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Health May 19, 2024

Beyond Traditional Diet Pills: Groundbreaking New Weight Loss Drug Is More Effective Than Current Treatments

A revolutionary study published in Nature introduces a new obesity treatment that surpasses the weight loss results of current drugs in mice. This method involves…

New Drug Makes Exercise Easier for People With Common Heart Condition

How a Newly Mapped Brain Circuit Could Transform Panic Disorder Treatment

Scientists Discover Potential Opioid Replacement for Back Pain

Pills in Disguise: The Surprising Surge of Fentanyl Seizures

Unlocking Cancer’s Code: Johns Hopkins Researchers Reveal How Cells Go Rogue

Earning Cash While Losing Pounds: “Game of Stones” Proves Successful

MIT Researchers Identify Genetic Markers That Could Revolutionize ALS Treatment

Outrunning the Grim Reaper: Study Shows That Elite Runners Live Nearly Five Years Longer Than the General Population

Health May 17, 2024

Scientists Uncover Unexpected Hidden Dangers of a Common Antibiotic

In emergency rooms and intensive care units nationwide, healthcare professionals must quickly decide on antibiotics for patients suspected of having severe infections. A recent study…

Lifesaving Discovery – First Effective Treatment Found for Spitting Cobra Snakebite

Scientists have developed a pioneering treatment for snakebites that effectively prevents the severe tissue damage inflicted by the venom of African spitting cobras. Spitting cobra…

Metformin Unveils Its Hidden Talent in Cancer Prevention

A study suggests that metformin, typically used for type 2 diabetes, may reduce the risk of myeloproliferative neoplasms (MPN) by leveraging its anti-inflammatory effects to…

Unlocking the Secrets of Aging: Chinese Researchers Discover Potential Key to Alzheimer’s Disease

A groundbreaking study conducted by Prof. Qiang Liu’s team at the University of Science and Technology of China (USTC), and published in the journal Cell…

Health May 16, 2024

Virtual Reality Shows Promise As Depression Treatment

A recent study published in JMIR Mental Health highlights the promising potential of virtual reality (VR) in treating major depressive disorder (MDD). Led by Dr….

Weight Loss Wonders: New Study Uncovers Surprising Benefits of the Protein Kallistatin

New research indicates that weight loss in overweight individuals boosts Kallistatin expression in fat tissue, enhancing metabolism and presenting a new target for treating obesity…

High-Potency Cannabis Doubles Psychosis Risk in Young Adults

A new study indicates that high-potency cannabis use between the ages of 16 and 18 doubles the risk of psychotic experiences from 19-24, compared to…

Alarming Virus Evolution – Scientists Identify First-Ever Mammal-to-Human Bird Flu Case

The Biological Threat Research Laboratory (BTRL) at Texas Tech University was instrumental in identifying the first case of highly pathogenic avian influenza (HPAI) A (H5N1)…

Assassin Gene Discovery Shifts Cancer Treatment Paradigms – “Very Unexpected Finding”

Scientists have discovered that the way cancer cells die from chemotherapy appears to be different than previously understood. New research highlights the Schlafen11 gene’s role…

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Epic science inside a cubic millimeter of brain

Venki Ramakrishnan.

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Science is making anti-aging progress. But do we want to live forever?

Nobel laureate details new book, which surveys research, touches on larger philosophical questions

Anne J. Manning

Harvard Staff Writer

Mayflies live for only a day. Galapagos tortoises can reach up to age 170. The Greenland shark holds the world record at over 400 years of life. 

Venki Ramakrishnan, Nobel laureate and author of the newly released “ Why We Die: The New Science of Aging and the Quest for Immortality ,” opened his packed Harvard Science Book Talk last week by noting the vast variabilities of lifespans across the natural world. Death is certain, so far as we know. But there’s no physical or chemical law that says it must happen at a fixed time, which raises other, more philosophical issues.

The “why” behind these enormous swings, and the quest to harness longevity for humans, have driven fevered attempts (and billions of dollars in research spending) to slow or stop aging. Ramakrishnan’s book is a dispassionate journey through current scientific understanding of aging and death, which basically comes down to an accumulation of chemical damage to molecules and cells.

“The question is whether we can tackle aging processes, while still keeping us who we are as humans,” said Ramakrishnan during his conversation with Antonio Regalado, a writer for the MIT Technology Review. “And whether we can do that in a safe and effective way.”

