence of extended spectrum beta lactamases from various clinical samples
Study of bacterial vaginosis in women of reproductive age by pH determination, direct gram stain and giemsa stain of vaginal discharge.
An assessment of the carcinogenicity of various infant milk formulae by microbiological and biochemical methods
Bacterial profile and their antibiotic susceptibility pattern in clinically diagnosed urinary tract infections
Microbial profile of aural discharges (otorrhoea) & antimicrobial susceptibility pattern of the common isolates
Study of susceptibility pattern of mycobacterial isolates from patients of pulmonary tuberculosis
Study of detection of human rotavirus in stool specimen by Elisa technique & association of enteric pathogens in childhood diarrhoea
A comparative antimicrobial analysis of various root canal irrigating solutions on endodontic pathogens: in – vitro study
Microbial etiological agents in chronic periodontitis
Identification of fungal infections in suspected clinical samples of superficial fungal infection and anti-fungal susceptibility testing
Serodiagnosis of dengue antibodies in suspected cases of dengue fever by Elisa technique
Comparative study of the prevalence of intestinal parasites in HIV-reactive and non-reactive individuals
Incidence of health care associated infection and antibiotic resistance of isolates in critical care patients of a tertiary care hospital
Isolation and identification of Acinetobacter species with special reference to antibiotic resistance
“Isolation and identification of mycobacterium tuberculosis from suspected cases of pulmonary tuberculosis and detection of multi-drug resistance tuberculosis”
Incidence of sepsis in the neonates admitted to a tertiary care hospital and antimicrobial susceptibility pattern of the isolates
“To compare the microbial colonization and patient’s comfort with absorbable and non-absorbable suture material in extraction socket suturing”.
“To evaluate efficacy of manuka honey dressing in the treatment of infected socket”.
“Documentation of the spectrum of microbiological flora and their antibiotic sensitivity in oral infections in local population in a tertiary care medical hospital.
“Prospective study of anaerobic isolates from deep-seated wound infections encountered in a tertiary care hospital”
“Spectrum and prevalence of fungi in soft tissue infections in a tertiary care hospital”
“Isolation of bacteria in acute diarrheal diseases in paediatric age group of patients attending to a tertiary care hospital and antimicrobial susceptibility pattern of the isolates”
“Comparison of efficacies of 5% povidone iodine solution and 0.2% chlorhexidine solution in controlling bacteraemia in patients undergoing surgical removal of mandibular third molar.”
The isolation and identification of nonfermenting organisms and their antibiogram from clinical samples in a tertiary care hospital
To isolate and identify the b- lactamases in Enterobacteriaceae among community acquired infections in a tertiary care hospital.
Antibiotic resistance pattern of bacteria, isolated from cases of ventilator associated pneumonia in a tertiary care hospital
A study of risk factors, occurrence and etiology of catheter associated urinary tract infections in criteria care unit of a tertiary care medical hospital.
Role of nitric oxide in pathogenesis of dengue fever
‘’phenotypic and genotypic characterization of multidrug resistant uropathogenic E. coli”
Evaluation of phenotypic and genotypic method for the detection of ESBL and MBL in germ negative bacilli isolated from clinical specimens
Epidemiology of MDR tuberculosis in a tertiary care hospital with special reference to rapid molecular diagnostic methods.
Study of epidemiological markers of pseudomonas aeruginosa isolated from various clinical samples received in tertiary care hospitals, India
Morphological and genotypic characterization of candida albicans isolated from clinical samples from a tertiary care hospital
Effect of extraction of different types of medicinal plants on ringworm
Microbiological and antibiotic profile of pus samples collected in a tertiary care centre.
Microbial profile & antibiogram pattern of bacterial isolates of urinary tract infection in pregnant women in tertiary care centre
Neonatal sepsis: bacteriological profile and antibiotic sensitivity pattern of isolates in a tertiary care setup
An assessment of minocycline sensitivity in multidrug-resistant gram-negative isolates in a tertiary care centre.
A study based on catheter-related bloodstream
Infections in intensive care units (ICU) in a tertiary care hospital
Cross sectional study to determine sero-prevalence of brucellosis and pattern of haematological, biochemical and immunological parameters in patients with febrile illness
Molecular characterization of extended spectrum of β lactamases producing hospital and community acquired klebsiella pneumoniae infections.
Epidemiological profile and genotypic characterization of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis.
Molecular epidemiology and genetic diversity” of circulating sars-cov-2 in a tertiary care medical hospital.
Correlation between clinical features and immunological parameters with viral load in covid positive patients
Study of colistin susceptibility and clinical profile of CRAB and CRE isolates from tertiary care hospital
Evaluation of rapid diagnostic method for molecular characterization of MDR genes from mycobacterium tuberculosis isolates from western part of India
A study on culture-based screening of aerobic microbial flora in chronic leg ulcers.
A study of microbial profile of bloodstream infections in critical care units in a tertiary care hospital
Prevalence and molecular characterisation of carbapenem resistant pseudomonas aeruginosa in the critical areas of a tertiary care centre.
Assessing effectiveness of cheap and practical ways of sputum disinfection for pulmonary tuberculosis patients in home scenario.
Prevalence of ESBL, AMPC and carbapenems among Enterobacteriaceae.
Comparative evaluation of latex agglutination with phenotypic methods for detection of methicillin-resistant staphylococcus aureus.
Surveillance of catheter related blood stream infections among adult patients in ICU.
Study of antibiogram of staphylococcus aureus in correlation with expression of surface proteins in a tertiary care hospital
Isolation, characterization and antibiotic susceptibility pattern in enterococci with special reference to vancomycin resistance.
Isolation speciation & antibiotic susceptibility pattern of enterococci from various clinical samples at a tertiary care medical hospital.
Seroprevalence of IgM rubella in antenatal women with bad obstetric history in a tertiary care hospital
A study on coagulase negative staphylococci at a tertiary care teaching hospital
Isolation, identification and study of virulence factors of uropathogenic escherichia coli in association with fluoroquinolone resistance in urinary tract infections.
A study on blood culture isolates in paediatric patients at a tertiary care teaching hospital.
Isolation, identification and speciation of non-fermenting gram negative bacilli from various clinical samples and their antibiotic susceptibility pattern
Spectrum of opportunistic infections and profile of CD4 count among HIV/AIDS patients encountered in a tertiary care hospital.
Vancomycin susceptibility of methicillin resistant staphylococcus aureus isolated from clinical specimens and its clinical outcome in vancomycin treated patients attending a tertiary care hospital.
Prospective study of microbiological diagnosis and treatment outcome of keratitis in a tertiary care hospital
Microbiological study of vaginitis among women of reproductive age group
Serological profile of hepatitis b vaccinated persons with special reference to quantitation of anti-HBS antibodies titres
Comparative study of Koch and calcofluor white staining, speciation & antifungal susceptibility of Malassezia species.
Detection of fluoroquinolone resistance among enteric fever isolates by disk diffusion, agar dilution, and e-test – a comparative study.
Comparative study of IgM ELISA and rapid diagnostic test in clinically suspected cases of scrub typhus.
Comparative analysis of non-structural protein 1 antigen detection by immunochromatography and enzyme linked immunosorbent assay for the diagnosis of acute dengue infection.
Device associated nosocomial infection in intensive care unit.
A case control study of risk factors for infections with extended spectrum beta lactamase and AMPC producing escherichia coli and klebsiella species.
Speciation and antifungal susceptibility testing of candida isolated from various clinical specimens using chrome agar candida and conventional methods.
Phenotypic detection of ESBL, AMPC & carbapenemase producing clinical isolates of E. coli and klebsiella pneumoniae
Characterisation and antimicrobial susceptibility pattern with special reference to vancomycin resistance in various clinical isolates of enterococci.
Comparative evaluation of phenotypic methods of ESBL detection in clinical isolates of E. coli
Study of the bacteriological profile of neonatal septicaemia and associated risk factors
Study of in vitro efficacy of colistin on clinical isolates of multidrug resistant gram-negative bacilli
Determination of susceptibility of clinical isolates of methicillin resistant staphylococci to glycopeptides, oxazolidinones, streptogramins.
Ventilator associated tracheobronchitis: incidence, etiology, predisposing risk factors and drug resistance
Clinico bacteriological study of neonatal septicaemia with special reference to c-reactive protein and drug resistance
Study of bacteriological profile and antibiotic susceptibility pattern of wound infections in a tertiary care hospital.
A prospective study on catheter associated urinary tract infections in ICU patients of a tertiary care hospital.
Bacteriological study (aerobic) of central venous catheter (CVC) related bloodstream infection in ICU patients at a tertiary care hospital.
Speciation of candida isolates from clinical samples: a comparison of two carbohydrate assimilation methods for efficacy, speed and accuracy with special reference to the sensitivity to commonly used antifungal agents
Isolation and characteristics of shigella from diarrheal stool samples received in a tertiary care hospital and determination of antimicrobial susceptibility.
Isolation and identification of Acinetobacter species from broncho -alveolar lavage samples from patients in the intensive & critical care units and determination of its mic to colistin in a tertiary care hospital
Comparison of colorimetric assay for pyrazinamide susceptibility testing using nicotinamide for mycobacterium tuberculosis with manual mycobacterium growth indicator tube (MGIT) assay
Comparative evaluation of dark field microscopy and IgM ELISA in the diagnosis of leptospiral infection from suspected clinical cases in a tertiary care hospital
A study to evaluate patterns of candida colonization in very low birth weight neonates and role of chlorhexidine skin cleansing in preventing candidemia
A study to evaluate the effect of nargenicin – a novel anti-bacterial agent against clinically isolated gram-positive bacteria.
Isolation and speciation of candida in various clinical specimens and their antifungal susceptibility patterns in a medical college.
Prevalence, bacteriological profile and antibiotic susceptibility pattern of symptomatic and asymptomatic bacteriuria during pregnancy
Bacteriological profile and antibiotic sensitivity testing of diabetic foot infections at a research centre.
Microbiological study of burn wound infections, antibiogram and metallo-beta-lactamase detection in gram negative isolates
Study of prevalence of bacterial vaginosis in women attending a tertiary care medical hospital.
Culture and sensitivity of blood culture from neonates with septicemia.

