clinical research scientist salary nz

• Compensation Data
• > Salary
• > Clinical Research Scientist
• > New Zealand

Last updated: May 25, 2024

Clinical Research Scientist Salary in New Zealand

This page is a promotion for ERI’s Assessor Series and is not intended for professional use. Professionals should subscribe to ERI’s Assessor Series .

NZD 145,378

Explore our salary database, salary recap.

The average pay for a Clinical Research Scientist is NZD 145,378 a year and NZD 70 an hour in New Zealand. The average salary range for a Clinical Research Scientist is between NZD 100,166 and NZD 177,361 . This compensation analysis is based on salary survey data collected directly from employers and anonymous employees in New Zealand.

ERI's  compensation data  are based on  salary surveys  conducted and researched by ERI. Cost of labor  data in the Assessor Series are based on actual housing sales data from commercially available sources, plus rental rates, gasoline prices, consumables, medical care premium costs, property taxes, effective income tax rates, etc.

Find actuarial salary survey data and benchmark salary and pay.

Powered by ERI's Database

Average Salary Chart

• Los Angeles
• United States

Get a free Salary Report tailored to your job title, experience and location

Salary Potential

Estimated salary in 2029:, 5 year change:, shift differentials, calculate your shift differential, what is shift differential pay, about new zealand, new zealand cost of living score:, job summary.

• Plans, organizes, and researches various assignments to increase scientific knowledge on medical-related topics.
• Specifies and researches complex problems.

You May Also Like

White papers.

ERI Economic Research Institute compiles the best salary, cost-of-living, and executive compensation survey data available.

Take the guess work out of setting pay

Determine competitive salary levels, compare employee compensation with market benchmarks, and get instant access to reliable salary survey data online., salaries by country, clinical research scientist, similar job titles, search error, an error occurred when attempting to execute your search., the not found., please try your search again..

• Skip to main navigation
• Skip to main content
• Skip to Chat now
• Skip to footer

Get in touch with us for career information.

We're here from 8:30am to 5pm Monday to Friday – except Wednesdays when we're here from 9.30am to 5pm.

We're closed on all public holidays, including Wellington Anniversary.

Call 0800 601 301

Email us with your career question

PLEASE NOTE: Job profile content may reflect pre-COVID-19 conditions.

• Job profiles

Medical Laboratory Scientist

Kaipūtaiao taiwhanga rongoā.

Alternative titles for Medical Laboratory Scientist:

• Clinical Biochemist
• Clinical Immunologist
• Haematologist
• Histologist
• Medical Cytologist
• Medical Microbiologist
• Transfusion Scientist
• Cytogeneticist

Medical laboratory scientists carry out laboratory tests on blood, tissues and other samples taken from patients.

Medical laboratory scientists usually earn

$52K-$73K per year

Senior medical laboratory scientists can earn

$77K-$106K per year

Source: Te Whatu Ora, 2021-23

Job opportunities

Length of training

4 years of training usually required.

Vocational Pathways More

• Social and community services
• Manufacturing and technology

About the job

Pay for medical laboratory scientists varies depending on experience and where they work.

• Trainee medical laboratory scientists working for Te Whatu Ora Health NZ (previously DHBs) usually earn $52,000 to $58,000 a year.
• Medical laboratory scientists working for Te Whatu Ora with one to six years' experience usually earn $58,000 to $73,000.
• Supervising or senior medical laboratory scientists at Te Whatu Ora can earn up to $106,000.

Sources: APEX and District Health Boards, 'Multi-employer Collective Agreement 2021-2023', 2021.

• PAYE.net.nz website - use this calculator to convert pay and salary information  

(This information is a guide only.  Find out more about the sources of our pay information )

What you will do

Medical laboratory scientists may do some or all of the following:

• test and study blood, tissue and fluid samples
• prepare samples for pathologists
• evaluate tests and report results to doctors
• test, set up, use and maintain laboratory equipment
• maintain laboratory quality assurance and safety standards
• supervise and train other staff such as medical laboratory technicians
• develop new methods and equipment for laboratory testing.