Even if immortality — or just living for a very, very long time — were theoretically possible through science, should we pursue it? Ramakrishnan likened the question to other moral ponderings.

“There’s no physical or chemical law that says we can’t colonize other galaxies, or outer space, or even Mars,” he said. “I would put it in that same category. And it would require huge breakthroughs, which we haven’t made yet.”

In fact, we’re a lot closer to big breakthroughs when it comes to chasing immortality. Ramakrishnan noted the field is moving so fast that a book like his can capture but a snippet. He then took the audience on a brief tour of some of the major directions of aging research. And much of it, he said, started in unexpected places.

Take rapamycin, a drug first isolated in the 1960s from a bacterium on Easter Island found to have antifungal, immunosuppressant, and anticancer properties. Rapamycin targets the TOR pathway, a large molecular signaling cascade within cells that regulates many functions fundamental to life. Rapamycin has garnered renewed attention for its potential to reverse the aging process by targeting cellular signaling associated with physiological changes and diseases in older adults.

Other directions include mimicking the anti-aging effects of caloric restriction shown in mice, as well as one particularly exciting area called cellular reprogramming. That means taking fully developed cells and essentially turning back the clock on their development.

The most famous foundational experiment in this area was by Kyoto University scientist and Nobel laureate Shinya Yamanaka, who showed that just four transcription factors could revert an adult cell all the way back to a pluripotent stem cell, creating what are now known as induced pluripotent stem cells.

Ramakrishnan , a scientist at England’s MRC Laboratory of Molecular Biology, won the 2009 Nobel Prize in chemistry for uncovering the structure of the ribosome. He said he felt qualified to write the book because he has “no skin in the game” of aging research. As a molecular biologist who has studied fundamental processes of how cells make proteins, he had connections in the field but wasn’t too close to any of it.

While researching the book, he took pains to avoid interviewing scientists with commercial ventures tied to aging.

The potential for conflicts of interest abound.

The world has seen an explosion in aging research in recent decades, with billions of dollars spent by government agencies and private companies . And the consumer market for products is forecast to hit $93 billion by 2027 .

As a result, false or exaggerated claims by companies promising longer life are currently on the rise, Ramakrishnan noted. He shared one example: Supplements designed to lengthen a person’s telomeres, or genetic segments that shrink with age, are available on Amazon.

“Of course, these are not FDA approved. There are no clinical trials, and it’s not clear what their basis is,” he said.

But still there appears to be some demand.

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Nih research matters.

December 22, 2021

2021 Research Highlights — Promising Medical Findings

Results with potential for enhancing human health.

With NIH support, scientists across the United States and around the world conduct wide-ranging research to discover ways to enhance health, lengthen life, and reduce illness and disability. Groundbreaking NIH-funded research often receives top scientific honors. In 2021, these honors included Nobel Prizes to five NIH-supported scientists . Here’s just a small sample of the NIH-supported research accomplishments in 2021.

Printer-friendly version of full 2021 NIH Research Highlights

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Advancing COVID-19 treatment and prevention

Amid the sustained pandemic, researchers continued to develop new drugs and vaccines for COVID-19. They found oral drugs that could  inhibit virus replication in hamsters and shut down a key enzyme that the virus needs to replicate. Both drugs are currently in clinical trials. Another drug effectively treated both SARS-CoV-2 and RSV, another serious respiratory virus, in animals. Other researchers used an airway-on-a-chip to screen approved drugs for use against COVID-19. These studies identified oral drugs that could be administered outside of clinical settings. Such drugs could become powerful tools for fighting the ongoing pandemic. Also in development are an intranasal vaccine , which could help prevent virus transmission, and vaccines that can protect against a range of coronaviruses .

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Developments in Alzheimer’s disease research

One of the hallmarks of Alzheimer’s is an abnormal buildup of amyloid-beta protein. A study in mice suggests that antibody therapies targeting amyloid-beta protein could be more effective after enhancing the brain’s waste drainage system . In another study, irisin, an exercise-induced hormone, was found to improve cognitive performance in mice . New approaches also found two approved drugs (described below) with promise for treating AD. These findings point to potential strategies for treating Alzheimer’s. Meanwhile, researchers found that people who slept six hours or less per night in their 50s and 60s were more likely to develop dementia later in life, suggesting that inadequate sleep duration could increase dementia risk.