Disclaimer!

There are many methods of sample size determination. It is one of the first hurdle when someone starts writing a thesis. I have tried to give simplest way of determination of sample size. You need to show the method to your PG teacher before you include this method in your thesis. First confirm from your PG teacher and then only proceed.

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Molecular Biosciences Theses and Dissertations

Theses/dissertations from 2023 2023.

Exploring strain variation and bacteriophage predation in the gut microbiome of Ciona robusta , Celine Grace F. Atkinson

Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression , Janine M. DeBlasi

Thermodynamic frustration of TAD2 and PRR contribute to autoinhibition of p53 , Emily Gregory

Utilization of Detonation Nanodiamonds: Nanocarrier for Gene Therapy in Non-Small Cell Lung Cancer , Allan E. Gutierrez

Role of HLA-DRB1 Fucosylation in Anti-Melanoma Immunity , Daniel K. Lester

Targeting BET Proteins Downregulates miR-33a To Promote Synergy with PIM Inhibitors in CMML , Christopher T. Letson

Regulated Intramembrane Proteolysis by M82 Peptidases: The Role of PrsS in the Staphylococcus aureus Stress Response , Baylie M. Schott

Histone Deacetylase 8 is a Novel Therapeutic Target for Mantle Cell Lymphoma and Preserves Natural Killer Cell Cytotoxic Function , January M. Watters

Theses/Dissertations from 2022 2022

Regulation of the Heat Shock Response via Lysine Acetyltransferase CBP-1 and in Neurodegenerative Disease in Caenorhabditis elegans , Lindsey N. Barrett

Determining the Role of Dendritic Cells During Response to Treatment with Paclitaxel/Anti-TIM-3 , Alycia Gardner

Cell-free DNA Methylation Signatures in Cancer Detection and Classification , Jinyong Huang

The Role Of Eicosanoid Metabolism in Mammalian Wound Healing and Inflammation , Kenneth D. Maus

A Holistic Investigation of Acidosis in Breast Cancer , Bryce Ordway

Characterizing the Impact of Postharvest Temperature Stress on Polyphenol Profiles of Red and White-Fruited Strawberry Cultivars , Alyssa N. Smith

Theses/Dissertations from 2021 2021

Multifaceted Approach to Understanding Acinetobacter baumannii Biofilm Formation and Drug Resistance , Jessie L. Allen

Cellular And Molecular Alterations Associated with Ovarian and Renal Cancer Pathophysiology , Ravneet Kaur Chhabra

Ecology and diversity of boletes of the southeastern United States , Arian Farid

CircREV1 Expression in Triple-Negative Breast Cancer , Meagan P. Horton

Microbial Dark Matter: Culturing the Uncultured in Search of Novel Chemotaxonomy , Sarah J. Kennedy

The Multifaceted Role of CCAR-1 in the Alternative Splicing and Germline Regulation in Caenorhabditis elegans , Doreen Ikhuva Lugano

Unraveling the Role of Novel G5 Peptidase Family Proteins in Virulence and Cell Envelope Biogenesis of Staphylococcus aureus , Stephanie M. Marroquin

Cytoplasmic Polyadenylation Element Binding Protein 2 Alternative Splicing Regulates HIF1α During Chronic Hypoxia , Emily M. Mayo

Transcriptomic and Functional Investigation of Bacterial Biofilm Formation , Brooke R. Nemec

A Functional Characterization of the Omega (ω) subunit of RNA Polymerase in Staphylococcus aureus , Shrushti B. Patil

The Role Of Cpeb2 Alternative Splicing In TNBC Metastasis , Shaun C. Stevens

Screening Next-generation Fluorine-19 Probe and Preparation of Yeast-derived G Proteins for GPCR Conformation and Dynamics Study , Wenjie Zhao

Theses/Dissertations from 2020 2020

Understanding the Role of Cereblon in Hematopoiesis Through Structural and Functional Analyses , Afua Adutwumwa Akuffo

To Mid-cell and Beyond: Characterizing the Roles of GpsB and YpsA in Cell Division Regulation in Gram-positive Bacteria , Robert S. Brzozowski

Spatiotemporal Changes of Microbial Community Assemblages and Functions in the Subsurface , Madison C. Davis

New Mechanisms That Regulate DNA Double-Strand Break-Induced Gene Silencing and Genome Integrity , Dante Francis DeAscanis

Regulation of the Heat Shock Response and HSF-1 Nuclear Stress Bodies in C. elegans , Andrew Deonarine

New Mechanisms that Control FACT Histone Chaperone and Transcription-mediated Genome Stability , Angelo Vincenzo de Vivo Diaz

Targeting the ESKAPE Pathogens by Botanical and Microbial Approaches , Emily Dilandro

Succession in native groundwater microbial communities in response to effluent wastewater , Chelsea M. Dinon

Role of ceramide-1 phosphate in regulation of sphingolipid and eicosanoid metabolism in lung epithelial cells , Brittany A. Dudley

Allosteric Control of Proteins: New Methods and Mechanisms , Nalvi Duro

Microbial Community Structures in Three Bahamian Blue Holes , Meghan J. Gordon

A Novel Intramolecular Interaction in P53 , Fan He

The Impact of Myeloid-Mediated Co-Stimulation and Immunosuppression on the Anti-Tumor Efficacy of Adoptive T cell Therapy , Pasquale Patrick Innamarato

Investigating Mechanisms of Immune Suppression Secondary to an Inflammatory Microenvironment , Wendy Michelle Kandell

Posttranslational Modification and Protein Disorder Regulate Protein-Protein Interactions and DNA Binding Specificity of p53 , Robin Levy

Mechanistic and Translational Studies on Skeletal Malignancies , Jeremy McGuire

Novel Long Non-Coding RNA CDLINC Promotes NSCLC Progression , Christina J. Moss

Genome Maintenance Roles of Polycomb Transcriptional Repressors BMI1 and RNF2 , Anthony Richard Sanchez IV

The Ecology and Conservation of an Urban Karst Subterranean Estuary , Robert J. Scharping

Biological and Proteomic Characterization of Cornus officinalis on Human 1.1B4 Pancreatic β Cells: Exploring Use for T1D Interventional Application , Arielle E. Tawfik

Evaluation of Aging and Genetic Mutation Variants on Tauopathy , Amber M. Tetlow

Theses/Dissertations from 2019 2019

Investigating the Proteinaceous Regulome of the Acinetobacter baumannii , Leila G. Casella

Functional Characterization of the Ovarian Tumor Domain Deubiquitinating Enzyme 6B , Jasmin M. D'Andrea

Integrated Molecular Characterization of Lung Adenocarcinoma with Implications for Immunotherapy , Nicholas T. Gimbrone

The Role of Secreted Proteases in Regulating Disease Progression in Staphylococcus aureus , Brittney D. Gimza

Advanced Proteomic and Epigenetic Characterization of Ethanol-Induced Microglial Activation , Jennifer Guergues Guergues

Understanding immunometabolic and suppressive factors that impact cancer development , Rebecca Swearingen Hesterberg

Biochemical and Proteomic Approaches to Determine the Impact Level of Each Step of the Supply Chain on Tomato Fruit Quality , Robert T. Madden

Enhancing Immunotherapeutic Interventions for Treatment of Chronic Lymphocytic Leukemia , Kamira K. Maharaj

Characterization of the Autophagic-Iron Axis in the Pathophysiology of Endometriosis and Epithelial Ovarian Cancers , Stephanie Rockfield

Understanding the Influence of the Cancer Microenvironment on Metabolism and Metastasis , Shonagh Russell

Modeling of Interaction of Ions with Ether- and Ester-linked Phospholipids , Matthew W. Saunders

Novel Insights into the Multifaceted Roles of BLM in the Maintenance of Genome Stability , Vivek M. Shastri

Conserved glycine residues control transient helicity and disorder in the cold regulated protein, Cor15a , Oluwakemi Sowemimo

A Novel Cytokine Response Modulatory Function of MEK Inhibitors Mediates Therapeutic Efficacy , Mengyu Xie

Novel Strategies on Characterizing Biologically Specific Protein-protein Interaction Networks , Bi Zhao

Theses/Dissertations from 2018 2018

Characterization of the Transcriptional Elongation Factor ELL3 in B cells and Its Role in B-cell Lymphoma Proliferation and Survival , Lou-Ella M.m. Alexander

Identification of Regulatory miRNAs Associated with Ethanol-Induced Microglial Activation Using Integrated Proteomic and Transcriptomic Approaches , Brandi Jo Cook

Molecular Phylogenetics of Floridian Boletes , Arian Farid

MYC Distant Enhancers Underlie Ovarian Cancer Susceptibility at the 8q24.21 Locus , Anxhela Gjyshi Gustafson

Quantitative Proteomics to Support Translational Cancer Research , Melissa Hoffman

A Systems Chemical Biology Approach for Dissecting Differential Molecular Mechanisms of Action of Clinical Kinase Inhibitors in Lung Cancer , Natalia Junqueira Sumi

Investigating the Roles of Fucosylation and Calcium Signaling in Melanoma Invasion , Tyler S. Keeley

Synthesis, Oxidation, and Distribution of Polyphenols in Strawberry Fruit During Cold Storage , Katrina E. Kelly

Investigation of Alcohol-Induced Changes in Hepatic Histone Modifications Using Mass Spectrometry Based Proteomics , Crystina Leah Kriss

Off-Target Based Drug Repurposing Using Systems Pharmacology , Brent M. Kuenzi

Investigation of Anemarrhena asphodeloides and its Constituent Timosaponin-AIII as Novel, Naturally Derived Adjunctive Therapeutics for the Treatment of Advanced Pancreatic Cancer , Catherine B. MarElia