Skills and knowledge

Medical laboratory scientists need to have:

• a good understanding of chemistry, biology, maths and physiology (the study of how living organisms work and respond to diseases)
• practical skills for performing experiments and operating scientific equipment
• thorough understanding of laboratory safety
• the ability to follow scientific procedures.

Working conditions

Medical laboratory scientists:

• do shift work, and may work weekends or be on call
• work in community, hospital, commercial or veterinary diagnostic laboratories
• may travel locally to take samples at doctors' surgeries, hospitals, rest homes, patients' homes and workplaces.

How to enter the job

Entry requirements.

To become a fully qualified medical laboratory scientist you need to:

• have a Bachelor of Medical Laboratory Science
• be registered as a Medical Laboratory Scientist with the Medical Sciences Council of New Zealand
• hold a current practising certificate
• work as a trainee medical laboratory scientist for at least six months.

Alternative entry paths

If you already have a degree.

If you already have a degree, you may be able to do a shorter qualification instead of the Bachelor of Medical Laboratory Science.

Contact the Medical Sciences Council of New Zealand to discuss suitable qualifications.

If you're a medical laboratory technician

If you're already a medical laboratory technician you may be able to do an extra qualification in medical laboratory science to become a medical laboratory scientist if you:

• are a registered medical laboratory technician
• have worked for at least a year in a New Zealand medical diagnostic laboratory
• have a Bachelor of Science or Bachelor of Biomedical Science.
• Medical Sciences Council of New Zealand website – contact details

Secondary education

A tertiary entrance qualification is needed to enter tertiary training. Useful subjects include biology, chemistry and maths.

Personal requirements

Medical laboratory scientists need to be:

• methodical and accurate
• careful and safety-conscious
• good at problem solving
• good at communicating.

Useful experience

Useful experience for medical laboratory scientists includes:

• laboratory work
• scientific work
• work in the health sector.

Registration

Medical laboratory scientists need to be registered with the Medical Sciences Council of New Zealand, and have an Annual Practising Certificate.

• Medical Sciences Council of New Zealand website - registration as a medical laboratory scientist
• Medical Sciences Council of New Zealand website - Annual Practising Certificates

Find out more about training

What are the chances of getting a job, shortage of medical laboratory scientists.

Demand for medical laboratory scientists is high due to:

• an ageing population with more health problems that require tests
• demand for new types of laboratory testing due to greater scientific understanding of biological processes.

Medical laboratory scientist (cytoscientist) appears on Immigration New Zealand's long-term skill shortage list. This means the Government is actively encouraging skilled medical laboratory scientists from overseas to work in New Zealand.

According to the Census, 1,773 medical laboratory scientists worked in New Zealand in 2018.

Chances better for highly skilled scientists

Demand is particularly high for medical laboratory scientists who:

• have experience managing laboratory teams
• have specialist knowledge in laboratory technologies due to technological advances in diagnostic laboratory testing and analytical instrumentation
• specialise in cytoscience as genetic technologies are rapidly advancing and there is a shortage of workers.

Types of employers varied

Most medical laboratory scientists work for hospitals and private laboratory services. 

Other employers include:

• scientific research laboratories
• the New Zealand Blood Service
• universities
• veterinary clinics.
• APEX and District Health Boards, 'Multi-employer Collective Agreement', 2021, (www.tas.health.nz).
• Auckland University of Technology, 'A Future in Medical Laboratory Science', August 2019, (www.aut.ac.nz).
• Broadbent, J, continuing professional development and membership co-ordinator, New Zealand Institute of Medical Laboratory Science, careers.govt.nz interview, April 2021.
• Immigration New Zealand, 'Long-term Skill Shortage List', 27 May 2019, (www.immigration.govt.nz).
• Medical Sciences Council, 'Annual Report: 1 April 2019-31 March 2020’, accessed April 2021, (www.mscouncil.org.nz).
• Medical Sciences Council, 'Medical Laboratory Scientist', accessed March 2021, (www.mscouncil.org.nz).
• New Zealand Institute of Medical Laboratory Science, 'A Career as a Medical Laboratory Scientist or Technician', accessed March 2021, (www.nzimls.org.nz).
• Stats NZ, '2018 Census Data', 2019.