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New uses for old drugs

Developing new drugs can be costly, and the odds of success can be slim. So, some researchers have turned to repurposing drugs that are already approved for other conditions. Scientists found that two FDA-approved drugs were associated with lower rates of Alzheimer’s disease. One is used for high blood pressure and swelling. The other is FDA-approved to treat erectile dysfunction and pulmonary hypertension. Meanwhile, the antidepressant fluoxetine was associated with reduced risk of age-related macular degeneration. Clinical trials will be needed to confirm these drugs’ effects.

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Making a wireless, biodegradable pacemaker

Pacemakers are a vital part of medical care for many people with heart rhythm disorders. Temporary pacemakers currently use wires connected to a power source outside the body. Researchers developed a temporary pacemaker that is powered wirelessly. It also breaks down harmlessly in the body after use. Studies showed that the device can generate enough power to pace a human heart without causing damage or inflammation.

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Fungi may impair wound healing in Crohn’s disease

Inflammatory bowel disease develops when immune cells in the gut overreact to a perceived threat to the body. It’s thought that the microbiome plays a role in this process. Researchers found that a fungus called  Debaryomyces hansenii  impaired gut wound healing in mice and was also found in damaged gut tissue in people with Crohn’s disease, a type of inflammatory bowel disease. Blocking this microbe might encourage tissue repair in Crohn’s disease.

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Nanoparticle-based flu vaccine

Influenza, or flu, kills an estimated 290,000-650,000 people each year worldwide. The flu virus changes, or mutates, quickly. A single vaccine that conferred protection against a wide variety of strains would provide a major boost to global health. Researchers developed a nanoparticle-based vaccine that protected against a broad range of flu virus strains in animals. The vaccine may prevent flu more effectively than current seasonal vaccines. Researchers are planning a Phase 1 clinical trial to test the vaccine in people.

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A targeted antibiotic for treating Lyme disease

Lyme disease cases are becoming more frequent and widespread. Current treatment entails the use of broad-spectrum antibiotics. But these drugs can damage the patient’s gut microbiome and select for resistance in non-target bacteria. Researchers found that a neglected antibiotic called hygromycin A selectively kills the bacteria that cause Lyme disease. The antibiotic was able to treat Lyme disease in mice without disrupting the microbiome and could make an attractive therapeutic candidate.

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Retraining the brain to treat chronic pain

More than 25 million people in the U.S. live with chronic pain. After a treatment called pain reprocessing therapy, two-thirds of people with mild or moderate chronic back pain for which no physical cause could be found were mostly or completely pain-free. The findings suggest that people can learn to reduce the brain activity causing some types of chronic pain that occur in the absence of injury or persist after healing.

2021 Research Highlights — Basic Research Insights >>

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Reproductive rights in America

Despite state bans, abortions nationwide are up, driven by telehealth.

Elissa Nadworny

Abortion rights activists at the Supreme Court in Washington, D.C. on March 26, the day the case about the abortion drug mifepristone was heard. The number of abortions in the U.S. increased, a study says, surprising researchers. Drew Angerer/AFP via Getty Images hide caption

Abortion rights activists at the Supreme Court in Washington, D.C. on March 26, the day the case about the abortion drug mifepristone was heard. The number of abortions in the U.S. increased, a study says, surprising researchers.

In the 18 months following the Supreme Court's decision that ended federal protection for abortion, the number of abortions in the U.S. has continued to grow, according to The Society of Family Planning's WeCount project .

"We are seeing a slow and small steady increase in the number of abortions per month and this was completely surprising to us," says Ushma Upadhyay , a professor and public health scientist at the University of California, San Francisco who co-leads the research. According to the report, in 2023 there were, on average, 86,000 abortions per month compared to 2022, where there were about 82,000 abortions per month. "Not huge," says Upadhyay, "but we were expecting a decline."

Shots - Health News

What's at stake in the supreme court mifepristone case.

The slight increase comes despite the fact that 14 states had total abortion bans in place during the time of the research. According to the report, there were about 145,000 fewer abortions in person in those states since the Dobbs decision, which triggered many of the restrictive state laws.

"We know that there are people living in states with bans who are not getting their needed abortions," says Upadhyay. "The concern we have is that that might be overlooked by these increases."

Florida, California and Illinois saw the largest surges in abortions, which is especially interesting given Florida's recent 6-week ban that started on May 1.