The Role of Phosphohistidine Phosphatase 1 in Ethanol-induced Liver Injury , Daniel Richard Martin

Theses/Dissertations from 2017 2017

Changing the Pathobiological Paradigm in Myelodysplastic Syndromes: The NLRP3 Inflammasome Drives the MDS Phenotype , Ashley Basiorka

Modeling of Dynamic Allostery in Proteins Enabled by Machine Learning , Mohsen Botlani-Esfahani

Uncovering Transcriptional Activators and Targets of HSF-1 in Caenorhabditis elegans , Jessica Brunquell

The Role of Sgs1 and Exo1 in the Maintenance of Genome Stability. , Lillian Campos-Doerfler

Mechanisms of IKBKE Activation in Cancer , Sridevi Challa

Discovering Antibacterial and Anti-Resistance Agents Targeting Multi-Drug Resistant ESKAPE Pathogens , Renee Fleeman

Functional Roles of Matrix Metalloproteinases in Bone Metastatic Prostate Cancer , Jeremy S. Frieling

Disorder Levels of c-Myb Transactivation Domain Regulate its Binding Affinity to the KIX Domain of CREB Binding Protein , Anusha Poosapati

Role of Heat Shock Transcription Factor 1 in Ovarian Cancer Epithelial-Mesenchymal Transition and Drug Sensitivity , Chase David Powell

Cell Division Regulation in Staphylococcus aureus , Catherine M. Spanoudis

A Novel Approach to the Discovery of Natural Products From Actinobacteria , Rahmy Tawfik

Non-classical regulators in Staphylococcus aureus , Andy Weiss

Theses/Dissertations from 2016 2016

In Vitro and In Vivo Antioxidant Capacity of Synthetic and Natural Polyphenolic Compounds Identified from Strawberry and Fruit Juices , Marvin Abountiolas

Quantitative Proteomic Investigation of Disease Models of Type 2 Diabetes , Mark Gabriel Athanason

CMG Helicase Assembly and Activation: Regulation by c-Myc through Chromatin Decondensation and Novel Therapeutic Avenues for Cancer Treatment , Victoria Bryant

Computational Modeling of Allosteric Stimulation of Nipah Virus Host Binding Protein , Priyanka Dutta

Cell Cycle Arrest by TGFß1 is Dependent on the Inhibition of CMG Helicase Assembly and Activation , Brook Samuel Nepon-Sixt

Gene Expression Profiling and the Role of HSF1 in Ovarian Cancer in 3D Spheroid Models , Trillitye Paullin

VDR-RIPK1 Interaction and its Implications in Cell Death and Cancer Intervention , Waise Quarni

Regulation of nAChRs and Stemness by Nicotine and E-cigarettes in NSCLC , Courtney Schaal

Targeting Histone Deacetylases in Melanoma and T-cells to Improve Cancer Immunotherapy , Andressa Sodre De Castro Laino

Nonreplicative DNA Helicases Involved in Maintaining Genome Stability , Salahuddin Syed

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Home > CNS > BIOCHEM > MCB > MCB_THESES

Molecular and Cellular Biology Masters Theses Collection

Theses from 2024 2024.

The Impact of a Non-ionic Adjuvant to the Persistence of Pesticides on Produce Surfaces , Daniel Barnes, Molecular & Cellular Biology

Investigating the Role of Got2 in Murine Organogenesis and Placenta Development , Olivia Macrorie, Molecular & Cellular Biology

Chromatin Accessibility Impacts Knockout of Mt-Bell4 Transcription Factor , Thomas Redden, Molecular & Cellular Biology

UNDERSTANDING THE FUNCTIONAL IMPACT OF DISEASE-ASSOCIATED PHOSPHORYLATION SITES ON THE NEURODEGENERATIVE PROTEIN TAU , Navya T. Sebastian, Molecular & Cellular Biology

Theses from 2023 2023

Elucidating the Priming Mechanism of ClpXP Protease by Single-Domain Response Regulator CpdR in Caulobacter crescentus , Kimberly E. Barker, Molecular & Cellular Biology

The Discovery of a Novel Bacteria from a Large Co-assembly of Metagenomes , Matthew Finkelberg, Molecular & Cellular Biology

Investigating Diterpene Biosynthesis in Medicago Truncatula , Sungwoo Hwang, Molecular & Cellular Biology

Combining Simulation and the MspA Nanopore to Study p53 Dynamics and Interactions , Samantha A. Schultz, Molecular & Cellular Biology

Caulobacter ClpXP Adaptor PopA’s Domain Interactions in the Adaptor Hierarchy of CtrA Degradation , Thomas P. Scudder, Molecular & Cellular Biology

Climate Change, Giant Viruses and Their Putative Hosts , Sarah K. Tucker, Molecular & Cellular Biology

Theses from 2022 2022

Changes in Gene Expression From Long-Term Warming Revealed Using Metatranscriptome Mapping to FAC-Sorted Bacteria , Christopher A. Colvin, Molecular & Cellular Biology

Determining CaMKII Variant Activities and Their Roles in Human Disease , Matthew J. Dunn, Molecular & Cellular Biology

Developmental Exposures to PFAS Mixtures Impair Elongation of the Exocrine Pancreas in Zebrafish (Danio rerio) , Emily M. Formato, Molecular & Cellular Biology

A Metatranscriptomic Analysis of the Long-Term Effects of Warming on the Harvard Forest Soil Microbiome , Brooke A. Linnehan, Molecular & Cellular Biology

Characterization of the Poly (ADP-Ribose) Polymerase Family in the Fusarium oxysporum Species Complex , Daniel Norment, Molecular & Cellular Biology

Theses from 2021 2021

Exploring Knockdown Phenotypes and Interactions between ATAD3 Proteins in Arabidopsis thaliana , Eli S. Gordon, Molecular & Cellular Biology

Development of a Site-Specific Labeling Assay to Study the Pseudomonas aeruginosa Type III Secretion Translocon in Native Membranes , Kyle A. Mahan, Molecular & Cellular Biology

Liposomal Nanoparticles Target TLR7/8-SHP2 to Repolarize Macrophages to Aid in Cancer Immunotherapy , Vaishali Malik, Molecular & Cellular Biology

Hsp70 Phosphorylation: A Case Study of Serine Residues 385 and 400 , Sashrika Saini, Molecular & Cellular Biology

Activation of Nrf2 at Critical Windows of Development Alters Protein S-Glutathionylation in the Zebrafish Embryo (Danio rerio) , Emily G. Severance, Molecular & Cellular Biology

Utilizing Fluorescence Microscopy to Characterize the Subcellular Distribution of the Novel Protein Acheron , Varun Sheel, Molecular & Cellular Biology

Theses from 2020 2020

The Association Between Sperm DNA Methylation and Sperm Mitochondrial DNA Copy Number , Emily Houle, Molecular & Cellular Biology

Gene Expression Regulation in the Mouse Liver by Mechanistic Target Of Rapamycin Complexes I and II , Anthony Poluyanoff, Molecular & Cellular Biology

Sperm Mitochondrial DNA Biomarkers as a Measure of Male Fecundity and Overall Sperm Quality , Allyson Rosati, Molecular & Cellular Biology

Exploration of the Association between Muscle Volume and Bone Geometry Reveals Surprising Relationship at the Genetic Level , Prakrit Subba, Molecular & Cellular Biology

Theses from 2019 2019

Studies on the Interaction and Organization of Bacterial Proteins on Membranes , Mariana Brena, Molecular & Cellular Biology

Investigating The Role Of LBH During Early Embryonic Development In Xenopus Laevis , Emma Weir, Molecular & Cellular Biology

Theses from 2018 2018

Exploring the Influence of PKC-theta Phosphorylation on Notch1 Activation and T Helper Cell Differentiation , Grace Trombley, Molecular & Cellular Biology

Theses from 2017 2017

Partial Craniofacial Cartilage Rescue in ace/fgf8 Mutants from Compensatory Signaling From the Ventricle of Danio Rerio , Douglas A. Calenda II, Molecular & Cellular Biology

THE FAR C-TERMINUS OF TPX2 CONTRIBUTES TO SPINDLE MORPHOGENESIS , Brett Estes, Molecular & Cellular Biology

Characterization of Calcium Homeostasis Parameters in TRPV3 and CaV3.2 Double Null Mice , Aujan Mehregan, Molecular & Cellular Biology

Microtransplantation of Rat Brain Neurolemma into Xenopus Laevis Oocytes to Study the Effect of Environmental Toxicants on Endogenous Voltage-Sensitive Ion Channels , Edwin Murenzi, Molecular & Cellular Biology

Regulation of Katanin Activity on Microtubules , Madison A. Tyler, Molecular & Cellular Biology

Theses from 2016 2016

The Role of MicroRNAs in Regulating the Translatability and Stability of Target Messenger RNAs During the Atrophy and Programmed Cell Death of the Intersegmental Muscles of the Tobacco Hawkmoth Manduca sexta. , Elizabeth Chan, Molecular & Cellular Biology

An in Vivo Study of Cortical Dynein Dynamics and its Contribution to Microtubule Sliding in the Midzone , Heather M. Jordan, Molecular & Cellular Biology

A Genetic Analysis of Cichlid Scale Morphology , Kenta C. Kawasaki, Molecular & Cellular Biology

Modulation of Notch in an Animal Model of Multiple Sclerosis , Manit Nikhil Munshi, Molecular & Cellular Biology

One-Carbon Metabolism Related B-Vitamins Alter The Expression Of MicroRNAS And Target Genes Within The Wnt Signaling Pathway In Mouse Colonic Epithelium , Riccardo Racicot, Molecular & Cellular Biology

Characterizing the Inhibition of Katanin Using Tubulin Carboxy-Terminal Tail Constructs , Corey E. Reed, Molecular & Cellular Biology

The Identification of Notch1 Functional Domains Responsible for its Physical Interaction with PKCθ , Wesley D. Rossiter, Molecular & Cellular Biology

Dynamics of Microtubule Networks with Antiparallel Crosslinkers , Kasimira T. Stanhope, Molecular & Cellular Biology