(This information is a guide only. Find out more about the sources of our job opportunities information )

Progression and specialisations

Medical laboratory scientists may progress into managerial or supervisory roles in a laboratory.

With further postgraduate study, they may do research into particular disciplines and scientific methods, or become university lecturers. They may also move into other areas such as teaching, animal health, the food industry, or working for commercial science companies.

Medical laboratory scientists usually specialise in two or more of the following disciplines:

Medical laboratory scientists run tests on body fluids for doctors

Related jobs:

Biochemist kairarau matū koiora.

Biochemists study the chemical structure and function of animals, plants and micro-organisms such as bacteria and viruses. They use this research to develop medical, industrial and agricultural products.

Medical Laboratory Technician Kaihangarau Taiwhanga Rongoā

Medical laboratory technicians take medical samples and run tests under the supervision of scientists and pathologists.

Microbiologist Kaimātai Koiora Mororiki

Microbiologists study micro-organisms, such as bacteria, viruses and fungi, and the effects they have on plants, animals and humans. They also develop products from micro-organisms to benefit humans or the environment.

Pathologist Kaimātai Mate Tangata

Pathologists are doctors who diagnose and study human diseases and conditions. They diagnose health problems by testing tissue and fluid samples taken from patients.

Science Technician Kaihangarau Pūtaiao

Science technicians help scientists carry out research, testing and experiments in areas such as chemistry, earth sciences, life sciences and physical sciences.

Related courses:

Laboratory technology, job vacancy websites:, view a list of job vacancy and recruitment websites.

Last updated 4 July 2023

Back to top

Researcher Salary in New Zealand

Researcher - average salary nz, researcher salary range, researcher - pay by experience level in new zealand, how work experience affects the pay of a researcher, gender breakdown, researcher - jobs by location, researcher - related salaries.

Frequently asked questions about the salary of the Researcher

For Employers

Salary assessor, executive compensation assessor, nonprofit comparables assessor, our process, global salary calculator, relocation assessor, geographic assessor, occupational assessor, request a quote, learn more about eri's assessor platform.

Try a Free Demo

For Job Seekers

Salary calculator, research salaries, cost of living comparison, research cost of living, get a detailed salary report.

Get Your Customized Pay Report

Why SalaryExpert

Want to learn more about our salary data.

Schedule Time to Learn More

White Papers

Webinar recordings, stay up to date on hr news, new zealand, clinical research scientist, $145,315 (nzd)/yr, $69.86 (nzd) /hr, $3,720 (nzd) /yr.

The average clinical research scientist gross salary in New Zealand is $145,315 or an equivalent hourly rate of $70. In addition, they earn an average bonus of $3,720. Salary estimates based on salary survey data collected directly from employers and anonymous employees in New Zealand. An entry level clinical research scientist (1-3 years of experience) earns an average salary of $101,941. On the other end, a senior level clinical research scientist (8+ years of experience) earns an average salary of $180,505.

Data powered by ERI's Salary Expert Database .

This page is a promotion for SalaryExpert’s Assessor Platform and is not intended for professional use.

Professionals should subscribe to SalaryExpert’s Assessor Platform .

ERI’s compensation data are based on salary surveys conducted and researched by ERI. Cost of labor data in the Assessor Series are based on actual housing sales data from commercially available sources, plus rental rates, gasoline prices, consumables, medical care premium costs, property taxes, effective income tax rates, etc.

$159,060 (NZD)

Based on our compensation data, the estimated salary potential for Clinical Research Scientist will increase 9 % over 5 years.

Education data not available for this job

Cost of living is calculated based on accumulating the cost of food, transportation, health services, rent, utilities, taxes, and miscellaneous.

New Zealand (Māori: Aotearoa [aɔˈtɛaɾɔa]) is an island country in the southwestern Pacific Ocean. It consists of two main landmasses—the North Island (Te Ika-a-Māui) and the South Island (Te Waipounamu)—and over 700 smaller islands. It is the sixth-largest island country by area and lies east of Australia across the Tasman Sea and south of the islands of New Caledonia, Fiji, and Tonga. The country's varied topography and sharp mountain peaks, including the Southern Alps, owe much to tectonic uplift...