Abortion rights opponents demonstrate in New York City, on March 23. Some states' abortion bans are known as "heartbeat bills," because they make abortion illegal after cardiac activity starts, usually around six weeks of pregnancy. Kena Betancur/AFP via Getty Images hide caption

Abortion rights opponents demonstrate in New York City, on March 23. Some states' abortion bans are known as "heartbeat bills," because they make abortion illegal after cardiac activity starts, usually around six weeks of pregnancy.

The latest report also captures for the first time the impact of providers offering telehealth abortions from states with protections for doctors and clinics known as shield laws – statutes that say they can't be prosecuted or held liable for providing abortion care to people from other states.

Between July and December 2023, more than 40,000 people in states with abortion bans and telehealth restrictions received medication abortion through providers in states protected by shield laws. Abortion pills can be prescribed via telehealth appointments and sent through the mail; the pills can safely end pregnancies in the first trimester.

The report includes abortions happening within the U.S. health care system, and does not include self-managed abortions, when people take pills at home without the oversight of a clinician. For that reason, researchers believe these numbers are still an undercount of abortions happening in the U.S.

Tessa Longbons Cox is a senior research associate at Charlotte Lozier Institute, a research organization that opposes abortion. She says the WeCount report, "highlights a concerning trend" that policies around mail-order abortion pills are boosting abortion rates. "By recklessly removing in-person medical visits and safeguards, abortion advocates have put women's health and safety last," Longbons Cox says in a statement.

Accounting for the increases

A major factor in the uptick in abortions nationwide is the rise of telehealth, made possible in part by regulations first loosened during the coronavirus pandemic.

According to the report, telehealth abortions now make up 19% of all abortions in the U.S. In comparison, the first WeCount report which spanned April 2022 through August 2022 showed telehealth abortions accounted for just 4% of all abortions. Research has shown that telehealth abortions are as safe and effective as in-clinic care.

"It's affordable, it's convenient, and it feels more private," says Jillian Barovick, a midwife in Brooklyn and one of the co-founders of Juniper Midwifery , which offers medication abortion via telehealth to patients in six states where abortion is legal. The organization saw its first patient in August 2022 and now treats about 300 patients a month.

A Supreme Court abortion pill case with potential consequences for every other drug

"Having an in-clinic abortion, even a medication abortion, you could potentially be in the clinic for hours, whereas with us you get to sort of bypass all of that," she says. Instead, patients can connect with a clinician using text messages or a secure messaging platform. In addition to charging $100 dollars for the consultation and medication – which is well below the average cost of an abortion – Barovick points to the cost savings of not having to take off work or arrange child care to spend multiple hours in a clinic.

She says her patients receive their medication within 1 to 4 business days, "often faster than you can get an appointment in a clinic."

A study published in JAMA Internal Medicine on Monday followed about 500 women who had medication abortions with the pills distributed via mail order pharmacy after an in-person visit with a doctor. More than 90% of the patients were satisfied with the experience; there were three serious adverse events that required hospitalization.

In addition to expansions in telehealth, there have been new clinics in states like Kansas, Illinois and New Mexico, and there's been an increase in funding for abortion care – fueled by private donors and abortion funds.

The impact of shield laws

During the period from October to December 2023, nearly 8,000 people per month in states with bans or severe restrictions accessed medication abortions from clinicians providing telehealth in the 5 states that had shield laws at the time. That's nearly half of all monthly telehealth abortions.

"It's telemedicine overall that is meeting the need of people who either want to or need to remain in their banned or restricted state for their care," says Angel Foster, who founded The MAP, a group practice operating a telehealth model under Massachusetts' shield laws. "If you want to have your abortion care in your state and you live in Texas or Mississippi or Missouri, right now, the shield law provision is by far the most dominant way that you'd be able to get that care."

Foster's group offers medication abortions for about 500 patients a month. About 90% of their patients are in banned or restrictive states; about a third are from Texas, their most common state of origin, followed by Florida.

"Patients are scared that we are a scam," she says, "they can't believe that we're legit."

Since the WeCount data was collected, additional states including Maine and California have passed shield laws protecting providers who offer care nationwide. The new shield laws circumvent traditional telemedicine laws, which often require out-of-state health providers to be licensed in the states where patients are located. States with abortion bans or restrictions and/or telehealth bans hold the provider at fault, not the patient.

The NPR Politics Podcast

One small pill — one big court case.