Modifications of Myofilament Structure and Function During Global Myocardial Ischemia , Mike K. Woodward, Molecular & Cellular Biology

Theses from 2015 2015

Regulation of Jak1 and Jak2 Synthesis through Non-Classical Progestin Receptors , Hillary Adams, Molecular & Cellular Biology

Antineoplastic Effects of Rhodiola Crenulata on B16-F10 Melanoma , Maxine Dudek, Molecular & Cellular Biology

RNAi Validation of Resistance Genes and Their Interactions in the Highly DDT-Resistant 91-R Strain of Drosophila Melanogaster , Kyle Gellatly, Molecular & Cellular Biology

Characterization of Protein-Protein Interactions for Therapeutic Drug Design Utilizing Mass Spectrometry , Alex J. Johnson, Molecular & Cellular Biology

Promoting Extracellular Matrix Crosslinking in Synthetic Hydrogels , Marcos M. Manganare, Molecular & Cellular Biology

Characterization of the Reconstituted and Native Pseudomonas aeruginosa Type III Secretion System Translocon , Kathryn R. Monopoli, Molecular & Cellular Biology

Thermocycle-regulated WALL REGULATOR INTERACTING bHLH Encodes a Protein That Interacts with Secondary-Cell-Wall-Associated Transcription Factors , Ian P. Whitney, Molecular & Cellular Biology

Theses from 2014 2014

Engineering Camelina sativa for Biofuel Production via increasing oil yield and tolerance to abiotic stresses , Kenny Ablordeppey, Molecular & Cellular Biology

Designing a Pore-Forming Toxin Cytolysin A (ClyA) Specific to Target Cancer Cells , Alzira Rocheteau Avelino, Molecular & Cellular Biology

The Role of the Novel Lupus Antigen, Acheron, in Moderating Life and Death Decisions , Ankur Sheel, Molecular & Cellular Biology

Expression and Purification of Human Lysosomal β-galactosidase from Pichia Pastoris , Sarah E. Tarullo, Molecular & Cellular Biology

Properties of Potential Substrates of a Cyanobacterial Small Heat Shock Protein , Yichen Zhang, Molecular & Cellular Biology

Theses from 2013 2013

Characterizing the Heavy Metal Chelator, Tpen, as a Ca2+ Tool in the Mammalian Oocyte , Robert A. Agreda Mccaughin, Molecular & Cellular Biology

Sustainable Biofuels Production Through Understanding Fundamental Bacterial Pathways Involved in Biomass Degradation and Sugar Utilization , James CM Hayes, Molecular & Cellular Biology

Stiffness and Modulus and Independent Controllers of Breast Cancer Metastasis , Dannielle Ryman, Molecular & Cellular Biology

Theses from 2012 2012

The Pyrethroid Deltamethrin, Which Causes Choreoathetosis with Salivation (CS-Syndrome), Enhances Calcium Ion Influx via Phosphorylated CaV2.2 expresssed in Xenopus laevis oocytes , Anna-maria Alves, Molecular & Cellular Biology

A Test of the Hypothesis That Environmental Chemicals Interfere With Thyroid Hormone Action in Human Placenta , Katherine Geromini, Molecular & Cellular Biology

Analyzing the Role of Reactive Oxygen Species in Male-Female Interactions in Arabidopsis thaliana. , Eric A. Johnson, Molecular & Cellular Biology

Rhythmic Growth And Vascular Development In Brachypodium Distachyon , Dominick A. Matos, Molecular & Cellular Biology

Polymer Prodrug Conjugation to Tumor Homing Mesenchymal Stem Cells , Nick Panzarino, Molecular & Cellular Biology

Investigation of Differential Vector Competence of Bartonella quintana in Human Head and Body Lice , Domenic j. Previte, Molecular & Cellular Biology

Downregulation of Cinnamyl Alcohol Dehydrogenase or Caffeic Acid O-Methyltransferase Leads to Improved Biological Conversion Efficiency in Brachypodium distachyon , Gina M. Trabucco, Molecular & Cellular Biology

Theses from 2011 2011

Evolutionary Relationship of the ampC Resistance Gene In E. cloacae , Shanika S. Collins, Molecular & Cellular Biology

Sex Difference in Calbindin Cell Number in the Mouse Preoptic Area: Effects of Neonatal Estradiol and Bax Gene Deletion , Richard F. Gilmore III, Molecular & Cellular Biology

In Vivo Investigations of Polymer Conjugates as Therapeutics , Elizabeth M. Henchey, Molecular & Cellular Biology

Examination of Sexually Dimorphic Cell Death in the Pubertal Mouse Brain , Amanda Holley, Molecular & Cellular Biology

Human Niemann-Pick Type C2 Disease Protein Expression, Purification and Crystallization , Yurie T. Kim, Molecular & Cellular Biology

Revealing the Localization of the Class I Formin Family in the Moss Physcomitrella patens Using Gene Targeting Strategies , Kelli Pattavina, Molecular & Cellular Biology

Connecting Motors and Membranes: A Quantitative Investigation of Dynein Pathway Components and in vitro Characterization of the Num1 Coiled Coil Domain , Bryan J. St. Germain, Molecular & Cellular Biology

Theses from 2010 2010

The Protective Effects A Full-term Pregnancy Plays Against Mammary Carcinoma , Matthew p. Carter, Molecular & Cellular Biology

Analysis Of An Actin Binding Guanine Exchange Factor, Gef8, And Actin Depolymerizing Factor In Arabidopsis Thaliana. , Aleksey Chudnovskiy, Molecular & Cellular Biology

The Role of Ykl-40, a Secreted Heparin-Binding Glycoprotein, in Tumor Angiogenesis, Metastasis, and Progression: a Potential Therapeutic Target , Michael Faibish, Molecular & Cellular Biology

In Vivo Visualization of Hedgehog Signaling in Zebrafish , Christopher J. Ferreira, Molecular & Cellular Biology

An In Vivo Study of the Mammalian Mitotic Kinesin Eg5 , Alyssa D. Gable, Molecular & Cellular Biology

Identification of Dynein Binding Sites in Budding Yeast Pac1/LIS1 , Christopher W. Meaden, Molecular & Cellular Biology

Functional Characterization of Arabidopsis Formin Homologues Afh1, Afh5, Afh6, Afh7 and Afh8 , Shahriar Niroomand, Molecular & Cellular Biology

Regulation of Crbp1 In Mammary Epithelial Cells , Stacy L. Pease, Molecular & Cellular Biology

In Vivo Labeling Of A Model β-Clam Protein With A Fluorescent Amino Acid , Mangayarkarasi Periasamy, Molecular & Cellular Biology

In Vivo Characterization of Interactions Among Dynein Complex Components at Microtubule Plus Ends , Karen M. Plevock, Molecular & Cellular Biology

Anti-Diabetic Potentials of Phenolic Enriched Chilean Potato and Select Herbs of Apiaceae and Lamiaceae Families , Fahad Saleem, Molecular & Cellular Biology

Interconversion of the Specificities of Human Lysosomal Enzymes , Ivan B. Tomasic, Molecular & Cellular Biology

Deletions of Fstl3 and/or Fst Isoforms 303 and 315 Results in Hepatic Steatosis , Nathan A. Ungerleider, Molecular & Cellular Biology

Theses from 2009 2009

A New Laser Pointer Driven Optical Microheater for Precise Local Heat Shock , Mike Placinta, Molecular & Cellular Biology

Theses from 2008 2008

Cysteine Dioxygenase: The Importance of Key Residues and Insight into the Mechanism of the Metal Center , Jonathan H. Leung, Molecular & Cellular Biology

Invertebrate Phenology and Prey Selection of Three Sympatric Species of Salmonids; Implications for Individual Fish Growth , Jeffrey V. Ojala, Wildlife & Fisheries Conservation

Paralemmin Splice Variants and mRNA and Protein Expression in Breast Cancer , Casey M. Turk, Molecular & Cellular Biology

Stability of the frog motor nerve terminal: roles of perisynaptic Schwann cells and muscle fibers , Ling Xin, Molecular & Cellular Biology

Theses from 2007 2007

Antioxidant Response Mechanism in Apples during Post-Harvest Storage and Implications for Human Health Benefits , Ishan Adyanthaya, Molecular & Cellular Biology

Progress Towards A Model Flavoenzyme System , Kevin M. Bardon, Molecular & Cellular Biology

The effect of Rhodiola crenulata on a highly metastatic murine mammary carcinoma , Jessica L. Doerner, Molecular & Cellular Biology

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Published by Robert Bruce at August 29th, 2023 , Revised On September 5, 2023

Biology Research Topics

Are you in need of captivating and achievable research topics within the field of biology? Your quest for the best biology topics ends right here as this article furnishes you with 100 distinctive and original concepts for biology research, laying the groundwork for your research endeavor.

Table of Contents

Our proficient researchers have thoughtfully curated these biology research themes, considering the substantial body of literature accessible and the prevailing gaps in research.

Should none of these topics elicit enthusiasm, our specialists are equally capable of proposing tailor-made research ideas in biology, finely tuned to cater to your requirements.

Thus, without further delay, we present our compilation of biology research topics crafted to accommodate students and researchers.

Research Topics in Marine Biology

Impact of climate change on coral reef ecosystems.
Biodiversity and adaptation of deep-sea organisms.
Effects of pollution on marine life and ecosystems.
Role of marine protected areas in conserving biodiversity.
Microplastics in marine environments: sources, impacts, and mitigation.

Biological Anthropology Research Topics

Evolutionary implications of early human migration patterns.
Genetic and environmental factors influencing human height variation.
Cultural evolution and its impact on human societies.
Paleoanthropological insights into human dietary adaptations.
Genetic diversity and population history of indigenous communities.

Biological Psychology Research Topics

Neurobiological basis of addiction and its treatment.
Impact of stress on brain structure and function.
Genetic and environmental influences on mental health disorders.
Neural mechanisms underlying emotions and emotional regulation.
Role of the gut-brain axis in psychological well-being.