How Much Should You Be Paid?

Learn About Our Products

• No similar job titles found for this position

Subscribe to SalaryExpert’s Emails

For the latest in HR and compensation news, subscribe to our monthly e-newsletters, blogs, and white papers. Subscribe

• Skip to main menu
• Skip to user menu

What Jobs Can You Get With A Biology Degree - A New Scientist Careers Guide

• Career guides

“What can I do with a biology degree?” is a question biology students often ask themselves. Everything from microscopic proteins and the DNA within the cells of all living organisms to how we interact with complex ecological systems on Earth falls under the realm of biology. Some of the major types of biology include molecular biology , anatomy, physiology and ecology .

With science becoming more interdisciplinary, new careers in biology are emerging as well. Indeed, a degree in biology provides you with knowledge and skills highly relevant to countless industries. 

Graduating from the best universities for biology in the UK, as ranked in the 2024 league table by the Complete University Guide, can lead to lucrative career opportunities. Top universities include Cambridge, University College London (UCL), Oxford, Imperial College London and Durham.

Popular areas where your biology degree will be highly valued include pure biology and life sciences , clinical science , technology and engineering , and environmental science . This article discusses the top three highest paying jobs with a biology degree in each of these fields.

Pure biology and life sciences

Traditional jobs for biology graduates typically involve teaching, research or health promotion. In these fields, you could inspire future biological scientists and conduct high-impact research. With experience and excellence, you could even become a pioneer in whichever area you work in, helping progress the field of biology as a whole.  

• Headteacher

Job role: Headteachers run schools and ensure their success. They are the face of the school and they set out the school’s values and agenda, devise strategies for areas of improvement, comply with health and safety standards, manage finances and foster relationships with students, parents, teachers and, sometimes, politicians. You can still continue to teach biology as a headteacher.

Route: With a biology degree, you could start teaching biology at school once you complete the qualified teacher status (QTS). Get involved with senior roles within your school and help with running the school. Ideally, complete the National Professional Qualification for Headship. After several years of experience as a senior teacher, you could become a headteacher. 

Average salary (experienced): £131,000  

• Professor of biology

Job role: Teaching biological sciences at higher education level is no small feat. Senior lecturers and academics at universities are typically pioneers in their area of interest and have contributed greatly to research, especially at renowned institutions.

Route: Once you have graduated with a BSc in biology, you usually need a Master’s to enter a PhD programme. After working as a research scientist, getting involved in lecturing and doing high-impact research as a postdoc for several years, you could apply for professorship. Senior academics usually end up doing research in a niche area of biology.

Average salary (experienced): £55,000; over £100,000 at certain universities e.g. Cambridge  

• Sports physiologist

Job role: Sports and exercise scientists apply their knowledge of human physiology to help people enhance their sporting performance and improve their overall health. Their working environment may include sports centres, hospitals or research facilities. Many work privately, seeing a range of clients including athletes.

Route: A degree in physiology or biology is typically required; a Master’s or PhD specifically in sports physiology or exercise science can further enhance your employability. After you have established a good reputation, you could manage your own consulting company or work exclusively for high-profile athletes.

Average salary (experienced): £60,000

Naturally, biology is at the heart of medicine and healthcare . Expertise in fields such as genetics , microbiology and biochemistry are driving innovation in the diagnosis and treatment of diseases. If you completed a biology degree, you could do a Master’s, clinical training or placements to qualify for a range of clinical careers.  

• Pathologist

Job role: Pathologists process and examine tissue samples collected from patients to aid the diagnosis of medical conditions. They work with high-tech machines and microscopes and are usually based in hospital labs.

Route: Relevant undergraduate degrees include biology or biomedical science. To work in the NHS, you must enrol onto the Scientist Training Programme (STP) and register with the Health and Care Professions Council (HCPC). You could additionally complete Higher Specialist Scientist Training (HSST) to obtain consultant status.