Existing lawsuits brought by abortion opponents, including the case awaiting a Supreme Court decision, have the potential to disrupt this telehealth surge by restricting the use of the drug mifepristone nationwide. If the Supreme Court upholds an appeals court ruling, providers would be essentially barred from mailing the drug and an in-person doctor visit would be required.

There is also an effort underway in Louisiana to classify abortion pills as a controlled substance.

• abortion bans
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Are We Talking Too Much About Mental Health?

Recent studies cast doubt on whether large-scale mental health interventions are making young people better. Some even suggest they can have a negative effect.

By Ellen Barry

In recent years, mental health has become a central subject in childhood and adolescence. Teenagers narrate their psychiatric diagnosis and treatment on TikTok and Instagram. School systems, alarmed by rising levels of distress and self-harm, are introducing preventive coursework in emotional self-regulation and mindfulness.

Now, some researchers warn that we are in danger of overdoing it. Mental health awareness campaigns, they argue, help some young people identify disorders that badly need treatment — but they have a negative effect on others, leading them to over-interpret their symptoms and see themselves as more troubled than they are.

The researchers point to unexpected results in trials of school-based mental health interventions in the United Kingdom and Australia: Students who underwent training in the basics of mindfulness , cognitive behavioral therapy and dialectical behavior therapy did not emerge healthier than peers who did not participate, and some were worse off, at least for a while.

And new research from the United States shows that among young people, “self-labeling” as having depression or anxiety is associated with poor coping skills, like avoidance or rumination.

In a paper published last year , two research psychologists at the University of Oxford, Lucy Foulkes and Jack Andrews, coined the term “prevalence inflation” — driven by the reporting of mild or transient symptoms as mental health disorders — and suggested that awareness campaigns were contributing to it.

“It’s creating this message that teenagers are vulnerable, they’re likely to have problems, and the solution is to outsource them to a professional,” said Dr. Foulkes, a Prudence Trust Research Fellow in Oxford’s department of experimental psychology, who has written two books on mental health and adolescence.

Until high-quality research has clarified these unexpected negative effects, they argue, school systems should proceed cautiously with large-scale mental health interventions.

“It’s not that we need to go back to square one, but it’s that we need to press pause and reroute potentially,” Dr. Foulkes said. “It’s possible that something very well-intended has overshot a bit and needs to be brought back in.”

This remains a minority view among specialists in adolescent mental health, who mostly agree that the far more urgent problem is lack of access to treatment.

About 60 percent of young Americans with severe depression receive no treatment, according to Mental Health America, a nonprofit research group. In crisis, desperate families fall back on emergency rooms, where teens often remain for days before a psychiatric bed opens up. There is good reason to embrace a preventive approach, teaching schoolchildren basic skills that might forestall crises later, experts say.

Dr. Foulkes said she understood that her argument runs counter to that consensus, and when she began to present it, she braced for a backlash. To her surprise, she said, many educators reached out to express quiet agreement.

“There’s definitely a fear about being the one to say it,” she said.

A deflating result

In the summer of 2022, the results of a landmark study on mindfulness training in British classrooms landed — like a lead balloon.

The trial, My Resilience in Adolescence, or MYRIAD, was ambitious, meticulous and expansive, following about 28,000 teenagers over eight years. It had been launched in a glow of optimism that the practice would pay off, improving the students’ mental health outcomes in later years.

Half of the teenagers were trained by their teachers to direct their attention to the present moment — breathing, physical sensations or everyday activities — in 10 lessons of 30 to 50 minutes apiece.

The results were disappointing . The authors reported “no support for our hypothesis” that mindfulness training would improve students’ mental health. In fact, students at highest risk for mental health problems did somewhat worse after receiving the training, the authors concluded.

But by the end of the eight-year project, “mindfulness is already embedded in a lot of schools, and there are already organizations making money from selling this program to schools,” said Dr. Foulkes, who had assisted on the study as a postdoctoral research associate. “And it’s very difficult to get the scientific message out there.”

Why, one might ask, would a mental health program do harm?

Researchers in the study speculated that the training programs “bring awareness to upsetting thoughts,” encouraging students to sit with darker feelings, but without providing solutions, especially for societal problems like racism or poverty. They also found that the students didn’t enjoy the sessions and didn’t practice at home.

Another explanation is that mindfulness training could encourage “co-rumination,” the kind of long, unresolved group discussion that churns up problems without finding solutions.