Cancer Biology Research Topics

Targeted therapies in precision cancer medicine.
Tumor microenvironment and its influence on cancer progression.
Epigenetic modifications in cancer development and therapy.
Immune checkpoint inhibitors and their role in cancer immunotherapy.
Early detection and diagnosis strategies for various types of cancer.

Cell Biology Research Topics

Mechanisms of autophagy and its implications in health and disease.
Intracellular transport and organelle dynamics in cell function.
Role of cell signaling pathways in cellular response to external stimuli.
Cell cycle regulation and its relevance to cancer development.
Cellular mechanisms of apoptosis and programmed cell death.

Developmental Biology Research Topics

Genetic and molecular basis of limb development in vertebrates.
Evolution of embryonic development and its impact on morphological diversity.
Stem cell therapy and regenerative medicine approaches.
Mechanisms of organogenesis and tissue regeneration in animals.
Role of non-coding RNAs in developmental processes.

Human Biology Research Topics

Genetic factors influencing susceptibility to infectious diseases.
Human microbiome and its impact on health and disease.
Genetic basis of rare and common human diseases.
Genetic and environmental factors contributing to aging.
Impact of lifestyle and diet on human health and longevity.

Molecular Biology Research Topics

CRISPR-Cas gene editing technology and its applications.
Non-coding RNAs as regulators of gene expression.
Role of epigenetics in gene regulation and disease.
Mechanisms of DNA repair and genome stability.
Molecular basis of cellular metabolism and energy production.

Research Topics in Biology for Undergraduates

41. Investigating the effects of pollutants on local plant species.
Microbial diversity and ecosystem functioning in a specific habitat.
Understanding the genetics of antibiotic resistance in bacteria.
Impact of urbanization on bird populations and biodiversity.
Investigating the role of pheromones in insect communication.

Synthetic Biology Research Topics

Design and construction of synthetic biological circuits.
Synthetic biology applications in biofuel production.
Ethical considerations in synthetic biology research and applications.
Synthetic biology approaches to engineering novel enzymes.
Creating synthetic organisms with modified functions and capabilities.

Animal Biology Research Topics

Evolution of mating behaviors in animal species.
Genetic basis of color variation in butterfly wings.
Impact of habitat fragmentation on amphibian populations.
Behavior and communication in social insect colonies.
Adaptations of marine mammals to aquatic environments.

Best Biology Research Topics

Unraveling the mysteries of circadian rhythms in organisms.
Investigating the ecological significance of cryptic coloration.
Evolution of venomous animals and their prey.
The role of endosymbiosis in the evolution of eukaryotic cells.
Exploring the potential of extremophiles in biotechnology.

Biological Psychology Research Paper Topics

Neurobiological mechanisms underlying memory formation.
Impact of sleep disorders on cognitive function and mental health.
Biological basis of personality traits and behavior.
Neural correlates of emotions and emotional disorders.
Role of neuroplasticity in brain recovery after injury.

Biological Science Research Topics:

Role of gut microbiota in immune system development.
Molecular mechanisms of gene regulation during development.
Impact of climate change on insect population dynamics.
Genetic basis of neurodegenerative diseases like Alzheimer’s.
Evolutionary relationships among vertebrate species based on DNA analysis.

Biology Education Research Topics

Effectiveness of inquiry-based learning in biology classrooms.
Assessing the impact of virtual labs on student understanding of biology concepts.
Gender disparities in science education and strategies for closing the gap.
Role of outdoor education in enhancing students’ ecological awareness.
Integrating technology in biology education: challenges and opportunities.

Biology-Related Research Topics

The intersection of ecology and economics in conservation planning.
Molecular basis of antibiotic resistance in pathogenic bacteria.
Implications of genetic modification of crops for food security.
Evolutionary perspectives on cooperation and altruism in animal behavior.
Environmental impacts of genetically modified organisms (GMOs).

Biology Research Proposal Topics

Investigating the role of microRNAs in cancer progression.
Exploring the effects of pollution on aquatic biodiversity.
Developing a gene therapy approach for a genetic disorder.
Assessing the potential of natural compounds as anti-inflammatory agents.
Studying the molecular basis of cellular senescence and aging.

Biology Research Topic Ideas

Role of pheromones in insect mate selection and behavior.
Investigating the molecular basis of neurodevelopmental disorders.
Impact of climate change on plant-pollinator interactions.
Genetic diversity and conservation of endangered species.
Evolutionary patterns in mimicry and camouflage in organisms.

Biology Research Topics for Undergraduates

Effects of different fertilizers on plant growth and soil health.
Investigating the biodiversity of a local freshwater ecosystem.
Evolutionary origins of a specific animal adaptation.
Genetic diversity and disease susceptibility in human populations.
Role of specific genes in regulating the immune response.

Cell and Molecular Biology Research Topics

Molecular mechanisms of DNA replication and repair.
Role of microRNAs in post-transcriptional gene regulation.
Investigating the cell cycle and its control mechanisms.
Molecular basis of mitochondrial diseases and therapies.
Cellular responses to oxidative stress and their implications in ageing.

These topics cover a broad range of subjects within biology, offering plenty of options for research projects. Remember that you can further refine these topics based on your specific interests and research goals.

Frequently Asked Questions

What are some good research topics in biology?

A good research topic in biology will address a specific problem in any of the several areas of biology, such as marine biology, molecular biology, cellular biology, animal biology, or cancer biology.

A topic that enables you to investigate a problem in any area of biology will help you make a meaningful contribution.

How to choose a research topic in biology?

Choosing a research topic in biology is simple.

Follow the steps:

Generate potential topics.
Consider your areas of knowledge and personal passions.
Conduct a thorough review of existing literature.
Evaluate the practicality and viability.
Narrow down and refine your research query.
Remain receptive to new ideas and suggestions.

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212 Unique Biology Research Topics For Students And Researchers

Every student studying something related to biology — botany, marine, animal, medicine, molecular or physical biology, is in an interesting field. It’s a subject that explores how animate and inanimate objects relate to themselves. The field unveils the past, the present, and what lies in the future of the relationship between the living and nonliving things.

This is precisely why you need custom and quality biology topics for your college and university essay or project. It’ll make it easy to brainstorm, research, and get to writing straight away. Before the deep dive, what is biology?

What Is Biology?

Everyone knows it’s the scientific study of life, but beyond that, biology facilitates the comprehension of living and nonliving things. It’s a branch that explores their anatomy, behavior, distribution, morphology, and physiology.

For example, it understands how genes are classified and constituted into generations. It encompasses various branches, including botany, medicine, genetics, ecology, marine biology, zoology, and molecular biology.

Here are what some of these mean:

Botany: This study of plants examines their structure, physiology, ecology, economic importance, and distribution, among others. It also deals with their biochemical processes, properties, and social interactions between plants. It extends to how plants are vital for human life, survival, and growth and how they play a significant role in stabilizing environmental health. Zoology: Zoology studies animal behavior, brain, structure, physiology, class, and distribution. It’s the general study of the lives of both living and extinct animals. It explains animal classification, the animal kingdom, evolution, habitat, embryology, and life span. Physiology: Physiology deals with the daily functions of the human body: How it works and the factors that make it work. It examines molecular behavior, the chemistry and physics behind locomotion, and how the cells in the living organisms’ body function. It helps understand how humans and animals get sick and what can be done to alleviate pain. Microbiology: Dealing with microorganisms, it examined how viruses, algae, fungi, bacteria, protozoa, and slime molds become parts of human life. They’re regarded as microbes, which play substantial roles in the human biochemical processes, including climate change, biodegradation, biodeterioration, food spoilage, biotech, and epidemiology. Marine Biology: This is the scientific study of organs in the sea. It understands their family classification, how they survive, and what makes wild marine animals different from domesticated and consumable ones. It also explores their interaction with the environment through several processes. The marine biologist studies marines in their natural environment, collects data on their characteristics, human impact on their living, and how they relate with themselves.

Now that you know all these, here are some custom biology topics to research for your university or college essay and paper.

Controversial Biology Topics

There are many controversial subjects in every field, and biology isn’t exempt from controversy. If you’d like to create an original essay through diverse opinions, here are biology topics for you:

What are your thoughts on the post-Roe V Wade world?
How can the post-Roe V Wade policy affect developing countries looking up to America for their laws?
Abortion and feminism: discuss
Does saving life justify cloning?
Explain the principle of abortion in medical practice
The effects of cloning in medicine
How does genetics contribute to obesity?
Explain why a parent could have Hepatitis B virus and only one of five offspring have the virus
Is homosexuality really in the gene?
How does depression correlate with genetics?
Additives and how they affect the genes
Examine how genetic mutations work
Discuss the grounds that you could prove for legalizing human cloning
Which is more immoral: Human or animal cloning?
How is nanotechnology different from biotechnology?
Discuss the manifestation of nanotechnology in science
Explain three instances where public opinion has held back scientific inventions
How does transgenic crop work?
Would you say genetically modified food is safe for consumption?
Explain why sexual abuse leads to trauma.

Biology Research Paper Topics

You’d need to write an extensive paper on biology one day. This could be when you’re in your final year in college or the university or submitting to a competition. You’d need Biology topics to research for brainstorming, and here are 30 of them:

Stem cells and tissue formation processes
Why are there different congenital disabilities?
Mixtures in anticancer drugs?
What are the complexities of existing HIV drugs?
What is the contribution of chemotherapy to cancer?
Examine the chemotherapy process and why it doesn’t work for some patients.
Explain the origin of developmental diseases
How do germs affect the cells?
What are the consequences of the sun on the white person’s and black person’s skin?
Why are some diseases treatable through drugs while some are not?
Scientific lessons learned from COVID-19 and ideas to tackle the next virus
If animals are carriers of the virus, what should be done to them?
Examine five animals in extinction and what led to it
Discuss the subject of endangered species and why people should care
Is a plant-based diet sustainable for human health?
Account for the consequence of living on Mars on human health
Discuss the inconveniences involved in space travel
How does space flight contribute to environmental disasters
Discuss the emergence of leukemia
Explain how the immune systems in humans work
Evaluate the factors that weaken the immunological system
What would you consider the deadliest virus?
Autoimmune: what is it, origin and consequences
Immune disorder: origin and how it affects the body
Does stress affect the ability to have sex?
Contribution of vaccine to eradicating disease: Discuss
What are the complexities in taking the Hepatitis B vaccine while being positive?
Allergies: why do humans have them?
DNA modification: how does it work?
Explain the misconceptions about the COVID-19 vaccines.