Average salary (experienced): £69,000

• Clinical scientist

Job role: Clinical scientists can work in a range of specialisms, such as neurophysiology, cardiac science or microbiology. They form a crucial part of a multidisciplinary team to deliver healthcare efficiently and safely. Your exact duties will depend on your chosen career path and may include working as a laboratory technician or seeing patients and performing tests.

Route: This job also involves completion of the STP and HCPC registration, and, optionally, HSST for consultancy. A biology degree is broad enough to allow you to move into most specialisms in clinical science. As a senior clinical scientist, you could take on managerial roles in your department or apply your expertise in biotech , e.g. quality control or research and development.

Average salary (experienced): £68,000

Job role: Geneticists analyse the genomics in all living organisms, but in a clinical setting their focus is limited to human genetics. They study genes involved in health and disease to help medical teams diagnose and offer targeted therapies for genetic conditions and cancers. 

Route: Relevant pre-STP degrees include genetics, biology or other life sciences. A Master’s or PhD is the norm, particularly in academic research. With experience, you could manage genomic research departments, become a professor or move into industries, e.g. the pharmaceutical sector.

Average salary (experienced): £58,000

Technology and engineering

As with most industries, research, medicine and agriculture are becoming heavily reliant on technology. Fields such as biotechnology, bioinformatics and biomedical engineering require excellent knowledge of biology as well as engineering and physics principles. As such, biology graduates with an interest in technological innovation can play a vital role in the biotech sector.

• Data scientist

Job role: Data science is one of the highest paying jobs in tech, particularly in life sciences that deal with large amounts of complex data. Data scientists with a background in biology perform complex data analysis for universities, research facilities or biotech companies with the aim of providing actionable insight.

Route: After a biology degree, you could either do a Master’s in data science or gain relevant experience to land a junior position. Learning advanced methods relating to machine learning and artificial intelligence can significantly boost your job prospects. With experience, you could become a principal data scientist at a biotech firm or an independent consultant data scientist.

Average salary (experienced): £82,500

• Software engineer

Job role: Software engineers with a background in biology design, build and test software for use in biological research at hospitals, labs or biotech firms. They ensure their programme meets their clients’ needs and troubleshoot any potential errors.

Route: A biology degree puts you in a good position to apply to biotech firms for junior positions as employers often prefer candidates with in-depth knowledge of the field. To gain programming skills, you can do a Master’s in software development or become self-taught. With experience, you could move into consultancy or run your own business.

Average salary (experienced): £70,000

• Biomedical engineer

Job role: Biomedical engineering combines principles from biology, physics and engineering to design medical machines and equipment, ranging from prosthetics and implants to surgical robots and scanners. Those in this field often conduct research to build new products to be used in healthcare.

Route: An undergraduate degree in biomedical engineering is the traditional route, but you can still enter this field with a biology degree if you do a relevant Master’s or gain relevant experience, e.g. working as a biological technician. 

As a senior biomedical engineer working in a specialised area, e.g. bionic eyes, you could move into industry and take on managerial roles in health-tech companies. You could also work for the NHS if you complete the STP and register with the HCPC.

Average salary (experienced): £50,000

Environmental and animal care

Biologists working in the environmental and animal care sector offer immense value when it comes to tackling global challenges such as sustainability, conservation , biodiversity and restoration. Environmental scientists can help shape policies and practices aimed at preserving natural environments and safeguarding animal welfare , ensuring a better, greener world.  

Job role: Agronomists supervise agricultural operations and offer guidance to farmers on enhancing soil health and increasing crop yields. Working environments include farms, laboratories and offices. They research soil properties, fertilisers and other substances, and innovate new farming techniques.

Route: A degree in biology with exposure to agriculture is typically sufficient to secure junior positions. Some employers prefer candidates with postgraduate qualifications in certain areas, e.g. crop technology. You could move into consultancy if you become a specialist in advanced methods such as laser weeding.

• Environmental consultant

Job role: Eco consultants investigate the effects of an organisation’s activities on the climate and vice versa. They provide guidance to organisations or governmental bodies on green energy, waste management and environmental regulations. 