As the MYRIAD results were being analyzed, Dr. Andrews led an evaluation of Climate Schools, an Australian intervention based on the principles of cognitive behavioral therapy, in which students observed cartoon characters navigating mental health concerns and then answered questions about practices to improve mental health.

Here, too, he found negative effects. Students who had taken the course reported higher levels of depression and anxiety symptoms six months and 12 months later.

Co-rumination appears to be higher in girls, who tend to come into the program more distressed, as well as more attuned to their friends, he said. “It might be,” he said, “that they kind of get together and make things a little bit worse for each other.”

Dr. Andrews, a Wellcome Trust research fellow, has since joined an effort to improve Climate Schools by addressing negative effects. And he has concluded that schools should slow down until “we know the evidence base a bit more.” Sometimes, he said, “doing nothing is better than doing something.”

The awareness paradox

One problem with mental health awareness, some research suggests, is that it may not help to put a label to your symptoms.

Isaac Ahuvia, a doctoral candidate at Stony Brook University, recently tested this in a study of 1,423 college students . Twenty-two percent “self-labeled” as having depression, telling researchers “I am depressed” or “I have depression,” but 39 percent met the diagnostic criteria for depression.

He found that the students who self-labeled felt that they had less control over depression and were more likely to catastrophize and less likely to respond to distress by putting their difficulties in perspective, compared with peers who had similar depression symptoms.

Jessica L. Schleider, a co-author of the self-labeling study, said this was no surprise. People who self-label “appear to be viewing depression as a biological inevitability,” she said. “People who don’t view emotions as malleable, view them as set and stuck and uncontrollable, tend to cope less well because they don’t see a point to trying.”

But Dr. Schleider, an associate professor of medical social sciences at Northwestern University and the director of the university’s Lab for Scalable Mental Health, pushed back on the prevalence inflation hypothesis. She disagreed with the claim that students are overdiagnosing themselves, noting that Mr. Ahuvia’s findings suggest otherwise.

Awareness campaigns are bound to have multiple effects, helping some students and not others. And ultimately, she argued, the priority for public health should be reaching young people in the most distress.

“The urgency of the mental health crisis is so clear,” she said. “In the partnerships that I have, the emphasis is on the kids truly struggling right now who have nothing — we need to help them — more so than a possible risk for a subset of kids who aren’t really struggling.”

Maybe, she said, we need to look beyond the “universal, school-assembly-style approach,” to targeted, light-touch interventions, which research has shown can be effective at decreasing anxiety and conduct disorders, especially in younger children.

“There is a risk of throwing the baby out with the bathwater,” Dr. Schleider said. “The response can’t be ‘Forget all of it.’ It should be ‘What about this intervention was unhelpful?’”

Other researchers echoed her concern, pointing to studies that show that on average, students benefit from social and emotional learning courses.

One of the largest, a 2023 meta-analysis of 252 classroom programs in 53 countries, found that students who participated performed better academically, displayed better social skills and had lower levels of emotional distress or behavioral problems. In that context, negative effects in a handful of trials appear modest, the researchers said.

“We clearly have not figured out how to do them yet, but I can’t imagine any population-based intervention that the field got right the first time,” said Dr. Andrew J. Gerber, the president and medical director of Silver Hill Hospital and a practicing child and adolescent psychiatrist.

“Really, if you think about almost everything we do in schools, we don’t have great evidence for it working,” he added. “That doesn’t mean we don’t do it. It just means that we’re constantly thinking about ways to improve it.”

‘We want everyone to have it’

These debates are taking place a long way away from classrooms, where mental health curriculums are increasingly commonplace.

Allyson Kangisser, a counselor at Woodsdale Elementary School in Wheeling, W.Va., said the focus in her school is on basic coping skills. In the early grades, students are asked, “What things can you do to take care of yourself when you’re having big feelings?”

Starting in third grade, they take on more complex material, such as watching cartoon characters to distinguish transient stress from chronic conditions like depression. “We’re not trying to have them diagnose themselves,” Ms. Kangisser said. “We are saying, what do you feel — this one? Or this one?”

At the school’s sixth annual mental health fair last month, Woodsdale students walked through a giant inflatable brain, its lobes neatly labeled. They did yoga stretches and talked about regulating their emotions. Ms. Kangisser said the event is valuable precisely because it is universal, so troubled children are not singled out.

“The mental health fair, everybody does it,” she said. “It’s not ‘You need it, and you don’t.’ We want everyone to have it, because you just never know.”