Interesting Biology Topics

Biology doesn’t have to be boring. Different aspects of biology could be fun to explore, especially if you’ve had a flair for the study since your elementary school classes.

You can either write an essay or paper with the following interesting biology research topics:

Human emotions and conflicts with their intellectual intelligence
Emotions: Its influence on art and music and how the perception of art influences the world
The consequences of marijuana and alcohol on teenagers
Compare and contrast how alcohol affects teenagers and adults
Discuss the contributions of neuroscience to the subject of emotional pain
Explain how the brain process speech
Discuss the factors that cause autism
Explain what is meant when people say humans are animals
Why do scientists say humans are pessimists?
Factors contributing to the dopamine levels human experience
How does isolation affect the human brain?
What factors contribute to instinctive responses?
Noise pollution: how it affects living organisms
Fire ecology: The contributions of plants to fire outbreak
Explain the science behind how hot temperature, soil, and dry grass start a fire
Microbes: what do you understand by bioremediation?
Explain urban ecology and the challenges it pokes to solve
Discuss how excessive internet usage affects the human memory
Evaluate how conservation biology contributes to the extinction prevention efforts
Discuss the role of satellites and drones in understanding the natural world
Why do we need space travel and studies?
Explain the limitations of limnology studies
What are infectious-disease-causing agents all about?
Discuss what epigenetics studies encompass
Why is cancer research essential to the world?
Discuss climate change: Governments are not interested, and there is no alternative
How is behavioral science studies a core part of the understanding of the world?
Discuss the issues with genetic engineering and why it’s a challenge
Evaluate the strengths and weaknesses in the arguments for a plant-based diet
Create a survey amongst students of biology asking why they chose to study the course.

Biology Research Topics For College Students

If you find any of the above beyond your intellectual and Research capacity, here are some topics you can handle. You can use these for your essays, projects, quizzes, or competitions.

These custom yet popular biology research topics will examine famous personalities and other discourse in biology:

Effects of the human hormone on the mind
Why do men get erect even when they’re absentminded?
How does women’s arousal work?
How can melatonin be valuable for therapy?
Risky behavior: Hormones responsible for the risk
Stem and cloning: what is the latest research on the subject?
Hormones: changes in pregnancy
Why do pregnant women have an appetite for random and remote things?
The role of physical activities in hormone development
Examine the benefits and threats of transgenic crops
The fight against COVID-19: assess current successes
The fight against smallpox: assess current successes
The fight against HIV: history, trends, and present research
Discuss the future of prosthetic appliances
Examine the research and the future of mind-controlled limbs
What does cosmetic surgery mean, and why is it needed?
Analyze the meaning and process of vascular surgery
Discuss the debate around changes in genital organs for males and females in transgender bodies
How do donors and organ transplants work?
Account for the work of Dr. Malcom E Miller
Discuss the contribution of Charles Darwin to human evolution
Explain the trends in biomedicine
Discuss the functions of x-rays in botany
Assess the most efficient systems for wildlife preservation
Examine how poverty contributes to climate hazards
Discuss the process involved in plant metabolism
The transformation of energy into a living thing: discuss
Prevention for sexually transmitted disease: What are the misconceptions?
Analyze how the human body reacts to poison
Russian Poisoning: What are the lessons scientists must learn?
COVID-19: Discuss the efforts by two or three governments to prevent the spread
Discuss the contributions of Pfizer during the pandemic.

Marine Biology Research Topics

This subject explains orgasms in the sea, how they survive, and their interaction with their environment. If you have a flair for this field, the following Biology research topics may interest you:

Discuss what quantitative ecology through modeling means
Smallest diatoms and marine logistics: discuss
How is the shark studied?
Acidification of seas: Causes and consequences
Discuss the concept of the immortality of Jellyfishes
Discuss the differences between seawater and freshwater in marine study
Account for some of the oldest marine species
Discuss the evolution of the deep sea
Explain whales’ communication techniques
What does plankton ecology encompass?
The importance of coral reefs to seawater
Challenges that encompass geological oceanography
How tourism affects natural animal habitat
Discuss some instances of the domestication of wild marine animals
Coastal zone: pros and cons of living in such areas
How do sharks perceive enemies?
Analyze why some animals can live in water but can’t live on land
Explain how plants survive in the sea
Compare and contrast the different two species of animals in the water
How can marine energy be generated, stored, and used?

Molecular Biology Research Topics

Focusing on the construct of cells and analysis of their composition, it understands the alteration and maintenance of cellular processes. If you’d like to focus on molecular biology, here are 15 good biology research topics for you:

Ethical considerations in molecular genetics
Discuss the structure and component of the gene
Examine the restrictions in DNA
What are the peculiarities in modern nucleic acid analysis
What goes into the Pharmaceutical production of drugs
Evaluate the building blocks of life
Discuss the systems of RNA translation to protein
PCR: How DNA is tested and analyzed
Why is prion disease so dangerous?
Compare and contrast recessive genes vs. dominant genes
Can there be damage to the human DNA, and can it be repaired?
Constraints in the research of microarray data analysis
Protein purification: How it evolves
Objectives of nucleic acid
Explain the structure of a prion.

Biology Research Topics For High School

Your teachers and professors will be awed if you create impeccable essays for your next report. You need to secure the best grades as you move closer to graduation, and brainstorming any of these popular biology research topics will help:

Identify the most endangered species
The challenges to animal extinction
What are the things everyone should know about sea life?
Discuss the history of genetics
Explain the biological theory of Charles Darwin
How did the lockdown affect social interaction?
Why do some people refuse the vaccine?
Origin of genetics
What is animal hunting, and why is it fashionable
Explain the evolution of a virus
Role of lockdown in preventing deaths and illnesses
Invasive species: What does it mean?
Endangered animals: How do they survive in the face of their hazards?
Lockdown and their role in reducing coronavirus transmission
Vaccine distribution: Ideas for global distribution
Why can viruses become less virulent?
Discuss the evolution of the world
Explain the evolution of the planet
Explain what Elon Musk means when he says life on Mars is possible
What does herd immunity mean?
Flu: why is there a low incidence in 2020?
Relationship between archaeology and biology
Antiviral drug: What it means
Factors leading to the evolution of humans
Give instances of what natural selection means
What is considered the dead branches of evolution
Whale hunting: What it means and the present trends
Who is Stephen Jay, and what is his role in paleontology?
Origin of diseases: why must humans fall sick?
Why are humans called higher animals?

Human Biology Research Topics

Human biology understands humans and their relationship between themselves and their environment. It also studies how the body works and the impediments to health. Here are some easy biology research topics to explore on the subject:

How do gut bacteria affect the brain?
What are the ethical concerns around organ transplants?
The consequence of alcohol on the liver
The consequences of extreme salt on the human body
Why do humans need to deworm regularly?
The relationship between obesity and genetics
Genetically modified foods: Why are they needed?
How sun exposure affects human skin
Latest trends: Depression is hereditary
Influence of music on the human brain
What are the stages of lung cancer
Forensic DNA: latest trends
How visual consumptions affect how humans think
What is the process that leads to pregnancy?
Explain the role of nanotechnology in HIV research
Discuss any experiment with stem cells you know about
Explain how humans consume food
Discuss the process of metabolism as well as its criticality to human health
Explore the consistent challenges technology poses to human health
Explain the process of body decay to a skeleton.

Cell Biology Research Topics

There are many evolutionary biology research paper topics formed not by the nomenclature but for what they stand for. Cell biology is one of the most complex branches of the field.

It examines minor units and the living organisms that make them up. The focus is on the relationship between the cytoplasm, membrane, and parts of the cell. Here are some topics to explore for your scientific dissertation writing :

How does chromatin engage in the alterations of gene expression?
What are the usual cell infections, and why does the body have immunity defections?
Identify and account for the heritage of Robert Brown in his core career focus
Explain the structure of the animal cell and why It’s what it is
Identify the cells in the human body as well as their functions
Explain a scenario and justify the context of animals photosynthesizing like plants
Why do bacteria invade the body, and how do they do it?
Why are mitochondria considered the powerhouse of the cell
Use the molecular analysis tool to explain multicellular organisms
Examine how the White blood cells fight disease
What do you understand about the role of cell biology in the treatment of Alzheimer’s Disease
What are the latest research methods in cell biology?
Identify the characteristics of viruses and why they threaten human existence.
Discuss the differences between DNA and RNA
What part of the body is responsible for human functionality for as long as the individual wants?

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Theses available at the Food Microbiology Laboratory

The Food Microbiology Laboratory provides the possibility for students to do their thesis in collaboration with our group. Below you can find a large variety of possible BSc and MSc thesis subjects.

Bachelor and Master thesis subjects

Ecology of pathogens.