Route: After your biology degree, ideally with a focus on ecology, you could complete a Master’s in environmental science to maximise your chances of landing a job and reaching consultancy level quickly. The Knowledge Transfer Partnership (KTP) may be of interest, as it offers postgraduate courses with academic and industrial research projects. With experience, you could become a chartered consultant.

Job role: Zoologists explore animals and their behaviours and may work in academia, wildlife conservation or government. They develop specialisation in one field, such as entomology (insects), ornithology (birds), herpetology (reptiles) or marine biology . Tasks vary based on the sector, but typically involve applying research methods in the field or laboratory to study animals.

Route: Aim to focus on zoology for your biology degree and gain exposure to wildlife conservation. A Master's or PhD degree can significantly enhance your prospects, particularly if you wish to conduct independent research. As you gain experience, you could manage zoology departments, become a consultant or move into environmental journalism.

Average salary (experienced): £48,000

Biology degrees provide a breadth of knowledge about all living organisms and how they interact with the world surrounding them. This, along with their critical thinking and transferable skills, make biology graduates highly employable across sectors. From analysing molecules in disease to building artificial organs or even conserving endangered species, there is no shortage of jobs involving biology .

• Explore careers | National Careers Service [Internet]. Available from: https://nationalcareers.service.gov.uk/explore-careers
• Biological Sciences Rankings 2024 [Internet]. The Complete University Guide. Available from: https://www.thecompleteuniversityguide.co.uk/league-tables/rankings/biological-sciences
• Get into teaching | Get into teaching GOV.UK [Internet]. Get Into Teaching. Available from: https://getintoteaching.education.gov.uk/
• Home | Advance HE [Internet]. Available from: https://www.advance-he.ac.uk/
• Academic jobs - Job Opportunities - University of Cambridge [Internet]. Available from: https://www.jobs.cam.ac.uk/job/?category=1
• NSHCS [Internet]. NSHCS. Available from: https://nshcs.hee.nhs.uk/healthcare-science/healthcare-science-specialisms-explained/
• NSHCS [Internet]. NSHCS. Available from: http://www.nshcs.hee.nhs.uk/programmes/stp
• Genetics Society. Education - genetics society [Internet]. Genetics Society. 2022. Available from: https://genetics.org.uk/careers/education/
• Institute of Analytics - The Future is Here! [Internet]. IoA - Institute of Analytics. Available from: https://ioaglobal.org/
• Get into tech: How to launch a career in IT | BCS [Internet]. Available from: https://www.bcs.org/it-careers/get-into-tech-how-to-build-a-career-in-it/
• Medical engineering [Internet]. Health Careers. 2019. Available from: https://www.healthcareers.nhs.uk/explore-roles/healthcare-science/roles-healthcare-science/physical-sciences-and-biomedical-engineering/medical-engineering
• Agronomist [Internet]. TIAH. Available from: https://beta.tiah.org/w/agronomist
• How to become an Ecologist or Environmental Manager - CIEEM [Internet]. CIEEM. 2024. Available from: https://cieem.net/i-want-to-be/how-to-become-an-eem/
• Science & Research | ZSL [Internet]. The Zoological Society of London. Available from: https://www.zsl.org/what-we-do/science-research

Share this article

Related articles

What Jobs Can You Get With A Criminology Degree - A New Scientist Careers Guide

Best Universities For Biomedical Science in the UK - A New Scientist Careers Guide

How To Become A Clinical Scientist - A New Scientist Careers Guide

Latest articles.