By the time the students reach college, they will have absorbed enormous amounts of information about mental health — from school, but also from social media and from one another.

Dr. Jessica Gold, chief wellness officer for the University of Tennessee system, said the college students she sees are recognizably different — more comfortable speaking about their emotions and more willing to be vulnerable. They also overuse diagnostic terms and have the self-assurance to question a psychiatrist’s judgment.

“It’s sort of a double-edged sword,” she said. “We want people to talk about this more, but we don’t want that to lead to overdiagnosis or incorrect diagnosis or overtreatment. We want it to lead to normalizing of having feelings.”

Lucy Kim, a Yale senior who has lobbied for better mental health support on campus, described the prevalence inflation hypothesis as “disheartening, dismissive and potentially dangerous,” providing another way to discount the experiences of young people.

“As a college student, I see a generation of young people around me impacted by a depth and breadth of loneliness, exhaustion and disillusionment suggestive of a malaise that goes deeper than the general vicissitudes of life,” said Ms. Kim, 23.

Overdiagnosis does happen, she said, and so does glorification of mental health disorders. But stigma and barriers to treatment remain the bigger problem. “I can confidently say I have never heard anyone respond to disclosures of depression with ‘That’s so cool, I wish I had that, too,’” she said.

Ellen Barry is a reporter covering mental health for The Times. More about Ellen Barry

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Sad Girl Playlists Aren’t Just Trendy—Study Finds Sad Music Can Boost Your Mental Health

• New research suggests that listening to sad music can positively impact a person’s mood based on the sense of connectedness it provides.
• Experts cite three responses to sad music: grief, melancholia, and sweet sorrow.
• Experts agree that music of all kinds can play a role in people’s mental health and mood, but music is a personal, unique experience for each listener.

A new study found that listening to sad music can impact a person’s mood positively, based on a revived sense of connectedness.

When you’re at a party or social gathering you may queue an upbeat song, such as “That’s What I Like” by Bruno Mars. On other days, you might just want to listen to something that’s a bit more gloomy and relatable like Taylor Swift’s “Anti-Hero.”

Whatever music you enjoy listening to most, whether that be hip-hop, country, rock, or jazz, it can oftentimes influence your mood and feelings.

This is especially true when it comes to sad music. Various features of a song, including tempo, mode, instrument choice, and dynamics, can prompt negative emotions in listeners, Tara Venkatesan, PhD, a cognitive scientist at Oxford University and an operatic soprano, told Health.

However, a new study published in the Journal of Aesthetic Education , which Venkatesan was a part of, suggests that while listening to sad music can certainly make people feel sad, doing so may also impact a person’s mood positively and allow them to feel a sense of connectedness.

“Our main point is that the value of sad music lies in its ability to create a sense of connection, regardless of whether it actually evokes sadness in the listener,” Venkatesan clarified. “And it’s that sense of connection, not necessarily the experience of sadness itself, which is what makes listening to sad music really great!”

Getty Images / Westend61

Why Do People Love Sad Music?

The researchers hypothesized that people value sad music for the same reasons they might value sad conversations—a sense of genuine connection.

For example, when someone tells you about their horrible break up, you might feel sad yourself because of how genuinely devastated and lonely they are feeling, Venkatesan explained. However, as you continue talking, you might feel like there’s something meaningful about that interaction and connected with this person in a unique way.

The research team demonstrated sad music’s ability to provide a sense of connection in two parts.

In the first part, the researchers wanted to show that emotional expression is a characteristic value of what music is all about. They gave nearly 400 participants a description of four different songs including:

• A song that “conveys deep and complex emotions” but is “technically very flawed”
• A song that is “technically flawless” but “does not convey deep or complex emotions”
• A song that is “deeply emotional” and “technically flawless”
• A song that is both unemotional and “technically flawed”

Participants were asked to rank songs based on which pieces embodied “what music is all about.”

They found that participants valued emotional expression more than technical proficiency when reviewing their song choices. Highly emotional songs, even of lesser technical value, were chosen at a much higher rate.

For the second part of their experiment, the authors asked 450 new participants to rate how connected they felt when listening to music or participating in conversations that expressed 72 different emotions, including inspiration, love, sadness, contempt, etc.

They found that the emotions that make people feel connected in conversation are also the emotions whose expression in music matched the “what music is all about” highly rated songs: sadness, love, joy, loneliness , and sorrow.