FHM-1.1 M: Antibacterial phytochemicals against Listeria monocytogenes
FHM-1.2 M: Hygiene in the household kitchen: Human and microbiological behaviour
FHM-1.3 M: Is there a microbiological selection bias in our enrichment-based detection method?
FHM-1.4 M: Survival and growth of Campylobacter and Salmonella on raw chicken meat under different storage conditions typical of developing countries
FHM-1.5 M: Quantitative microbial risk assessment of Salmonella and Campylobacter during consumer preparation
FHM-1.6 M: Quantifying the microbial risk associated with chicken slaughter processes
BSc-MSc Food Fermentation 2018-2019 Nov.pdf (621,12 kb)

Food Fermentation

FHM-2.1 M: Fight or flight: improving starter culture production and functionality
FHM-2.2 M: Exploring novel dairy applications for under-exploited food grade Propionibacterium species
FHM-2.3 M: Thiamine as precursor for meat aroma compounds
FHM-2.4 M: Innovation of tempeh using lupine
FHM-2.5 M: Wild-card project as follow-up of PToFF project
FHM-2.6 M: Stronger together: how complex and simple microbial communities from fermented milk affect the gut microbiota composition in a simulated model system (SHIME)
FHM-2.7 M: Bacterial dispersal via fungal "highways" on cheese surface
FHM-2.8 B: Global diversity in fermented food products
BSc-MSc Ecology of Pathogens 2018-2019 Nov.pdf (343,08 kb)

Physiology of Food-related Micro-organisms

FHM-4.1 M: Stress-response and survival strategies of Bacillus cereus
FHM-4.2 M: Identification of genes and molecular mechanisms involved in biofilm formation
FHM-4.3 M: Resistant variants in bacterial populations
FHM-4.4 M: Production and physiological functions of bacterial extracellular vesicles (EVs)
FHM-4.5 M: Dry biofilms on food processing surfaces
BSc-MSc Physiology of Food-related Micro-organisms 2018-2019 Nov.pdf (639,08 kb)

Quantitative Microbiology & Food Safety Management

FHM-5.1 B/M: How heat resistant are microorganisms?
FHM-5.2 B/M: What are the growth kinetics of microorganisms?
FHM-5.3 B/M: Milk spoilage at 0°C: what are main spoilers and their kinetics
FHM-5.4 B/M: Food safety in balance with food security and sustainability
FHM-5.5 B/M: Validation of food preparation practices
BSc-MSc Quantitative Microbiology 2018-2019 Nov.pdf (552,91 kb)

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Dissertations / Theses on the topic 'Soil microbiology'

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Jeffery, Simon. "The microbiology of arable soil surfaces." Thesis, Cranfield University, 2007. http://dspace.lib.cranfield.ac.uk/handle/1826/2245.

Jones, Frances Patricia. "The microbiology of lean and obese soil." Thesis, University of Reading, 2017. http://centaur.reading.ac.uk/69408/.

Paulse, Arnelia N. (Arnelia Natalie). "Soil stabilization by microbial activity." Thesis, Stellenbosch : Stellenbosch University, 2003. http://hdl.handle.net/10019.1/53593.

Wagai, Rota. "Climatic and Lithogenic Controls on Soil Organic Matter-Mineral Associations." Fogler Library, University of Maine, 2005. http://www.library.umaine.edu/theses/pdf/WagaiR2005.pdf.

Marí, Marí Teresa. "Changes in soil biodiversity and activity along management and climatic gradients." Doctoral thesis, Universitat de Lleida, 2017. http://hdl.handle.net/10803/457976.

Rodriguez, Luis A. (Luis Antonio). "Adenylate Energy Charge Determinations of Soil Bacteria Grown in Soil Extract Medium." Thesis, University of North Texas, 1988. https://digital.library.unt.edu/ark:/67531/metadc500662/.

Bester, Reinhard. "Growth and survival of Saccharomyces cerevisiae in soil." Thesis, Stellenbosch : University of Stellenbosch, 2011. http://hdl.handle.net/10019.1/16597.

Coyle, Kieran. "An investigation of the role of soil micro-organisms in phosphorus mobilisation : a report submitted to fulfil the requrements of the degree of Doctor of Philosophy." Title page, table of contents and abstract only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09phc8814.pdf.

Hoyle, Frances Carmen. "The effect of soluble organic carbon substrates, and environmental modulators on soil microbial function and diversity /." Connect to this title, 2006. http://theses.library.uwa.edu.au/adt-WU2007.0050.

Jenkins, Anthony Blaine. "Organic carbon and fertility of forest soils on the Allegheny Plateau of West Virginia." Morgantown, W. Va. : [West Virginia University Libraries], 2002. http://etd.wvu.edu/templates/showETD.cfm?recnum=2486.

Menefee, Dorothy. "Anthropogenic influences on soil microbial properties." Thesis, Kansas State University, 2016. http://hdl.handle.net/2097/32657.

Sutanto, Yovita. "Manure from grazing cattle effects on soil microbial communities and soil quality in northern West Virginia pastures /." Morgantown, W. Va. : [West Virginia University Libraries], 2005. https://etd.wvu.edu/etd/controller.jsp?moduleName=documentdata&jsp%5FetdId=3933.

Sheremata, Tamara W. "The influence of soil organic matter on the fate of trichloroethylene in soil." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0017/NQ44582.pdf.

Blair, Jennifer M. "Mechanistic modelling of bioavailability : putting soil microbiology in its pore scale context." Thesis, Abertay University, 2007. https://rke.abertay.ac.uk/en/studentTheses/bf7beb4b-07fa-41a8-8eeb-25aabf2669a7.

Williams, David. "Ecophysiological studies of soil ammonia oxidising bacteria." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources, 2009. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=26464.

Watts, Dexter Brown. "Mineralization in soils amended with manure as affected by environmental conditions." Auburn, Ala. :, 2007. http://repo.lib.auburn.edu/2007%20Spring%20Dissertations/WATTS_DEXTER_20.pdf.

Jones, Hilary A. "The oxidation of methane in landfill soil cover." Thesis, University of Essex, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306045.

Herron, Paul Robert. "Interactions between actinophage and streptomycetes in soil." Thesis, University of Warwick, 1991. http://wrap.warwick.ac.uk/79686/.

Trubl, Gareth. "Pioneering Soil Viromics to Elucidate Viral Impacts on Soil Ecosystem Services." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1543425468999981.

Padua, Roberto R. "Purification and characterization of an antimicrobial compound secreted by a soil bacterium /." Abstract Full Text (HTML) Full Text (PDF), 2008. http://eprints.ccsu.edu/archive/00000530/02/1979FT.htm.

Mansoor, E. Y. "Immunological approaches to the ecology of Arthrobacter in soil." Thesis, University of Essex, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315755.

Lynch, Ryan P. "Controlling Soilborne Diseases of Potato and Influencing Soil Microbiology with Brassica Cover Crops." Fogler Library, University of Maine, 2008. http://www.library.umaine.edu/theses/pdf/LynchRP2008.pdf.

Kinneer, Krista L. "Size fractionation of bacterial functional diversity within soils." Morgantown, W. Va. : [West Virginia University Libraries], 1999. http://etd.wvu.edu/templates/showETD.cfm?recnum=1095.

Caleb, Oluwafemi James. "Microbial community structure as an indicator of soil health in apple orchards." Thesis, Stellenbosch : University of Stellenbosch, 2010. http://hdl.handle.net/10019.1/4133.

Moodley, Kamini. "Microbial diversity of Antarctic Dry Valley mineral soil." Thesis, University of the Western Cape, 2004. http://etd.uwc.ac.za/index.php?module=etd&amp.

Rhode, Owen H. J. "Intraspecies diversity of Cryptococcus laurentii (Kufferath) C.E. Skinner and Cryptococcus podzolicus (Bab’eva & Reshetova) originating from a single soil sample." Thesis, Stellenbosch : University of Stellenbosch, 2005. http://hdl.handle.net/10019.1/1812.

Kumaresa, Deepak. "Molecular ecology of methanotrophs in a landfill cover soil." Thesis, University of Warwick, 2009. http://wrap.warwick.ac.uk/2771/.

Pino, Vanessa. "Soil Microbial Diversity Across Different Agroecological Zones in New South Wales." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/16705.

AraÃjo, Jackson de Lima. "Arthropods and attributes soil microbiology in fruit trees en Vale do Curu-CE, Brasil." Universidade Federal do CearÃ, 2014. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=13481.

Cartwright, Colin. "Biodegradation and impact of phthalate plasticisers on a soil microbial community." Thesis, University of Kent, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264768.

Burden, John P. "The survival, activity and distribution of gentamicin-producing Micromonospora in soil." Thesis, University of Warwick, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302692.

Kurtboke, Dilber Ipek. "New approaches to the isolation of non-streptomycete actinomycetes from soil." Thesis, University of Liverpool, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314514.

Leech, Fiona. "Influence of alternative fertilizers on pasture production, soil properties and soil microbial community structure." Thesis, The University of Sydney, 2019. https://hdl.handle.net/2123/21460.

Wang, Jing, and 王静. "Culture-independent analysis of anammox, AOA and AOB in paddy soil of Sanjiang Plain in Northeast China." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B4622158X.

Walter, Diana Joyce, and dianawalter@internode on net. "The Environmental Impact of Genetically Modified Crop Plants on the Microbiology of the Rhizosphere." Flinders University. Biotechnology, 2005. http://catalogue.flinders.edu.au./local/adt/public/adt-SFU20070301.161014.

Quinones, Casilda. "Influence of three organic solvents on soil microbial activity." Thesis, The University of Arizona, 1985. http://etd.library.arizona.edu/etd/GetFileServlet?file=file:///data1/pdf/etd/azu_e9791_1985_420_sip1_w.pdf&type=application/pdf.

Barakat, Mohammad 1962. "Seasonal fluctuation in soil and thatch microbial populations in an 80%:20% sand:peat creeping bentgrass putting green." Thesis, The University of Arizona, 1991. http://hdl.handle.net/10150/277909.

Chapman, Joshua A. "Soil microbial communities from the alimentary canal of the earthworm Lumbricus terrestris (Oligochaeta: lumbricidae)." Morgantown, W. Va. : [West Virginia University Libraries], 2006. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=4756.

Millar, Neville. "The effect of improved fallow residue quality on nitrous oxide emissions from tropical soils." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268667.

Woodward, Rebecca Stanton Wain. "Analysis of tetracycline resistance in compost bacilli." Thesis, University of Liverpool, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259753.