Quantification supports amyloid-PET visual assessment of challenging cases: results from the AMYPAD-DPMS study

• Find this author on Google Scholar
• Find this author on PubMed
• Search for this author on this site
• ORCID record for Lyduine E Collij
• For correspondence: [email protected]
• ORCID record for Gerard N Bischof
• ORCID record for Daniele Altomare
• ORCID record for David Vallez Garcia
• ORCID record for Andrew Stephens
• ORCID record for Zuzana Walker
• ORCID record for Philip Scheltens
• ORCID record for Agneta Nordberg
• ORCID record for Juan Domingo Gispert
• ORCID record for Andres Perissinotti
• ORCID record for Silvia Morbelli
• ORCID record for Valentina Garibotto
• ORCID record for Giovanni B Frisoni
• ORCID record for Frederik Barkhof
• Info/History
• Supplementary material
• Preview PDF

ABSTRACT Several studies have demonstrated the high agreement between routine clinical visual assessment and quantification, suggesting that quantification approaches could support the assessment of less experienced readers and/or in challenging cases. However, all studies to date have implemented a retrospective case collection and challenging cases were generally underrepresented. Methods: In this prospective study, we included all participants (N=741) from the AMYPAD Diagnostic and Patient Management Study (DPMS) with available baseline amyloid-PET quantification. Quantification was done with the PET-only AmyPype pipeline, providing global Centiloid (CL) and regional z-scores. Visual assessment was performed by local readers for the entire cohort. From the total cohort, we selected a subsample of 85 cases 1) for which the amyloid status based on the local reader s visual assessment and CL classification (cut-off=21) was discordant and/or 2) that were assessed with a low confidence (i.e. ≤3 on a 5-point scale) by the local reader. In addition, concordant negative (N=8) and positive (N=8) scans across tracers were selected. In this sample, (N=101 cases: ([18F]flutemetamol, N=48; [18F]florbetaben, N=53) the visual assessments and corresponding confidence by 5 certified independent central readers were captured before and after disclosure of the quantification results. Results: For the AMYPAD-DPMS whole cohort, the overall assessment of local readers highly agreed with CL status (κ=0.85, 92.3% agreement). This was consistently observed within disease stages (SCD+: κ=0.82/92.3%; MCI: κ=0.80/89.8%; dementia: κ=0.87/94.6%). Across all central reader assessments in the challenging subsample, global CL and regional z-scores quantification were considered supportive of visual read in 70.3% and 49.3% of assessments, respectively. After disclosure of quantitative results, we observed an improvement in concordance between the 5 readers (κbaseline=0.65/65.3%; κpost-disclosure=0.74/73.3%) and a significant increase in reader confidence (Mbaseline=4.0 vs. Mpost-disclosure=4.34, W=101056, p<0.001). Conclusion: In this prospective study enriched for challenging amyloid-PET cases, we demonstrate the value of quantification to support visual assessment. After disclosure, both inter-reader agreement and confidence showed a significant improvement. These results are important considering the arrival of anti-amyloid therapies, which utilized the Centiloid metric for trial inclusion and target-engagement. Moreover, quantification could support determining Aβ status with high certainty, an important factor for treatment initiation.

Competing Interest Statement

DISCLOSURES DA, IB, DVG, ILA, AP, and GBF report no relevant disclosures. LEC has received research support from GE Healthcare and Springer Healthcare (funded by Eli Lilly), both paid to institution. Dr. Collij s salary is supported by the MSCA postdoctoral fellowship research grant (#101108819) and the Alzheimer Association Research Fellowship (AARF) grant (#23AARF-1029663). GNB is funded by the Deutsche Forschungsgemeinschaft (DFG) Project ID 431549029 - SFB 1451 and partially by DFG, DR 445/9 1. MB is employed by GE HealthCare. RW is employed by IXICO ltd. RG is employed by Life Molecular Imaging AWS is employed by Life Molecular Imaging ZW has received research support from GE Healthcare. PS is employed by EQT Life Sciences team. AN has received consulting fee from H Lundbeck AB, AVVA pharmaceuticals and honoraria for lecture from Hoffman La Roche. JDG has received research support from GE HealthCare, Roche Diagnostics and Hoffmann La Roche, speaker/consulting fees from Roche Diagnostics, Esteve, Philips Nederlands, Biogen and Life Molecular Imaging and serves in the Molecular Neuroimaging Advisory Board of Prothena Biosciences. AD has received research support from: Siemens Healthineers, Life Molecular Imaging, GE Healthcare, AVID Radiopharmaceuticals, Sofie, Eisai, Novartis/AAA, Ariceum Therapeutics, speaker Honorary/Advisory Boards: Siemens Healthineers, Sanofi, GE Healthcare, Biogen, Novo Nordisk, Invicro, Novartis/AAA, Bayer Vital, Lilly Stock: Siemens Healthineers, Lantheus Holding, Structured therapeutics, Lilly. Patents: Patent for 18F JK PSMA 7 (Patent No.: EP3765097A1; Date of patent: Jan. 20, 2021). SM received speaker honoraria from GE Healthcare, Eli Lilly and Life Molecular Imaging. CB is employed by GE HealthCare. VG is supported by the Swiss national science foundation (project n.320030_185028 and 320030_169876), the Aetas Foundation, the Schmidheiny Foundation, the Velux Foundation, the Fondation privee des HUG. She received support for research and speakers fees from Siemens Healthineers, GE HealthCare, Janssen, Novo Nordisk, all paid to institution. GF is employed by GE HealthCare. FB is supported by the NIHR biomedical research centre at UCLH. Steering committee or Data Safety Monitoring Board member for Biogen, Merck, Eisai and Prothena. Advisory board member for Combinostics, Scottish Brain Sciences. Consultant for Roche, Celltrion, Rewind Therapeutics, Merck, Bracco. Research agreements with ADDI, Merck, Biogen, GE Healthcare, Roche. Co-founder and shareholder of Queen Square Analytics LTD.