Furthermore, participants said that songs expressing sad emotions like suffering and despair are unpleasant to listen to but still capture the essence of what music is all about and make for high-connection conversations.

“In other words, regardless of whether we enjoy sad music, we value sad music because it creates a sense of connection,” Venkatesan explained.

Other research has suggested that people listen to sad music for no particular motivation other than the fact that they like this music or band. In fact, a 2014 study highlights that nearly a third of participants listened to sad music when they were in a positive mood.

Does Listening to Sad Music Evoke Sadness? 

Whether or not sad music makes a person feel sad depends on each individual and their experience, Shannon Bennett, PhD , site clinical director for NewYork-Presbyterian’s Center for Youth Mental Health, told Health .

For example, a person might feel sad when they hear a certain song because that song might be connected to a particular memory. Since our emotions and memories are very connected, when we listen to a song that evokes a certain memory, it can cause us to feel sad.

“If a piece of music is connected to either of those experiences that could then bring on a real feeling of sadness,” Bennett explained. “But that to me is a more personal experience in terms of how intense that feeling is, how long it lasts, and then importantly what we do with it.”

This aligns with a 2016 study that found people who listen to sad music can perpetuate cycles of negative thinking and often prompts them to think about sad memories or negative thoughts.

Music, and our response to it, is a unique and personal experience.

While sad music can generally make people feel sad, depending on the mental health state of an individual, it can evoke other emotions as well, added Venkatesan. She cited previous research on people’s experience of sad music and noted three main categories expressed: grief, melancholia, and sweet sorrow.

“While grief consisted mainly of negative emotions like despair, both melancholia and sweet sorrow consisted of more mixed emotions like longing and nostalgia and even positive emotions like comfort and pleasure,” she said.

Music and Mental Health

Bennett clarified that sad music does not automatically indicate sad emotion for the listener—it can actually impact the listener’s mental health positively.

“Music can be a way to practice just sitting with a feeling that sometimes is harder to sit with and that is actually emotionally very helpful,” she added. “We call that an emotional exposure that in fact is used in some very well-researched therapy protocols to help us to sit with emotions that we sometimes don’t want to sit with.”

Sad music can also make people feel connected in the same way a heartfelt conversation makes us feel connected, said Venkatesan. “It is very likely that the sense of connection we experience when listening to sad music has positive health benefits.”

Some studies suggest that listening to sad music creates a feeling of “emotional communion” where you share feelings of sadness with the singer or composer. Venkatesan explained that in this case, listening to sad songs may act as a form of virtual contact which can help people feel accepted, understood, and less lonely.

She added that other studies suggest that listening to sad songs allows us to connect with ourselves and reflect on our own emotional experiences which can help with mood regulation.

Venkatesan noted that music, in general, has a profound effect on our brains and physiology and therefore can also impact our mood.

For example, some research suggests that relaxing music can decrease levels of salivary cortisol and psychological stress, which is an indicator of decreased stress and better regulation when responding to a stressor.

Bennett noted in the same way that a sad song might evoke a sad emotional state, there are ways to use music to evoke a positive emotional state. There are also ways that people can choose positive behaviors that might move them in the direction of positive emotion.

Bennett concluded, “My hope is that this research will help people just recognize that feeling sad is okay and also that there are things that we can do to help us move out of that feeling.”

Attie-Picker M, Venkatesan T, Newman GE, Knobe J. On the value of sad music . J Aesthet Educ . Published online April 18, 2023.

Tallahassee Memorial Healthcare. How music affects your mind, mood and body. 

Taruffi L, Koelsch S. The paradox of music-evoked sadness: an online survey . PLoS One . 2014;9(10):e110490. doi:10.1371/journal.pone.0110490

Garrido S, Schubert E, Bangert D. Musical prescriptions for mood improvement: an experimental study . Arts Psychother . 2016;51:46-53. doi:10.1016/j.aip.2016.09.002

Van den Tol AJM, Edwards J, Heflick NA. Sad music as a means for acceptance-based coping . Music Sci . 2016;20(1):68-83. doi:10.1177/1029864915627844

Ooishi Y, Mukai H, Watanabe K, Kawato S, Kashino M. Increase in salivary oxytocin and decrease in salivary cortisol after listening to relaxing slow-tempo and exciting fast-tempo music . PLoS One . 2017;12(12):e0189075. doi:10.1371/journal.pone.0189075

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