Edvantoro, Bagus Bina. "Bioavailability, toxicity and microbial volatilisation of arsenic in soils from cattle dip sites." Title page, Contents and Abstract only, 2000. http://web4.library.adelaide.edu.au/theses/09A/09ae24.pdf.

Johnson-Rollings, Ashley S. "A polyphasic approach to the study of chitinolytic bacteria in soil." Thesis, University of Warwick, 2012. http://wrap.warwick.ac.uk/51637/.

Mueller, Sabrina R. "Chromium, DNA, and Soil Microbial Communities." Cincinnati, Ohio : University of Cincinnati, 2006. http://rave.ohiolink.edu/etdc/view.cgi?acc_num=ucin1141334651.

Nielsen, Uffe Nygaard. "Influences on species richness and composition of belowground communities at multiple spatial scales." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources, 2008. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=24811.

Iker, Brandon Charles. "Application of Advanced Molecular Techniques in Applied Environmental Microbiology." Diss., The University of Arizona, 2013. http://hdl.handle.net/10150/301699.

Cogram, Kirstie J. "The effects of seaweed extracts on soilborne diseases, soil microbiology and the growth of wheat." Thesis, University of Bristol, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336244.

Parekh, Nisha Rajnikant Parekh. "New approaches to the selective isolation of wall chemotype IV actinomycestes from soil." Thesis, University of Liverpool, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333669.

Cundiff, Gary Thomas. "Using Arbuscular Mycorrhizae to Influence Yield, Available Soil Nutrients and Soil Quality in Conventional VS. Organic Vegetable Production." TopSCHOLAR®, 2012. http://digitalcommons.wku.edu/theses/1155.

Davies, Nicholas Julian. "Microbial response to simulated climate change in Antarctic fellfield soil." Thesis, University of Kent, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242859.

Chattopadhyay, Suhana. "Ecosystem Controls on Soil Microbial Guilds: dynamics and carbon sequestration." Kent State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=kent1397749555.

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Gene variants foretell the biology of future breast cancers in Stanford Medicine study

In a finding that vastly expands the understanding of tumor evolution, researchers discover genetic biomarkers that can predict the breast cancer subtype a patient is likely to develop.

May 30, 2024 - By Krista Conger

Stanford Medicine researchers found that inherited gene sequences can predict what type of breast cancer a patient is likely to develop, along with how aggressive that cancer may be. Emily Moskal

A Stanford Medicine study of thousands of breast cancers has found that the gene sequences we inherit at conception are powerful predictors of the breast cancer type we might develop decades later and how deadly it might be.

The study challenges the dogma that most cancers arise as the result of random mutations that accumulate during our lifetimes. Instead, it points to the active involvement of gene sequences we inherit from our parents — what’s known as your germline genome — in determining whether cells bearing potential cancer-causing mutations are recognized and eliminated by the immune system or skitter under the radar to become nascent cancers.

“Apart from a few highly penetrant genes that confer significant cancer risk, the role of hereditary factors remains poorly understood, and most malignancies are assumed to result from random errors during cell division or bad luck,” said Christina Curtis , PhD, the RZ Cao Professor of Medicine and a professor of genetics and of biomedical data science. “This would imply that tumor initiation is random, but that is not what we observe. Rather, we find that the path to tumor development is constrained by hereditary factors and immunity. This new result unearths a new class of biomarkers to forecast tumor progression and an entirely new way of understanding breast cancer origins.”

Curtis is the senior author of the study, which will be published May 31 in Science . Postdoctoral scholar Kathleen Houlahan , PhD, is the lead author of the research.

“Back in 2015, we had posited that some tumors are ‘born to be bad’ — meaning that their malignant and even metastatic potential is determined early in the disease course,” Curtis said. “We and others have since corroborated this finding across multiple tumors, but these findings cast a whole new light on just how early this happens.”

A new take on cancer’s origin

The study, which gives a nuanced and powerful new understanding of the interplay between newly arisen cancer cells and the immune system, is likely to help researchers and clinicians better predict and combat breast tumors.

Currently, only a few high-profile cancer-associated mutations in genes are regularly used to predict cancers, but these account for a small minority of cases. Those include BRCA1 and BRCA2, which occur in about one of every 500 women and confer an increased risk of breast or ovarian cancer, and rarer mutations in a gene called TP53 that causes a disease called Li Fraumeni syndrome, which predisposes to childhood and adult-onset tumors.

Christina Curtis

The findings suggest there are tens or hundreds of additional gene variants — identifiable in healthy people — that through interactions with the immune system pull the strings that determine why some people remain cancer-free throughout their lives.

“Our findings not only explain which subtype of breast cancer an individual is likely to develop,” Houlahan said, “but they also hint at how aggressive and prone to metastasizing that subtype will be. Beyond that, we speculate that these inherited variants may influence a person’s risk of developing breast cancer. However, future studies will be needed to examine this.”

The genes we inherit from our parents are known as our germline genome. They’re mirrors of our parents’ genetic makeup, and they can vary among people in small ways that give some of us blue eyes, brown hair or type O blood. Some inherited genes include mutations that confer increased cancer risk from the get-go, such as BRCA1, BRCA2 and TP53.

In contrast, most cancer-associated genes are part of what’s known as our somatic genome. As we live our lives, our cells divide and die in the tens of millions. Each time the DNA in a cell is copied, mistakes happen and mutations can accumulate. DNA in tumors is often compared with the germline genomes in blood or normal tissues in an individual to pinpoint which changes likely led to the cell’s cancerous transformation.

Classifying breast cancers

In 2012, Curtis began a deep dive — assisted by machine learning — into the types of somatic mutations that occur in thousands of breast cancers. She was eventually able to categorize the disease into 11 subtypes with varying prognoses and risk of recurrence, finding that four of the 11 groups were significantly more likely to recur even 10 or 20 years after diagnosis — critical information for clinicians making treatment decisions and discussing long-term prognoses with their patients.

Prior studies had shown that people with inherited BRCA1 mutations tend to develop a subtype of breast cancer known as triple negative breast cancer. This correlation implies some behind-the-scenes shenanigans by the germline genome that affects what subtype of breast cancer someone might develop.

“We wanted to understand how inherited DNA might sculpt how a tumor evolves,” Houlahan said. To do so, they took a close look at the immune system.

It’s a quirk of biology that even healthy cells routinely decorate their outer membranes with small chunks of the proteins they have bobbing in their cytoplasm — an outward display that reflects their inner style.

Kathleen Houlahan

The foundations for this display are what’s known as HLA proteins, and they are highly variable among individuals. Like fashion police, immune cells called T cells prowl the body looking for any suspicious or overly flashy bling (called epitopes) that might signal something is amiss inside the cell. A cell infected with a virus will display bits of viral proteins; a sick or cancerous cell will adorn itself with abnormal proteins. These faux pas trigger the T cells to destroy the offenders.

Houlahan and Curtis decided to focus on oncogenes, normal genes that, when mutated, can free a cell from regulatory pathways meant to keep it on the straight and narrow. Often, these mutations take the form of multiple copies of the normal gene, arranged nose to tail along the DNA — the result of a kind of genomic stutter called amplification. Amplifications in specific oncogenes drive different cancer pathways and were used to differentiate one breast cancer subtype from another in Curtis’ original studies.

The importance of bling

The researchers wondered whether highly recognizable epitopes would be more likely to attract T cells’ attention than other, more modest displays (think golf-ball-sized, dangly turquoise earrings versus a simple silver stud). If so, a cell that had inherited a flashy version of an oncogene might be less able to pull off its amplification without alerting the immune system than a cell with a more modest version of the same gene. (One pair of overly gaudy turquoise earrings can be excused; five pairs might cause a patrolling fashionista T cell to switch from tutting to terminating.)

The researchers studied nearly 6,000 breast tumors spanning various stages of disease to learn whether the subtype of each tumor correlated with the patients’ germline oncogene sequences. They found that people who had inherited an oncogene with a high germline epitope burden (read: lots of bling) — and an HLA type that can display that epitope prominently — were significantly less likely to develop breast cancer subtypes in which that oncogene is amplified.

There was a surprise, though. The researchers found that cancers with a large germline epitope burden that manage to escape the roving immune cells early in their development tended to be more aggressive and have a poorer prognosis than their more subdued peers.

“At the early, pre-invasive stage, a high germline epitope burden is protective against cancer,” Houlahan said. “But once it’s been forced to wrestle with the immune system and come up with mechanisms to overcome it, tumors with high germline epitope burden are more aggressive and prone to metastasis. The pattern flips during tumor progression.”

“Basically, there is a tug of war between tumor and immune cells,” Curtis said. “In the preinvasive setting, the nascent tumor may initially be more susceptible to immune surveillance and destruction. Indeed, many tumors are likely eliminated in this manner and go unnoticed. However, the immune system does not always win. Some tumor cells may not be eliminated and those that persist develop ways to evade immune recognition and destruction. Our findings shed light on this opaque process and may inform the optimal timing of therapeutic intervention, as well as how to make an immunologically cold tumor become hot, rendering it more sensitive to therapy.”

The researchers envision a future when the germline genome is used to further stratify the 11 breast cancer subtypes identified by Curtis to guide treatment decisions and improve prognoses and monitoring for recurrence. The study’s findings may also give additional clues in the hunt for personalized cancer immunotherapies and may enable clinicians to one day predict a healthy person’s risk of developing an invasive breast cancer from a simple blood sample.

“We started with a bold hypothesis,” Curtis said. “The field had not thought about tumor origins and evolution in this way. We’re examining other cancers through this new lens of hereditary and acquired factors and tumor-immune co-evolution.”

The study was funded by the National Institutes of Health (grants DP1-CA238296 and U54CA261719), the Canadian Institutes of Health Research and the Chan Zuckerberg Biohub.

About Stanford Medicine

Stanford Medicine is an integrated academic health system comprising the Stanford School of Medicine and adult and pediatric health care delivery systems. Together, they harness the full potential of biomedicine through collaborative research, education and clinical care for patients. For more information, please visit med.stanford.edu .

Hope amid crisis

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