Funding Statement

ACKNOWLEDGMENTS The project leading to this paper has also received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 115952. This Joint Undertaking receives the support from the European Union s Horizon 2020 research and innovation programme and EFPIA. This communication reflects the views of the authors and neither IMI nor the European Union and EFPIA are liable for any use that may be made of the information contained herein.

Author Declarations

I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

The details of the IRB/oversight body that provided approval or exemption for the research described are given below:

All participants gave written informed consent. The trial was registered with EudraCT (2017-002527-21). The study was approved by the CCER (Commission Cantonale d Ethique de la Recherche) in Geneva Switzerland (#2017-01408).

I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals.

I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).

I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable.

Data Availability

Data is available upon request through the ADDI platform

https://amypad.eu/

View the discussion thread.

Supplementary Material

Thank you for your interest in spreading the word about medRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Citation Manager Formats

• EndNote (tagged)
• EndNote 8 (xml)
• RefWorks Tagged
• Ref Manager
• Tweet Widget
• Facebook Like
• Google Plus One
• Addiction Medicine (324)
• Allergy and Immunology (632)
• Anesthesia (168)
• Cardiovascular Medicine (2399)
• Dentistry and Oral Medicine (289)
• Dermatology (207)
• Emergency Medicine (381)
• Endocrinology (including Diabetes Mellitus and Metabolic Disease) (850)
• Epidemiology (11795)
• Forensic Medicine (10)
• Gastroenterology (705)
• Genetic and Genomic Medicine (3766)
• Geriatric Medicine (350)
• Health Economics (637)
• Health Informatics (2408)
• Health Policy (939)
• Health Systems and Quality Improvement (905)
• Hematology (342)
• HIV/AIDS (786)
• Infectious Diseases (except HIV/AIDS) (13346)
• Intensive Care and Critical Care Medicine (769)
• Medical Education (368)
• Medical Ethics (105)
• Nephrology (401)
• Neurology (3523)
• Nursing (199)
• Nutrition (528)
• Obstetrics and Gynecology (679)
• Occupational and Environmental Health (667)
• Oncology (1832)
• Ophthalmology (538)
• Orthopedics (221)
• Otolaryngology (287)
• Pain Medicine (234)
• Palliative Medicine (66)
• Pathology (447)
• Pediatrics (1037)
• Pharmacology and Therapeutics (426)
• Primary Care Research (424)
• Psychiatry and Clinical Psychology (3187)
• Public and Global Health (6178)
• Radiology and Imaging (1290)
• Rehabilitation Medicine and Physical Therapy (751)
• Respiratory Medicine (832)
• Rheumatology (380)
• Sexual and Reproductive Health (373)
• Sports Medicine (324)
• Surgery (403)
• Toxicology (50)
• Transplantation (172)
• Urology (147)